Abstract:
:DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate), a calmodulin antagonist, provides protection against Ca(2+) overload-associated cytotoxicity and brain injury after cerebral ischemia in rats. In this study, we assessed the effect of DY-9760e on ischemic infarct volume in cats subjected to permanent focal cerebral ischemia. DY-9760e was infused for 6 h, beginning 5 min after occlusion of the middle cerebral artery. The infarct volume was measured at the end of drug infusion. DY-9760e, at the dose of 0.25 but not 0.1 mg/kg/h, significantly reduced cerebral infarct volume without affecting any physiological parameters, and its protective effect was mainly evident in the cerebral cortex, where the penumbra, a salvageable zone, exists. The present study demonstrates that DY-9760e protects against brain injury after focal ischemia in a gyrencephalic animal as well as in the rodents reported previously and suggests its therapeutic value for the treatment of acute stroke.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Sugimura M,Takamori H,Fukushi H,Kitano Y,Kanazawa Y,Shirasaki Ydoi
10.1248/bpb.28.629subject
Has Abstractpub_date
2005-04-01 00:00:00pages
629-33issue
4eissn
0918-6158issn
1347-5215pii
JST.JSTAGE/bpb/28.629journal_volume
28pub_type
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