Ferulic acid induces mammalian target of rapamycin inactivation in cultured mammalian cells.

abstract：:Acute toxicity (24 h) and general behavior in mice of a lignan from Justicia hyssopifolia, a beta-D-glucoside (elenoside), was studied, and the cytotoxic activity was performed. Elenoside (arylnaphthalene lignan) in mice showed a moderate toxicity order (305 mg/kg) and central depressive properties at doses of 25, 50,...

journal_title：Biological & pharmaceutical bulletin

authors： Navarro E,Alonso SJ,Alonso PJ,Trujillo J,Jorge E,Perez C

更新日期：2001-03-01 00:00:00

abstract：:Ceramide kinase (CerK) and ceramide-1-phosphate (C1P) are involved in various cellular functions, while regulation of the enzyme activity has not been well elucidated. We herein investigated the effects of several glycerophospholipids on human recombinant CerK activity with CaCl2 and MgCl2 by measuring the formation o...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuzaki W,Takahashi H,Nakamura H,Murayama T

更新日期：2016-01-01 00:00:00

abstract：:Fragility fractures associated with age-related bone loss are of urgent concern worldwide because they reduce QOL and pose financial burdens for health care services. Currently, national data in Japan are limited. This study provides quantitative data for older patients throughout Japan who, although otherwise relativ...

journal_title：Biological & pharmaceutical bulletin

authors： Iihara N,Ohara E,Bando Y,Yoshida T,Ohara M,Kirino Y

更新日期：2019-01-01 00:00:00

abstract：:The purpose of this study was to elucidate the transport mechanism(s) of L-glutamate (L-Glu), a neuroexcitatory neurotransmitter, in the inner blood-retinal barrier (BRB). The L-Glu transport was evaluated by an in vitro uptake study with a conditionally-immortalized rat retinal capillary endothelial cell line, TR-iBR...

journal_title：Biological & pharmaceutical bulletin

authors： Sakurai T,Akanuma S,Usui T,Kubo Y,Tachikawa M,Hosoya K

更新日期：2015-01-01 00:00:00

abstract：:Endometriosis, a disease affecting 5-15% of women of reproductive age, is characterized by the ectopic growth of endometrial tissue. Costunolide, a sesquiterpene lactone, has anti-proliferative and pro-apoptotic activities that may be efficacious in therapy for endometriosis. In the present study, we investigated the ...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JH,Yang YI,Lee KT,Park HJ,Choi JH

更新日期：2011-01-01 00:00:00

abstract：:As an attempt to identify bioactive natural products with anti-inflammatory activity, we evaluated the effects of the methanol extract of the semen of Xanthium strumarium L. (MEXS) on lipopolysaccharide (LPS)-induced nitric oxide (NO), prostaglandin E2 (PGE2) and tumor necrosis factor-alpha (TNF-alpha) production in R...

journal_title：Biological & pharmaceutical bulletin

authors： Kim IT,Park YM,Won JH,Jung HJ,Park HJ,Choi JW,Lee KT

更新日期：2005-01-01 00:00:00

abstract：:Hydroxylysylpyridinoline (HP), an intermolecular cross-linking amino acid, is present only in bone and cartilage collagen. We examined urinary HP levels in order to assess bone collagen metabolism using HPLC. Urinary HP excretion levels (nmol/mmol creatinine) of healthy control groups gradually increased with aging. U...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshihara K,Nemoto S,Nagata M

更新日期：1994-06-01 00:00:00

abstract：:Buckwheat is an ancient and specialty grain in China. Due to its unique chemical and bio-activity components, buckwheat has been found to have many uses in food products and medicine. However, very little is known about the toxicity of protease inhibitors from buckwheat. Here, the possible effects of a recombinant buc...

journal_title：Biological & pharmaceutical bulletin

authors： Wang ZH,Gao L,Li YY,Zhang Z,Yuan JM,Wang HW,Zhang L,Zhu L

更新日期：2007-04-01 00:00:00

abstract：:Using a validated high-performance liquid chromatographic (HPLC) method, the pharmacokinetics of multi-constituents in Huangqin-Tang decoction were simultaneously studied both in the compound prescription and in each single herb decoction. At different intervals (0, 1, 2, 4, 8, 12, 24, 36, 48 h) after oral administrat...

journal_title：Biological & pharmaceutical bulletin

authors： Zuo F,Zhou ZM,Zhang Q,Mao D,Xiong YL,Wang YL,Yan MZ,Liu ML

更新日期：2003-07-01 00:00:00

abstract：:The effects of nefiracetam on the cerebral adenylyl cyclase (AC) activity of animals with microsphere embolism-induced memory dysfunction were examined. Sustained cerebral ischemia in the right cerebral hemisphere was induced by an injection of microspheres into the right internal carotid artery of rats. To examine le...

journal_title：Biological & pharmaceutical bulletin

authors： Takeo S,Miyake-Takagi K,Kikuchi K,Ando T,Ichikawa T,Omino K,Kajihara H,Takagi N,Tanonaka K

更新日期：2003-03-01 00:00:00

abstract：:Sec61β is the β subunit of the Sec61 translocon and is responsible for expression and delivery of basolateral membrane proteins, including claudins, major constituents of tight junction (TJ). In the present study, the effect of Sec61β overexpression on TJ barrier functions in Madin-Darby canine kidney (MDCK) cells wer...

journal_title：Biological & pharmaceutical bulletin

authors： Washiyama M,Koizumi N,Fujii M,Watanabe Y

更新日期：2014-01-01 00:00:00

abstract：:We aimed to identify a novel flavonoid from the in-house natural products to suppress matrix metalloproteases (MMPs), which is responsible for degradation of collagen and other extracellular matrix proteins. Total eight natural products were screened for identification of a novel MMP-9 suppressor using MMP-9 reporter ...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JJ,Korm S,Kim WS,Kim OS,Lee JS,Min HG,Chin YW,Cha HJ

更新日期：2014-01-01 00:00:00

abstract：:Topiramate pharmacokinetics is influenced by individual factors such as patient age, renal function and co-treatment. The aim of this study was to develop a population pharmacokinetic model of topiramate to assist dosage adjustments in individual patients. Steady-state topiramate plasma concentrations in patients with...

journal_title：Biological & pharmaceutical bulletin

authors： Vovk T,Jakovljević MB,Kos MK,Janković SM,Mrhar A,Grabnar I

更新日期：2010-01-01 00:00:00

abstract：:Although hypokalemia is an adverse effect of Yokukansan preparation, especially in geriatric patients, its association with age is unclear. We investigated whether age is a risk factor for hypokalemia. This single-center retrospective cohort study, conducted at Tokyo Women's Medical University, Medical Center East bet...

journal_title：Biological & pharmaceutical bulletin

authors： Hirai T,Yamaga R,Kei M,Hosohata K,Itoh T

更新日期：2020-01-01 00:00:00

abstract：:Japanese allergic subjects are commonly sensitized to both house dust mite (HDM) and Japanese cedar pollen (JCP) and combined treatment with sublingual immunotherapy (SLIT) tablets is desirable. However, mixing extracts of two non-homologous allergens may compromise allergen stability and affect the clinical outcome. ...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe A,Yamamoto T,Matsuhara H,Matsui H,Nakazawa H,Lund K,Ohashi-Doi K

更新日期：2020-10-01 00:00:00

abstract：:It is therapeutically important to elucidate the factors involved in the radiation resistance of tumors. We previously showed that ATP is released from mouse melanoma B16 cells in response to γ-irradiation, but the role of adenosine, a metabolite of ATP, is still unclear. Here, we show that the adenosine A2B receptor ...

journal_title：Biological & pharmaceutical bulletin

authors： Tanaka Y,Kitabatake K,Abe R,Tsukimoto M

更新日期：2020-03-01 00:00:00

abstract：:The inhibitory effects of some flavonoids on the infectivity of rotavirus, which predominantly causes sporadic diarrhea in infants and young children, were investigated. Among tested flavonoids, diosmin and hesperidin had the most potent inhibitory activity on rotavirus infection. The fifty percent inhibitory concentr...

journal_title：Biological & pharmaceutical bulletin

authors： Bae EA,Han MJ,Lee M,Kim DH

更新日期：2000-09-01 00:00:00

abstract：:Mucus on the nasal mucosa is translocated to the pharynx by ciliary beating, which is an important nonspecific defense mechanism called mucociliary clearance (MC). MC is one of the important factors determining the rate and extent of drug absorption after nasal application. The purpose of this study is to evaluate MC ...

journal_title：Biological & pharmaceutical bulletin

authors： Inoue D,Furubayashi T,Ogawara K,Kimura T,Higaki K,Katsumi H,Sakane T,Yamamoto A,Higashi Y

更新日期：2012-01-01 00:00:00

abstract：:Dopamine agonists have neuroprotective properties in addition to their original pharmacologic function. We examined the effects of pergolide mesilate (PM) on the levels of metallothionein mRNA expression and lipid peroxidation in the corpus striata of 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine (MPTP)-induced Parkins...

journal_title：Biological & pharmaceutical bulletin

authors： Ono S,Hirai K,Tokuda E

更新日期：2009-10-01 00:00:00

abstract：:The uptake of low molecular weight fractionated [3H]heparin (LMWFH: 7000 Da) was examined, for comparison with that of high molecular weight fractionated [3H]heparin (HMWFH:20000 Da), in a primary culture of rat hepatocytes. The uptake of LMWFH increased almost linearly with time up to 60 min (extended uptake), althou...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe J,Urano K,Muranishi H,Haba M,Yuasa H

更新日期：1995-03-01 00:00:00

abstract：:Transdermal nicotine patch (TNP) contains approximately 16.6 and 24.9 mg of nicotine per 20 and 30 cm2 (TNP-20 and TNP-30). The aims of the study are to investigate linearity of nicotine pharmacokinetics after single application of different strengths of TNP and to directly compare plasma nicotine concentrations with ...

journal_title：Biological & pharmaceutical bulletin

authors： Sobue S,Sekiguchi K,Kikkawa H,Akasaki M,Irie S

更新日期：2006-05-01 00:00:00

abstract：:The present study investigated whether Astragalus polysaccharide (APS) possessed immunotherapeutic effects on type 1 diabetes mellitus. Diabetic mice induced by multiple low dose streptozotocin (MLD-STZ) were administered either APS (100, 200, 400 mg/kg body weight) or saline intraperitoneally daily, and sacrificed af...

journal_title：Biological & pharmaceutical bulletin

authors： Li RJ,Qiu SD,Chen HX,Tian H,Wang HX

更新日期：2007-03-01 00:00:00

abstract：:Diosgenyl saponins are the most abundant steroid saponins, and exert a large variety of biological functions. In a previous report, we showed that dioscin was able to induce cytotoxicity and apoptosis in human myeloblast leukemia HL-60 cells. This study further investigated the action mechanisms underlying this effect...

journal_title：Biological & pharmaceutical bulletin

authors： Liu MJ,Wang Z,Ju Y,Zhou JB,Wang Y,Wong RN

更新日期：2004-07-01 00:00:00

abstract：:Alkyl viologens showed cytotoxicity when incubated with cultured murine leukemia L1210 cells for 48 h, whereas they were not cytotoxic when briefly incubated for 10 min. Under the permeabilizing conditions achieved by vortex-stirring with a high molecular weight polyacrylic acid (A-119), appreciable cytotoxicity was s...

journal_title：Biological & pharmaceutical bulletin

authors： Shimizu N,Wu W,Kohara A,Kohda K,Suzuki T,Kawazoe Y

更新日期：1997-02-01 00:00:00

abstract：:The quantification of tenofovir, a nucleoside reverse transcriptase inhibitor prescribed once daily, in human plasma is important due to a recent increase in its use. HPLC, however, can not easily detect and quantify tenofovir because of interfering peaks. Therefore, we developed a rapid and conventional LC-MS method,...

journal_title：Biological & pharmaceutical bulletin

authors： Takahashi M,Kudaka Y,Okumura N,Hirano A,Banno K,Kaneda T

更新日期：2007-09-01 00:00:00

abstract：:This study was designed to test the efficacy of eugenol, a compound obtained from the essential oil of cloves (Syzygium aromaticum) in collagen-induced arthritis (CIA), a well characterized murine model of rheumatoid arthritis. Macroscopic clinical evidence of CIA manifests first as periarticular erythema and edema in...

journal_title：Biological & pharmaceutical bulletin

authors： Grespan R,Paludo M,Lemos Hde P,Barbosa CP,Bersani-Amado CA,Dalalio MM,Cuman RK

更新日期：2012-01-01 00:00:00

abstract：:The in vitro release of bumetanide from macrogol suppositories with and without weak acids (citric acid and tartaric acid) was studied. The release of bumetanide was not affected when weak acids were added to the suppositories. The in vivo rectal absorption of bumetanide from the suppositories was evaluated in rabbits...

journal_title：Biological & pharmaceutical bulletin

authors： Yagi N,Kenmotsu H,Shimode Y,Oda K,Sekikawa H,Takada M

更新日期：1993-03-01 00:00:00

abstract：:Nicotine, an addictive substance, is absorbed from the lungs following inhalation of tobacco smoke, and distributed to various tissues such as liver, brain, and retina. Recent in vivo and in vitro studies suggest the involvement of a carrier-mediated transport process in nicotine transport in the lung, liver, and inne...

journal_title：Biological & pharmaceutical bulletin

authors： Tega Y,Yamazaki Y,Akanuma SI,Kubo Y,Hosoya KI

更新日期：2018-01-01 00:00:00

abstract：:A calcium-induced alginate gel bead (Alg-CS) containing chitosan (CS) and 2-(4-chlorophenoxy)-2-methylpropionic acid (CMP) was prepared. We then investigated (a) CMP release from Alg-CS, and (b) uptake of bile acid into the Alg-CS, within the gastrointestinal tract. Dried Alg-CS gradually swelled in taurocholate solut...

journal_title：Biological & pharmaceutical bulletin

authors： Murata Y,Hirai D,Kofuji K,Miyamoto E,Kawashima S

更新日期：2004-03-01 00:00:00

abstract：:To analyze the renal handling of therapeutic compounds observed as a non-linear process with a diffusion phenomenon, we employed a non-linear dispersion model described with a partial differential equation and solved it by using the finite difference method with an implicit scheme in a model dependent analysis. In thi...

journal_title：Biological & pharmaceutical bulletin

authors： Aiba T,Kubota S,Koizumi T

更新日期：1999-06-01 00:00:00