Structural diversity of mammalian hepatic dermatan sulfates.

Abstract:

:Dermatan sulfate-proteoglycans (DS-PGs) were extracted from rabbit, rat and bovine defatted livers by magnesium chloride extraction and DEAE-cellulose chromatography, and then submitted successively to Asahipak GS-520 gel filtration chromatography, Asahipak ES-502N anion exchange chromatography, and cellulose acetate membrane electrophoresis. The disaccharide composition of the glycosaminoglycan chains was determined by differential digestion by chondroitinase ABC, AC, ACII and/or B followed by HPLC for analysis of the resulting unsaturated disaccharides. The hepatic dermatan sulfate chains contained disulfated disaccharide units; Di-diSB and Di-diSE. The hepatic DS-PGs were divided into two groups; Di-diSE-poor DS-PGs and Di-diSE-rich DS-PGs. The iduronic acid content of Di-diSE-poor dermatan sulfate chains was higher than that of Di-diSE-rich ones.

journal_name

Biol Pharm Bull

authors

Koshiishi I,Motoki K,Qiu G,Imanari T

doi

10.1248/bpb.16.335

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

335-9

issue

4

eissn

0918-6158

issn

1347-5215

journal_volume

16

pub_type

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