Effect of 4-(4-chlorobenzyl)pyridine on rat hepatic microsomal cytochrome P450 and drug-metabolizing enzymes in vivo and in vitro.

abstract：:Cerebral ischemia causes the depletion of oxygen and nutrition from brain tissues, and when persistent, results in irreversible damage to the cell function and survival. The cellular response to ischemic conditions and its mechanisms have been investigated widely in in vivo and in vitro experimental models, yet no stu...

journal_title：Biological & pharmaceutical bulletin

authors： Ujita S,Mizunuma M,Matsuki N,Ikegaya Y

更新日期：2011-01-01 00:00:00

abstract：:The effects of exogenously applied gibberellic acid (GA(3)) or brassinolide (BL) on the H(+)-pumps and aquaporin in the vacuolar membrane of rice seedling leaf sheath were investigated. Antibodies against mung bean H(+)-PPase, the B subunit of V-ATPase, and radish tonoplast intrinsic protein (TIP) cross-reacted with t...

journal_title：Biological & pharmaceutical bulletin

authors： Yang S,Maeshima M,Tanaka Y,Komatsu S

更新日期：2003-01-01 00:00:00

abstract：:Spermatogenesis associated 4 (SPATA4) is a testis-specific gene first cloned by our laboratory, and plays an important role in maintaining the physiological function of germ cells. Accumulated evidence suggests that SPATA4 might be associated with apoptosis. Here we established HeLa cells that stably expressed SPATA4 ...

journal_title：Biological & pharmaceutical bulletin

authors： Jiang J,Li L,Xie M,Fuji R,Liu S,Yin X,Li G,Wang Z

更新日期：2015-01-01 00:00:00

abstract：:Formation of DNA breaking hydroxyfuranone and hydroxypyranone derivatives in the Maillard reaction of glucose and bovine serum albumin (BSA) under physiological conditions was investigated. A mixture of glucose and BSA was incubated at 37 degrees C in water or in 1 M phosphate buffer (pH 7.4). The ethyl acetate/2-prop...

journal_title：Biological & pharmaceutical bulletin

authors： Hiramoto K,Ishihara A,Sakui N,Daishima S,Kikugawa K

更新日期：1998-02-01 00:00:00

abstract：:We investigated the effect of components in grapefruit juice (GFJ) on the transport of vinblastine, a substrate of P-glycoprotein (P-gp), across Caco-2 cells. The apical to basolateral flux of [3H]vinblastine was increased in the presence of GFJ extracts. The steady-state uptake of [3H]vinblastine from the apical side...

journal_title：Biological & pharmaceutical bulletin

authors： Takanaga H,Ohnishi A,Matsuo H,Sawada Y

更新日期：1998-10-01 00:00:00

abstract：:Daiokanzoto (DKT) and lubiprostone (LPS) are drugs used for constipation, but few studies have compared them. This study examined the effectiveness, adverse events, and medical economic efficiency of DKT and LPS for constipation. Patients who received DKT (DKT group) and those who received LPS (LPS group) during admis...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshida A,Hirose T,Kuroda A,Mitsuoka M,Shinoda Y,Mori K,Kawachi Y,Tanaka K,Takeda A,Sugiyama T,Yoshimura T

更新日期：2019-01-01 00:00:00

abstract：:Cisplatin-induced nephrotoxicity is related to an increase in lipid peroxidation and oxygen free radicals in a kidney. In the present study, we investigated the effect of the dietary antioxidants, capsaicin (Cap), against cisplatin-induced lipid peroxidation and nephrotoxicity in rats. Nephrotoxicity induced by treatm...

journal_title：Biological & pharmaceutical bulletin

authors： Shimeda Y,Hirotani Y,Akimoto Y,Shindou K,Ijiri Y,Nishihori T,Tanaka K

更新日期：2005-09-01 00:00:00

abstract：:Schwann cell injury is observed in diabetic neuropathy. It is speculated that glycolaldehyde (GA), a precursor of advanced glycation end products (AGEs), contributes to the pathogenesis and development of diabetic neuropathy. Here, we demonstrated for the first time that GA at near-physiological concentration decrease...

journal_title：Biological & pharmaceutical bulletin

authors： Sato K,Tatsunami R,Yama K,Tampo Y

更新日期：2013-01-01 00:00:00

abstract：:This study investigated the effects of compounds isolated from 70% ethanol (EtOH) extraction of Smilax china L. (SCE), a plant belonging to the family Smilacaceae on nicotine-induced endothelial dysfunction (ED) in human umbilical vein endothelial cells. We isolated 10 compounds from ethyl acetate (EtOAc) fraction of ...

journal_title：Biological & pharmaceutical bulletin

authors： Lincha VR,Zhao BT,Woo MH,Yang IJ,Shin HM

更新日期：2016-01-01 00:00:00

abstract：:Oyaksungisan, the herbal prescription composed of eleven herbs, has been widely used in treatment of cerebral infarct in Oriental Medicine. However, the mechanisms by which the herbal formula affects on the production of pro- and anti-inflammatory cytokines in cerebral infarction patients remain unknown yet. The secre...

journal_title：Biological & pharmaceutical bulletin

authors： Kim Y,So HS,Kim JK,Park C,Lee JH,Woo WH,Cho KH,Moon BS,Park R

更新日期：2007-06-01 00:00:00

abstract：:Ras, a small G-protein, physiologically directs cell proliferation and cell cycle via regulation of mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling cascade. Dysregulation of Ras/MEK/ERK signaling has been reported to cause tumorigenesis and gliomas. Nobiletin, a citr...

journal_title：Biological & pharmaceutical bulletin

authors： Aoki K,Yokosuka A,Mimaki Y,Fukunaga K,Yamakuni T

更新日期：2013-01-01 00:00:00

abstract：:Microsomal enzyme inducers are known to influence the expression of many transporter proteins and mRNA. In this study, we examined the effects of microsomal enzyme inducers on the mRNA expression of Breast Cancer Resistance Protein (BCRP) and Multidrug Resistance Associated Protein 2 (MRP2) in BALB/c mice. mRNA expres...

journal_title：Biological & pharmaceutical bulletin

authors： Han Y,Sugiyama Y

更新日期：2006-05-01 00:00:00

abstract：:Although macrophage phagocytoses modified low-density lipoprotein (LDL), excessive accumulation of modified LDL induces macrophage foam cell formation, which is a feature of atherosclerotic plaque. Thus, the identification of scavenger receptor for modified LDL will provide better understanding of an atherosclerotic e...

journal_title：Biological & pharmaceutical bulletin

authors： Miki Y,Tachibana Y,Ohminato Y,Fujiwara Y

更新日期：2015-01-01 00:00:00

abstract：:Doxorubicin (DOX) is a potent antitumor agent, but the cardiotoxicity mediated by the formation of reactive oxygen species limit its clinical use. The present study aims to explore electrocardiographic and biochemical evidence for the cardioprotective effect of two antioxidants, Lycium barbarum polysaccharides (LBP, t...

journal_title：Biological & pharmaceutical bulletin

authors： Xin Y,Zhang S,Gu L,Liu S,Gao H,You Z,Zhou G,Wen L,Yu J,Xuan Y

更新日期：2011-01-01 00:00:00

abstract：:Transport mechanisms of p-aminohippurate (PAH) were investigated in rat renal brush-border membrane vesicles. The uptake of PAH was stimulated by an inside-positive membrane potential created by K+ and valinomycin. This potential-stimulated uptake of PAH was inhibited by various anion transport inhibitors and was satu...

journal_title：Biological & pharmaceutical bulletin

authors： Ohoka K,Takano M,Okano T,Maeda S,Inui K,Hori R

更新日期：1993-04-01 00:00:00

abstract：:Using a surface plasmon resonance (SPR) system, we investigated the lipid membrane-binding properties of four analogues of the 18-residue linear amphipathic beta-sheet cationic antimicrobial peptide (KIGAKI)3-NH2, each of which contains a single isoleucine-to-tryptophan substitution. The results of the SPR study revea...

journal_title：Biological & pharmaceutical bulletin

authors： Kamimori H,Blazyk J,Aguilar MI

更新日期：2005-01-01 00:00:00

abstract：:We investigated the cytotoxicity of eight vitamin K3 (VK3) analogs against neuroblastoma cell lines (IMR-32, LA-N-1, NB-39, and SK-N-SH) and normal cell lines (human umbilical vein endothelial cells (HUVEC) and human dermal fibroblasts (HDF)) using a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) a...

journal_title：Biological & pharmaceutical bulletin

authors： Kitano T,Yoda H,Tabata K,Miura M,Toriyama M,Motohashi S,Suzuki T

更新日期：2012-01-01 00:00:00

abstract：:This study aimed to investigate the mechanism underlying the protective effects of manganese complexes of curcumin (Cp-Mn) and diacetylcurcumin (DiAc-Cp-Mn) on kainic acid (KA)-induced excitotoxicity in the rat hippocampus. Systemic injection of KA (10 mg/kg, i.p.) caused seizures and increased the expression of neuro...

journal_title：Biological & pharmaceutical bulletin

authors： Sumanont Y,Murakami Y,Tohda M,Vajragupta O,Watanabe H,Matsumoto K

更新日期：2007-09-01 00:00:00

abstract：:The purpose of the present study was to investigate the efficacy of a liquid culture filtrates of the entomogenous fungus Paecilomyces tenuipes (PTCF) and its main active glycoprotein-enriched (PGF) fraction against hematotoxicity in mice treated with 5-fluorouracil (5-FU). Oral administration of PTCF (100 mg/kg/d) fo...

journal_title：Biological & pharmaceutical bulletin

authors： Takata T,Tanaka T,Yahagi N,Yahagi R,Tsuchida H,Ishigaki Y,Tomosugi N,Fushiya S,Takano F,Ohta T

更新日期：2008-08-01 00:00:00

abstract：:In an effort to characterize active principles for diabetic complication from medicinal mushroom, aldose reductase inhibitors were isolated from the fruiting body of Phellinus linteus and identified as hispidin (5), phelligridimer A (6), davallialactone (7), methyldavallialactone (8), hypholomine B (9), interfungins A...

journal_title：Biological & pharmaceutical bulletin

authors： Lee YS,Kang YH,Jung JY,Kang IJ,Han SN,Chung JS,Shin HK,Lim SS

更新日期：2008-04-01 00:00:00

abstract：:This study aims to determine the potential renal protective effects of Opuntia ficus-indica (L.) Miller (OFI) fruits against cisplatin-induced nephrotoxicity in mice. The antioxidant activity of OFI methanol extract was calculated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulfo...

journal_title：Biological & pharmaceutical bulletin

authors： Okur ME,Ayla Ş,Karadağ AE,Çiçek Polat D,Demirci S,Seçkin İ

更新日期：2020-01-01 00:00:00

abstract：:The liver contrast effects of Sonazoid in two ultrasonographic imaging modes, gray-scale conventional and harmonic, were examined as a time-related study in normal rabbits, and evaluated quantitatively and visually with tumor-model rabbits to estimate the diagnostic potential. Peak enhancement of vessels and parenchym...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe R,Matsumura M,Chen CJ,Kaneda Y,Ishihara M,Fujimaki M

更新日期：2003-09-01 00:00:00

abstract：:DJ-1 was first identified as a novel candidate of an oncogene product in cooperation with an activated ras, and DJ-1 was later found to be a positive regulator of the androgen receptor (AR) transcription activity that was repressed by PIASxalpha. DJ-1 was also found to be an infertility-related protein that was reduce...

journal_title：Biological & pharmaceutical bulletin

authors： Taira T,Iguchi-Ariga SM,Ariga H

更新日期：2004-04-01 00:00:00

abstract：:We examined the protective ability of tea melanin against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced toxicity in C57BL6J mice. Reduced tea melanin (RTM) and non-reduced tea melanin (NRTM) were incorporated to distinguish anti-oxidant activity from alternative pathways. The mice were given a single oral dose of...

journal_title：Biological & pharmaceutical bulletin

authors： Hung YC,Huang GS,Sava VM,Blagodarsky VA,Hong MY

更新日期：2006-11-01 00:00:00

abstract：:This study was designed to test the efficacy of eugenol, a compound obtained from the essential oil of cloves (Syzygium aromaticum) in collagen-induced arthritis (CIA), a well characterized murine model of rheumatoid arthritis. Macroscopic clinical evidence of CIA manifests first as periarticular erythema and edema in...

journal_title：Biological & pharmaceutical bulletin

authors： Grespan R,Paludo M,Lemos Hde P,Barbosa CP,Bersani-Amado CA,Dalalio MM,Cuman RK

更新日期：2012-01-01 00:00:00

abstract：:The recent emergence of multidrug-resistant pathogens and/or pharmacokinetics-pharmacodynamics considerations may result in off-label use of a certain class of antibacterials, including tigecycline. This study was performed to clarify the safety profile of tigecycline in the user-derived manner and to compare it with ...

journal_title：Biological & pharmaceutical bulletin

authors： Kadoyama K,Sakaeda T,Tamon A,Okuno Y

更新日期：2012-01-01 00:00:00

abstract：:Aconitine and higenamine are the major cardioactive compounds obtained from processed aconite. The chronotropic interaction between these two compounds was investigated in isolated right atria of mice. Both aconitine and higenamine potentiated the action of the other. Practolol (1 nM), a selective beta 1-adrenergic an...

journal_title：Biological & pharmaceutical bulletin

authors： Kimura I,Islam MA,Kimura M

更新日期：1996-08-01 00:00:00

abstract：:Platelet activating factor (PAF)-acetylhydrolase (PAF-AH) is an enzyme that hydrolyzes the acetyl ester at the sn-2 position of PAF, and converts it to the inactive metabolite, lyso PAF. This enzyme is distributed widely in the intracellular as well as the extracellular matrix and is believed to be a defense mechanism...

journal_title：Biological & pharmaceutical bulletin

authors： Lee E,Lee SJ,Lee TY,Chang HW

更新日期：2005-04-01 00:00:00

abstract：:We investigated the properties of honokiol, a natural rexinoid, as a regulator of retinoid X receptor (RXR) heterodimers with various partner nuclear receptors (NRs), in comparison with those of the synthetic rexinoid bexarotene. Honokiol alone was hardly capable of activating peroxisome proliferator-activated recepto...

journal_title：Biological & pharmaceutical bulletin

authors： Kotani H,Tanabe H,Mizukami H,Amagaya S,Inoue M

更新日期：2012-01-01 00:00:00

abstract：:The purpose of this study was to investigate the absorption behavior of an ophthalmic drug injected in rabbit periocular tissues. After intracapsular, retrobulbar and palpebral conjunctival injections of 150 microl and 50 microl fluorescein isothiocyanate dextran (FITC-dextran, average molecular weight 11000), leakage...

journal_title：Biological & pharmaceutical bulletin

authors： Sasaki H,Kashiwagi S,Mukai T,Nishida K,Nakamura J,Nakashima M,Ichikawa M

更新日期：1999-09-01 00:00:00