Neuroprotective effect of kaempferol against a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease.

abstract：:Alzheimer's disease (AD) is pathologically characterized by accumulation of amyloid β (Aβ) and hyperphosphorylated tau, and thereby induction of neuronal cell death. The Aβ-induced neuronal cell death has been shown to occur by several modes, such as apoptosis, necrosis, and necroptosis. Interestingly, in AD patients,...

journal_title：Biological & pharmaceutical bulletin

authors： Tagai N,Tanaka A,Sato A,Uchiumi F,Tanuma SI

更新日期：2020-01-01 00:00:00

abstract：:The interaction of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonist YM90K with the competitive N-methyl-D-aspartate (NMDA) antagonist CGS19755 or with the NMDA channel blocker MK801 on the spatial memory of rats was examined by the 4-arm-baited radial maze task. When administered alone, t...

journal_title：Biological & pharmaceutical bulletin

authors： Li H,Matsumoto K,Watanabe H

更新日期：1998-11-01 00:00:00

abstract：:Potent ligands of peroxisome proliferator-activated receptor γ (PPARγ) such as thiazolidinediones (pioglitazone, troglitazone, etc.) improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with insulin sensitivity in adipose tissue. Several constituents from medicinal...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuda H,Nakamura S,Yoshikawa M

更新日期：2014-01-01 00:00:00

abstract：:Seventeen thiopaeonimetabolin-I adducts were obtained as mixtures of diastereoisomers after incubation of paeoniflorin with Lactobacillus brevis in the presence of various thiols. The anticonvulsant activity of the adducts was investigated in mice using the maximal subcutaneous pentylenetetrazol seizure test and sodiu...

journal_title：Biological & pharmaceutical bulletin

authors： Abdel-Hafez AA,Meselhy MR,Nakamura N,Hattori M,Watanabe H,Murakami Y,El-Gendy MA,Mahfouz NM,Mohamed TA

更新日期：1999-05-01 00:00:00

abstract：:T cells play a principal role in cellular immunity and govern the regulatory mechanism in humoral immunity. Therefore, T cells play a key role as either effectors or regulators in the immune network. Mizoribine (MZR), an immunosuppressive agent, suppresses both humoral and cellular immunity by acting on both T cells a...

journal_title：Biological & pharmaceutical bulletin

authors： Kamada H,Inoue N,Takaoka Y,Nakagami K,Mori H,Nagai H

更新日期：1996-09-01 00:00:00

abstract：:The effects of various surfactants and protease inhibitors on the nasal absorption of recombinant human granulocyte colony-stimulating factor (rhG-CSF) were examined in rats. No effects of bile salts and acids such as sodium glycocholate or taurocholic acid, amphoteric surfactants such as lauryldimethyl betaine, or an...

journal_title：Biological & pharmaceutical bulletin

authors： Machida M,Sano K,Arakawa M,Hayashi M,Awazu S

更新日期：1994-10-01 00:00:00

abstract：:Chitooligosaccharides, the oligomers made up of beta-1,4-linked D-glucosamine, are obtained by partial hydrolysis of chitosan, a deacetylation product of chitin. The antioxidant activity of various chitooligosaccharides was tested in vitro with aminoguanidine, pyridoxamine, and Trolox as reference compounds. Hydroxyla...

journal_title：Biological & pharmaceutical bulletin

authors： Chen AS,Taguchi T,Sakai K,Kikuchi K,Wang MW,Miwa I

更新日期：2003-09-01 00:00:00

abstract：:The involvement of the peripheral serotonin2A (5-HT2A) receptor in alpha-methyl-5-HT-induced hyperglycemia was examined in rats. The 5-HT2A receptor antagonist, ketanserin, significantly inhibited alpha-methyl-5-HT-elicited hyperglycemia. Taken together with a previous report that 5-HT-induced hyperglycemia was preven...

journal_title：Biological & pharmaceutical bulletin

authors： Sugimoto Y,Yamada J,Yoshikawa T,Horisaka K

更新日期：1996-10-01 00:00:00

abstract：:Novel delivery technology using cell-penetrating peptides (CPPs) have recently shown their potential and are emerging as promising candidates for an oral protein and peptide delivery systems. As with for the development of any absorption enhancer that is meant to function across an epithelial layer covering a surface ...

journal_title：Biological & pharmaceutical bulletin

authors： Nielsen EJ,Kamei N,Takeda-Morishita M

更新日期：2015-01-01 00:00:00

abstract：:The effects of various absorption promoters on the pulmonary absorption of drugs with different molecular weights were examined in rats. Phenol red and fluorescein isothiocyanate-labeled dextrans (FDs) with various molecular weights were used as model drugs and the absorption promoters used in this study were sodium g...

journal_title：Biological & pharmaceutical bulletin

authors： Morita T,Yamamoto A,Hashida M,Sezaki H

更新日期：1993-03-01 00:00:00

abstract：:In Parkinson's disease, while dopamine (DA) replacement therapy, such as with L-DOPA (levodopa), improves the symptoms, it does not inhibit the degeneration of DA neurons in the substantia nigra. Numerous studies have suggested that both endogenous and environmental neurotoxins and oxidative stress may participate in ...

journal_title：Biological & pharmaceutical bulletin

authors： Kitamura Y,Kakimura J,Taniguchi T

更新日期：2002-03-01 00:00:00

abstract：:In a previous report, we had demonstrated the antioxidant activity of the sialic acid N-acetylneuraminic acid (Neu5Ac, NANA). This activity can counteract the cytotoxicity of hydrogen peroxide (H2O2), and the antitoxicity is a result of a direct chemical reaction, whereby NANA reduces H2O2 in the culture media. The in...

journal_title：Biological & pharmaceutical bulletin

authors： Iijima R,Takahashi H,Ikegami S,Yamazaki M

更新日期：2007-03-01 00:00:00

abstract：:Agaricus blazei is a medicinal mushroom native to Brazil. It used to be a source of anti-tumor and immunmoactive compounds and considered a health food in many countries. However, its specific effect against mast cell-mediated anaphylactic reactions is still unknown. In the present study, we investigated the effect of...

journal_title：Biological & pharmaceutical bulletin

authors： Choi YH,Yan GH,Chai OH,Choi YH,Zhang X,Lim JM,Kim JH,Lee MS,Han EH,Kim HT,Song CH

更新日期：2006-07-01 00:00:00

abstract：:The bioavailability of morphine after rectal administration using three types of suppositories containing morphine hydrochloride (10 mg) in different added forms was evaluated in rabbits. Three types of suppositories were constructed with a base material (Witepsol H-15): a conventional suppository containing morphine ...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumoto Y,Watanabe Y,Yamamoto I,Matsumoto M

更新日期：1993-02-01 00:00:00

abstract：:There are many important considerations in the interactions among the herbal constituents in a prescription of traditional Chinese medicine (TCM). Ephedra Herb [Chinese characters: see text] (Eph) is described a warm and acrid agent in TCM. The combination of Eph and Gypsum [Chinese characters: see text] (Eph-Gyp) sho...

journal_title：Biological & pharmaceutical bulletin

authors： Yuan D,Sunouchi H,Sakurai T,Saito K,Kano Y

更新日期：2002-07-01 00:00:00

abstract：:The present study was conducted to evaluate the effects of Paeoniae Radix (PR), one of the most famous tonic traditional Chinese medicines, on the pharmacokinetics of carbamazepine (CBZ) in rats and to determine the possible interactions between PR and CBZ. The significant decrease in Tmax indicated that simultaneous ...

journal_title：Biological & pharmaceutical bulletin

authors： Chen LC,Chen YF,Chou MH,Lin MF,Yang LL,Yen KY

更新日期：2002-04-01 00:00:00

abstract：:The genome sequencing project revealed presence of two active chalcone synthase (CHS) homologues (At1g02050 and At4g34850) in the model plant Arabidopsis thaliana. We report herein the two genes encode closely related novel plant-specific type III polyketide synthases (PKSs) that produces long-chain alkyl alpha-pyrone...

journal_title：Biological & pharmaceutical bulletin

authors： Mizuuchi Y,Shimokawa Y,Wanibuchi K,Noguchi H,Abe I

更新日期：2008-12-01 00:00:00

abstract：:Although macrophage phagocytoses modified low-density lipoprotein (LDL), excessive accumulation of modified LDL induces macrophage foam cell formation, which is a feature of atherosclerotic plaque. Thus, the identification of scavenger receptor for modified LDL will provide better understanding of an atherosclerotic e...

journal_title：Biological & pharmaceutical bulletin

authors： Miki Y,Tachibana Y,Ohminato Y,Fujiwara Y

更新日期：2015-01-01 00:00:00

abstract：:The free radical scavenging activities of Panax ginseng C.A. MEYER are known to increase by heat processing. Phenolic acids and Maillard reaction products (MRPs) have been suggested as active free radical scavenging components from our previous research, but heat processing-induced chemical and activity changes of gin...

journal_title：Biological & pharmaceutical bulletin

authors： Kang KS,Kim HY,Baek SH,Yoo HH,Park JH,Yokozawa T

更新日期：2007-04-01 00:00:00

abstract：:Pairs of forward and reverse primers and TaqMan probes specific to each of 15 human sulfotransferases were prepared. The mRNA expression level of each target enzyme was analyzed in total RNA from single and pooled specimens of various human tissues (adrenal gland, bone marrow, brain, colon, heart, kidney, liver, lung,...

journal_title：Biological & pharmaceutical bulletin

authors： Nishimura M,Naito S

更新日期：2007-04-01 00:00:00

abstract：:In this study, we developed a new hollow-type suppository containing elcatonin ((Asu1,7)-eel calcitonin, ECT), a synthetic derivative of eel calcitonin, which produces hypocalcemia, as a pharmaceutical preparation for self administration, to be used instead of parenteral injections for patients with osteoporosis. The ...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe Y,Mizufune Y,Kubomura A,Kiriyama M,Utoguchi N,Matsumoto M

更新日期：1998-11-01 00:00:00

abstract：:Cell-penetrating peptides (CPPs) have been highly anticipated as an efficient delivery system due to their ability to cross biological membranes and transport various cargoes into cells. In the present study, we have identified adenovirus-derived CPPs using various capsid-mutant adenovirus (Ad) vectors. First, we exam...

journal_title：Biological & pharmaceutical bulletin

authors： Hirai T,Yamagishi Y,Koizumi N,Nonaka M,Mochida R,Shida K,Nomura T,Fujii M,Sakurai F,Mizuguchi H,Watanabe Y,Utoguchi N

更新日期：2017-01-01 00:00:00

abstract：:Two subclones (K562-L and -H) were previously isolated from K562 human leukemic cells according to hemoglobin production: K562-L was expressed in less than 5% and K562-H in more than 90% of dianisidine positive cells. 12-O-Tetradecanoylphorbol-13- acetate (TPA) suppressed the expression of the erythrocytic (glycophori...

journal_title：Biological & pharmaceutical bulletin

authors： Sasaki D,Kosunago S,Mikami T,Matsumoto T,Suzuki M

更新日期：1993-10-01 00:00:00

abstract：:We investigated the effects of restraint and footshock stress and norepinephrine treatment on gastric emptying. The gastric emptying was significantly inhibited by restraint stress. beta(3)-adrenergic antagonist canceled the inhibition of gastric emptying caused by restraint stress, while beta(1)-, beta(2)-, alpha(1)-...

journal_title：Biological & pharmaceutical bulletin

authors： Tsukada F,Nagura Y,Abe S,Sato N,Ohkubo Y

更新日期：2003-03-01 00:00:00

abstract：:A novel constituent, shamimicin, 1"', 1"'-bis-2-(3,4-dihydroxyphenyl)-3,4-dihydro-3,7-dihydroxy-5-O-xylopyranosyloxy-2H-1-benzopyran along with lupeol, which possesses potent hypotensive activity, has been isolated from Bombax ceiba stem bark. BCBMM--one of the most active hypotensive fractions has revealed its advers...

journal_title：Biological & pharmaceutical bulletin

authors： Saleem R,Ahmad SI,Ahmed M,Faizi Z,Zikr-ur-Rehman S,Ali M,Faizi S

更新日期：2003-01-01 00:00:00

abstract：:The mature form of rat adrenodoxin (Ad) was purified from a heterologous direct expression system in Escherichia coli with a yield of 56 mg/l culture. The purified Ad showed a A414/A280 ratio of 0.91 and the sequence of 10 amino terminal residues was identical with that of authentic rat Ad. By Time of Flight/Mass spec...

journal_title：Biological & pharmaceutical bulletin

authors： Sagara Y,Aramaki H

更新日期：1998-10-01 00:00:00

abstract：:Butylbenzyl phthalate (BBzP) is used as a plasticizer to import flexibility to polyvinylchloride plastics. In this study, hydrolysis of BBzP to monobutyl phthalate (MBP) and monobenzyl phthalate (MBzP) in liver microsomes of humans, monkeys, dogs, rats and mice was examined. The kinetics for MBP formation by human, do...

journal_title：Biological & pharmaceutical bulletin

authors： Takahara Y,Kinashi Y,Takahara Y,Hichiya H,Okada K,Murata M,Shigeyama M,Hanioka N

更新日期：2014-01-01 00:00:00

abstract：:We examine the pharmacokinetic profile of cyclosporin A (CyA) after intravenous administration to rats prepared as models of various disease states found in patients who receive organ transplantations. After intravenous bolus administration to normal rats, the total blood clearance (CLt) of CyA showed a dose-dependent...

journal_title：Biological & pharmaceutical bulletin

authors： Shibata N,Shimakawa H,Minouchi T,Yamaji A

更新日期：1993-11-01 00:00:00

abstract：:(1-->3)-beta-D-Glucans exhibit a variety of biological and immunopharmacological activities, and the degree of these activities depends on the nature of the individual glucans e.q. molecular weight, degree of branching and conformation. Based on the generally accepted evidence that the conformation of Sonifilan (SPG) ...

journal_title：Biological & pharmaceutical bulletin

authors： Miura NN,Ohno N,Adachi Y,Aketagawa J,Tamura H,Tanaka S,Yadomae T

更新日期：1995-01-01 00:00:00

abstract：:DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate), a calmodulin antagonist, provides protection against Ca(2+) overload-associated cytotoxicity and brain injury after cerebral ischemia in rats. In this study, we assessed the e...

journal_title：Biological & pharmaceutical bulletin

authors： Sugimura M,Takamori H,Fukushi H,Kitano Y,Kanazawa Y,Shirasaki Y

更新日期：2005-04-01 00:00:00