Anti-inflammatory effect of oyaksungisan in peripheral blood mononuclear cells from cerebral infarction patients.

abstract：:Studies were performed to characterize the opioid receptors in guinea pig brain using the radiolabeled opioid antagonists, [3H]naloxone and [3H]diprenorphine and the kappa-agonist [3H]U-69593. The binding of [3H]U-69593 to guinea pig cerebellar membranes was reduced by NaCl, guanyl-5'yl-imidodiphosphate (GppNHp) and N...

journal_title：Biological & pharmaceutical bulletin

authors： Ishige K,Makimura M,Ito Y,Murakoshi Y

更新日期：1993-09-01 00:00:00

abstract：:Alpha1-adrenoceptor antagonists are clinically useful for the improvement of urinary obstruction due to benign prostatic hyperplasia (BPH), and their therapeutic effects are mediated through the blockade of prostatic alpha(1)-adrenoceptors. The present study was undertaken to predict the magnitude and duration of alph...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada S,Kato Y,Okura T,Kagawa Y,Kawabe K

更新日期：2007-07-01 00:00:00

abstract：:The inhibitory effects of various sulfated compounds on the activities of sialidases purified from porcine liver and human placenta were investigated. Among the sulfated compounds tested, heparin, dextran sulfate, condroitin sulfates and sulfatide significantly inhibited the 4-methylumbelliferyl-alpha-N-acetylneuramin...

journal_title：Biological & pharmaceutical bulletin

authors： Nagaoka M,Shiraishi T,Furuhata K,Uda Y

更新日期：1998-11-01 00:00:00

abstract：:An efficient delivery system is required if antisense oligodeoxynucleotides (ODN) are to be utilized for gene therapy. We report herein on the development of a novel ODN delivery system, ODN-encapsulated nano particles (ODN-ENP) using an efficient and simple packaging method. The ODN-ENP consists of a condensed ODN pa...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada Y,Kogure K,Nakamura Y,Inoue K,Akita H,Nagatsugi F,Sasaki S,Suhara T,Harashima H

更新日期：2005-10-01 00:00:00

abstract：:Auditory neuropathy (AN) is a hearing disorder characterized by an abnormal auditory brainstem response (ABR). This study examined experimental AN model induced in mice following increased dosages of pyridoxine. Induced AN was examined for < or =10 weeks following the last pyridoxine treatment. To assess AN, we evalua...

journal_title：Biological & pharmaceutical bulletin

authors： Hong BN,Yi TH,Kim SY,Kang TH

更新日期：2009-04-01 00:00:00

abstract：:The protective effect of panduratin A, isolated from Kaempferia pandurata ROXB. (Zingiberaceae), against tert-butylhydroperoxide (t-BHP)-induced cytotoxicity was investigated in a human hepatoma cell line, HepG2. The tetrazolium dye colorimetric test (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) ...

journal_title：Biological & pharmaceutical bulletin

authors： Sohn JH,Han KL,Lee SH,Hwang JK

更新日期：2005-06-01 00:00:00

abstract：:Chloroplast trnK gene sequences of Cnidium officinale and Ligusticum chuanxiong were determined to establish an effective method for identifying Japanese Senkyu and Chinese Chuanxiong, the two which have the same drug name in Chinese characters, similar external feature, but different botanical origins. Three sites of...

journal_title：Biological & pharmaceutical bulletin

authors： Zhu S,Fushimi H,Han G,Tsuchida T,Uno T,Takano A,Komatsu K

更新日期：2007-03-01 00:00:00

abstract：:Four lavandulyl flavanones, (2S)-2'-methoxykurarinone (1), sophoraflavanone G (2), leachianone A (3), and (-)-kurarinone (4), which are isolated from the roots of Sophora flavescens have been tested for in vitro antimalarial activity against Plasmodium falciparum. Compounds 1-3 showed moderate antimalarial activities ...

journal_title：Biological & pharmaceutical bulletin

authors： Kim YC,Kim HS,Wataya Y,Sohn DH,Kang TH,Kim MS,Kim YM,Lee GM,Chang JD,Park H

更新日期：2004-05-01 00:00:00

abstract：:We determined the in vivo and in vitro antitumor activities of gambogic acid (GA) and one of the possible mechanisms for its inhibitory activities. In vivo antitumor activity of GA was evaluated by the relative tumor growth ratio (T/C) in nude mice, and in vitro inhibition of SPC-A1 cells was measured by 3-(4,5-dimeth...

journal_title：Biological & pharmaceutical bulletin

authors： Wu ZQ,Guo QL,You QD,Zhao L,Gu HY

更新日期：2004-11-01 00:00:00

abstract：:A previous study showed that macelignan extracted from Myristica fragrans has anti-inflammatory properties using hippocampal neuronal and primary microglial cells. Subsequently, a study using animals with chronic lipopolysaccharide (LPS) infusion into the brain showed that oral treatments of macelignan reduced the hip...

journal_title：Biological & pharmaceutical bulletin

authors： Ma J,Hwang YK,Cho WH,Han SH,Hwang JK,Han JS

更新日期：2009-06-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) plays a crucial role in tumor angiogenesis and represents an attractive anticancer target. We have previously demonstrated that a redox-silent analogue of α-tocotrienol, 6-O-carboxypropyl-α-tocotrienol (T3E) exhibits potent anti-carcinogenic property in human malignant mesothe...

journal_title：Biological & pharmaceutical bulletin

authors： Sato A,Virgona N,Ando A,Ota M,Yano T

更新日期：2014-01-01 00:00:00

abstract：:The uric acid concentration in blood has been widely accepted as a diagnostic indicator of hyperuricemia and gout, and its assay method is well established. In the present study, we developed a simple and rapid method for the determination of uric acid in hair, which can be obtained non-invasively. The concentration (...

journal_title：Biological & pharmaceutical bulletin

authors： Kobayashi K,Morioka Y,Isaka Y,Tozawa T

更新日期：1998-04-01 00:00:00

abstract：:A new HPLC method has been developed for measuring clonazepam (CZP) in plasma, using a reversed-phase non-porous silica column packed with 2 microm particles. CZP in plasma was first purified with a column extraction technique and injected onto a non-porous silica column. The calibration curve was linear from 5-200 ng...

journal_title：Biological & pharmaceutical bulletin

authors： Nakamura M,Fukawa K,Sugiyama T,Katagiri Y

更新日期：2004-06-01 00:00:00

abstract：:Two subclones (K562-L and -H) were previously isolated from K562 human leukemic cells according to hemoglobin production: K562-L was expressed in less than 5% and K562-H in more than 90% of dianisidine positive cells. 12-O-Tetradecanoylphorbol-13- acetate (TPA) suppressed the expression of the erythrocytic (glycophori...

journal_title：Biological & pharmaceutical bulletin

authors： Sasaki D,Kosunago S,Mikami T,Matsumoto T,Suzuki M

更新日期：1993-10-01 00:00:00

abstract：:The pharmacokinetics of ketotifen fumarate (KF) was examined after administration in rabbits through four different routes (intravenous, intranasal, oral and rectal). The time-course of the plasma concentration of KF after intravenous administration (1 mg/kg dose) fitted a two-compartment open model. KF was rapidly ab...

journal_title：Biological & pharmaceutical bulletin

authors： Yagi N,Taniuchi Y,Hamada K,Sudo J,Sekikawa H

更新日期：2002-12-01 00:00:00

abstract：:Monoclonal antibodies are widely used for the treatment of various diseases, and because therapeutic monoclonal antibodies are stored in an aqueous solution or in a lyophilized state, the preparation of a stabilizing formulation that prevents their deterioration (degradation and aggregation) is crucial. Given the stru...

journal_title：Biological & pharmaceutical bulletin

authors： Ishikawa T,Ito T,Endo R,Nakagawa K,Sawa E,Wakamatsu K

更新日期：2010-01-01 00:00:00

abstract：:Dermatan sulfate-proteoglycans (DS-PGs) were extracted from rabbit, rat and bovine defatted livers by magnesium chloride extraction and DEAE-cellulose chromatography, and then submitted successively to Asahipak GS-520 gel filtration chromatography, Asahipak ES-502N anion exchange chromatography, and cellulose acetate ...

journal_title：Biological & pharmaceutical bulletin

authors： Koshiishi I,Motoki K,Qiu G,Imanari T

更新日期：1993-04-01 00:00:00

abstract：:R(-)-Apomorphine is a dopamine agonist used for rescue management of motor function impairment associated with levodopa therapy in Parkinson's disease patients. The aim of this study was to examine the role of proton-coupled organic cation antiporter in uptake of R(-)-apomorphine and its S-enantiomer in human brain, u...

journal_title：Biological & pharmaceutical bulletin

authors： Okura T,Higuchi K,Kitamura A,Deguchi Y

更新日期：2014-01-01 00:00:00

abstract：:We investigated the relationship between noradrenaline (NAd)-induced contractions, endothelial function, and hypertension in femoral arteries isolated from spontaneously hypertensive rats (SHR). In the femoral arteries of SHR, vs. age-matched control Wistar Kyoto (WKY) rats, contractions induced by NAd were increased....

journal_title：Biological & pharmaceutical bulletin

authors： Matsumoto T,Watanabe S,Iguchi M,Ando M,Oda M,Nagata M,Yamada K,Taguchi K,Kobayashi T

更新日期：2016-01-01 00:00:00

abstract：:Buckwheat is an ancient and specialty grain in China. Due to its unique chemical and bio-activity components, buckwheat has been found to have many uses in food products and medicine. However, very little is known about the toxicity of protease inhibitors from buckwheat. Here, the possible effects of a recombinant buc...

journal_title：Biological & pharmaceutical bulletin

authors： Wang ZH,Gao L,Li YY,Zhang Z,Yuan JM,Wang HW,Zhang L,Zhu L

更新日期：2007-04-01 00:00:00

abstract：:The overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) switches the function of NO from a physiological neuromodulator to a neurotoxic effector in central nervous system (CNS) after brain injury. From the methanol extracts of Psoralea corylifolia, we purified two inhibitors of NO production ...

journal_title：Biological & pharmaceutical bulletin

authors： Lee MH,Kim JY,Ryu JH

更新日期：2005-12-01 00:00:00

abstract：:Meiosis activating sterol (MAS), the intermediate of cholesterol biosynthesis, is an important substance to stimulate oocytes maturation in FSH-induced signal transduction pathway. Lanosterol 14alpha-demethylase (CYP51) converts lanosterol to MAS. Although MAS is firstly isolated from bovine testis, the information ab...

journal_title：Biological & pharmaceutical bulletin

authors： Wang F,Shen Y,Song X,Xia G,Chen X,Zhou B,Lei L

更新日期：2006-03-01 00:00:00

abstract：:The constituents of the stem bark of Garcinia subelliptica (Guttiferae) were investigated based on its trypanocidal activity against epimastigotes of Trypanosoma cruzi, the etiologic agent for Chagas' disease. As the active components, nine xanthones were isolated including two new ones, 4-hydroxybrasilixanthone B and...

journal_title：Biological & pharmaceutical bulletin

authors： Abe F,Nagafuji S,Okabe H,Higo H,Akahane H

更新日期：2003-12-01 00:00:00

abstract：:A series of anthracene derivatives have been synthesized, and their potential individual cytotoxicity was evaluated using Jurkat T cells and peripheral blood mononuclear cells (PBMCs) in vitro. These compounds, except for 2l, showed less cytotoxicity in PBMCs than mitoxantrone. We also analyzed the antiproliferative a...

journal_title：Biological & pharmaceutical bulletin

authors： Chen RF,Chou CL,Wang MR,Chen CF,Liao JF,Ho LK,Tao CW,Huang HS

更新日期：2004-06-01 00:00:00

abstract：:The effect of aging on the intestinal transport of hydrophilic drugs (and probe compounds) was investigated in the rat small intestine. Passive transport was suggested to be unchanged with aging from 8 (young) to 54 (old) and further to 101 (very old) weeks old, as shown for D-xylose and urea in single-pass intestinal...

journal_title：Biological & pharmaceutical bulletin

authors： Yuasa H,Soga N,Kimura Y,Watanabe J

更新日期：1997-11-01 00:00:00

abstract：:We examined the effects of purified tannins and related compounds (33 species) on NADH-ubiquinone-1 oxidoreductase activity in four kinds of organism (Paracoccus denitrificans, Bacillus subtilis, Photobacterium phosphoreum, and Thermus thermophilus HB-8) and rat liver mitochondria. In addition to pentagalloylglucose, ...

journal_title：Biological & pharmaceutical bulletin

authors： Konishi K,Adachi H,Ishigaki N,Kanamura Y,Adachi I,Tanaka T,Nishioka I,Nonaka G,Horikoshi I

更新日期：1993-07-01 00:00:00

abstract：:D-Aspartate (D-Asp), a free D-amino acid found in mammals, plays crucial roles in the neuroendocrine, endocrine, and central nervous systems. Recent studies have implicated D-Asp in the pathophysiology of infertility and N-methyl-D-Asp receptor-related diseases. D-Asp oxidase (DDO), a degradative enzyme that is stereo...

journal_title：Biological & pharmaceutical bulletin

authors： Katane M,Kawata T,Nakayama K,Saitoh Y,Kaneko Y,Matsuda S,Saitoh Y,Miyamoto T,Sekine M,Homma H

更新日期：2015-01-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) plays an important role in the development of glomerulonephritis. The study of experimental glomerulonephritis in rats was performed to examine the antinephritic effects of TJN-331, a new herbally-derived chemical compound. To clarify the action of TJN-331 ((E)-N-(3,4-dimet...

journal_title：Biological & pharmaceutical bulletin

authors： Saegusa Y,Sadakane C,Koseki J,Hasegawa Y,Shindo S,Maruyama H,Takeda S,Takeda H,Hattori T

更新日期：2010-01-01 00:00:00

abstract：:Nine murine monoclonal antibodies (MAbs) raised against recombinant soluble intercellular adhesion molecule-1 (sICAM-1) were evaluated by means of ELISAs, and their neutralizing activity was investigated in two bioassays employing Raji cells activated with phorbol myristate acetate. Three of the MAbs inhibited autoagg...

journal_title：Biological & pharmaceutical bulletin

authors： Inuzuka H,Seita T,Okamoto K,Iida K,Ogawa Y,Iwasa S

更新日期：1995-08-01 00:00:00

abstract：:As an attempt to find bioactive medicinal herbs exerting anti-asthmatic activity, the effects of an ethanol extract from the parts of Saururus chinensis were evaluated in both in vitro and in vivo. The ethanol extract of S. chinensis (ESC) inhibited generation of the cyclooxygenase-2 (COX-2) dependent phases of prosta...

journal_title：Biological & pharmaceutical bulletin

authors： Lee E,Haa K,Yook JM,Jin MH,Seo CS,Son KH,Kim HP,Bae KH,Kang SS,Son JK,Chang HW

更新日期：2006-02-01 00:00:00