Antidepressant activity of astilbin: involvement of monoaminergic neurotransmitters and BDNF signal pathway.

Abstract:

:Depression and related mood disorders are among the world's greatest public health problems. Previous studies have demonstrated that astilbin (AST) has broad pharmacological functions which may modulate numerous pathways, such as antioxidant, scavenging free radicals, anti-inflammatory and so on, similarly to some of other flavonoids. In this study, the antidepressant-like effect of AST was investigated using chronic unpredictable mild stress (CUMS) model of depression in mice. The results showed that chronic administration of AST at doses of 10, 20 and 40 mg/kg (intraperitoneally (i.p.), 21 d) reduced depressive-like behaviors of mice in the forced swim test (FST), tail suspension test (TST) and sucrose preference test (SPT) without affecting locomotor activity. AST increased the contents of serotonin (5-HT) and dopamine (DA) in the frontal cortex of CUMS mice. Additionally, it was shown that AST treatment restored the CUMS-induced inhibition of extracellular signal-regulated kinase (ERK) 1/2 and AKT phosphorylation in the frontal cortex, conformed to the brain-derived neurotrophic factor (BDNF) expression. Our findings suggest that AST has antidepressant activities and the mechanisms, at least in part, relate to up-regulation of monoaminergic neurotransmitters (5-HT and DA) and activation of the BDNF signaling pathway.

journal_name

Biol Pharm Bull

authors

Lv QQ,Wu WJ,Guo XL,Liu RL,Yang YP,Zhou DS,Zhang JX,Liu JY

doi

10.1248/bpb.b13-00968

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

987-95

issue

6

eissn

0918-6158

issn

1347-5215

pii

DN/JST.JSTAGE/bpb/b13-00968

journal_volume

37

pub_type

杂志文章
  • Cyclooxygenase-2 inhibitory 1,4-naphthoquinones from Impatiens balsamina L.

    abstract::Significant selective cyclooxygenase-2 (COX-2) inhibitory activities were observed for two new 1,4-naphthoquinone sodium salts, sodium 3-hydroxide-2[[sodium 3-hydroxide-1,4-dioxo(2-naphthyl)]ethyl]naphthalene-1,4-dione (impatienolate) (1) and sodium 2-hydroxide-3-(2-hydroxyethyl)naphthalene-1,4-dione (balsaminolate) (...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.25.658

    authors: Oku H,Ishiguro K

    更新日期:2002-05-01 00:00:00

  • Pharmacokinetic study on the multi-constituents of Huangqin-Tang decoction in rats.

    abstract::Using a validated high-performance liquid chromatographic (HPLC) method, the pharmacokinetics of multi-constituents in Huangqin-Tang decoction were simultaneously studied both in the compound prescription and in each single herb decoction. At different intervals (0, 1, 2, 4, 8, 12, 24, 36, 48 h) after oral administrat...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.26.911

    authors: Zuo F,Zhou ZM,Zhang Q,Mao D,Xiong YL,Wang YL,Yan MZ,Liu ML

    更新日期:2003-07-01 00:00:00

  • Relationship between lipophilicity and skin permeability of various drugs from an ethanol/water/lauric acid system.

    abstract::The in vitro skin permeability of 16 drugs with a wide range of lipophilicity (log P; -0.95-4.40) was evaluated by the use of an ethanol/water (60/40) binary vehicle with or without lauric acid as a permeation enhancer. The enhancing effect by the addition of lauric acid to the ethanol/water (60/40) binary vehicle cou...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.17.1421

    authors: Lee CK,Uchida T,Kitagawa K,Yagi A,Kim NS,Goto S

    更新日期:1994-10-01 00:00:00

  • Isolation of sulfated galactan from Codium fragile and its antiviral effect.

    abstract::A sulfated galactan (FG) was isolated from the green alga, Codium fragile. Chemical analysis revealed that FG mainly consisted of D-galactose with pyruvic acid (12.3%) and sulfate (11.0%). Methylation and NMR analyses showed that FG was composed of -->3)-beta-D-Galp-(1-->, beta-D-Galp-(1--> and -->3,6)-beta-D-Galp-(1-...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.32.892

    authors: Ohta Y,Lee JB,Hayashi K,Hayashi T

    更新日期:2009-05-01 00:00:00

  • Effects of novel synthesized pyridothiazines on various guinea pig heart muscle preparations.

    abstract::Calcium channel blockers have become important tools in the treatment of cardiovascular disorders and other diseases. Hybridization of well established calcium antagonist subclasses was an attempt to optimize their pharmacological profile. The intension of this study was to investigate the electrophysiological propert...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.27.1364

    authors: Schade B,Erker T,Weber M,Studenik C

    更新日期:2004-09-01 00:00:00

  • Madecassoside reduces ischemia-reperfusion injury on regional ischemia induced heart infarction in rat.

    abstract::Madecassoside (MA), one of the principle terpenoids in Centella asiatica, has shown protect effect on isolated rat hearts and isolated cardiomyocytes against reperfusion injury in our previous studies. The aim of this study is to investigate if MA also protected against myocardial ischemia-reperfusion injury in vivo. ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.31.458

    authors: Bian GX,Li GG,Yang Y,Liu RT,Ren JP,Wen LQ,Guo SM,Lu QJ

    更新日期:2008-03-01 00:00:00

  • Suppression of inflammatory reactions by terpinen-4-ol, a main constituent of tea tree oil, in a murine model of oral candidiasis and its suppressive activity to cytokine production of macrophages in vitro.

    abstract::The onset of oral candidiasis is accompanied by inflammatory symptoms such as pain in the tongue, edema or tissue damage and lowers the quality of life (QOL) of the patient. In a murine oral candidiasis model, the effects were studied of terpinen-4-ol (T-4-ol), one of the main constituents of tea tree oil, Melaleuca a...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b13-00033

    authors: Ninomiya K,Hayama K,Ishijima SA,Maruyama N,Irie H,Kurihara J,Abe S

    更新日期:2013-01-01 00:00:00

  • Detoxification of paraquat poisoning: effects of alkylsulfates and alkylsulfonates on paraquat poisoning in mice and rats.

    abstract::The study revealed that high molecular polyvinyl sulfate (PVP) or sulfonate (PVS), and low molecular alkyldisulfonates (NaO3S(CH2)nSO3Na, n = 2--5: EDS, TDS, BDS and PDS) can alleviate acute toxicity of the herbicide, paraquat dichloride (PQ) in mice. Their activity as antidotes and the mode of the action varied depen...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.18.523

    authors: Tsuchiya T,Yoshida T,Imaeda A,Kiho T,Ukai S

    更新日期:1995-04-01 00:00:00

  • Echinacoside, an Active Constituent of Cistanche Herba, Exerts a Neuroprotective Effect in a Kainic Acid Rat Model by Inhibiting Inflammatory Processes and Activating the Akt/GSK3β Pathway.

    abstract::Echinacoside is a major compound of Cistanche Herb and has glutamate release-inhibiting activity in the brain. Given the involvement of excitotoxicity caused by massive glutamate in the pathophysiology of epilepsy, we explored the antiepileptic effect of echinacoside on kainic acid-induced seizures in rats. The rats w...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b18-00407

    authors: Lu CW,Hsieh HL,Lin TY,Hsieh TY,Huang SK,Wang SJ

    更新日期:2018-11-01 00:00:00

  • A nonlinear mixed effects modelling analysis of topiramate pharmacokinetics in patients with epilepsy.

    abstract::Topiramate pharmacokinetics is influenced by individual factors such as patient age, renal function and co-treatment. The aim of this study was to develop a population pharmacokinetic model of topiramate to assist dosage adjustments in individual patients. Steady-state topiramate plasma concentrations in patients with...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.33.1176

    authors: Vovk T,Jakovljević MB,Kos MK,Janković SM,Mrhar A,Grabnar I

    更新日期:2010-01-01 00:00:00

  • Reversal of fibrogenic events in liver by Emblica officinalis (fruit), an Indian natural drug.

    abstract::A hydroalcoholic (50%) extract of Emblica officinalis (fruit) (EO-50) reduced the severity of hepatic fibrosis induced by carbon tetrachloride (CCl4) and thioacetamide (TAA). Improved liver function was observed by measuring the levels of aspartate aminotransaminase (AST), alanine aminotransferase (ALT), alkaline phos...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.28.1304

    authors: Tasduq SA,Mondhe DM,Gupta DK,Baleshwar M,Johri RK

    更新日期:2005-07-01 00:00:00

  • Biological activity of tropolone.

    abstract::Tropolone (1). showed strong insecticidal activity on Tyrophagus putrescentiae and Dermatophagoides farinae. The insecticidal effect of 1 on both insects was stronger than that of hinokitiol (2, 4-isopropyltropolone: major component of Thujopsis dolabrata SIEB. et ZUCC. hondai MAKINO). The insecticidal activity of bot...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.26.1487

    authors: Morita Y,Matsumura E,Okabe T,Shibata M,Sugiura M,Ohe T,Tsujibo H,Ishida N,Inamori Y

    更新日期:2003-10-01 00:00:00

  • Inhibition of the Inflammatory Pathway Enhances Both the in Vitro and in Vivo Transfection Activity of Exogenous in Vitro-Transcribed mRNAs Delivered by Lipid Nanoparticles.

    abstract::While the use of in vitro-transcribed mRNA (IVT-mRNA) in therapeutics is a rapidly expanding area, the transfection of the exogenous IVT-mRNA is accompanied by a risk of immune activation. This immunological defense mechanism suppresses cellular translation process and can reduce transfection efficiency to a considera...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b18-00783

    authors: Ohto T,Konishi M,Tanaka H,Onomoto K,Yoneyama M,Nakai Y,Tange K,Yoshioka H,Akita H

    更新日期:2019-01-01 00:00:00

  • Bioavailability and diuretic effect of furosemide following administration of tablets and retarded capsules to human subjects.

    abstract::Two kinds of dosage forms (tablets and retarded capsules) of furosemide (F) were compared in vitro dissolution profile and in vivo absorption studies. The dissolution of F from retarded capsules was extremely restricted in the first fluid of the JP XII disintegration test (within 0.8%), while the dissolution of F from...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.19.616

    authors: Yagi N,Kiuchi T,Satoh H,Terashima Y,Kenmotsu H,Sekikawa H,Takada M

    更新日期:1996-04-01 00:00:00

  • Oxidation of flavonoids which promote DNA degradation induced by bleomycin-Fe complex.

    abstract::Sixteen flavonoids including quercetin and kaempferol and their relatives were examined for their ability to promote DNA degradation induced by the bleomycin (BLM)-Fe complex. Three hydroxyl groups in the flavonoidal nucleus were proposed as a crucial structural requirement for effectively promoting DNA degradation: 1...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.26.1108

    authors: Sugihara N,Kaneko A,Furuno K

    更新日期:2003-08-01 00:00:00

  • Free 4-hydroxyproline content in serum of bedridden aged people is elevated due to fracture.

    abstract::Hydroxyproline (Hyp) content in biological fluids is used as a parameter of collagen catabolism, especially bone resorption. In this paper, we examined the relationship between aging and serum free 4-Hyp and proline (Pro) content using a newly introduced analytical technique which is chemiluminescence determination wi...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.23.101

    authors: Koike K,Li Y,Seo M,Sakurada I,Tezuka K,Uchikura K

    更新日期:2000-01-01 00:00:00

  • Folate-targeted gadolinium-lipid-based nanoparticles as a bimodal contrast agent for tumor fluorescent and magnetic resonance imaging.

    abstract::To enhance tumor magnetic resonance imaging (MRI) signals via the selective accumulation of contrast agents, we prepared folate-modified gadolinium-lipid-based nanoparticles as MRI contrast agents. Folate-modified nanoparticles were comprised of polyethylene glycol (PEG)-lipid, gadolinium diethylenetriamine pentaaceti...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b13-00484

    authors: Nakamura T,Kawano K,Shiraishi K,Yokoyama M,Maitani Y

    更新日期:2014-01-01 00:00:00

  • In Vitro Inhibitory Effects of Sesamin on CYP4F2 Activity.

    abstract::Sesamin is a major lignan in sesame seeds, and a recent meta-analysis of controlled trials indicated that sesamin intake decreases blood pressure. The antihypertensive effect of sesamin has been suggested to be due to sesamin-mediated suppression of 20-hydroxyeicosatetraenoic acid production catalyzed by CYP4F2. Howev...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b19-00953

    authors: Watanabe H,Yamaori S,Kamijo S,Aikawa K,Ohmori S

    更新日期:2020-01-01 00:00:00

  • Construction of an aptamer modified liposomal system targeted to tumor endothelial cells.

    abstract::We describe herein the development of a high affinity and specific DNA aptamer as a new ligand for use in liposomal nanoparticles to target cultured mouse tumor endothelial cells (mTECs). Active targeted nanotechnology based drug delivery systems are currently of great interest, due to their potential for reducing sid...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b14-00338

    authors: Ara MN,Matsuda T,Hyodo M,Sakurai Y,Ohga N,Hida K,Harashima H

    更新日期:2014-01-01 00:00:00

  • Influence of hypothyroidism induced by thiamazole on the toxic interaction between propranolol and disopyramide in chick embryos.

    abstract::The effect of the hypothyroidism induced by thiamazole on toxic interactions between propranolol and disopyramide were studied in chick embryos. Fertilized eggs of White Leghorns were incubated and investigated. 1.2 mg/0.2 ml/egg of thiamazole was injected into the albumen of fertilized eggs on the 9th day of incubati...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.28.1983

    authors: Yoshiyama Y,Kanke M

    更新日期:2005-10-01 00:00:00

  • Inhibitory effects of pentamidine on N-methyl-D-aspartate (NMDA) receptor/channels in the rat brain.

    abstract::Effects of pentamidine, a therapeutic drug for Pneumocystis carinii pneumonia (PCP) in acquired immunodeficiency syndrome (AIDS), on specific bindings of [3H](+)-5-methyl-10,11-dihydro-5H- dibenzo[a,d]cyclohepten-5,11-imine maleate (MK-801) and [3H]nitrendipine were investigated in crude synaptic membranes (CSM) of ra...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.18.234

    authors: Kitamura Y,Arima T,Sato T,Nakamura J,Nomura Y

    更新日期:1995-02-01 00:00:00

  • Effect of Acori graminei Rhizoma on contractile dysfunction of ischemic and reperfused rat heart.

    abstract::Acori graminei Rhizoma is one of the best-known traditional herbal medicines frequently used for the treatment of cardiovascular symptoms in Asian countries. The anti-ischemic effect of Acori graminei Rhizoma on ischemia-induced isolated rat heart was investigated through analysis of changes in perfusion pressure, aor...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.29.483

    authors: Kang M,Kim JH,Cho C,Chung HS,Yoon YS,Lee Y,Hong M,Shin M,Bae H

    更新日期:2006-03-01 00:00:00

  • Pharmacokinetics of ketotifen fumarate after intravenous, intranasal, oral and rectal administration in rabbits.

    abstract::The pharmacokinetics of ketotifen fumarate (KF) was examined after administration in rabbits through four different routes (intravenous, intranasal, oral and rectal). The time-course of the plasma concentration of KF after intravenous administration (1 mg/kg dose) fitted a two-compartment open model. KF was rapidly ab...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.25.1614

    authors: Yagi N,Taniuchi Y,Hamada K,Sudo J,Sekikawa H

    更新日期:2002-12-01 00:00:00

  • Down-regulation of the large-conductance Ca(2+)-activated K+ channel, K(Ca)1.1 in the prostatic stromal cells of benign prostate hyperplasia.

    abstract::Large-conductance Ca(2+)-activated K(+) (BK(Ca)) channel encoded by K(Ca)1.1 plays an important role in the control of smooth muscle tone by modulating membrane potential and intracellular Ca(2+) mobilization. BK(Ca) channel is functionally expressed in prostatic smooth muscle cells, and is activated by α(1)-adrenocep...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.35.737

    authors: Niwa S,Ohya S,Kojima Y,Sasaki S,Yamamura H,Sakuragi M,Kohri K,Imaizumi Y

    更新日期:2012-01-01 00:00:00

  • Total peroxynitrite scavenging capacity of phenylethanoid and flavonoid glycosides from the flowers of Buddleja officinalis.

    abstract::Nine compounds, including six phenylethanoid glycosides: acteoside (1); bioside (2); echinacoside (3); poliumoside (4); phenylethyl glycoside (5); salidroside (6) and three flavonoids; linarin (7); apigenin (8); isorhoifolin (9), were isolated from the flowers of Buddleja officinalis MAXIM. (Buddlejaceae). Chemical st...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.32.1952

    authors: Tai BH,Jung BY,Cuong NM,Linh PT,Tung NH,Nhiem NX,Huong TT,Anh NT,Kim JA,Kim SK,Kim YH

    更新日期:2009-12-01 00:00:00

  • Baicalin Protects against TNF-α-Induced Injury by Down-Regulating miR-191a That Targets the Tight Junction Protein ZO-1 in IEC-6 Cells.

    abstract::Tumor necrosis factor-alpha (TNF-α) plays an important role in the developing process of inflammatory bowel disease. Tight junction protein zonula occludens-1 (ZO-1), one of epithelial junctional proteins, maintains the permeability of intestinal barrier. The objective of this study was to investigate the mechanism of...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b16-00789

    authors: Wang L,Zhang R,Chen J,Wu Q,Kuang Z

    更新日期:2017-04-01 00:00:00

  • High performance liquid chromatographic assay of saikosaponins from radix Bupleuri in China.

    abstract::In this study, the quantitative analysis of saikosaponins from Radix Bupleuri in China was performed by high performance liquid chromatography. Saikosaponin-a and -d were converted completely into saikosaponin-b1 and -b2 by mild acid treatment. Distinctive measuring of these converted diene-saponins provided a rapid a...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.28.1736

    authors: Li XQ,Gao QT,Chen XH,Bi KS

    更新日期:2005-09-01 00:00:00

  • Anti-hyperliposis effect of maitake fruit body (Grifola frondosa). I.

    abstract::Experimental rat models (5-week-old Sprague-Dawley rats) with hyperlipemia were prepared by feeding high-cholesterol feed containing sodium cholate and casein as a protein source. Dried maitake (Grifola frondosa) powder was mixed with the basic high-cholesterol feed and the serum lipids were periodically measured. Val...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.20.781

    authors: Kubo K,Nanba H

    更新日期:1997-07-01 00:00:00

  • Effects of erythromycin, clarithromycin and rokitamycin on nifedipine metabolism in rats.

    abstract::The effects of erythromycin, clarithromycin and rokitamycin on the metabolism of nifedipine were studied in vitro and in situ. Erythromycin, clarithromycin or rokitamycin added to nifedipine did not inhibit the formation of metabolite, M-1, of nifedipine, whereas pretreatment with erythromycin or clarithromycin signif...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.20.411

    authors: Tsuruta S,Nakamura K,Arimori K,Nakano M

    更新日期:1997-04-01 00:00:00

  • Effects of β-Naphthoflavone on Ugt1a6 and Ugt1a7 Expression in Rat Brain.

    abstract::Uridine 5'-diphosphate-glucuronosyltransferase (UGT) catalyzes a major phase II reaction in a drug-metabolizing enzyme system. Although the UGT1A subfamily is expressed mainly in the liver, it is also expressed in the brain. The purpose of the present study was to elucidate the effect of β-naphthoflavone (BNF), one of...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b15-00578

    authors: Sakakibara Y,Katoh M,Kondo Y,Nadai M

    更新日期:2016-01-01 00:00:00