In Vitro Inhibitory Effects of Sesamin on CYP4F2 Activity.

abstract：:The hepatoprotecive effects of recombinant human epidermal growth factor (hEGF) on chemically and immunologically induced experimental liver injury models were examined. The hEGF clearly decreased serum transaminase levels in D-galactosamine (D-GalN) and D-GalN/lipopolysaccharide (LPS)-induced liver injury models unde...

journal_title：Biological & pharmaceutical bulletin

authors： Cho JY,Yeon JD,Kim JY,Yoo ES,Yu YH,Park MH

更新日期：2000-10-01 00:00:00

abstract：:Reprogramming differentiated cells toward stem cells may have long-term applications in stem-cell research and regenerative medicine. Here we report on the dedifferentiation of human epidermal keratinocytes into their precursor cells in vitro with basic fibroblast growth factor (bFGF) but not external gene interventio...

journal_title：Biological & pharmaceutical bulletin

authors： Sun X,Fu X,Han W,Zhao Y,Liu H,Sheng Z

更新日期：2011-01-01 00:00:00

abstract：:We examined the effects of purified tannins and related compounds (33 species) on NADH-ubiquinone-1 oxidoreductase activity in four kinds of organism (Paracoccus denitrificans, Bacillus subtilis, Photobacterium phosphoreum, and Thermus thermophilus HB-8) and rat liver mitochondria. In addition to pentagalloylglucose, ...

journal_title：Biological & pharmaceutical bulletin

authors： Konishi K,Adachi H,Ishigaki N,Kanamura Y,Adachi I,Tanaka T,Nishioka I,Nonaka G,Horikoshi I

更新日期：1993-07-01 00:00:00

abstract：:Acute pancreatitis (AP) is one kind of acute surgical abdominal disease in the world. It causes intestinal damage with subsequent bacterial migration, endotoxemia and secondary pancreatic infections. In this investigation, we determined that edaravone (EDA) reduces pancreatic and intestinal injury after AP in mice. Th...

journal_title：Biological & pharmaceutical bulletin

authors： Wang B,Lin W

更新日期：2020-01-01 00:00:00

abstract：:Auditory neuropathy (AN) is a hearing disorder characterized by an abnormal auditory brainstem response (ABR). This study examined experimental AN model induced in mice following increased dosages of pyridoxine. Induced AN was examined for < or =10 weeks following the last pyridoxine treatment. To assess AN, we evalua...

journal_title：Biological & pharmaceutical bulletin

authors： Hong BN,Yi TH,Kim SY,Kang TH

更新日期：2009-04-01 00:00:00

abstract：:Transient receptor potential vanilloid 1 (TRPV1) is primarily expressed in central and peripheral terminals of non-myelinated primary afferent neurons. We previously showed that AS1928370, a novel TRPV1 antagonist that can prevent ligand-induced activation but not proton-induced activation, ameliorates neuropathic pai...

journal_title：Biological & pharmaceutical bulletin

authors： Watabiki T,Kiso T,Tsukamoto M,Aoki T,Matsuoka N

更新日期：2011-01-01 00:00:00

abstract：:Chinese medicinal prescriptions were screened for their effects on alpha-amylase activity in mouse plasma. Daio-kanzo-to, Hange-koboku-to, Saiko-ka-ryukotsu-borei-to, Saiko-keishi-kankyo-to and Mao-to changed the activity in isolated mouse plasma greatly and concentration dependently. However, no prescription influenc...

journal_title：Biological & pharmaceutical bulletin

authors： Kobayashi K,Funayama N,Suzuki R,Yoshizaki F

更新日期：2002-08-01 00:00:00

abstract：:To develop potent paclitaxel (PTX) formulations for cancer chemotherapy, we formulated PTX into polymeric nanoparticles composed of polyethylene glycol (PEG) and polylactic acid (PLA) block copolymer (PN-PTX). First, the physicochemical properties of PN-PTX prepared were assessed; the mean particle size was around 80 ...

journal_title：Biological & pharmaceutical bulletin

authors： Araki T,Kono Y,Ogawara K,Watanabe T,Ono T,Kimura T,Higaki K

更新日期：2012-01-01 00:00:00

abstract：:We previously isolated berberine from aqueous extracts of tsu-kan-gan, a Kampo formula used for the treatment of osteoporosis. Berberine caused an inhibitory effect on parathyroid hormone (PTH)-stimulated bone resorption in neonatal mouse bone. In this report we describe the inhibitory effect of berberine on the forma...

journal_title：Biological & pharmaceutical bulletin

authors： Li H,Miyahara T,Tezuka Y,Namba T,Suzuki T,Dowaki R,Watanabe M,Nemoto N,Tonami S,Seto H,Kadota S

更新日期：1999-04-01 00:00:00

abstract：:The effects of nefiracetam on the cerebral adenylyl cyclase (AC) activity of animals with microsphere embolism-induced memory dysfunction were examined. Sustained cerebral ischemia in the right cerebral hemisphere was induced by an injection of microspheres into the right internal carotid artery of rats. To examine le...

journal_title：Biological & pharmaceutical bulletin

authors： Takeo S,Miyake-Takagi K,Kikuchi K,Ando T,Ichikawa T,Omino K,Kajihara H,Takagi N,Tanonaka K

更新日期：2003-03-01 00:00:00

abstract：:Bee pollen consists of floral pollen mixed with bee secretions and nectar. It has been considered as a functional food and has different kinds of biologically active ingredients, such as flavonoids, polyphenols, phytosterols and minerals. However, its function in cognition has yet been investigated. In the present stu...

journal_title：Biological & pharmaceutical bulletin

authors： Liao Y,Bae HJ,Zhang J,Kwon Y,Koo B,Jung IH,Kim HM,Park JH,Lew JH,Ryu JH

更新日期：2019-01-01 00:00:00

abstract：:Nicotiflorin is a single component extracted from traditional Chinese medicine Flos Carthami. In this study, we investigated its neuroprotection in permanent focal cerebral ischemia model in rats, and in an in vitro model of ischemia. At doses of 2.5, 5 and 10 mg/kg, nicotiflorin administered immediately after the ons...

journal_title：Biological & pharmaceutical bulletin

authors： Li R,Guo M,Zhang G,Xu X,Li Q

更新日期：2006-09-01 00:00:00

abstract：:Liposomes were prepared from hydrogenated lecithin (H-PC) by sonication (S) or injection (I) of H-PC dissolved in ethanol containing dl-tocopherol acetate (VEA). The effects of liposomes on the dermal absorption of VEA were studied. The particle diameter of S-liposomes was smaller than that of I-liposomes. The penetra...

journal_title：Biological & pharmaceutical bulletin

authors： Natsuki R,Morita Y,Osawa S,Takeda Y

更新日期：1996-05-01 00:00:00

abstract：:The characteristics of the binding of human lactoferrin (LF) to the cells of a human monocytic leukemia cell line, THP-1, were investigated. 125I-Labeled LF (125I-LF) bound to THP-1 cells, and the binding increased markedly as the cells matured into macrophages (THP-1 macrophages) by stimulation with phorbol 12-myrist...

journal_title：Biological & pharmaceutical bulletin

authors： Eda S,Kikugawa K,Beppu M

更新日期：1996-02-01 00:00:00

abstract：:This study was conducted to demonstrate the inhibitory effect of saucerneol G (SG), a new lignan, isolated from the aerial part of Saururus chinensis (Saururaceae) on lipopolysaccharide (LPS)-stimulated matrix metalloproteinase-9 (MMP)-9 inductions in RAW 264.7 cells. Aimed at evaluating the mechanism of action by whi...

journal_title：Biological & pharmaceutical bulletin

authors： Lu Y,Hong TG,Jin M,Yang JH,Suh SJ,Piao DG,Ko HK,Seo CS,Chang YC,Kim CH,Son JK,Chang HW

更新日期：2010-01-01 00:00:00

abstract：:The overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) switches the function of NO from a physiological neuromodulator to a neurotoxic effector in central nervous system (CNS) after brain injury. From the methanol extracts of Psoralea corylifolia, we purified two inhibitors of NO production ...

journal_title：Biological & pharmaceutical bulletin

authors： Lee MH,Kim JY,Ryu JH

更新日期：2005-12-01 00:00:00

abstract：:Significant selective cyclooxygenase-2 (COX-2) inhibitory activities were observed for two new 1,4-naphthoquinone sodium salts, sodium 3-hydroxide-2[[sodium 3-hydroxide-1,4-dioxo(2-naphthyl)]ethyl]naphthalene-1,4-dione (impatienolate) (1) and sodium 2-hydroxide-3-(2-hydroxyethyl)naphthalene-1,4-dione (balsaminolate) (...

journal_title：Biological & pharmaceutical bulletin

authors： Oku H,Ishiguro K

更新日期：2002-05-01 00:00:00

abstract：:The uric acid concentration in blood has been widely accepted as a diagnostic indicator of hyperuricemia and gout, and its assay method is well established. In the present study, we developed a simple and rapid method for the determination of uric acid in hair, which can be obtained non-invasively. The concentration (...

journal_title：Biological & pharmaceutical bulletin

authors： Kobayashi K,Morioka Y,Isaka Y,Tozawa T

更新日期：1998-04-01 00:00:00

abstract：:The purpose of this study was to investigate the absorption behavior of an ophthalmic drug injected in rabbit periocular tissues. After intracapsular, retrobulbar and palpebral conjunctival injections of 150 microl and 50 microl fluorescein isothiocyanate dextran (FITC-dextran, average molecular weight 11000), leakage...

journal_title：Biological & pharmaceutical bulletin

authors： Sasaki H,Kashiwagi S,Mukai T,Nishida K,Nakamura J,Nakashima M,Ichikawa M

更新日期：1999-09-01 00:00:00

abstract：:Studies on drug disposition in inflamed skin are important for safe and effective application of topical drugs. Here, the absorption of flurbiprofen (FP) through inflamed skin was examined in vivo and in a skin-mimicking artificial model system. The model skin system consisted of a silicone membrane acting as a model ...

journal_title：Biological & pharmaceutical bulletin

authors： Oshima S,Suzuki C,Yajima R,Egawa Y,Hosoya O,Juni K,Seki T

更新日期：2012-01-01 00:00:00

abstract：:The effects of two saline cathartics (sodium chloride and sodium citrate) on the adsorptive capacity of activated charcoal (AC) for rifampicin were studied. Solutions of rifampicin alone and rifampicin with 7.5 mg/ml cathartic solution were vortex-mixed for 30 s with different quantities of AC. These were incubated fo...

journal_title：Biological & pharmaceutical bulletin

authors： Orisakwe OE,Afonne OJ,Agbasi PU,Ilondu NA,Ofoefule SI,Obi E

更新日期：2001-06-01 00:00:00

abstract：:A quantitative structure activity relationship, Hansch approach was applied on twenty compounds of chromene derivatives as Lanosterol 14alpha-demethylase inhibitory activity against eight fungal organisms. Various physicochemical descriptors and reported minimum inhibitory concentration values of different fungal orga...

journal_title：Biological & pharmaceutical bulletin

authors： Vasanthanathan P,Lakshmi M,Arockia Babu M,Kaskhedikar SG

更新日期：2006-06-01 00:00:00

abstract：:Depression and related mood disorders are among the world's greatest public health problems. Previous studies have demonstrated that astilbin (AST) has broad pharmacological functions which may modulate numerous pathways, such as antioxidant, scavenging free radicals, anti-inflammatory and so on, similarly to some of ...

journal_title：Biological & pharmaceutical bulletin

authors： Lv QQ,Wu WJ,Guo XL,Liu RL,Yang YP,Zhou DS,Zhang JX,Liu JY

更新日期：2014-01-01 00:00:00

abstract：:To improve bioavailability of pueraria flavones (PF), a self-microemulsifying drug delivery system (SMEDDS) dropping pills composed of PF, Crodamol GTCC, Maisine 35-1, Cremophor RH 40, 1,2-propylene glycol and polyethylene glycol 6000 (PEG6000) was developed. Particle size, zeta potential, morphology and in vitro drug...

journal_title：Biological & pharmaceutical bulletin

authors： Guan Q,Zhang G,Sun S,Fan H,Sun C,Zhang S

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:To investigate the clinical effects and security of YiSuiShengXueGranule (YSSXG) on treating 156 patients with beta-thalassemia major. METHODS:YSSXG was given orally to 156 patients with beta-thalassemia in GuangXi Autonomous Region (the high incidence area of beta-thalassemia in China) for 3 months as one t...

journal_title：Biological & pharmaceutical bulletin

authors： Fang S,Wu Z,Zhang X,Liu Y,Wang W,Chai L,Cai H,Yi J,Wang L,Chen Y,Lv X,Huang Y,Wang R,Chen P

更新日期：2007-11-01 00:00:00

abstract：:Aconitine administered intraperitoneally (i.p.) produces bradycardia mainly by a central muscarinic action. The involvement of hypothalamic regions in the occurrence of aconitine-induced bradycardia was investigated in hypothalamus-lesioned mice. The lesions were made by passing a direct current (1.5 mA, 13 s) through...

journal_title：Biological & pharmaceutical bulletin

authors： Kimura I,Takada M,Nojima H

更新日期：1997-08-01 00:00:00

abstract：:Oxidized low-density lipoprotein (oxLDL) and reactive oxygen species (ROS) play key roles in the early stage of atherosclerosis. Nitric oxide (NO) and ROS are responsible for regulation of the transcriptional pathways of nuclear Factor-kappaB (NF-kappaB) and mitogen-activated protein kinase (MAPK), key regulators of c...

journal_title：Biological & pharmaceutical bulletin

authors： Han JM,Jin YY,Kim HY,Park KH,Lee WS,Jeong TS

更新日期：2010-01-01 00:00:00

abstract：:The blood clearance, tissue uptake and antitumor efficacy against liver metastasis of M5076 reticulosarcoma in mice and against primary liver cancer in rats of doxorubicin (DOX) encapsulated in two types of liposomes, with and without a soYbean-derived sterylglucoside mixture (SG), were examined. Liposomes entrapping ...

journal_title：Biological & pharmaceutical bulletin

authors： Shimizu K,Qi XR,Maitani Y,Yoshii M,Kawano K,Takayama K,Nagai T

更新日期：1998-07-01 00:00:00

abstract：:Hydroxylysylpyridinoline (HP), an intermolecular cross-linking amino acid, is present only in bone and cartilage collagen. We examined urinary HP levels in order to assess bone collagen metabolism using HPLC. Urinary HP excretion levels (nmol/mmol creatinine) of healthy control groups gradually increased with aging. U...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshihara K,Nemoto S,Nagata M

更新日期：1994-06-01 00:00:00

abstract：:Early diagnosis of Niemann-Pick diseases (NPDs) is important for better prognosis of such diseases. N-Palmitoyl-O-phosphocholine-serine (PPCS) is a new NPD biomarker possessing high sensitivity, and with its combination with sphingosylphosphocholine (SPC) it may be possible to distinguish NPD-C from NPD-A/B. In this s...

journal_title：Biological & pharmaceutical bulletin

authors： Iwahori A,Maekawa M,Narita A,Kato A,Sato T,Ogura J,Sato Y,Kikuchi M,Noguchi A,Higaki K,Okuyama T,Takahashi T,Eto Y,Mano N

更新日期：2020-09-01 00:00:00