Effect of modification of the carboxyl groups of the sialic acid binding lectin from bullfrog (Rana catesbeiana) oocyte on anti-tumor activity.

abstract：:A previous study showed that macelignan extracted from Myristica fragrans has anti-inflammatory properties using hippocampal neuronal and primary microglial cells. Subsequently, a study using animals with chronic lipopolysaccharide (LPS) infusion into the brain showed that oral treatments of macelignan reduced the hip...

journal_title：Biological & pharmaceutical bulletin

authors： Ma J,Hwang YK,Cho WH,Han SH,Hwang JK,Han JS

更新日期：2009-06-01 00:00:00

abstract：:The anti-inflammatory effects of 1,6-anhydro-3,4-dideoxy-2-furfuryl-beta-D-threo-3-enopyranose (MT2221) were investigated using animal models and compared with the effects of dexamethasone (DEX) and cyclosporin A (CYA). MT2221 inhibited carrageenan-induced acute inflammation and adjuvant arthritis in rats, as well as ...

journal_title：Biological & pharmaceutical bulletin

authors： Mizukoshi S,Tsukamoto M,Tanaka H,Nakamura K,Kato F

更新日期：1994-08-01 00:00:00

abstract：:In the present study, we investigated the neuroprotective effects of kaempferol in the mouse model of Parkinson's disease, which was induced by neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). We confirmed that MPTP led to behavioral deficits, depletion of dopamine and its metabolites, reduction in supe...

journal_title：Biological & pharmaceutical bulletin

authors： Li S,Pu XP

更新日期：2011-01-01 00:00:00

abstract：:The MeOH and water extracts of the Netherlands propolis were tested for their inhibitory activity toward nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage-like J774.1 cells. Both of the extract possessed significant NO inhibitory activity with IC(50) values of 23.8 and 51.5 microg/ml...

journal_title：Biological & pharmaceutical bulletin

authors： Nagaoka T,Banskota AH,Tezuka Y,Midorikawa K,Matsushige K,Kadota S

更新日期：2003-04-01 00:00:00

abstract：:While the use of in vitro-transcribed mRNA (IVT-mRNA) in therapeutics is a rapidly expanding area, the transfection of the exogenous IVT-mRNA is accompanied by a risk of immune activation. This immunological defense mechanism suppresses cellular translation process and can reduce transfection efficiency to a considera...

journal_title：Biological & pharmaceutical bulletin

authors： Ohto T,Konishi M,Tanaka H,Onomoto K,Yoneyama M,Nakai Y,Tange K,Yoshioka H,Akita H

更新日期：2019-01-01 00:00:00

abstract：:A rat model of early sepsis induced by lipopolysaccharide (LPS) combined with interleukin-2 (IL-2) was developed. The primary aim was to assess the pharmacokinetics of gentamicin and sepsis-induced pathophysiological changes. Moreover, the effects on the glomerular filtration rate and tubular function were studied in ...

journal_title：Biological & pharmaceutical bulletin

authors： Studena S,Martinkova J,Slizova D,Krs O,Senkerik M,Springer D,Chládek J

更新日期：2012-01-01 00:00:00

abstract：:Endogenously produced reactive oxygen species reportedly stimulate insulin secretion from islet β-cells. However, the molecular machinery that governs the oxidant-induced insulin secretion has yet to be determined. The present study demonstrates, using rat islet β-cell-derived RINm5F cells, the involvement of the tran...

journal_title：Biological & pharmaceutical bulletin

authors： Numazawa S,Takase M,Ahiko T,Ishii M,Shimizu S,Yoshida T

更新日期：2012-01-01 00:00:00

abstract：:Astragali Radix (AR), is a popular herbal medicine used to treat allergic diseases in Korea, Japan and China. Our study examined the effect of an AR ethanol extract on both in vitro and in vivo murine CD4 T cells' differentiation into Th1 and Th2 subsets. CD4 T cells from Balb/c mice were activated with anti-CD3/anti-...

journal_title：Biological & pharmaceutical bulletin

authors： Kang H,Ahn KS,Cho C,Bae HS

更新日期：2004-12-01 00:00:00

abstract：:Assessment of biological potency and its comparison with clinical effects are important in the quality control of therapeutic glycoproteins. Animal models are usually used for evaluating bioactivity of these compounds. However, alternative methods are required to simplify the bioassay and avoid ethical issues associat...

journal_title：Biological & pharmaceutical bulletin

authors： Yanagihara S,Taniguchi Y,Hosono M,Yoshioka E,Ishikawa R,Shimada Y,Kadoya T,Kutsukake K

更新日期：2010-01-01 00:00:00

abstract：:Chinese medicinal prescriptions were screened for their effects on alpha-amylase activity in mouse plasma. Daio-kanzo-to, Hange-koboku-to, Saiko-ka-ryukotsu-borei-to, Saiko-keishi-kankyo-to and Mao-to changed the activity in isolated mouse plasma greatly and concentration dependently. However, no prescription influenc...

journal_title：Biological & pharmaceutical bulletin

authors： Kobayashi K,Funayama N,Suzuki R,Yoshizaki F

更新日期：2002-08-01 00:00:00

abstract：:We studied the protective effects of Echinacea purpurea against radiation by evaluating changes in the peripheral blood cell count and peripheral blood antioxidant activity. E. purpurea administration had a suppressive effect on radiation-induced leukopenia, especially on lymphocytes and monocytes, and resulted in a f...

journal_title：Biological & pharmaceutical bulletin

authors： Mishima S,Saito K,Maruyama H,Inoue M,Yamashita T,Ishida T,Gu Y

更新日期：2004-07-01 00:00:00

abstract：:Recently we showed significance of biosurfactants in the field of non-viral vectors for gene transfection. There, a biosurfactant, mannosylerythritol lipid A (MEL-A), especially increased the efficiency of gene transfection mediated with cationic liposomes. However, the molecular mechanism has not been well-understood...

journal_title：Biological & pharmaceutical bulletin

authors： Ueno Y,Hirashima N,Inoh Y,Furuno T,Nakanishi M

更新日期：2007-01-01 00:00:00

abstract：:Beta-D-Xylosidase (EC 3.2.1.37) has been purified from ginsenoside Ra-metabolizing Bifidobacterium breve K-110, which was isolated from human intestinal microflora. beta-D-Xylosidase was purified to apparent homogeneity by a combination of ammonium sulfate precipitation, QAE-cellulose, butyl-toyopearl, hydroxyapatit a...

journal_title：Biological & pharmaceutical bulletin

authors： Shin HY,Lee JH,Lee JY,Han YO,Han MJ,Kim DH

更新日期：2003-08-01 00:00:00

abstract：:To clarify the pathogenicity and the pathogenic factors of Candida tropicalis strains, five strains, IFO 0199, IFO 0587, IFO 0589, IFO 1400, and IFO 1647, of C. tropicalis were tested for their lethality to mice, adherence to Hela cells, hydrophobicity, cell growth under acidic conditions (pH 2.0-5.9), and sucrose ass...

journal_title：Biological & pharmaceutical bulletin

authors： Okawa Y,Miyauchi M,Kobayashi H

更新日期：2008-08-01 00:00:00

abstract：:Using the par to rep region of the 24653 bp plasmid pN315, which is present in Staphylococcus aureus strain N315, we constructed three vectors that can be shuttled between Escherichia coli and S. aureus and maintained stably in S. aureus. Due to plasmid incompatibility, the resident plasmid in S. aureus cells can be r...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuo M,Kurokawa K,Lee BL,Sekimizu K

更新日期：2010-01-01 00:00:00

abstract：:Changes in carbonyl reductase (CR) activity towards seven substrates in adrenal glands of female rats were investigated during estrous cycle and the circadian patterns of adrenal CR activity towards seven substrates in male rats were examined. The localization of the enzyme protein in the adrenal gland was carried out...

journal_title：Biological & pharmaceutical bulletin

authors： Inazu N,Nagashima Y,Satoh T

更新日期：1995-05-01 00:00:00

abstract：:It has been identified that skeletal muscle is an endocrine tissue. Since skeletal muscle aging affects not only to muscle strength and function but to systemic aging and lifespan, myokines secreted from skeletal muscle may be crucial factors for intertissue communication during aging. In the present study, we investi...

journal_title：Biological & pharmaceutical bulletin

authors： Ito T,Nakanishi Y,Yamaji N,Murakami S,Schaffer SW

更新日期：2018-01-01 00:00:00

abstract：:A DNA fragment responsible for resistance to antimicrobial agents was cloned from chromosomal DNA of Enterococcus faecium FN-1, a clinically isolated strain. Escherichia coli KAM32, a drug-hypersusceptible mutant, was used as a host for gene cloning. Cells of E. coli KAM32 harboring a recombinant plasmid (pTFM8) carry...

journal_title：Biological & pharmaceutical bulletin

authors： Nishioka T,Ogawa W,Kuroda T,Katsu T,Tsuchiya T

更新日期：2009-03-01 00:00:00

abstract：:The in vitro percutaneous permeation of diclofenac from various vehicles was examined using rat abdominal skin as a model membrane. The oleaginous vehicles used in this study consisted of three components: i.e. fatty acid, fatty acid ester and nonpolar oil. The solubilities of sodium diclofenac in formulated vehicles ...

journal_title：Biological & pharmaceutical bulletin

authors： Takahashi K,Suzuki T,Sakano H,Mizuno N

更新日期：1995-04-01 00:00:00

abstract：:The uric acid concentration in blood has been widely accepted as a diagnostic indicator of hyperuricemia and gout, and its assay method is well established. In the present study, we developed a simple and rapid method for the determination of uric acid in hair, which can be obtained non-invasively. The concentration (...

journal_title：Biological & pharmaceutical bulletin

authors： Kobayashi K,Morioka Y,Isaka Y,Tozawa T

更新日期：1998-04-01 00:00:00

abstract：:Preparation of the fatty alcohol propylene glycol (FAPG) ointment base plays an important role in controlling the physicochemical properties of ointments. These essay investigates the effects of preparative conditions such as cooling rate and stirring rate on the percutaneous absorption of norfloxacin from FAPG ointme...

journal_title：Biological & pharmaceutical bulletin

authors： Lin HH,Hsu LR,Wu PC,Tsai YH

更新日期：1995-11-01 00:00:00

abstract：:A sulfated galactan (FG) was isolated from the green alga, Codium fragile. Chemical analysis revealed that FG mainly consisted of D-galactose with pyruvic acid (12.3%) and sulfate (11.0%). Methylation and NMR analyses showed that FG was composed of -->3)-beta-D-Galp-(1-->, beta-D-Galp-(1--> and -->3,6)-beta-D-Galp-(1-...

journal_title：Biological & pharmaceutical bulletin

authors： Ohta Y,Lee JB,Hayashi K,Hayashi T

更新日期：2009-05-01 00:00:00

abstract：:It has been suggested that the activities of type IV collagenase and/or ectopeptidases possessed by malignant cells are related to their metastatic potentials. In the present study, we examined the activities of three aminopeptidases, two serine proteases, as well as type IV collagenase, in three kinds of cell lines o...

journal_title：Biological & pharmaceutical bulletin

authors： Funahashi T,Shimamura M,Kocha T,Fukuda T,Aoyagi T

更新日期：1994-08-01 00:00:00

abstract：:In vitro release behavior and cytotoxic activity, and in vivo plasma disposition of newly synthesized macromolecular derivatives of cisplatin (CDDP) were investigated and compared with CDDP. The derivatives included oxidized dextran conjugate of CDDP (OX-Dex/CDDP) and dicarboxymethylated dextran conjugate of CDDP (DCM...

journal_title：Biological & pharmaceutical bulletin

authors： Nakashima M,Ichinose K,Kanematsu T,Masunaga T,Ohya Y,Ouchi T,Tomiyama N,Sasaki H,Ichikawa M

更新日期：1999-07-01 00:00:00

abstract：:We previously reported that the topical application of ascorbic acid 2-O-alpha-glucoside (AA-2G) suppressed the cutaneous inflammation by ultraviolet irradiation in human and guinea pigs (Miyai et al., Nishinihon J. Dermatol., 58, 439-443 (1996)). In this paper, the effect of AA-2G on the lethal damage induced by ultr...

journal_title：Biological & pharmaceutical bulletin

authors： Miyai E,Yanagida M,Akiyama J,Yamamoto I

更新日期：1997-06-01 00:00:00

abstract：:Using a validated high-performance liquid chromatographic (HPLC) method, the pharmacokinetics of multi-constituents in Huangqin-Tang decoction were simultaneously studied both in the compound prescription and in each single herb decoction. At different intervals (0, 1, 2, 4, 8, 12, 24, 36, 48 h) after oral administrat...

journal_title：Biological & pharmaceutical bulletin

authors： Zuo F,Zhou ZM,Zhang Q,Mao D,Xiong YL,Wang YL,Yan MZ,Liu ML

更新日期：2003-07-01 00:00:00

abstract：:Alzheimer's disease (AD) is pathologically characterized by accumulation of amyloid β (Aβ) and hyperphosphorylated tau, and thereby induction of neuronal cell death. The Aβ-induced neuronal cell death has been shown to occur by several modes, such as apoptosis, necrosis, and necroptosis. Interestingly, in AD patients,...

journal_title：Biological & pharmaceutical bulletin

authors： Tagai N,Tanaka A,Sato A,Uchiumi F,Tanuma SI

更新日期：2020-01-01 00:00:00

abstract：:PEGylation is an established method for improving the pharmacokinetic properties and pharmacodynamic effects of therapeutic proteins. Amino conjugation by N-hydroxysuccinimide activated polyethylene glycol (PEG-NHS) represents the most common modification of the target proteins. In this study, we compared the reaction...

journal_title：Biological & pharmaceutical bulletin

authors： Nojima Y,Iguchi K,Suzuki Y,Sato A

更新日期：2009-03-01 00:00:00

abstract：:Transient receptor potential vanilloid 1 (TRPV1) is primarily expressed in central and peripheral terminals of non-myelinated primary afferent neurons. We previously showed that AS1928370, a novel TRPV1 antagonist that can prevent ligand-induced activation but not proton-induced activation, ameliorates neuropathic pai...

journal_title：Biological & pharmaceutical bulletin

authors： Watabiki T,Kiso T,Tsukamoto M,Aoki T,Matsuoka N

更新日期：2011-01-01 00:00:00

abstract：:Tubeimoside I (TBMS I), an extract from Chinese herbal medicine Bolbostemma paniculatum (MAXIM.) FRANQUET (Cucurbitaceae) has been shown as a potent anti-tumor agent for a variety of human cancers, but yet to be evaluated for hepatoma that is highly prevalent in Eastern Asian countries including China. Here, we examin...

journal_title：Biological & pharmaceutical bulletin

authors： Wang Y,Deng L,Zhong H,Wang Y,Jiang X,Chen J

更新日期：2011-01-01 00:00:00