Cyclooxygenase-2 inhibitory 1,4-naphthoquinones from Impatiens balsamina L.

Abstract:

:Significant selective cyclooxygenase-2 (COX-2) inhibitory activities were observed for two new 1,4-naphthoquinone sodium salts, sodium 3-hydroxide-2[[sodium 3-hydroxide-1,4-dioxo(2-naphthyl)]ethyl]naphthalene-1,4-dione (impatienolate) (1) and sodium 2-hydroxide-3-(2-hydroxyethyl)naphthalene-1,4-dione (balsaminolate) (2), which were isolated from the corolla of Impatiens balsamina L. (Balsaminaceae). Their structures were elucidated by spectral techniques. Our results offer evidence supporting the use of I. balsamina L. to treat articular rheumatism, pain, and swelling.

journal_name

Biol Pharm Bull

authors

Oku H,Ishiguro K

doi

10.1248/bpb.25.658

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

658-60

issue

5

eissn

0918-6158

issn

1347-5215

journal_volume

25

pub_type

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