Current status and prospects of polyethyleneglycol-modified medicines.

Abstract:

:Polyethyleneglycol (PEG) compounds have a large hydrogen bonding capability and possess various functions that depend on the length of the chain and conformational diversity. Modification of a drug with PEG is a well-known technology for improving the physicochemical properties and biological responses of a drug. There are many reports about the modification of small molecules with PEG, however, there are no modified small molecule products currently on the market. Several protein products for medical use are commercially available. In this review, the effects of modification with PEG on biopharmaceuticals are described through the comparison of two interferon-α products modified with PEG, one with 12 kDa linear PEG and the other 40 kDa branched PEG. There is one original drug delivery system product, Doxil(®)/Caelyx(®), on the market in which liposomes modified with PEG and encapsulating doxorubicin are stabilized sterically and invisible to the reticuloendothelial system. The benefits of modification with PEG are described here with examples of modified products on the market and used in clinical trials.

journal_name

Biol Pharm Bull

authors

Ishihara H

doi

10.1248/bpb.b13-00087

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

883-8

issue

6

eissn

0918-6158

issn

1347-5215

pii

DN/JST.JSTAGE/bpb/b13-00087

journal_volume

36

pub_type

杂志文章,评审
  • Reducing the impact of binding of UCN-01 to human alpha1-acid glycoprotein by encapsulation in liposomes.

    abstract::A liposomal formulation of UCN-01 was studied to prevent binding of drug to human alpha1-acid glycoprotein (hAGP). The release of drug from liposomes added to various media was investigated by monitoring the concentration of UCN-01 in different fractions. Protein bound UCN-01 was separated from liposomal UCN-01 and fr...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.28.1259

    authors: Yamauchi M,Kusano H,Nakakura M,Kato Y

    更新日期:2005-07-01 00:00:00

  • Cytolethality of glutathione conjugates with monomethylarsenic or dimethylarsenic compounds.

    abstract::Arsenicals are known to be toxic and carcinogenic in humans. Inorganic arsenicals are enzymatically methylated to monomethylarsonic acid (MMAsV) and dimethylarsinic acid (DMAsV), which are the major pentavalent methyl arsenic metabolites. Recent reports indicate that trivalent methyl arsenicals are produced through me...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.28.1827

    authors: Kojima C,Sakurai T,Waalkes MP,Himeno S

    更新日期:2005-10-01 00:00:00

  • Adverse event profile of tigecycline: data mining of the public version of the U.S. Food and Drug Administration adverse event reporting system.

    abstract::The recent emergence of multidrug-resistant pathogens and/or pharmacokinetics-pharmacodynamics considerations may result in off-label use of a certain class of antibacterials, including tigecycline. This study was performed to clarify the safety profile of tigecycline in the user-derived manner and to compare it with ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.35.967

    authors: Kadoyama K,Sakaeda T,Tamon A,Okuno Y

    更新日期:2012-01-01 00:00:00

  • Antihypertensive actions of methylripariochromene A from Orthosiphon aristatus, an Indonesian traditional medicinal plant.

    abstract::Methylripariochromene A (MRC) was isolated from the leaves of Orthosiphon aristatus (Lamiaceae) and subjected to the examination of several pharmacological actions related to antihypertensive activity. The following four findings were revealed from the present study: 1) MRC caused a continuous decrease in systolic blo...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.22.1083

    authors: Matsubara T,Bohgaki T,Watarai M,Suzuki H,Ohashi K,Shibuya H

    更新日期:1999-10-01 00:00:00

  • Regorafenib is transported by the organic anion transporter 1B1 and the multidrug resistance protein 2.

    abstract::Regorafenib is a small molecule inhibitor of tyrosine kinases, and has been shown to improve the outcomes of patients with advanced colorectal cancer and advanced gastrointestinal stromal tumors. The transport profiles of regorafenib by various transporters were evaluated. HEK293/organic anion transporting polypeptide...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b14-00740

    authors: Ohya H,Shibayama Y,Ogura J,Narumi K,Kobayashi M,Iseki K

    更新日期:2015-01-01 00:00:00

  • Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Induced by Repeated Forced Swimming in Mice.

    abstract::Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by disabling fatigue of at least 6 months, in addition to symptoms such as muscle pain and muscle weakness. There is no treatment provides long-term benefits to most patients. Recently, clinical research suggested the involvement of pyruvate ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b19-00009

    authors: Ohba T,Domoto S,Tanaka M,Nakamura S,Shimazawa M,Hara H

    更新日期:2019-01-01 00:00:00

  • Antioxidative effect of sesamol and related compounds on lipid peroxidation.

    abstract::The effect of sesamol and 20 related compounds on the lipid peroxidation of liposomes induced by Fe(2)+, on the lipid peroxidation of rat liver microsomes induced by CCl(4) or NADPH and on the lipid peroxidation of mitochondria induced by ascorbate/Fe(2)+ were demonstrated. Consequently, sesamol and related compounds,...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.19.623

    authors: Uchida M,Nakajin S,Toyoshima S,Shinoda M

    更新日期:1996-04-01 00:00:00

  • The Ameliorating Effects of Bee Pollen on Scopolamine-Induced Cognitive Impairment in Mice.

    abstract::Bee pollen consists of floral pollen mixed with bee secretions and nectar. It has been considered as a functional food and has different kinds of biologically active ingredients, such as flavonoids, polyphenols, phytosterols and minerals. However, its function in cognition has yet been investigated. In the present stu...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b18-00552

    authors: Liao Y,Bae HJ,Zhang J,Kwon Y,Koo B,Jung IH,Kim HM,Park JH,Lew JH,Ryu JH

    更新日期:2019-01-01 00:00:00

  • Highly sensitive measurement of P-glycoprotein-mediated transport activity in Caco-2 cells.

    abstract::We established a highly sensitive method for evaluating P-glycoprotein activity in Caco-2 cells. Using time-lapse confocal laser-scanning microscopy, we measured the change in fluorescence of residual rhodamine 123 in Caco-2 cells. Horizontal fluorescence images of rhodamine 123 in the apical and central parts of thes...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.33.1238

    authors: Wakuda H,Nejime N,Tada Y,Kagota S,Umegaki K,Yamada S,Shinozuka K

    更新日期:2010-01-01 00:00:00

  • Development of imaging mass spectrometry.

    abstract::We have developed a mass microscope in which a microscope is combined with high-resolution matrix assisted laser desorption/ionization-imaging mass spectrometry (MALDI-IMS). This technique is a powerful tool for investigating the spatial distribution of biomolecules without the need for any time-consuming extraction, ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章,评审

    doi:10.1248/bpb.b212007

    authors: Saito Y,Waki M,Hameed S,Hayasaka T,Setou M

    更新日期:2012-01-01 00:00:00

  • Tumorigenicity studies for human pluripotent stem cell-derived products.

    abstract::Human pluripotent stem cells (hPSCs), i.e. human embryonic stem cells and human induced pluripotent stem cells, are able to self-renew and differentiate into multiple cell types. Because of these abilities, numerous attempts have been made to utilize hPSCs in regenerative medicine/cell therapy. hPSCs are, however, als...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章,评审

    doi:10.1248/bpb.b12-00970

    authors: Kuroda T,Yasuda S,Sato Y

    更新日期:2013-01-01 00:00:00

  • Antiproliferative constituents in plants 9. Aerial parts of Lippia dulcis and Lippia canescens.

    abstract::The antiproliferative constituents in the MeOH extracts of the aerial parts of Lippia dulcis Trev. and Lippia canescens Kunth (Verbenaceae) were investigated. Activity-guided chemical investigation of the MeOH extracts resulted in the isolation of the three bisabolane-type sesquiterpenes [(+)-hernandulcin (1), (-)-epi...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.25.920

    authors: Abe F,Nagao T,Okabe H

    更新日期:2002-07-01 00:00:00

  • Glutathione-dependent cell cycle G1 arrest and apoptosis induction in human lung cancer A549 cells caused by methylseleninic acid: comparison with sodium selenite.

    abstract::The aim of the present study was to clarify the mechanism underlying the inhibition of cell proliferation in human lung cancer A549 cells by selenium (Se) compounds. Methylseleninic acid (CH3SeO2H, abbreviated as MSA), a synthetic Se compound, is a direct precursor of active methylselenol (CH3SeH) and is considered to...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b14-00453

    authors: Okuno T,Honda E,Arakawa T,Ogino H,Ueno H

    更新日期:2014-01-01 00:00:00

  • Identification of human drug-metabolizing enzymes involved in the metabolism of SNI-2011.

    abstract::In vitro studies were conducted to identify human drug-metabolizing enzymes involved in the metabolism of SNI-2011 ((+/-)-cis-2-methylspiro [1,3-oxathiolane-5,3'-quinuclidine] monohydrochloride hemihydrate, cevimeline hydrochloride hydrate). When 14C-SNI-2011 was incubated with human liver microsomes, SNI-2011 trans-s...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.24.1263

    authors: Washio T,Arisawa H,Kohsaka K,Yasuda H

    更新日期:2001-11-01 00:00:00

  • Effects of histamine H1-antagonists on sleep-awake state in rats placed on a grid suspended over water or on sawdust.

    abstract::The present study was performed to investigate the effects of histamine H(1)-antagonists on the sleep-awake state in rats placed on a grid suspended over water in comparison with rats placed on sawdust. When rats were placed on the grid suspended over water, significant increases in the awake time and decreases in non...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.32.51

    authors: Tokunaga S,Tsutsui R,Obara Y,Ishida T,Kamei C

    更新日期:2009-01-01 00:00:00

  • Effects of some beta-adrenoceptor antagonists on orthostatic hypotension in repeatedly cold- (SART-) stressed rats.

    abstract::Rats stressed by specific alternation of rhythm in temperature (SART) show various symptoms of disautonomia, increased pulse rates, continuous hypotension, and severe orthostatic hypotension (OH) when they are subjected to postural change. The OH symptoms are improved by muscarinic M2-receptor blockers. In the present...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.30.303

    authors: Funakami Y,Hata T,Itoh E,Itano S

    更新日期:2007-02-01 00:00:00

  • Allergen Stability and Immunological Reactivity during Co-dissolution and Incubation of House Dust Mite and Japanese Cedar Pollen SLIT-Tablets.

    abstract::Japanese allergic subjects are commonly sensitized to both house dust mite (HDM) and Japanese cedar pollen (JCP) and combined treatment with sublingual immunotherapy (SLIT) tablets is desirable. However, mixing extracts of two non-homologous allergens may compromise allergen stability and affect the clinical outcome. ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b20-00330

    authors: Watanabe A,Yamamoto T,Matsuhara H,Matsui H,Nakazawa H,Lund K,Ohashi-Doi K

    更新日期:2020-10-01 00:00:00

  • Changes in the expression of cytochrome P450 genes in hemin-induced differentiated K562 cells.

    abstract::We have previously reported the expression of CYP genes in human myeloblastic and lymphoid cell lines, and the induction of the CYP3A4 and GSTP1 genes by oxidative stress in the human erythroleukemia cell line, K562. To further elucidate the role of drug metabolizing enzymes in hematogenesis, we have characterized the...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.30.1954

    authors: Nagai F,Shimizu M,Sakamoto T,Kobayashi T,Tamura H

    更新日期:2007-10-01 00:00:00

  • Preparation and in vivo evaluation of piroxicam-loaded gelatin microcapsule by spray drying technique.

    abstract::To develop a piroxicam-loaded gelatin microcapsule with enhanced bioavailability, a gelatin microcapsule encapsulated ethanol and piroxicam has been formulated by using gelatin as a water-soluble polymer shell. The aqueous solubility and bioavailability of piroxicam in piroxicam-loaded microcapsule in rats were then e...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.31.1284

    authors: Piao MG,Yang CW,Li DX,Kim JO,Jang KY,Yoo BK,Kim JA,Woo JS,Lyoo WS,Han SS,Lee YB,Kim DD,Yong CS,Choi HG

    更新日期:2008-06-01 00:00:00

  • Repression of acyl-CoA:cholesterol acyltransferase by a traditional herbal medicine (Kampo medicine), Ogi-Keishi-Gomotsu-To-Ka-Kojin.

    abstract::Ogi-Keishi-Gomotsu-To-Ka-Kojin (OKGK) is a traditional herbal medicine (Kampo medicine) which has been found to ameliorate hypercholesterolemia and hypertriglyceridemia in rats and rabbits. In the present study, the effect of OKGK on acyl-CoA:cholesterol acyltransferase (ACAT) was studied in order to elucidate the mec...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.22.994

    authors: Wu CZ,Inoue M,Ogihara Y

    更新日期:1999-09-01 00:00:00

  • Purification and determination of the chemical structure of the tyrosinase inhibitor produced by Trichoderma viride strain H1-7 from a marine environment.

    abstract::Tyrosinase is a key enzyme in the synthesis of melanin and is widely distributed in animals, plants, and microorganisms. As excessive melanin production causes not only hyperpigmenting effects on human skin but also melanosis in various foods, an inhibitor of tyrosinase has become of interest lately from a practical p...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.31.1618

    authors: Tsuchiya T,Yamada K,Minoura K,Miyamoto K,Usami Y,Kobayashi T,Hamada-Sato N,Imada C,Tsujibo H

    更新日期:2008-08-01 00:00:00

  • Inhibition of eosinophil survival by a selective inhibitor of phosphodiesterase 4 via the induction of apoptosis.

    abstract::Selective inhibitors of phosphodiesterases (PDEs) have been suggested to have anti-inflammatory effects on bronchial asthma through the inhibition of chemotaxis, adhesion, degranulation, the respiratory burst, and survival prolongation of eosinophils. However, the mechanisms by which these agents inhibit eosinophil su...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.28.515

    authors: Wang W,Masu K,Tamura G,Suzuki K,Ohwada K,Okuyama K,Shirato K,Takayanagi M,Ohno I

    更新日期:2005-03-01 00:00:00

  • Protective effect of celosian, an acidic polysaccharide, on chemically and immunologically induced liver injuries.

    abstract::Hepatoprotective effect of celosian, an acidic polysaccharide isolated from the water extract of the seed of Celosia argentea, was investigated using chemical and immunological liver injury models. Celosian inhibited the elevation of serum enzyme (GPT, GOT, LDH) and bilirubin levels on carbon tetrachloride (CC1(4))-in...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.19.567

    authors: Hase K,Kadota S,Basnet P,Takahashi T,Namba T

    更新日期:1996-04-01 00:00:00

  • Diphenyleneiodonium chloride, an inhibitor of reduced nicotinamide adenine dinucleotide phosphate oxidase, suppresses light-dependent induction of clock and DNA repair genes in zebrafish.

    abstract::In most species, solar light is both a DNA-damaging agent and the key entraining stimulus for the endogenous circadian clock. The zebrafish is an attractive vertebrate system in which to study the influence of light on gene expression because the DNA repair proteins and circadian oscillators in this species are light-...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.34.1343

    authors: Osaki T,Uchida Y,Hirayama J,Nishina H

    更新日期:2011-01-01 00:00:00

  • Echinacoside, an Active Constituent of Cistanche Herba, Exerts a Neuroprotective Effect in a Kainic Acid Rat Model by Inhibiting Inflammatory Processes and Activating the Akt/GSK3β Pathway.

    abstract::Echinacoside is a major compound of Cistanche Herb and has glutamate release-inhibiting activity in the brain. Given the involvement of excitotoxicity caused by massive glutamate in the pathophysiology of epilepsy, we explored the antiepileptic effect of echinacoside on kainic acid-induced seizures in rats. The rats w...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b18-00407

    authors: Lu CW,Hsieh HL,Lin TY,Hsieh TY,Huang SK,Wang SJ

    更新日期:2018-11-01 00:00:00

  • Aconitine induces bradycardia through a transmission pathway including the anterior hypothalamus in conscious mice.

    abstract::Aconitine administered intraperitoneally (i.p.) produces bradycardia mainly by a central muscarinic action. The involvement of hypothalamic regions in the occurrence of aconitine-induced bradycardia was investigated in hypothalamus-lesioned mice. The lesions were made by passing a direct current (1.5 mA, 13 s) through...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.20.856

    authors: Kimura I,Takada M,Nojima H

    更新日期:1997-08-01 00:00:00

  • Effects of Various 5,7-Dihydroxyflavone Analogs on Adipogenesis in 3T3-L1 Cells.

    abstract::We studied the effects of twelve 5,7-dihydroxyflavone analogs on adipogenesis in 3T3-L1 cells. Among the compounds, luteolin, diosmetin, and chrysoeriol partly inhibited adipogenesis by blocking the accumulation of triacylglycerol in the cells. Conversely, tricetin facilitated triacylglycerol accumulation in the cells...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b15-00489

    authors: Nishina A,Ukiya M,Fukatsu M,Koketsu M,Ninomiya M,Sato D,Yamamoto J,Kobayashi-Hattori K,Okubo T,Tokuoka H,Kimura H

    更新日期:2015-01-01 00:00:00

  • Peroxiredoxin I is an indicator of microglia activation and protects against hydrogen peroxide-mediated microglial death.

    abstract::Imbalance between oxidative stress and antioxidative defence system is generally known as one of mechanisms causing an oxidative stress-medieated neuropathogenesis. Peroxiredoxins (Prxs), a family of antioxidative enzymes neutralizing cellular hydroperoxides, was characterized recently, but their distributions and rol...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.31.820

    authors: Kim SU,Hwang CN,Sun HN,Jin MH,Han YH,Lee H,Kim JM,Kim SK,Yu DY,Lee DS,Lee SH

    更新日期:2008-05-01 00:00:00

  • Anti-Inflammatory properties of a lipid fraction obtained from Sideritis javalambrensis.

    abstract::A lipid fraction obtained by activity-guided fractionation from the hexane extract of Sideritis javalambrensis was evaluated for anti-inflammatory activity. This fraction significantly inhibited paw oedema induced by carrageenan as well as ear oedema induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) in mice after ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.23.1193

    authors: Godo A,de Heras BL,Vivas JM,Villar A

    更新日期:2000-10-01 00:00:00

  • Pharmacodynamic and pharmacokinetic evaluation of CS-526 in cynomolgus monkeys.

    abstract::In the present study, we evaluated the effect of the novel acid pump antagonist 7-(4-fluorobenzyloxy)-2,3-dimethyl-1-{[(1S,2S)-2-methylcyclopropyl]methyl}-1H-pyrrolo[2,3-d]pyridazine (CS-526) on the intragastric acidity of cynomolgus monkeys. The study was performed in a crossover manner with five male animals. CS-526...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.32.2010

    authors: Ito K,Kinoshita K,Yamamura N,Tomizawa A,Inaba F,Morikawa-Inomata Y,Tabata K,Shibakawa N

    更新日期:2009-12-01 00:00:00