Influence of thermodynamic parameter in Lanosterol 14alpha-demethylase inhibitory activity as antifungal agents: a QSAR approach.


:A quantitative structure activity relationship, Hansch approach was applied on twenty compounds of chromene derivatives as Lanosterol 14alpha-demethylase inhibitory activity against eight fungal organisms. Various physicochemical descriptors and reported minimum inhibitory concentration values of different fungal organisms were used as independent variables and dependent variable respectively. The best models for eight different fungal organisms were first validated by leave-one-out cross validation procedure. It was revealed that thermodynamic parameters were found to have overall significant correlationship with anti fungal activity and these studies provide an insight to design new molecules.


Biol Pharm Bull


Vasanthanathan P,Lakshmi M,Arockia Babu M,Kaskhedikar SG




Has Abstract


2006-06-01 00:00:00














  • Anti-apoptotic function and mechanism of ginseng saponins in Rattus pancreatic β-cells.

    abstract::Apoptosis is the main form of β-cell death in diabetes. Ginseng has been used as an anti-diabetic herb for several thousand years in Asia with ginsenoside Rg1 and ginsenoside Rb1 as important active ingredients. In this study, we demonstrated ginsenoside Rg1 and Rb1 protect β-cells from high glucose/cytokine-induced p...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Chen F,Chen Y,Kang X,Zhou Z,Zhang Z,Liu D

    更新日期:2012-01-01 00:00:00

  • Metallothionein induction in rat liver by dietary restriction or exercise and reduction of exercise-induced hepatic lipid peroxidation.

    abstract::Metallothioneins (MTs) occur throughout the animal kingdom and they are induced in vivo by metals, hormones, cytotoxic agents, and some kind of stress. It is well known that various stresses such as starvation and immobilization can induce MT synthesis in animal tissues, but the influence of dietary restriction is unk...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Shinogi M,Sakaridani M,Yokoyama I

    更新日期:1999-02-01 00:00:00

  • Blood cell and vessel formation following transplantation of activin-treated explants in Xenopus.

    abstract::Treatment of Xenopus blastula with activin converts undifferentiated presumptive ectoderm (animal cap) into mesoderm and endoderm in a dose-dependent manner. At low concentrations, activin induces ventral mesoderm such as blood cells. Here we show that activin-treated aggregates of animal cap cells prepared from undif...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Nagamine K,Furue M,Fukui A,Matsuda A,Hori T,Asashima M

    更新日期:2007-10-01 00:00:00

  • Effects of tea from Turnera ulmifolia L. on mouse gastric mucosa support the Turneraceae as a new source of antiulcerogenic drugs.

    abstract::Turnera ulmifolia is a plant belonging to the family Turneraceae, popularly known in Brazil as chanana. This species is distributed from Guyana to southern Brazil where it is considered a weed. The plant occurs in tropical rain forest, fields, and gardens. Chanana tea is used in Brazilian folk medicine for the treatme...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Gracioso Jde S,Vilegas W,Hiruma-Lima CA,Souza Brito AR

    更新日期:2002-04-01 00:00:00

  • Identification of a tryptanthrin metabolite in rat liver microsomes by liquid chromatography/electrospray ionization-tandem mass spectrometry.

    abstract::Tryptanthrin originally isolated from Isatis tinctoria L. has been characterized to have anti-inflammatory activities through the dual inhibition of cyclooxygenase-2 and 5-lipoxygenase mediated prostaglandin and leukotriene syntheses. To characterize phase I metabolite(s), tryptanthrin was incubated with rat liver mic...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Lee SK,Kim GH,Kim DH,Kim DH,Jahng Y,Jeong TC

    更新日期:2007-10-01 00:00:00

  • Expression and Characterization of the Human Intestinal Bacterial Enzyme Which Cleaves the C-Glycosidic Bond in 3″-Oxo-puerarin.

    abstract::Puerarin (daidzein 8-C-glucoside) is an isoflavone C-glucoside contained in the roots of Pueraria lobata OHWI. We have previously isolated the human intestinal bacterium, strain PUE, which metabolizes puerarin to daidzein, though the enzyme which cleaves C-glycosidic bond has not been clarified. Here, we identified on...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Nakamura K,Zhu S,Komatsu K,Hattori M,Iwashima M

    更新日期:2019-03-01 00:00:00

  • Liposomes as immunomodulator--inhibitory effect of liposomes on NO production from macrophages.

    abstract::Liposomes have been artificially made into membranous vesicles composed essentially of naturally occurring phospholipids and have been found to serve as a carrier of drugs and an immunological adjuvant. After being intravenously injected, they are quickly removed from the blood circulation and trapped by Kupffer cells...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章,评审


    authors: Aramaki Y

    更新日期:2000-11-01 00:00:00

  • Vasodilatation produced by orientin and its mechanism study.

    abstract::In this paper we investigated the vascular activity and possible mechanism of Orientin, from bamboo leaves (Phyllostachys nigra), in isolated thoracic aortic rings from New Zealand rabbit. Among the four compounds, studied, only Orientin relaxed phenylephrine-induced contractions with an IC50 value of 2.28 microM in t...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Fu XC,Wang MW,Li SP,Zhang Y,Wang HL

    更新日期:2005-01-01 00:00:00

  • Costunolide induces apoptosis in human endometriotic cells through inhibition of the prosurvival Akt and nuclear factor kappa B signaling pathway.

    abstract::Endometriosis, a disease affecting 5-15% of women of reproductive age, is characterized by the ectopic growth of endometrial tissue. Costunolide, a sesquiterpene lactone, has anti-proliferative and pro-apoptotic activities that may be efficacious in therapy for endometriosis. In the present study, we investigated the ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kim JH,Yang YI,Lee KT,Park HJ,Choi JH

    更新日期:2011-01-01 00:00:00

  • Animal models of attention-deficit/hyperactivity disorder.

    abstract::Attention-deficit hyperactivity disorder (AD/HD) is a clinically heterogenous disorder including hyperactivity, impulsivity, and inattention. Both psychostimulant and non-psychostimulant drugs such as methylphenidate and atomoxetine, respectively, to modulate catecholeamine neurotransmission are used as current pharma...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Arime Y,Kubo Y,Sora I

    更新日期:2011-01-01 00:00:00

  • Separation of phospholipase A2 in Habu snake venom by glycyrrhizin (GL)-affinity column chromatography and identification of a GL-sensitive enzyme.

    abstract::By means of glycyrrhizin (GL)-affinity and Mono S column chromatographies (HPLC), at least four GL-binding proteins (p25, p17, p15-1 and p15-2) in the two Superdex fractions (P-II and P-III fractions) from Habu snake venom were selectively purified. By determination of their N-terminal partial amino acid sequences, a ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ohtsuki K,Abe Y,Shimoyama Y,Furuya T,Munakata H,Takasaki C

    更新日期:1998-06-01 00:00:00

  • The Role of dihydropyrazines in accelerated death of Escherichia coli on addition of copper(II).

    abstract::Dihydropyrazines (DHPs), which are derived from sugars, inhibit the growth of Escherichia coli. Addition of copper(II) ion (Cu2+) accelerates the effect of DHPs, resulting in cell death. Investigation of the lethal effect in several DNA repair-deficient or detoxifying enzyme-deficient mutant strains and radical scaven...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Takeda O,Takechi S,Katoh T,Yamaguchi T

    更新日期:2005-07-01 00:00:00

  • Structure-activity relationship of (1-->3)-beta-D-glucans in the induction of cytokine production from macrophages, in vitro.

    abstract::In a previous study, we reported that one of the gel-forming (1-->3)-beta-D-glucans, grifolan (from Grifola frondosa, GRN), stimulated cytokine production from macrophages in vitro. However, several other gel-forming (1-->3)-beta-D-glucans, such as sonifilan (SPG) and SSG, did not induce cytokine production from macro...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Okazaki M,Adachi Y,Ohno N,Yadomae T

    更新日期:1995-10-01 00:00:00

  • Enhancement of neuroprotection of mulberry leaves (Morus alba L.) prepared by the anaerobic treatment against ischemic damage.

    abstract::Several neurological disorders such as Alzheimer's and Parkinson's diseases have been attributed to gamma-aminobutyric acid (GABA) depletion in the brain. In order to provide a pharmacological basis for the neuroprotective actions of the enhanced accumulation of GABA in mulberry leaves (ML) against cerebral ischemia i...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kang TH,Oh HR,Jung SM,Ryu JH,Park MW,Park YK,Kim SY

    更新日期:2006-02-01 00:00:00

  • Prevention of Atherosclerosis by the Induction of Microbial Polyamine Production in the Intestinal Lumen.

    abstract::Low molecular weight metabolites produced by the intestinal microbiome that have been associated with health and disease as metabolites need to be constantly absorbed from the intestinal lumen and transported to intestinal epithelial cells and blood. Polyamines, especially spermidine and spermine, are bioactive chemic...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章,评审


    authors: Matsumoto M

    更新日期:2020-01-01 00:00:00

  • Studies on kochiae fructus. III. Antinociceptive and antiinflammatory effects of 70% ethanol extract and its component, momordin Ic from dried fruits of Kochia scoparia L.

    abstract::The 70% ethanol extract (KS-ext) from Kochiae Fructus (dried fruits of Kochia scoparia L.) was screened for its activity on nociceptive and inflammatory responses in experimental animals. Although KS-ext at an oral administration of 500 mg/kg had an antinociceptive effect on writhing responses induced by acetic acid, ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Matsuda H,Dai Y,Ido Y,Ko S,Yoshikawa M,Kubo M

    更新日期:1997-10-01 00:00:00

  • Pharmacokinetic study on the multi-constituents of Huangqin-Tang decoction in rats.

    abstract::Using a validated high-performance liquid chromatographic (HPLC) method, the pharmacokinetics of multi-constituents in Huangqin-Tang decoction were simultaneously studied both in the compound prescription and in each single herb decoction. At different intervals (0, 1, 2, 4, 8, 12, 24, 36, 48 h) after oral administrat...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Zuo F,Zhou ZM,Zhang Q,Mao D,Xiong YL,Wang YL,Yan MZ,Liu ML

    更新日期:2003-07-01 00:00:00

  • Neural mechanisms of swallowing and effects of taste and other stimuli on swallow initiation.

    abstract::Swallowing involves several motor processes such as bolus formation and intraoral transport of a food bolus (oral stage) and a series of visceral events that occur in a relatively fixed timed sequence but are to some degree modifiable (pharyngeal stage or swallow reflex). Reflecting the progressive aging of society, p...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章,评审


    authors: Yamamura K,Kitagawa J,Kurose M,Sugino S,Takatsuji H,Mostafeezur RM,Zakir HM,Yamada Y

    更新日期:2010-01-01 00:00:00

  • Uptake of low molecular weight fractionated [3H]heparin by rat hepatocytes in the primary culture.

    abstract::The uptake of low molecular weight fractionated [3H]heparin (LMWFH: 7000 Da) was examined, for comparison with that of high molecular weight fractionated [3H]heparin (HMWFH:20000 Da), in a primary culture of rat hepatocytes. The uptake of LMWFH increased almost linearly with time up to 60 min (extended uptake), althou...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Watanabe J,Urano K,Muranishi H,Haba M,Yuasa H

    更新日期:1995-03-01 00:00:00

  • Anti-hyperliposis effect of maitake fruit body (Grifola frondosa). I.

    abstract::Experimental rat models (5-week-old Sprague-Dawley rats) with hyperlipemia were prepared by feeding high-cholesterol feed containing sodium cholate and casein as a protein source. Dried maitake (Grifola frondosa) powder was mixed with the basic high-cholesterol feed and the serum lipids were periodically measured. Val...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kubo K,Nanba H

    更新日期:1997-07-01 00:00:00

  • Butylbenzyl phthalate hydrolysis in liver microsomes of humans, monkeys, dogs, rats and mice.

    abstract::Butylbenzyl phthalate (BBzP) is used as a plasticizer to import flexibility to polyvinylchloride plastics. In this study, hydrolysis of BBzP to monobutyl phthalate (MBP) and monobenzyl phthalate (MBzP) in liver microsomes of humans, monkeys, dogs, rats and mice was examined. The kinetics for MBP formation by human, do...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Takahara Y,Kinashi Y,Takahara Y,Hichiya H,Okada K,Murata M,Shigeyama M,Hanioka N

    更新日期:2014-01-01 00:00:00

  • The effect of zaldaride maleate, an antidiarrheal compound, on acetylcholine-induced intestinal electrolyte secretion.

    abstract::The effect of zaldaride on acetylcholine-induced colonic electrolyte secretion was examined. The short-circuit current response to acetylcholine was partially reduced by tetrodotoxin, a neuronal blocker, and was completely inhibited by atropine, an acetylcholine M receptor antagonist, in the rat colonic preparations. ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Aikawa N,Kishibayashi N,Karasawa A,Ohmori K

    更新日期:2000-11-01 00:00:00

  • Drug absorption behavior after periocular injections.

    abstract::The purpose of this study was to investigate the absorption behavior of an ophthalmic drug injected in rabbit periocular tissues. After intracapsular, retrobulbar and palpebral conjunctival injections of 150 microl and 50 microl fluorescein isothiocyanate dextran (FITC-dextran, average molecular weight 11000), leakage...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Sasaki H,Kashiwagi S,Mukai T,Nishida K,Nakamura J,Nakashima M,Ichikawa M

    更新日期:1999-09-01 00:00:00

  • Preparation and characteristics of antibacterial sepiolite containing povidone-iodine as a useful pharmaceutical product for patient care.

    abstract::Povidone-iodine (PVP-I), an antibacterial medicine, was infiltrated in sepiolite (SPL). The available iodine content in this new pharmaceutical product, a sepiolite preparation containing povidone-iodine (PVP-I-SPL), was retained at 98.9 and 98.3% during storage at 40 degrees C for 3 and 6 months, respectively. The ef...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ohta S,Nagai K,Maruyama M,Inoue H,Katsuyama Y,Atobe O,Ogata H,Yamato S,Tachikawa E,Zenda H

    更新日期:1999-01-01 00:00:00

  • Effect of vehicles on diclofenac permeation across excised rat skin.

    abstract::The in vitro percutaneous permeation of diclofenac from various vehicles was examined using rat abdominal skin as a model membrane. The oleaginous vehicles used in this study consisted of three components: i.e. fatty acid, fatty acid ester and nonpolar oil. The solubilities of sodium diclofenac in formulated vehicles ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Takahashi K,Suzuki T,Sakano H,Mizuno N

    更新日期:1995-04-01 00:00:00

  • Elenoside, a new cytotoxic drug, with cardiac and extracardiac activity.

    abstract::This paper deals with the effects of elenoside, (3-hidroxymethyl-1-methoxy-5,6-methylene-dioxy-4-(3,4-methylenedioxyphenyl)-2-naftoic acid lactone-beta-D-glucoside) an arylnaphthalene lignan with broad spectrum cytotoxicity in a human tumor cell line panel, isolated from Justicia hyssopifolia (Acanthaceae) grown in th...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Navarro E,Alonso SJ,Trujillo J,Jorge E,Pérez C,Hernández-Calzadilla C

    更新日期:2002-08-01 00:00:00

  • Transport mechanism of anthracycline derivatives in human leukemia cell lines: uptake and efflux of daunorubicin and doxorubicin in HL60 and its resistant cells and comparison with those of pirarubicin.

    abstract::We examined the transport mechanisms of daunorubicin (DNR) and doxorubicin (ADR) in HL60 and HL60/THP cells which were the non-P-glycoprotein-mediated resistant clone of the parent HL60 cells and showed a low degree of resistance, and compared them with those of pirarubicin (THP). In both lines, it appeared that the u...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Nagasawa K,Natazuka T,Nomiyama M,Ohnishi N,Yokoyama T

    更新日期:1996-01-01 00:00:00

  • The cytotoxic activity of the total alkaloids isolated from different parts of Solanum pseudocapsicum.

    abstract::The total alkaloid fractions of the methanolic extracts of the leaves, ripe fruits, roots, seeds and stem of Solanum pseudocapsicum were subjected to in-vitro cytotoxicity, short-term toxicity and long-term survival studies. All the five fractions exhibited potent activity. The total alkaloid fraction of leaves was fo...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Vijayan P,Vijayaraj P,Setty PH,Hariharpura RC,Godavarthi A,Badami S,Arumugam DS,Bhojraj S

    更新日期:2004-04-01 00:00:00

  • Antiproliferative activity of cardenolides isolated from Streptocaulon juventas.

    abstract::Sixteen cardenolides, two hemiterpenoids, two phenylpropanoids and a phenylethanoid isolated from the roots of Streptocaulon juventas (LOUR.) MERR. were examined for their antiproliferative activity toward three human-derived (HT-1080 fibrosarcoma, lung A549 adenocarcinoma, cervix HeLa adenocarcinoma) and three murine...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ueda JY,Tezuka Y,Banskota AH,Tran QL,Tran QK,Saiki I,Kadota S

    更新日期:2003-10-01 00:00:00

  • Expression of adenovirus type 5 E1A in the methylotrophic yeast Pachia pastoris and the inhibitory effect on S-180 tumor growth.

    abstract::The human adenovirus type 5 (Ad5) early-region 1A (E1A) proteins have been shown to have strong tumor-suppressive activities in human tumor cells and to enhance the sensitivity of a variety of malignant tumors to apoptosis induced by ionizing radiation and chemotherapeutic agents. However, the inherent limitations of ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ma Y,Zhou X,Zhao Q,Li Y,Liu Y,Wang Z,Zhang Y

    更新日期:2003-02-01 00:00:00