Abstract:
:Tulobuterol patches are long-acting bronchodilators for percutaneous absorption including the β(2)-adrenoreceptor agonist tulobuterol, as a main ingredient, used for long-term management of pediatric asthma. Since patients who have pediatric asthma often also have atopic dermatitis in which the skin barrier is impaired, we compared the skin penetration profiles of the brand and generic patches using a skin barrier-impaired rat model. Skin penetration was significantly (p<0.001) higher in the generic patches compared with the brand patch, suggesting that it is important to understand the pharmaceutical properties of available products by giving careful consideration not only to the patient's asthma control but also to their skin condition before using tulobuterol patches.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Yoshihara S,Fukuda H,Abe T,Arisaka Odoi
10.1248/bpb.33.1763subject
Has Abstractpub_date
2010-01-01 00:00:00pages
1763-5issue
10eissn
0918-6158issn
1347-5215pii
JST.JSTAGE/bpb/33.1763journal_volume
33pub_type
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