Abstract:
:The cardiac toxicity of amitriptyline and the effect of the light schedule on it were studied in chick embryos. Fertilized eggs of White Leghorns were incubated under dark conditions and investigated, on two occasions, in the light phase and in the dark phase. Amitriptyline was injected into the air sac of fertilized eggs on the 16th day of incubation. Electrocardiograms were recorded 0 to 60 min after the injection. After the administration of amitriptyline 1 mg/egg in the light phase, the heart rate did not differ compared with that in controls. However, the heart rate was significantly decreased by the administration of amitriptyline 2.5 mg/egg and 5 mg/egg in the light phase. The heart rate was significantly decreased by the administration of amitriptyline 1 mg/egg under dark conditions. In addition, arrhythmia was produced by the administration of amitriptyline under dark conditions. These findings indicate that manipulation of the light schedule has a marked influence on the toxicity of amitriptyline in chick embryos.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Yoshiyama Y,Sugiyama T,Kanke Mdoi
10.1248/bpb.27.229subject
Has Abstractpub_date
2004-02-01 00:00:00pages
229-31issue
2eissn
0918-6158issn
1347-5215journal_volume
27pub_type
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