TC10-like/TC10betaLong regulates adipogenesis by controlling mitotic clonal expansion.

abstract：:To develop a piroxicam-loaded gelatin microcapsule with enhanced bioavailability, a gelatin microcapsule encapsulated ethanol and piroxicam has been formulated by using gelatin as a water-soluble polymer shell. The aqueous solubility and bioavailability of piroxicam in piroxicam-loaded microcapsule in rats were then e...

journal_title：Biological & pharmaceutical bulletin

authors： Piao MG,Yang CW,Li DX,Kim JO,Jang KY,Yoo BK,Kim JA,Woo JS,Lyoo WS,Han SS,Lee YB,Kim DD,Yong CS,Choi HG

更新日期：2008-06-01 00:00:00

abstract：:Endothelin-1 (ET-1) has been reported to be expressed in human epidermis at both the gene and protein levels. ET-1 plays a pivotal role in ultraviolet B (UVB)-induced pigmentation due to its accentuated secretion after UVB irradiation and its function as a mitogen and as a melanogen for human melanocytes. We have rece...

journal_title：Biological & pharmaceutical bulletin

authors： Hachiya A,Kobayashi A,Ohuchi A,Kitahara T,Takema Y

更新日期：2001-06-01 00:00:00

abstract：:The present study investigated the effect of 4[(5,6,7,8-tetrahydro-5,5,8,8,-tetramethyl-2-naphthalenyl)carbamoyl] benzoic acid (Am-80), a synthetic retinoid, on spinal cord injury (SCI) in rats. Treatment with Am-80 (orally and subcutaneously) significantly promoted recovery from SCI-induced motor dysfunction. On day ...

journal_title：Biological & pharmaceutical bulletin

authors： Takenaga M,Ohta Y,Tokura Y,Hamaguchi A,Shudo K,Okano H,Igarashi R

更新日期：2009-02-01 00:00:00

abstract：:Resveratrol, which is found in grapes, red wine, and berries, has many beneficial health effects, such as anti-cancer, neuro-protective, anti-inflammatory, and life-prolonging effects. However, the cellular mechanisms by which resveratrol acts are relatively unknown, especially in terms of possible regulation of recep...

journal_title：Biological & pharmaceutical bulletin

authors： Lee BH,Hwang SH,Choi SH,Shin TJ,Kang J,Lee SM,Nah SY

更新日期：2011-01-01 00:00:00

abstract：:The liposome, a closed phospholipid bilayered vesicular system, has received considerable attention as a pharmaceutical carrier of great potential over the past 30 years. The ability of liposomes to encapsulate both hydrophilic and hydrophobic drugs, coupled with their biocompatibility and biodegradability, make lipos...

journal_title：Biological & pharmaceutical bulletin

authors： Abu Lila AS,Ishida T

更新日期：2017-01-01 00:00:00

abstract：:In the process of lipolysis, adipocytes are stimulated by catecholamines through beta(1), beta(2), and beta(3) adrenergic receptors (ARs). So far, beta(2) and beta(3) AR polymorphisms have been reported related to obesity. However, the relation of beta(1)AR polymorphisms to obesity has not been evaluated. In the prese...

journal_title：Biological & pharmaceutical bulletin

authors： Nonen S,Yamamoto I,Liu J,Maeda M,Motomura T,Igarashi T,Fujio Y,Azuma J

更新日期：2008-02-01 00:00:00

abstract：:We determined the in vivo and in vitro antitumor activities of gambogic acid (GA) and one of the possible mechanisms for its inhibitory activities. In vivo antitumor activity of GA was evaluated by the relative tumor growth ratio (T/C) in nude mice, and in vitro inhibition of SPC-A1 cells was measured by 3-(4,5-dimeth...

journal_title：Biological & pharmaceutical bulletin

authors： Wu ZQ,Guo QL,You QD,Zhao L,Gu HY

更新日期：2004-11-01 00:00:00

abstract：:The reaction of malondialdehyde (MDA) with alpha-N-acetyl-histidine (Ac-His) in the presence of alkanal was investigated. MDA alone did not react with Ac-His but when alkanal was present, a reaction took place. A similar result was obtained for the reaction of MDA with imidazole in the presence of alkanal. In addition...

journal_title：Biological & pharmaceutical bulletin

authors： Ohya T

更新日期：1994-04-01 00:00:00

abstract：:The present work aimed to investigate the vasorelaxant effect of isotirumalin, a dihydroflavonol isolated from Derris urucu (Leguminosae). The vasorelaxant effect of isotirumalin was investigated in the rat aorta, in the presence and in the absence of a functional endothelium. The production of nitric oxide (NO) induc...

journal_title：Biological & pharmaceutical bulletin

authors： Mendes LJ,Capettini LS,Lôbo LT,da Silva GA,Arruda MS,Lemos VS,Côrtes SF

更新日期：2011-01-01 00:00:00

abstract：:As a study to assess the potential application of milk fat-globule membrane (MFGM), which is of natural origin and expected to be a safer alternative to synthetic emulsifiers, to pharmaceutical dosage forms, the oral absorption of alpha-linolenic acid was evaluated by the analysis of gastrointestinal disposition after...

journal_title：Biological & pharmaceutical bulletin

authors： Yuasa H,Sekiya M,Ozeki S,Watanabe J

更新日期：1994-09-01 00:00:00

abstract：:The present study was performed to investigate the effects of histamine H(1)-antagonists on the sleep-awake state in rats placed on a grid suspended over water in comparison with rats placed on sawdust. When rats were placed on the grid suspended over water, significant increases in the awake time and decreases in non...

journal_title：Biological & pharmaceutical bulletin

authors： Tokunaga S,Tsutsui R,Obara Y,Ishida T,Kamei C

更新日期：2009-01-01 00:00:00

abstract：:Early diagnosis of Niemann-Pick diseases (NPDs) is important for better prognosis of such diseases. N-Palmitoyl-O-phosphocholine-serine (PPCS) is a new NPD biomarker possessing high sensitivity, and with its combination with sphingosylphosphocholine (SPC) it may be possible to distinguish NPD-C from NPD-A/B. In this s...

journal_title：Biological & pharmaceutical bulletin

authors： Iwahori A,Maekawa M,Narita A,Kato A,Sato T,Ogura J,Sato Y,Kikuchi M,Noguchi A,Higaki K,Okuyama T,Takahashi T,Eto Y,Mano N

更新日期：2020-09-01 00:00:00

abstract：:Di-n-butyl phthalate (DBP), a phthalate ester, has been shown to have an adjuvant effect on fluorescein isothiocyanate (FITC)-induced contact hypersensitivity (CHS) mouse models. Di-n-butyl maleate (DBM), widely used as a plasticizer for industrial application, has been reported to cause dermatitis in humans. DBM is a...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuoka T,Kurohane K,Suzuki W,Ogawa E,Kobayashi K,Imai Y

更新日期：2016-01-01 00:00:00

abstract：:Chemoprevention has emerged as a very effective preventive measure against carcinogenesis. Several bioactive compounds present in fruits and vegetables have revealed their cancer curative potential on benzo(a)pyrene (B(a)P) induced carcinogenesis. In the present study, the efficacy of quercetin on the level of lipid p...

journal_title：Biological & pharmaceutical bulletin

authors： Kamaraj S,Vinodhkumar R,Anandakumar P,Jagan S,Ramakrishnan G,Devaki T

更新日期：2007-12-01 00:00:00

abstract：:This study was conducted to demonstrate the inhibitory effect of saucerneol G (SG), a new lignan, isolated from the aerial part of Saururus chinensis (Saururaceae) on lipopolysaccharide (LPS)-stimulated matrix metalloproteinase-9 (MMP)-9 inductions in RAW 264.7 cells. Aimed at evaluating the mechanism of action by whi...

journal_title：Biological & pharmaceutical bulletin

authors： Lu Y,Hong TG,Jin M,Yang JH,Suh SJ,Piao DG,Ko HK,Seo CS,Chang YC,Kim CH,Son JK,Chang HW

更新日期：2010-01-01 00:00:00

abstract：:3',4'-Diisovalerylkhellactone diester (PJ-1) is a coumarin derivative purified from the medicinal herb Peucedanum japonicum Thunb. We examined its in vitro effects on various aspects of platelet reactivity. PJ-1 inhibited the aggregation and ATP release of rabbit platelets induced by PAF (platelet-activating factor) a...

journal_title：Biological & pharmaceutical bulletin

authors： Hsiao G,Ko FN,Jong TT,Teng CM

更新日期：1998-07-01 00:00:00

abstract：:We previously screened the anti-itching activities of 33 herbal medicines in substance P (SP)-induced itching model mice. One of the most potent antipruritogenic extracts, the methanol extract of fruits of Cnidium monnieri (Cnidii Fructus) was studied further. The chloroform-soluble fraction of the methanol extract ma...

journal_title：Biological & pharmaceutical bulletin

authors： Basnet P,Yasuda I,Kumagai N,Tohda C,Nojima H,Kuraishi Y,Komatsu K

更新日期：2001-09-01 00:00:00

abstract：:Distigmine bromide (distigmine) is a reversible carbamate cholinesterase (ChE) inhibitor. Its principle clinical application is in the treatment of myasthenia gravis. Distigmine is also used as a remedy for dysuria and glaucoma. Its effectiveness in the management of dysuria has been demonstrated in several clinical r...

journal_title：Biological & pharmaceutical bulletin

authors： Obara K,Tanaka Y

更新日期：2019-01-01 00:00:00

abstract：:Baculovirus vectors (BVs) enable safe and efficient gene delivery to mammalian cells and are useful in a wide range of applications, including gene therapy and in vivo analysis of gene functions. We previously developed BVs expressing malaria sporozoite surface proteins for targeting liver cells or hepatocytes. Howeve...

journal_title：Biological & pharmaceutical bulletin

authors： Kawai Y,Kawabata C,Sakaguchi M,Tamura T

更新日期：2018-01-01 00:00:00

abstract：:We have observed the surface images of dimyristoylphosphatidylcholine (DMPC) monolayer and DMPC vesicles with an atomic force microscope (AFM). It was confirmed that the lattice structure of polar head groups of DMPC molecules in a Langmuir-Blodgett monolayer is similar to those of large unilamellar DMPC vesicles. AFM...

journal_title：Biological & pharmaceutical bulletin

authors： Sato Y,Chen Z,Takahashi T,Suzuki Y

更新日期：1994-12-01 00:00:00

abstract：:Biomacromolecules (>40 kDa) have been developed as drug delivery system (DDS) carriers of low-molecular weight drugs to promote these drugs' uptake by cancer tissues via enhanced permeability and retention (EPR) effects. Human serum albumin (HSA) has been found to accumulate in cancer tissues via this EPR effect. HSA ...

journal_title：Biological & pharmaceutical bulletin

authors： Ishima Y

更新日期：2017-01-01 00:00:00

abstract：:We investigated the effect of components in grapefruit juice (GFJ) on the transport of vinblastine, a substrate of P-glycoprotein (P-gp), across Caco-2 cells. The apical to basolateral flux of [3H]vinblastine was increased in the presence of GFJ extracts. The steady-state uptake of [3H]vinblastine from the apical side...

journal_title：Biological & pharmaceutical bulletin

authors： Takanaga H,Ohnishi A,Matsuo H,Sawada Y

更新日期：1998-10-01 00:00:00

abstract：:We have found a new compound from thermophile extracts which inhibits antigen presentation on mouse macrophages. The substance inhibits the expression of the class II major histocompatibility molecule (Ia). It was extracted from Bacillus stearothermophilus UBT8038 and purified by silica gel column chromatography. The ...

journal_title：Biological & pharmaceutical bulletin

authors： Kohama Y,Itoh M,Tanaka K,Senba T,Itoh S,Mimura T

更新日期：1994-07-01 00:00:00

abstract：:We investigated the possible protective effects of benidipine (Coniel), a calcium antagonist, on mechanical dysfunction, metabolic damage and changes in vascular reactivity during ischemia and reperfusion in the Langendorff-perfused rat heart. The responses of perfusion pressure to U-46619, a vasoconstrictor, and acet...

journal_title：Biological & pharmaceutical bulletin

authors： Yao K,Karasawa A

更新日期：1994-04-01 00:00:00

abstract：:We previously prepared 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) solutions containing disulfiram (DSF) and hydroxypropylmethylcellulose (HPMC, DSF solutions), and found the instillation of this DSF solutions delayed lens opacification in ICR/f rats, a recessive-type hereditary cataractous strain. In this study, we ...

journal_title：Biological & pharmaceutical bulletin

authors： Nagai N,Inomata M,Ito Y

更新日期：2008-07-01 00:00:00

abstract：:Morinda citrifolia L., known as noni, originated from Indonesia exhibits various pharmacological activities including anti-inflammatory properties. However, the validity of noni fruit juice as a treatment for rheumatoid arthritis (RA), an autoimmune disorder, has not been confirmed yet. Therefore, the main purpose of ...

journal_title：Biological & pharmaceutical bulletin

authors： Kustiarini DA,Nishigaki T,Kanno H,To H

更新日期：2019-01-01 00:00:00

abstract：:The sialic acid binding lectin from bullfrog Rana catesbeiana oocyte (cSBL) is known to have anti-tumor activity. In order to investigate the relationship between the net charge of cSBL and its anti-tumor effect, cSBL was modified with a water-soluble carbodiimide (EDC) in the presence of three kinds of nucleophiles, ...

journal_title：Biological & pharmaceutical bulletin

authors： Iwama M,Ogawa Y,Sasaki N,Nitta K,Takayanagi Y,Ohgi K,Tsuji T,Irie M

更新日期：2001-09-01 00:00:00

abstract：:Indole-3-carbinol (I3C) is a natural compound found in a wide variety of plant food substances including members of the family Cruciferae with antioxidant and potential chemopreventive properties. In a previous study, I3C exhibited broad spectrum antibacterial activities. Particularly, it showed a more potent antibact...

journal_title：Biological & pharmaceutical bulletin

authors： Sung WS,Lee DG

更新日期：2008-09-01 00:00:00

abstract：:6-(10-Hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone) has been found to have a membrane-stabilizing activity in studies using lysosomes. Using dimyristoyl L-alpha-phosphatidylcholine (DMPC) as a substrate, the effects of idebenone and related benzoquinones on phospholipid digestion by phospholipase A...

journal_title：Biological & pharmaceutical bulletin

authors： Amano T,Terao S,Imada I

更新日期：1995-05-01 00:00:00

abstract：:Granisetron (GRN) is widely used for patients with various cancers who suffer from chemotherapy-induced vomiting and nausea. The, pharmacokinetics of GRN has not been fully evaluated in such patients, however, and its dosage regimen is still controversial. In this study, we determined GRN levels in serum and urine fro...

journal_title：Biological & pharmaceutical bulletin

authors： Wada I,Takeda T,Sato M,Saitoh H,Nakabayashi T,Mino K,Honma T,Takada M,Hirano K

更新日期：2001-04-01 00:00:00