In vitro evaluation of nasal mucociliary clearance using excised rat nasal septum.

abstract：:Pairs of forward and reverse primers and TaqMan probes specific to each of 15 human sulfotransferases were prepared. The mRNA expression level of each target enzyme was analyzed in total RNA from single and pooled specimens of various human tissues (adrenal gland, bone marrow, brain, colon, heart, kidney, liver, lung,...

journal_title：Biological & pharmaceutical bulletin

authors： Nishimura M,Naito S

更新日期：2007-04-01 00:00:00

abstract：:We investigated the genotypic status of thiopurine methyltransferase (TPMT) polymorphism to evaluate the possible risk of the toxicity of azathioprine (AZA) in 68 patients with systemic lupus erythematosus (SLE). The allele frequency of TPMT mutation in the SLE group (2.9%) was higher than that in 174 Japanese healthy...

journal_title：Biological & pharmaceutical bulletin

authors： Okada Y,Nakamura K,Kodama T,Ueki K,Tsukada Y,Maezawa A,Tsukamoto N,Nojima Y,Ishizaki T,Horiuchi R,Yamamoto K

更新日期：2005-11-01 00:00:00

abstract：:We examined the effects of purified tannins and related compounds (33 species) on NADH-ubiquinone-1 oxidoreductase activity in four kinds of organism (Paracoccus denitrificans, Bacillus subtilis, Photobacterium phosphoreum, and Thermus thermophilus HB-8) and rat liver mitochondria. In addition to pentagalloylglucose, ...

journal_title：Biological & pharmaceutical bulletin

authors： Konishi K,Adachi H,Ishigaki N,Kanamura Y,Adachi I,Tanaka T,Nishioka I,Nonaka G,Horikoshi I

更新日期：1993-07-01 00:00:00

abstract：:Propiverine hydrochloride, oxybutynin hydrochloride and terodiline hydrochloride have both anticholinergic and antispasmodic effects, and are used for the management of urinary frequency and incontinence. The average standard therapeutic doses of these drugs differ greatly. We retrospectively analyzed their pharmacolo...

journal_title：Biological & pharmaceutical bulletin

authors： Takayanagi R,Mizushima H,Ozeki T,Yokoyama H,Iga T,Yamada Y

更新日期：2007-07-01 00:00:00

abstract：:Accumulation of β-amyloid peptide (Aβ) in the brain plays an important role in the pathogenesis of Alzheimer’s disease (AD). Previous studies have demonstrated the neuroprotective role of osthole against oxygen and glucose deprivation in cortical neurons. However, the effects of osthole on Aβ-induced neurotoxicity in ...

journal_title：Biological & pharmaceutical bulletin

authors： Hu Y,Wen Q,Liang W,Kang T,Ren L,Zhang N,Zhao D,Sun D,Yang J

更新日期：2013-01-01 00:00:00

abstract：:Two C-type lectins (OLLafs and OLLafl) were isolated from Osmerus (Spirinchus) lanceolatus eggs using asialofetuin-Sepharose column. OLLafs and OLLafl were eluted with 0.2 M sucrose and 0.2 M lactose from the same column, respectively. OLLafl has been estimated to be a heterodimeric protein composed of H- and L-subuni...

journal_title：Biological & pharmaceutical bulletin

authors： Sugawara S,Hosono M,Ogawa Y,Takayanagi M,Nitta K

更新日期：2005-05-01 00:00:00

abstract：:Tulobuterol patches are long-acting bronchodilators for percutaneous absorption including the β(2)-adrenoreceptor agonist tulobuterol, as a main ingredient, used for long-term management of pediatric asthma. Since patients who have pediatric asthma often also have atopic dermatitis in which the skin barrier is impaire...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshihara S,Fukuda H,Abe T,Arisaka O

更新日期：2010-01-01 00:00:00

abstract：:To elucidate drug interaction between human immunodeficiency virus (HIV) protease inhibitors (PIs), the effect of indinavir (IDV) on the intestinal exsorption of other HIV PIs, amprenavir (APV), saquinavir (SQV) and nelfinavir (NFV) was investigated in rats using an in situ single perfusion method. IDV in the intestin...

journal_title：Biological & pharmaceutical bulletin

authors： Gao W,Kageyama M,Inoue Y,Tadano J,Fukumoto K,Fukushima K,Yamasaki D,Nishimura A,Yoshikawa Y,Shibata N,Takada K

更新日期：2003-02-01 00:00:00

abstract：:Turnera ulmifolia is a plant belonging to the family Turneraceae, popularly known in Brazil as chanana. This species is distributed from Guyana to southern Brazil where it is considered a weed. The plant occurs in tropical rain forest, fields, and gardens. Chanana tea is used in Brazilian folk medicine for the treatme...

journal_title：Biological & pharmaceutical bulletin

authors： Gracioso Jde S,Vilegas W,Hiruma-Lima CA,Souza Brito AR

更新日期：2002-04-01 00:00:00

abstract：:4-Acetyltropolone, a minor component of Thujopsis dolabrata SIEB. et Zucc. hondai MAKINO, showed antimicrobial activity against various microorganisms including wood-rotting fungi, a phytogrowth-inhibitory effect with chlorophyll biosynthesis inhibition, cytotoxic effect and inhibitory activity on metalloproteases. Th...

journal_title：Biological & pharmaceutical bulletin

authors： Morita Y,Matsumura E,Tsujibo H,Yasuda M,Okabe T,Sakagami Y,Kumeda Y,Ishida N,Inamor Y

更新日期：2002-08-01 00:00:00

abstract：:To determine the mechanism involved, the incorporation rate (ICR) of drugs into hair was compared to melanin affinity, lipophilicity and membrane permeability. The following 20 drugs were tested; amphetamine, methamphetamine, p-hydroxyamphetamine, p-hydroxymethamphetamine, cocaine, benzoylecgonine, ecgonine methyl est...

journal_title：Biological & pharmaceutical bulletin

authors： Nakahara Y,Takahashi K,Kikura R

更新日期：1995-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common type of liver cancer with high mortality worldwide. Traditional chemotherapy for HCC is not widely accepted by clinical practitioners because of its toxic side effects. Thus, there is a need to identify chemotherapeutic drugs against HCC. AMP-activated protein kinase (...

journal_title：Biological & pharmaceutical bulletin

authors： Sul YH,Lee MS,Cha EY,Thuong PT,Khoi NM,Song IS

更新日期：2013-01-01 00:00:00

abstract：:It has been well known that 3-O-methyldopa (3-OMD) is a metabolite of L-3,4-dihydroxyphenylalanine (L-DOPA) formed by catechol O-methyltransferase (COMT), and 3-OMD blood level often reaches higher than physiological level in Parkinson's disease (PD) patients receiving long term L-DOPA therapy. However, the physiologi...

journal_title：Biological & pharmaceutical bulletin

authors： Onzawa Y,Kimura Y,Uzuhashi K,Shirasuna M,Hirosawa T,Taogoshi T,Kihira K

更新日期：2012-01-01 00:00:00

abstract：:Plasma hyaluronan biding protein (PHBP) is a novel serine protease, which has an amino acid sequence homology to that of hepatocyte growth factor activator (HGFA), and has a similar domain structure to that of urinary plasminogen activator (u-PA), found in human plasma. We searched the PHBP substrate in human plasma b...

journal_title：Biological & pharmaceutical bulletin

authors： Choi-Miura NH,Yoda M,Saito K,Takahashi K,Tomita M

更新日期：2001-02-01 00:00:00

abstract：:Transdermal nicotine patch (TNP) contains approximately 16.6 and 24.9 mg of nicotine per 20 and 30 cm2 (TNP-20 and TNP-30). The aims of the study are to investigate linearity of nicotine pharmacokinetics after single application of different strengths of TNP and to directly compare plasma nicotine concentrations with ...

journal_title：Biological & pharmaceutical bulletin

authors： Sobue S,Sekiguchi K,Kikkawa H,Akasaki M,Irie S

更新日期：2006-05-01 00:00:00

abstract：:Although distigmine is known to sometimes cause severe adverse drug reactions (ADRs), such as cholinergic crisis, there are limited data on the risk factors for these ADRs. In this study, we defined a serum cholinesterase (sChE) cutoff level for early detection of ADRs to distigmine and sought to identify risk factors...

journal_title：Biological & pharmaceutical bulletin

authors： Mitsuboshi S,Nagai K,Okajima H

更新日期：2020-01-01 00:00:00

abstract：:The permeability of murine leukemia L1210 cells toward non-permeant fluorescent Lucifer Yellow (LY) was evaluated by flow cytometry following vortex-stirring of cells with LY in the presence of high molecular weight polyacrylic acid (A-119). Permeabilization by this technique was greatly enhanced in growth phase cells...

journal_title：Biological & pharmaceutical bulletin

authors： Noda Y,Shimizu N,Kawazoe Y

更新日期：1996-12-01 00:00:00

abstract：:The genome sequencing project revealed presence of two active chalcone synthase (CHS) homologues (At1g02050 and At4g34850) in the model plant Arabidopsis thaliana. We report herein the two genes encode closely related novel plant-specific type III polyketide synthases (PKSs) that produces long-chain alkyl alpha-pyrone...

journal_title：Biological & pharmaceutical bulletin

authors： Mizuuchi Y,Shimokawa Y,Wanibuchi K,Noguchi H,Abe I

更新日期：2008-12-01 00:00:00

abstract：:We determined the binding affinity of tamsulosin, a selective α(1)-adrenoceptor antagonist, for human α(1)-adrenoceptor subtypes in comparison with those of other α(1)-adrenoceptor antagonists including silodosin, prazosin, 5-methylurapidil, terazosin, alfuzosin, nafopidil, urapidil and BMY7378. The association and di...

journal_title：Biological & pharmaceutical bulletin

authors： Sato S,Hatanaka T,Yuyama H,Ukai M,Noguchi Y,Ohtake A,Taguchi K,Sasamata M,Miyata K

更新日期：2012-01-01 00:00:00

abstract：:The aqueous extract of whole plant of Coronopus didymus LINN (CD) [Family: Bracicacea] was screened for antiallergic, antipyretic and hepatoprotective effects in rats and hypoglycemic activity in mice. The extract showed significant antiallergic, antipyretic, hypoglycemic and hepatoprotective activity at 200 and 400 m...

journal_title：Biological & pharmaceutical bulletin

authors： Mantena SK,Mutalik S,Srinivasa H,Subramanian GS,Prabhakar KR,Reddy KR,Srinivasan KK,Unnikrishnan MK

更新日期：2005-03-01 00:00:00

abstract：:Vonoprazan fumarate (vonoprazan) is a new kind of acid suppressant with potent acid inhibitory effects. Therefore, it has been administered to kidney transplant recipients for treatment or prophylaxis of steroid ulcers, refractory peptic ulcers, and gastroesophageal reflux disease. Because tacrolimus, which is a well-...

journal_title：Biological & pharmaceutical bulletin

authors： Mei T,Noguchi H,Suetsugu K,Hisadome Y,Kaku K,Okabe Y,Masuda S,Nakamura M

更新日期：2020-01-01 00:00:00

abstract：:Sesamin is a major lignan in sesame seeds, and a recent meta-analysis of controlled trials indicated that sesamin intake decreases blood pressure. The antihypertensive effect of sesamin has been suggested to be due to sesamin-mediated suppression of 20-hydroxyeicosatetraenoic acid production catalyzed by CYP4F2. Howev...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe H,Yamaori S,Kamijo S,Aikawa K,Ohmori S

更新日期：2020-01-01 00:00:00

abstract：:Glucocorticoids have multiple systemic effects that may influence bone metabolism but also directly affect osteoblasts by decreasing their proliferation. Using human osteoblastic SaM-1 cells, we examined whether the effects of hydrocortisone on cellular proliferation are mediated by hepatocyte growth factor (HGF). Hum...

journal_title：Biological & pharmaceutical bulletin

authors： Tsunashima Y,Kondo A,Matsuda T,Togari A

更新日期：2011-01-01 00:00:00

abstract：:The objective of this study was to evaluate the interactions between various drugs and aojiru (green juice), a popular health food in Japan, using a simple centrifugation method. The mixture of drug solution and aojiru suspension was gently shaken and centrifuged. The drug concentration in the supernatant fluid was th...

journal_title：Biological & pharmaceutical bulletin

authors： Iwao K,Kawai RT,Oda M,Saitoh H

更新日期：2017-01-01 00:00:00

abstract：:Polyporus (P.) umbellatus, an endangered medicinal fungus in China, is distributed throughout most areas of the country. Thirty-seven natural P. umbellatus samples collected from 12 provinces in China were subjected to the inter-simple sequence repeat (ISSR) assay to investigate the genetic diversity within and among ...

journal_title：Biological & pharmaceutical bulletin

authors： Liu MM,Xing YM,Guo SX

更新日期：2015-01-01 00:00:00

abstract：:The overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) switches the function of NO from a physiological neuromodulator to a neurotoxic effector in central nervous system (CNS) after brain injury. From the methanol extracts of Psoralea corylifolia, we purified two inhibitors of NO production ...

journal_title：Biological & pharmaceutical bulletin

authors： Lee MH,Kim JY,Ryu JH

更新日期：2005-12-01 00:00:00

abstract：:The pharmacological characteristics of Ryokan-kyomi-shinge-nin-to (RKS), a traditional oriental herbal (Kampo) medicine which has been used for the treatment of allergic asthma and rhinitis, were investigated. The number of sneezes by actively sensitized mice after a topical antigen challenge was significantly reduced...

journal_title：Biological & pharmaceutical bulletin

authors： Sakaguchi M,Ikeda Y,Kido T,Yuzurihara M,Kase Y,Yamamoto M,Ishige A,Sasaki H

更新日期：2002-12-01 00:00:00

abstract：:The number of alkalotolerant intestinal bacteria was 1% of the total flora in humans and 0.8% of those in rats. The beta-glucosidase and beta-glucuronidase activity of these intestinal bacteria was induced by elevating the pH of the medium, but the growth was not changed. The enzyme activity in a medium of pH 7 was 5-...

journal_title：Biological & pharmaceutical bulletin

authors： Kim DH,Kang HJ,Park SH,Kobashi K

更新日期：1994-03-01 00:00:00

abstract：:The aim of the present study is to discover multidrug resistance-associated protein (MRP) inhibitors with neuroblastoma-selective cytotoxicity by means of fluorescence assay with a membrane-permeable fluorescent dye, Fluo-8 AM, based on our observation that gene expression of Mrp3 in neuroblastoma Neuro2a cells was re...

journal_title：Biological & pharmaceutical bulletin

authors： Nakamichi N,Ishimoto T,Yamauchi Y,Masuo Y,Kato Y

更新日期：2016-01-01 00:00:00

abstract：:Mast cells are critical for initiating innate immune and inflammatory responses by releasing a number of pro-inflammatory mediators. The potential immunomodulatory properties of hydrogenated aromatic hydrocarbons have been the subject of extensive investigation, as the immune system is a sensitive target for hydrogena...

journal_title：Biological & pharmaceutical bulletin

authors： Kwon O,Lee E,Moon TC,Jung H,Lin CX,Nam KS,Baek SH,Min HK,Chang HW

更新日期：2002-09-01 00:00:00