Abstract:
:Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) play a key role in the inflammatory processes. Improper overproduction of NO and prostaglandins by both enzymes are also believed to be involved in the pathogenesis of certain human cancers. Crude extracts of Selaginella tamariscina are used as an oriental medicine, which has been reported to inhibit the production of proinflammatory cytokines and cause cell cycle arrest. We isolated 2',8''-biapigenin from S. tamariscina and investigated whether it modulates iNOS and COX-2 expressions in Raw264.7 macrophages stimulated with lipopolysaccharide (LPS). We found that 2',8''-biapigenin blocked the transactivations of iNOS and COX-2 genes via the inactivation of nuclear factor-kappaB by preventing the nuclear translocation of p65. Hence, it may be possible to develop S. tamariscina extracts or 2',8''-biapigenin as a useful agent for cancer chemoprevention or for the treatment of inflammatory diseases.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Woo ER,Pokharel YR,Yang JW,Lee SY,Kang KWdoi
10.1248/bpb.29.976subject
Has Abstractpub_date
2006-05-01 00:00:00pages
976-80issue
5eissn
0918-6158issn
1347-5215pii
JST.JSTAGE/bpb/29.976journal_volume
29pub_type
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