Impacts of diversification of cytochrome P450 on plant metabolism.

Abstract:

:Cytochrome P450 monooxygenases (P450s) catalyze a wide variety of monooxygenation reactions in primary and secondary metabolism in plants. The share of P450 genes in each plant genome is estimated to be up to 1%. This implies that the diversification of P450 has made a significant contribution to the ability to acquire the emergence of new metabolic pathways during land plant evolution. The P450 families conserved universally in land plants contribute to their chemical defense mechanisms. Several P450s are involved in the biosynthesis and catabolism of plant hormones. Species-specific P450 families are essential for the biosynthetic pathways of phytochemicals such as terpenoids and alkaloids. Genome wide analysis of the gene clusters including P450 genes will provide a clue to defining the metabolic roles of orphan P450s. Metabolic engineering with plant P450s is an important technology for large-scale production of valuable phytochemicals such as medicines.

journal_name

Biol Pharm Bull

authors

Mizutani M

doi

10.1248/bpb.35.824

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

824-32

issue

6

eissn

0918-6158

issn

1347-5215

pii

DN/JST.JSTAGE/bpb/35.824

journal_volume

35

pub_type

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