Effect of 12-O-tetradecanoylphorbol-13-acetate on expression of cell surface antigens in two subclones of human leukemia K562 cells.

abstract：:Hinokitiol (beta-thujaplicin), beta-dolabrin and gamma-thujaplicin isolated from Thujopsis dolabrata SIEB. et ZUCC var hondai MAKINO showed antifungal activities against all of the wood-rotting fungi examined. The antifungal activity of three compounds on Daedalea dickinsii IFO-4979 was especially strong, their minimu...

journal_title：Biological & pharmaceutical bulletin

authors： Inamori Y,Sakagami Y,Morita Y,Shibata M,Sugiura M,Kumeda Y,Okabe T,Tsujibo H,Ishida N

更新日期：2000-08-01 00:00:00

abstract：:The fat-specific protein 27 (Fsp27) gene belongs to the cell death-inducing DNA fragmentation factor 45-like effector family. Fsp27 is highly expressed in adipose tissue as well as the fatty liver of ob/ob mice. Fsp27 is directly regulated by the peroxisome proliferator-activated receptor γ (PPARγ) in livers of geneti...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuo K,Matsusue K,Aibara D,Takiguchi S,Gonzalez FJ,Yamano S

更新日期：2017-01-01 00:00:00

abstract：:An alkaloid piperine isolated from the Piper Nigrum was found to inhibit lipid droplet accumulation in mouse macrophages, and especially inhibited cholesteryl ester (CE) synthesis (IC50: 25 microM). The metabolism of cholesterol from lysosome to lipid droplet was inhibited with a similar IC50 (18 microM), indicating t...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuda D,Ohte S,Ohshiro T,Jiang W,Rudel L,Hong B,Si S,Tomoda H

更新日期：2008-06-01 00:00:00

abstract：:Two different forms of oxytocinase (L-cystine aminopeptidase, CAP; EC 3.4.11.3) were purified from the 9000 g and 105000 g precipitate fractions of human placenta homogenate by sequential chromatography on columns of hydroxyapatite, DE-32, nickel ion affinity, and Sephadex G-200. One species (CAP-I) purifed from the m...

journal_title：Biological & pharmaceutical bulletin

authors： Itoh C,Watanabe M,Nagamatsu A,Soeda S,Kawarabayashi T,Shimeno H

更新日期：1997-01-01 00:00:00

abstract：:We investigated whether tumor necrosis factor (TNF) and caspase-3 activity are involved in the induction of hepatocellular apoptosis in D-galactosamine (D-GalN)-induced hepatotoxicity in mice. Acute hepatotoxicity was induced by the intraperitoneal injection of D-GalN into female BALB/c mice. D-GalN (0.75-3.0 g/kg) in...

journal_title：Biological & pharmaceutical bulletin

authors： Itokazu Y,Segawa Y,Inoue N,Omata T

更新日期：1999-10-01 00:00:00

abstract：:Ge-132 is a synthetic organic germanium that is used as a dietary supplement. The antioxidant activity of Ge-132 on cultured mammalian cells was investigated in this study. First, Ge-132 cytotoxicity on mammalian cultured cells was determined by measuring lactate dehydrogenase (LDH) levels. Ge-132 had no cytotoxic eff...

journal_title：Biological & pharmaceutical bulletin

authors： Wada T,Hanyu T,Nozaki K,Kataoka K,Kawatani T,Asahi T,Sawamura N

更新日期：2018-05-01 00:00:00

abstract：:The radioprotective effects of propolis and polyphenolic compounds from propolis on the radiation-induced mortality of mice exposed to 9 Gy of gamma-irradiation were studied. Intraperitoneal (i.p.) treatment of mice at doses of 100 mg kg(-1) body weight of propolis (water or ethanolic extract; WSDP or EEP) or its poly...

journal_title：Biological & pharmaceutical bulletin

authors： Orsolić N,Benković V,Horvat-Knezević A,Kopjar N,Kosalec I,Bakmaz M,Mihaljević Z,Bendelja K,Basić I

更新日期：2007-05-01 00:00:00

abstract：:This study examined the osteoblast-like MC3T3-E1 cell responses to poly(DL-lactide) (PDLLA) and poly(L-lactide) (PLLA) with different weight average molecular weight (M.W.). Colony formation of MC3T3-E1 cells on the PLLA with M.W. 270000 or 1370000 was slightly lower than that on glass. The protein, DNA and hydroxypro...

journal_title：Biological & pharmaceutical bulletin

authors： Ikarashi Y,Tsuchiya T,Kaniwa M,Nakamura A

更新日期：2000-12-01 00:00:00

abstract：:Many anti-epileptic drugs (AEDs) that mainly target ion channels or post-synaptic receptors are in clinical use, but a proportion of patients are resistant to these traditional AEDs and experience repeated severe break-out seizures. Given its involvement in the etiology of epilepsy, the neurotransmitter glycine may se...

journal_title：Biological & pharmaceutical bulletin

authors： Zhao J,Tao H,Xian W,Cai Y,Cheng W,Yin M,Liang G,Li K,Cui L,Zhao B

更新日期：2016-01-01 00:00:00

abstract：:Costunolide, isolated from the stem bark of Magnolia sieboldii, is a sesquiterpene lactone that exhibits various biological and immunological actions. We investigated the induction mechanism of apoptosis by costunolide in a human B cell leukemia NALM-6 cell culture system. Costunolide (10 microM)-induced apoptosis tim...

journal_title：Biological & pharmaceutical bulletin

authors： Kanno S,Kitajima Y,Kakuta M,Osanai Y,Kurauchi K,Ujibe M,Ishikawa M

更新日期：2008-05-01 00:00:00

abstract：:Qingkailing injection is a well-known composite formula of traditional Chinese medicine and is commonly used in clinical practice, which could offer immunomodulatory effect from our clinical experience on uveitis treatment by Qingkailing. We did the experiment in order to investigate the curative effect and mechanism ...

journal_title：Biological & pharmaceutical bulletin

authors： Tian Q,Bi H,Cui Y,Guo D,Xie X,Su W,Wang X

更新日期：2012-01-01 00:00:00

abstract：:Protein purification is a key technique for the identification of novel sensory nerve-specific proteins. A 35 kDa protein, the sensory neuronal specific protein, was isolated and purified from rabbit spinal ganglia and sensory fibers by homogenizing and deriving soluble extracts, followed by ion exchange chromatograph...

journal_title：Biological & pharmaceutical bulletin

authors： Ping XP,Wang JZ

更新日期：2000-05-01 00:00:00

abstract：:In brain ischemia, cell destructive necrosis occurs in the core, which in turn links to cell death expansion in the vicinity. Apoptosis, on the other hand, occurs in the surroundings of the core, called the penumbra, several days later. As cells showing apoptosis disappear by microglial phagocytosis in the brain, cell...

journal_title：Biological & pharmaceutical bulletin

authors： Ueda H,Fujita R

更新日期：2004-07-01 00:00:00

abstract：:Microsomal enzyme inducers are known to influence the expression of many transporter proteins and mRNA. In this study, we examined the effects of microsomal enzyme inducers on the mRNA expression of Breast Cancer Resistance Protein (BCRP) and Multidrug Resistance Associated Protein 2 (MRP2) in BALB/c mice. mRNA expres...

journal_title：Biological & pharmaceutical bulletin

authors： Han Y,Sugiyama Y

更新日期：2006-05-01 00:00:00

abstract：:Proteasome inhibitors are a novel class of molecular-targeted anti-cancer drugs that suppress the degradation of malfolded proteins, trigger endoplasmic reticulum (ER) stress, and activate apoptosis signals. Glucose-regulated protein 78 (GRP78), a major ER chaperone, is one of the most important molecules for transduc...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumura K,Sakai C,Kawakami S,Yamashita F,Hashida M

更新日期：2014-01-01 00:00:00

abstract：:The inhibitory effects of a potent nitric oxide (NO) synthase inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME), on 2-deoxy-D-glucose (2-DG)-induced hyperglycemia were investigated in rats. L-NAME significantly inhibited 2-DG-induced hyperglycemia, although N(G)-nitro-D-arginine methyl ester (D-NAME) did not affe...

journal_title：Biological & pharmaceutical bulletin

authors： Sugimoto Y,Yamada J,Yoshikawa T,Horisaka K

更新日期：1997-12-01 00:00:00

abstract：:The utility of using a multifunctional envelope-type nano device (MEND) for delivering a gene to the liver was examined. Lipotrust, a commercially available transfection reagent whose lipid composition is DC6- 14 :DOPE: cholesterol=4 : 3 : 3, was used as a reference. When Lipotrust was administrated intravenously, luc...

journal_title：Biological & pharmaceutical bulletin

authors： Yamauchi J,Hayashi Y,Kajimoto K,Akita H,Harashima H

更新日期：2010-01-01 00:00:00

abstract：:We attempted to produce a model mouse with a liver injury resulting from an immunological mechanism in C57BL/6J mice, and the effect of hepatitis on the hepatic microsomal mixed-function oxidase system was studied. An experimental immunological liver injury model was caused by the intravenous injection of an anti-basi...

journal_title：Biological & pharmaceutical bulletin

authors： Ishikawa M,Takayanagi Y,Sasaki K

更新日期：1993-10-01 00:00:00

abstract：:We have developed a mass microscope in which a microscope is combined with high-resolution matrix assisted laser desorption/ionization-imaging mass spectrometry (MALDI-IMS). This technique is a powerful tool for investigating the spatial distribution of biomolecules without the need for any time-consuming extraction, ...

journal_title：Biological & pharmaceutical bulletin

authors： Saito Y,Waki M,Hameed S,Hayasaka T,Setou M

更新日期：2012-01-01 00:00:00

abstract：:The immunoreactivity (specific binding) of three Gly(A1)-sulfobenzoxadiazole-labeled insulins which have different spacer groups, Gly(A1)-[3-(4-sulfobenzoxadiazol-7-ylthio)propanoyl]-insulin , Gly(A1)-[2-(4-sulfobenzoxadiazol-7-ylthio)acetyl]-insulin, Gly(A1)-[3-carboxy-2(or 3)-(4-sulfobenzoxadiazol-7-ylthio)propanoyl...

journal_title：Biological & pharmaceutical bulletin

authors： Nanami M,Zaitsu K,Ohkura Y

更新日期：1993-05-01 00:00:00

abstract：:The intestinal expression of the CYP3A subfamily was investigated in female rats, and the intestinal metabolism of two CYP3A substrates, testosterone and rifabutin, was examined and compared between males and females. CYP3A1/23 and CYP3A2 intestinal expression was barely detected in male and female rats. Although CYP3...

journal_title：Biological & pharmaceutical bulletin

authors： Aiba T,Yoshinaga M,Ishida K,Takehara Y,Hashimoto Y

更新日期：2005-02-01 00:00:00

abstract：:The sialic acid binding lectin from bullfrog Rana catesbeiana oocyte (cSBL) is known to have anti-tumor activity. In order to investigate the relationship between the net charge of cSBL and its anti-tumor effect, cSBL was modified with a water-soluble carbodiimide (EDC) in the presence of three kinds of nucleophiles, ...

journal_title：Biological & pharmaceutical bulletin

authors： Iwama M,Ogawa Y,Sasaki N,Nitta K,Takayanagi Y,Ohgi K,Tsuji T,Irie M

更新日期：2001-09-01 00:00:00

abstract：:Recently, Banhabackchulchunmatang (HMC05) has been implicated as a preventive and/or therapeutic candidate for cardiovascular diseases due to its inhibition of atherosclerosis lesions and its reduction of neointima formation. Knowledge of the mechanism of HMC05 in smooth muscle cells (SMC) is limited. However, SMC may...

journal_title：Biological & pharmaceutical bulletin

authors： Gum SI,Shin HM,Cho MK

更新日期：2014-01-01 00:00:00

abstract：:Hepatoprotective effect of celosian, an acidic polysaccharide isolated from the water extract of the seed of Celosia argentea, was investigated using chemical and immunological liver injury models. Celosian inhibited the elevation of serum enzyme (GPT, GOT, LDH) and bilirubin levels on carbon tetrachloride (CC1(4))-in...

journal_title：Biological & pharmaceutical bulletin

authors： Hase K,Kadota S,Basnet P,Takahashi T,Namba T

更新日期：1996-04-01 00:00:00

abstract：:The present study was conducted to evaluate the effects of Paeoniae Radix (PR), one of the most famous tonic traditional Chinese medicines, on the pharmacokinetics of carbamazepine (CBZ) in rats and to determine the possible interactions between PR and CBZ. The significant decrease in Tmax indicated that simultaneous ...

journal_title：Biological & pharmaceutical bulletin

authors： Chen LC,Chen YF,Chou MH,Lin MF,Yang LL,Yen KY

更新日期：2002-04-01 00:00:00

abstract：:Sixteen cardenolides, two hemiterpenoids, two phenylpropanoids and a phenylethanoid isolated from the roots of Streptocaulon juventas (LOUR.) MERR. were examined for their antiproliferative activity toward three human-derived (HT-1080 fibrosarcoma, lung A549 adenocarcinoma, cervix HeLa adenocarcinoma) and three murine...

journal_title：Biological & pharmaceutical bulletin

authors： Ueda JY,Tezuka Y,Banskota AH,Tran QL,Tran QK,Saiki I,Kadota S

更新日期：2003-10-01 00:00:00

abstract：:A lipid fraction obtained by activity-guided fractionation from the hexane extract of Sideritis javalambrensis was evaluated for anti-inflammatory activity. This fraction significantly inhibited paw oedema induced by carrageenan as well as ear oedema induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) in mice after ...

journal_title：Biological & pharmaceutical bulletin

authors： Godo A,de Heras BL,Vivas JM,Villar A

更新日期：2000-10-01 00:00:00

abstract：:It has been well known that 3-O-methyldopa (3-OMD) is a metabolite of L-3,4-dihydroxyphenylalanine (L-DOPA) formed by catechol O-methyltransferase (COMT), and 3-OMD blood level often reaches higher than physiological level in Parkinson's disease (PD) patients receiving long term L-DOPA therapy. However, the physiologi...

journal_title：Biological & pharmaceutical bulletin

authors： Onzawa Y,Kimura Y,Uzuhashi K,Shirasuna M,Hirosawa T,Taogoshi T,Kihira K

更新日期：2012-01-01 00:00:00

abstract：:We have found a new compound from thermophile extracts which inhibits antigen presentation on mouse macrophages. The substance inhibits the expression of the class II major histocompatibility molecule (Ia). It was extracted from Bacillus stearothermophilus UBT8038 and purified by silica gel column chromatography. The ...

journal_title：Biological & pharmaceutical bulletin

authors： Kohama Y,Itoh M,Tanaka K,Senba T,Itoh S,Mimura T

更新日期：1994-07-01 00:00:00

abstract：:The medial prefrontal cortex (mPFC) plays critical roles in the development of cocaine addiction. Numerous studies have reported about the effects of cocaine on neuronal and synaptic activities in the nucleus accumbens and ventral tegmental area, which are brain regions associated with cocaine addiction; however, a li...

journal_title：Biological & pharmaceutical bulletin

authors： Sasase H,Izumi S,Deyama S,Hinoi E,Kaneda K

更新日期：2019-01-01 00:00:00