Effect of restraint and footshock stress and norepinephrine treatment on gastric emptying in rats.

abstract：:In a previous study, we reported that one of the gel-forming (1-->3)-beta-D-glucans, grifolan (from Grifola frondosa, GRN), stimulated cytokine production from macrophages in vitro. However, several other gel-forming (1-->3)-beta-D-glucans, such as sonifilan (SPG) and SSG, did not induce cytokine production from macro...

journal_title：Biological & pharmaceutical bulletin

authors： Okazaki M,Adachi Y,Ohno N,Yadomae T

更新日期：1995-10-01 00:00:00

abstract：:Daikenchuto (DKT) has been widely used for the treatment of postsurgical ileus in Japan. However, its effect on postsurgical adhesion formation has been obscure. In this study, the effect of DKT on postsurgical adhesion formation induced by cecum cauterization or cecum abrasion in mice was investigated. First, the exp...

journal_title：Biological & pharmaceutical bulletin

authors： Wu S,Uyama N,Itou RA,Hatano E,Tsutsui H,Fujimoto J

更新日期：2019-01-01 00:00:00

abstract：:We have recently demonstrated that Bak Foong Pills (BFP), a well-known Chinese medicine widely used for treating gynecological disorders, stimulates human colonic epithelial anion secretion, which was mediated by intracellular cAMP and Ca(2+). The present study further investigated the effect of BFP on exocrine pancre...

journal_title：Biological & pharmaceutical bulletin

authors： Tang N,Zhu JX,Zhao WC,Xing Y,Gou YL,Rowlands DK,Chung YW,Chan HC

更新日期：2003-10-01 00:00:00

abstract：:Monoclonal antibodies are widely used for the treatment of various diseases, and because therapeutic monoclonal antibodies are stored in an aqueous solution or in a lyophilized state, the preparation of a stabilizing formulation that prevents their deterioration (degradation and aggregation) is crucial. Given the stru...

journal_title：Biological & pharmaceutical bulletin

authors： Ishikawa T,Ito T,Endo R,Nakagawa K,Sawa E,Wakamatsu K

更新日期：2010-01-01 00:00:00

abstract：:The purpose of this study was to develop a method for the measurement of the cell kinetics of spleen lymphocytes using the ROSA 26 transgenic mouse ubiquitously expressing beta-galactosidase (beta-gal). Spleen lymphocytes were isolated from ROSA 26 mice and intravenously inoculated into C57BL/6 mice under normal condi...

journal_title：Biological & pharmaceutical bulletin

authors： Hosoya K,Takashima T,Matsuda K,Terasaki T

更新日期：2002-10-01 00:00:00

abstract：:A possible evaluation technique was devised for examing timely cholesterol synthetic activity in the rat liver. The principle of the technique is to measure the incorporation rate of 14C atoms into a few target metabolites excreted in bile with time after an intraportal injection of [1,2-14C] acetate to the conscious ...

journal_title：Biological & pharmaceutical bulletin

authors： Okuyama M,Tsunogai M,Watanabe N,Asakura Y,Shigematsu A

更新日期：1995-11-01 00:00:00

abstract：:Swallowing involves several motor processes such as bolus formation and intraoral transport of a food bolus (oral stage) and a series of visceral events that occur in a relatively fixed timed sequence but are to some degree modifiable (pharyngeal stage or swallow reflex). Reflecting the progressive aging of society, p...

journal_title：Biological & pharmaceutical bulletin

authors： Yamamura K,Kitagawa J,Kurose M,Sugino S,Takatsuji H,Mostafeezur RM,Zakir HM,Yamada Y

更新日期：2010-01-01 00:00:00

abstract：:Despite the relatively high prevalence of migraine or headache, the pathophysiological mechanisms triggering headache-associated peripheral hypersensitivities, are unknown. Since nitric oxide (NO) is well known as a causative factor in the pathogenesis of migraine or migraine-associated hypersensitivities, a mouse mod...

journal_title：Biological & pharmaceutical bulletin

authors： Kim SJ,Yeo JH,Yoon SY,Kwon SG,Lee JH,Beitz AJ,Roh DH

更新日期：2018-02-01 00:00:00

abstract：:Recently, a silent polymorphism of C3435T of the MDR1 gene, encoding the multidrug resistant transporter MDR1/P-glycoprotein, has been found to be associated with susceptibility to ulcerative colitis (UC), but this remains controversial. This study was conducted to find a possible reason for the discrepancies, and it ...

journal_title：Biological & pharmaceutical bulletin

authors： Osuga T,Sakaeda T,Nakamura T,Yamada T,Koyama T,Tamura T,Aoyama N,Okamura N,Kasuga M,Okumura K

更新日期：2006-02-01 00:00:00

abstract：:Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) play a key role in the inflammatory processes. Improper overproduction of NO and prostaglandins by both enzymes are also believed to be involved in the pathogenesis of certain human cancers. Crude extracts of Selaginella tamariscina are used as an ori...

journal_title：Biological & pharmaceutical bulletin

authors： Woo ER,Pokharel YR,Yang JW,Lee SY,Kang KW

更新日期：2006-05-01 00:00:00

abstract：:A lower serum cholesterol level was recently shown to be one of the causes of stroke in an epidemiological study. Spontaneously hypertensive rats stroke-prone (SHRSP) have lower serum cholesterol levels than normotensive Wistar-Kyoto rats (WKY). To elucidate the mechanisms responsible for the lower serum cholesterol l...

journal_title：Biological & pharmaceutical bulletin

authors： Michihara A,Mido M,Matsuoka H,Mizutani Y

更新日期：2015-01-01 00:00:00

abstract：:Polyethyleneglycol (PEG) compounds have a large hydrogen bonding capability and possess various functions that depend on the length of the chain and conformational diversity. Modification of a drug with PEG is a well-known technology for improving the physicochemical properties and biological responses of a drug. Ther...

journal_title：Biological & pharmaceutical bulletin

authors： Ishihara H

更新日期：2013-01-01 00:00:00

abstract：:Coagulase-negative Staphylococcus (CNS) strains are frequently associated with bacteremia and hospital-acquired infections. 293 CNS strains were isolated from 744 samples from a dialysis center in S. M. de Tucumán, Argentina, from hemocultures, catheters and urine and identified as S. epidermidis, S. haemolyticus, S. ...

journal_title：Biological & pharmaceutical bulletin

authors： de Allori MC,Jure MA,Romero C,de Castillo ME

更新日期：2006-08-01 00:00:00

abstract：:A previous study showed that macelignan extracted from Myristica fragrans has anti-inflammatory properties using hippocampal neuronal and primary microglial cells. Subsequently, a study using animals with chronic lipopolysaccharide (LPS) infusion into the brain showed that oral treatments of macelignan reduced the hip...

journal_title：Biological & pharmaceutical bulletin

authors： Ma J,Hwang YK,Cho WH,Han SH,Hwang JK,Han JS

更新日期：2009-06-01 00:00:00

abstract：:Trimidox (3,4,5-trihydroxybenzamidoxime) is one of the most potent ribonucleotide reductase inhibitors, revealing an antitumor effect in several experimental studies. We have examined the effect of trimidox on the induction of cytotoxicity and apoptosis via oxidative stress by typical free radical inducers, hydrogen p...

journal_title：Biological & pharmaceutical bulletin

authors： Kanno S,Kakuta M,Kitajima Y,Osanai Y,Kurauchi K,Ohtake T,Ujibe M,Uwai K,Takeshita M,Ishikawa M

更新日期：2007-05-01 00:00:00

abstract：:Temozolomide (TMZ) is currently the first-line drug used for clinical postoperative or non-surgical chemotherapy for glioma, but acquired and intrinsic resistance to TMZ limits its application. The anti-proliferative effect of formononetin on human glioma cells had been confirmed. To improve therapeutic effects of TMZ...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang X,Ni Q,Wang Y,Fan H,Li Y

更新日期：2018-08-01 00:00:00

abstract：:Nine alkaloid constituents in the root of Aconitum yesoense var. macroyesoense, as well as three acetylated derivatives, were examined for their peripheral vaso-activities by measuring laser-flowmetrically the cutaneous blood flow in the hind foot of mice after intravenous administration. The major constitutive delcos...

journal_title：Biological & pharmaceutical bulletin

authors： Wada K,Ishizuki S,Mori T,Bando H,Murayama M,Kawahara N

更新日期：1997-09-01 00:00:00

abstract：:The aim of the present study was to clarify the mechanism underlying the inhibition of cell proliferation in human lung cancer A549 cells by selenium (Se) compounds. Methylseleninic acid (CH3SeO2H, abbreviated as MSA), a synthetic Se compound, is a direct precursor of active methylselenol (CH3SeH) and is considered to...

journal_title：Biological & pharmaceutical bulletin

authors： Okuno T,Honda E,Arakawa T,Ogino H,Ueno H

更新日期：2014-01-01 00:00:00

abstract：:In this study, we examined the usefulness of a tissue-clearing technique for the evaluation of the lung distribution of aerosolized drugs. An aerosol formulation of TexasRed dextran (70 kDa), a model compound of drug carrier for aerosolized drugs, was administered intrapulmonarily to mice using a MicroSprayer, and the...

journal_title：Biological & pharmaceutical bulletin

authors： Togami K,Kitayama A,Daisho T,Wang R,Tada H,Chono S

更新日期：2018-01-01 00:00:00

abstract：:Oral tolerance is thought to have a role in preventing allergic responses and immune-mediated diseases. Modulation of this tolerance by drugs and chemicals can cause or suppress them. An improved model of oral tolerance to ovalbumin (OVA) in mice was developed to detect modulators of the tolerance and to apply it to s...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JH,Ohsawa M

更新日期：1995-06-01 00:00:00

abstract：:Telekin, a eudesmane-type sesquiterpene lactone compound isolated from Chinese folk medicine Carpesium divaricatum, has been reported to strongly inhibit the proliferation of cancer cells. In this study, the involvement of a mitochondria-mediated pathway in the pro-apoptotic action of telekin was investigated in human...

journal_title：Biological & pharmaceutical bulletin

authors： Zheng B,Wu L,Ma L,Liu S,Li L,Xie W,Li X

更新日期：2013-01-01 00:00:00

abstract：:Our previous work has shown that the amino acid residues around 62-67 located in the connecting loop between helix I and II of human growth hormone (hGH) are important in eliciting the differentiation of preadipose 3T3-F442A cells to adipocytes. In this study, we evaluated the role of the charged residues around 62-67...

journal_title：Biological & pharmaceutical bulletin

authors： Uchida E,Shimokawa S,Takasu H,Ikehara M,Uesugi S,Tomita K,Tanaka A,Morikawa M,Nishikawa S,Hayakawa T

更新日期：1995-06-01 00:00:00

abstract：:The study revealed that high molecular polyvinyl sulfate (PVP) or sulfonate (PVS), and low molecular alkyldisulfonates (NaO3S(CH2)nSO3Na, n = 2--5: EDS, TDS, BDS and PDS) can alleviate acute toxicity of the herbicide, paraquat dichloride (PQ) in mice. Their activity as antidotes and the mode of the action varied depen...

journal_title：Biological & pharmaceutical bulletin

authors： Tsuchiya T,Yoshida T,Imaeda A,Kiho T,Ukai S

更新日期：1995-04-01 00:00:00

abstract：:Potent ligands of peroxisome proliferator-activated receptor γ (PPARγ) such as thiazolidinediones (pioglitazone, troglitazone, etc.) improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with insulin sensitivity in adipose tissue. Several constituents from medicinal...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuda H,Nakamura S,Yoshikawa M

更新日期：2014-01-01 00:00:00

abstract：:We studied in vitro metabolites of 2,4,6,2',4',6'-hexachlorobiphenyl (HCB, IUPAC PCB No. 155) produced by liver microsomes of a phenobarbital (PB)-treated beagle dog. The major metabolites were 3-hydroxy-2,4,6,2',4',6'-HCB (M-1), 4-hydroxy-2,6,2',4',6'-pentachlorobiphenyl (PenCB, M-2) and 3,4-dihydroxy-2,6,2',4',6'-Pe...

journal_title：Biological & pharmaceutical bulletin

authors： Ariyoshi N,Yoshimura H,Oguri K

更新日期：1993-09-01 00:00:00

abstract：:Nafamostat mesilate, an ester drug with extensive hydrolysis in vivo, exhibits species difference in the relative contribution for its hydrolysis in blood and tissues. For the rat, the main hydrolysis site may be blood and human may be tissue (mainly by liver). The paper gave in vivo evidence that human tissue may giv...

journal_title：Biological & pharmaceutical bulletin

authors： Cao YG,Chen YC,Hao K,Zhang M,Liu XQ

更新日期：2008-11-01 00:00:00

abstract：:A hydroalcoholic (50%) extract of Emblica officinalis (fruit) (EO-50) reduced the severity of hepatic fibrosis induced by carbon tetrachloride (CCl4) and thioacetamide (TAA). Improved liver function was observed by measuring the levels of aspartate aminotransaminase (AST), alanine aminotransferase (ALT), alkaline phos...

journal_title：Biological & pharmaceutical bulletin

authors： Tasduq SA,Mondhe DM,Gupta DK,Baleshwar M,Johri RK

更新日期：2005-07-01 00:00:00

abstract：:A significant sex-related difference was observed for the pharmacokinetics of acetohexamide in Wistar-Imamichi (Wistar-IM) rats. However, there was no sex difference of the in vitro reductive metabolism of acetohexamide in the liver or kidney of these rats. Testectomy was found to decrease the plasma clearance (CLp) o...

journal_title：Biological & pharmaceutical bulletin

authors： Imamura Y,Kaneko M,Mori Y,Otagiri M

更新日期：1999-04-01 00:00:00

abstract：:To analyze the renal handling of therapeutic compounds observed as a non-linear process with a diffusion phenomenon, we employed a non-linear dispersion model described with a partial differential equation and solved it by using the finite difference method with an implicit scheme in a model dependent analysis. In thi...

journal_title：Biological & pharmaceutical bulletin

authors： Aiba T,Kubota S,Koizumi T

更新日期：1999-06-01 00:00:00

abstract：:Selective inhibitors of phosphodiesterases (PDEs) have been suggested to have anti-inflammatory effects on bronchial asthma through the inhibition of chemotaxis, adhesion, degranulation, the respiratory burst, and survival prolongation of eosinophils. However, the mechanisms by which these agents inhibit eosinophil su...

journal_title：Biological & pharmaceutical bulletin

authors： Wang W,Masu K,Tamura G,Suzuki K,Ohwada K,Okuyama K,Shirato K,Takayanagi M,Ohno I

更新日期：2005-03-01 00:00:00