Abstract:
:Albumin extracted from serum by a simple technique using trichloroacetic acid and ethanol has been applied to a fructosamine assay using nitroblue tetrazolium. A fructosamine assay using extracted albumin sample was carried out without interference from low molecular weight substances with reducing activities and other proteins with varying concentrations, half-lives and reducing activities. 1-Deoxy-1-p-toluidino-D-fructose (DTF) was selected as a calibrator for the assay because it is a stable Amadori reaction product with a constant glycation rate. Albumin fructosamine value was calculated using the calibration curve of DTF. The corrected albumin fructosamine value was expressed as the amount of albumin fructosamine per gram of extracted albumin taking into consideration the variation in albumin concentrations in sera from patients. The corrected albumin fructosamine values correlated more closely with the fasting blood glucose levels (r=0.735) than the serum fructosamine values corrected for albumin concentrations (r=0.514) (p<0.05).
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Ohkawara E,Nohara Y,Kanno Y,Suzuki H,Matsumoto G,Kinoshita T,Watanabe Mdoi
10.1248/bpb.25.1121subject
Has Abstractpub_date
2002-09-01 00:00:00pages
1121-4issue
9eissn
0918-6158issn
1347-5215journal_volume
25pub_type
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