Influence of thermodynamic parameter in Lanosterol 14alpha-demethylase inhibitory activity as antifungal agents: a QSAR approach.

Abstract:

:A quantitative structure activity relationship, Hansch approach was applied on twenty compounds of chromene derivatives as Lanosterol 14alpha-demethylase inhibitory activity against eight fungal organisms. Various physicochemical descriptors and reported minimum inhibitory concentration values of different fungal organisms were used as independent variables and dependent variable respectively. The best models for eight different fungal organisms were first validated by leave-one-out cross validation procedure. It was revealed that thermodynamic parameters were found to have overall significant correlationship with anti fungal activity and these studies provide an insight to design new molecules.

journal_name

Biol Pharm Bull

authors

Vasanthanathan P,Lakshmi M,Arockia Babu M,Kaskhedikar SG

doi

10.1248/bpb.29.1262

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

1262-6

issue

6

eissn

0918-6158

issn

1347-5215

pii

JST.JSTAGE/bpb/29.1262

journal_volume

29

pub_type

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