Mechanism of inhibition of small intestinal motility by restraint stress differs from that with norepinephrine treatment in rats.

abstract：:When normal rabbits were administered various samples of deep-sea water, their biochemical values changed within normal limits, and no differences from distilled water administration (control) group levels were observed. Furthermore, no histopathological changes were observed in internal organs on the 28th day after a...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshioka S,Hamada A,Cui T,Yokota J,Yamamoto S,Kusunose M,Miyamura M,Kyotani S,Kaneda R,Tsutsui Y,Odani K,Odani I,Nishioka Y

更新日期：2003-11-01 00:00:00

abstract：:Curcumin, a bioactive component in tumeric, has been shown to exert antioxidant, anti-inflammatory, anticarcinogenic, hepatoprotective, and neuroprotective effects, but the effects of curcumin against manganese (Mn)-mediated neurotoxicity have not been studied. This study examined the protective effects of curcumin on...

journal_title：Biological & pharmaceutical bulletin

authors： Park E,Chun HS

更新日期：2017-08-01 00:00:00

abstract：:We investigated the effect of components in grapefruit juice (GFJ) on the transport of vinblastine, a substrate of P-glycoprotein (P-gp), across Caco-2 cells. The apical to basolateral flux of [3H]vinblastine was increased in the presence of GFJ extracts. The steady-state uptake of [3H]vinblastine from the apical side...

journal_title：Biological & pharmaceutical bulletin

authors： Takanaga H,Ohnishi A,Matsuo H,Sawada Y

更新日期：1998-10-01 00:00:00

abstract：:Microanalytical methods were developed for measuring galactosyl-beta-cyclodextrin (Gal-betaCD) and mannosyl (Man)-betaCD in biological matrices of the rat by HPLC with pulsed amperometric detection. Then, using these methods, the absorption, distribution and excretion of intravenously and orally administered Gal-betaC...

journal_title：Biological & pharmaceutical bulletin

authors： Kubota Y,Sanbe H,Koizumi K

更新日期：2000-04-01 00:00:00

abstract：:A lower serum cholesterol level was recently shown to be one of the causes of stroke in an epidemiological study. Spontaneously hypertensive rats stroke-prone (SHRSP) have lower serum cholesterol levels than normotensive Wistar-Kyoto rats (WKY). To elucidate the mechanisms responsible for the lower serum cholesterol l...

journal_title：Biological & pharmaceutical bulletin

authors： Michihara A,Mido M,Matsuoka H,Mizutani Y

更新日期：2015-01-01 00:00:00

abstract：:P-Glycoprotein (ABCB1-type P-gp), a membrane protein encoded by the multi drug resistant gene (MDR1), expressing on the blood brain barrier protects the brain from many drugs including dexamethasone. Psychiatric disorders, schizophrenia and depression, have known to have abnormal hypothalamus-pituitary-adrenal (HPA) a...

journal_title：Biological & pharmaceutical bulletin

authors： Qian W,Homma M,Itagaki F,Tachikawa H,Kawanishi Y,Mizukami K,Asada T,Inomata S,Honda K,Ohkohchi N,Kohda Y

更新日期：2006-12-01 00:00:00

abstract：:To elucidate molecular mechanisms of adipocyte differentiation, we previously isolated TC10-like/TC10betaLong (TCL/TC10betaL), regulators of G protein signaling 2 (RGS2), factor for adipocyte differentiation (fad) 104 and fad158, which were transiently expressed in the early phase of adipogenesis. These four genes see...

journal_title：Biological & pharmaceutical bulletin

authors： Kawaji A,Nishizuka M,Osada S,Imagawa M

更新日期：2010-01-01 00:00:00

abstract：:A pharmacokinetic analysis program based on a tank-in-series model, MULTI(TIS), was developed for the evaluation of dose-dependency in the local disposition of a drug. The program written in FORTRAN was constructed by expanding MULTI(RUNGE). The reliability of MULTI(TIS) was verified by analyzing the experimental data...

journal_title：Biological & pharmaceutical bulletin

authors： Fukumura K,Yamaoka K,Higashimori M,Nakagawa T

更新日期：1998-12-01 00:00:00

abstract：:The purpose of this research is improvement of therapeutic treatment for periodontitis by using lipophilic and/or hydrophilic zinc materials. The sample suspension injections were prepared from zinc octanate (C8Zn), zinc stearate (C18Zn), zinc sulfate hepta-hydrate (ZnSO4) and tricalcium phosphate (ZnTCP) containing 6...

journal_title：Biological & pharmaceutical bulletin

authors： Tokudome Y,Otsuka M

更新日期：2012-01-01 00:00:00

abstract：:The uric acid concentration in blood has been widely accepted as a diagnostic indicator of hyperuricemia and gout, and its assay method is well established. In the present study, we developed a simple and rapid method for the determination of uric acid in hair, which can be obtained non-invasively. The concentration (...

journal_title：Biological & pharmaceutical bulletin

authors： Kobayashi K,Morioka Y,Isaka Y,Tozawa T

更新日期：1998-04-01 00:00:00

abstract：:We examined the feasibility of using submicron-sized liposomes (ssLips) for retinal delivery of hydrophilic compounds, which would also have a wide range of applications. To evaluate the uptake into conjunctival cell line and the intraocular behavior of hydrophilic compound-containing ssLips after eyedrop application,...

journal_title：Biological & pharmaceutical bulletin

authors： Hironaka K,Fujisawa T,Sasaki H,Tozuka Y,Tsuruma K,Shimazawa M,Hara H,Takeuchi H

更新日期：2011-01-01 00:00:00

abstract：:Microglia activation-mediated neuroinflammation plays an important role in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and human immunodeficiency virus (HIV)-associated dementia. Inhibition of microglia activation may alleviate neurodegeneration ...

journal_title：Biological & pharmaceutical bulletin

authors： Zhou X,Gan P,Hao L,Tao L,Jia J,Gao B,Liu JY,Zheng LT,Zhen X

更新日期：2014-01-01 00:00:00

abstract：:Treatment with antipsychotic drugs has been associated with hyperprolactinemia. The same antipsychotic drugs have also been associated with side effects such as menstruation disorders. The aim of this study was to evaluate the prevalence of hyperprolactinemia and menstruation disorders in women undergoing antipsychoti...

journal_title：Biological & pharmaceutical bulletin

authors： Takechi K,Yoshioka Y,Kawazoe H,Tanaka M,Takatori S,Kobayashi M,Matsuoka I,Yanagawa H,Zamami Y,Imanishi M,Ishizawa K,Tanaka A,Araki H

更新日期：2017-01-01 00:00:00

abstract：:Orally disintegrating tablets (ODTs) are formulated to disintegrate upon contact with saliva, allowing administration without water. Olopatadine hydrochloride, a second-generation antihistamine, is widely used for treating allergic rhinitis. However, it has a bitter taste; therefore, the development of taste-masked ol...

journal_title：Biological & pharmaceutical bulletin

authors： Sotoyama M,Uchida S,Tanaka S,Hakamata A,Odagiri K,Inui N,Watanabe H,Namiki N

更新日期：2017-01-01 00:00:00

abstract：:We reported previously that N-linked glycoproteins were accumulated in the cytosol of the normal aging rat brain, and that one protein had been identified as cathepsin D (Mech. Ageing Dev., 127, 771-778 (2006)). In this study, to elucidate the mechanism of cathepsin D accumulation in the cytosol, we examined the effec...

journal_title：Biological & pharmaceutical bulletin

authors： Miura Y,Sakurai Y,Hayakawa M,Shimada Y,Zempel H,Sato Y,Hisanaga S,Endo T

更新日期：2010-01-01 00:00:00

abstract：:Ceramide kinase (CerK) and ceramide-1-phosphate (C1P) are involved in various cellular functions, while regulation of the enzyme activity has not been well elucidated. We herein investigated the effects of several glycerophospholipids on human recombinant CerK activity with CaCl2 and MgCl2 by measuring the formation o...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuzaki W,Takahashi H,Nakamura H,Murayama T

更新日期：2016-01-01 00:00:00

abstract：:Reprogramming differentiated cells toward stem cells may have long-term applications in stem-cell research and regenerative medicine. Here we report on the dedifferentiation of human epidermal keratinocytes into their precursor cells in vitro with basic fibroblast growth factor (bFGF) but not external gene interventio...

journal_title：Biological & pharmaceutical bulletin

authors： Sun X,Fu X,Han W,Zhao Y,Liu H,Sheng Z

更新日期：2011-01-01 00:00:00

abstract：:Recently, a silent polymorphism of C3435T of the MDR1 gene, encoding the multidrug resistant transporter MDR1/P-glycoprotein, has been found to be associated with susceptibility to ulcerative colitis (UC), but this remains controversial. This study was conducted to find a possible reason for the discrepancies, and it ...

journal_title：Biological & pharmaceutical bulletin

authors： Osuga T,Sakaeda T,Nakamura T,Yamada T,Koyama T,Tamura T,Aoyama N,Okamura N,Kasuga M,Okumura K

更新日期：2006-02-01 00:00:00

abstract：:The tumor microenvironment is one of the key factors contributing to the efficiency of drug delivery to a tumor. It has been reported that lymphangiogenesis is induced in certain tumors. Because the lymphatic system functions as a drainage one, it is possible that tumor lymphatic vessels alter not only the tumor micro...

journal_title：Biological & pharmaceutical bulletin

authors： Shimizu K,Ikeuchi SY,Okajima A,Nakamura G,Muraoka E,Oku N

更新日期：2018-01-01 00:00:00

abstract：:Systems for delivering nucleic acids are now fundamental technologies for realizing personalized medicine. Among the various nucleic acid delivery systems that are currently available, lipid-nanoparticles (LNPs) that contain short interfering RNA (siRNA) have been extensively investigated for clinical applications. LN...

journal_title：Biological & pharmaceutical bulletin

authors： Shirane D,Tanaka H,Nakai Y,Yoshioka H,Akita H

更新日期：2018-01-01 00:00:00

abstract：:Lymphocyte homing is mediated by a specific interaction between the lymphocyte homing receptor L-selectin and its sulfated glycoprotein ligands, which are expressed on high endothelial venules (HEV) in the lymph nodes. To examine the significance of the sulfation of L-selectin ligands, our group has generated gene-tar...

journal_title：Biological & pharmaceutical bulletin

authors： Kawashima H

更新日期：2006-12-01 00:00:00

abstract：:Nonalcoholic steatohepatitis (NASH) is the most frequent cause of liver dysfunction and a common global problem. Gypenosides can decrease pathological modifications of high-fat diet-induced rat atherosclerosis; however, its effect and mechanism on NASH remain unclear. In this study, rats were randomly divided into nor...

journal_title：Biological & pharmaceutical bulletin

authors： Li H,Ying H,Hu A,Hu Y,Li D

更新日期：2017-01-01 00:00:00

abstract：:Using a surface plasmon resonance (SPR) system, we investigated the lipid membrane-binding properties of four analogues of the 18-residue linear amphipathic beta-sheet cationic antimicrobial peptide (KIGAKI)3-NH2, each of which contains a single isoleucine-to-tryptophan substitution. The results of the SPR study revea...

journal_title：Biological & pharmaceutical bulletin

authors： Kamimori H,Blazyk J,Aguilar MI

更新日期：2005-01-01 00:00:00

abstract：:Platelet activating factor (PAF)-acetylhydrolase (PAF-AH) is an enzyme that hydrolyzes the acetyl ester at the sn-2 position of PAF, and converts it to the inactive metabolite, lyso PAF. This enzyme is distributed widely in the intracellular as well as the extracellular matrix and is believed to be a defense mechanism...

journal_title：Biological & pharmaceutical bulletin

authors： Lee E,Lee SJ,Lee TY,Chang HW

更新日期：2005-04-01 00:00:00

abstract：:Here, we confirmed that stable expression of B-cell lymphoma-xL (Bcl-xL) in N18TG neuroglioma cells could suppress c-Jun N-terminal protein kinase (JNK) activation, nuclear fragmentation, and cell death caused by etoposide treatment. Moreover, additional overexpression of JNK1 led to partially antagonize the antiapopt...

journal_title：Biological & pharmaceutical bulletin

authors： Jeong HS,Choi HY,Choi TW,Kim BW,Kim JH,Lee ER,Cho SG

更新日期：2008-09-01 00:00:00

abstract：:The present study describes the activity of Ca(2+)-ATPase in liver plasma membrane and cytosolic-free Ca2+ concentration ([Ca2+]i) in an individual vital cell in mouse liver 18 h after endotoxin administration. Ca(2+)-ATPase activity in liver plasma membrane in the poisoned mice was markedly decreased to 28% of that i...

journal_title：Biological & pharmaceutical bulletin

authors： Sakaguchi S,Tsutsumi E,Yokota K

更新日期：1993-08-01 00:00:00

abstract：:Disulfiram (DSF) is a dimer of diethyldithiocarbamate (DDC) that we previously added to a solution of 2-hydroxypropyl-β-cyclodextrin (DSF solution). We found that the instillation of this DSF solution delayed lens opacification in a hereditary cataractous ICR/f rat. In this study, we attempted to design an ophthalmic ...

journal_title：Biological & pharmaceutical bulletin

authors： Nagai N,Mano Y,Ito Y

更新日期：2016-01-01 00:00:00

abstract：:Albumin extracted from serum by a simple technique using trichloroacetic acid and ethanol has been applied to a fructosamine assay using nitroblue tetrazolium. A fructosamine assay using extracted albumin sample was carried out without interference from low molecular weight substances with reducing activities and othe...

journal_title：Biological & pharmaceutical bulletin

authors： Ohkawara E,Nohara Y,Kanno Y,Suzuki H,Matsumoto G,Kinoshita T,Watanabe M

更新日期：2002-09-01 00:00:00

abstract：:Selective inhibitors of phosphodiesterases (PDEs) have been suggested to have anti-inflammatory effects on bronchial asthma through the inhibition of chemotaxis, adhesion, degranulation, the respiratory burst, and survival prolongation of eosinophils. However, the mechanisms by which these agents inhibit eosinophil su...

journal_title：Biological & pharmaceutical bulletin

authors： Wang W,Masu K,Tamura G,Suzuki K,Ohwada K,Okuyama K,Shirato K,Takayanagi M,Ohno I

更新日期：2005-03-01 00:00:00

abstract：:The fundamental role that receptor tyrosine kinases play in cancer and other proliferative diseases has provided the impetus for an extensive effort on the part of both academic and pharmaceutical laboratories to develop highly specific inhibitors. In this study, inhibitory activity of previously synthesized arylaceti...

journal_title：Biological & pharmaceutical bulletin

authors： Altuntas TG,Olgen S,Nebioglu D,Akaho E

更新日期：2004-01-01 00:00:00