Abstract:
:Qingkailing injection is a well-known composite formula of traditional Chinese medicine and is commonly used in clinical practice, which could offer immunomodulatory effect from our clinical experience on uveitis treatment by Qingkailing. We did the experiment in order to investigate the curative effect and mechanism of Qingkailing injection to rat experimental autoimmune uveitis (EAU). EAU was induced in Lewis rats by immunization IRBP1177-1191 in complete Freund's adjuvant in multi-point. We found that Qingkailing injection can alleviate autoimmune uveitis in rats, inhibit the differentiation toward Th1 and Th17 effector cells and the relevant cytokines secretion. The therapeutic effect may also be regulated through increased secretion of interleukin (IL)-10.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Tian Q,Bi H,Cui Y,Guo D,Xie X,Su W,Wang Xdoi
10.1248/bpb.b12-00449subject
Has Abstractpub_date
2012-01-01 00:00:00pages
1991-6issue
11eissn
0918-6158issn
1347-5215pii
DN/JST.JSTAGE/bpb/b12-00449journal_volume
35pub_type
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