Enhanced cytotoxicity of alkyl viologens and N,N'-diamino analogs toward cultured murine leukemia L1210 cells under vortex-stirring with a high molecular weight polyacrylic acid.

abstract：:Nonalcoholic steatohepatitis (NASH) is the most frequent cause of liver dysfunction and a common global problem. Gypenosides can decrease pathological modifications of high-fat diet-induced rat atherosclerosis; however, its effect and mechanism on NASH remain unclear. In this study, rats were randomly divided into nor...

journal_title：Biological & pharmaceutical bulletin

authors： Li H,Ying H,Hu A,Hu Y,Li D

更新日期：2017-01-01 00:00:00

abstract：:To find new antipruritic herbal medicines for pruritus, we screened the methanol extracts of seven herbal medicines which have been used to treat dermatologic diseases, testing them on mouse models of acute and chronic itch. When administrated perorally (p.o.) at a dose of 200 mg/kg, methanol extracts of Sophora flave...

journal_title：Biological & pharmaceutical bulletin

authors： Yamaguchi-Miyamoto T,Kawasuji T,Kuraishi Y,Suzuki H

更新日期：2003-05-01 00:00:00

abstract：:Acetohexamide (AH) is reduced to its alcohol metabolite by carbonyl reductase. We have previously shown that carbonyl reductase present in the liver microsomes of rats is a male-specific and androgen-dependent enzyme. In the present study, the role of microsomal carbonyl reductase in the pharmacokinetics of AH was exa...

journal_title：Biological & pharmaceutical bulletin

authors： Imamura Y,Shimada H

更新日期：2005-01-01 00:00:00

abstract：:The oral administration of the water extract of Ginseng Radix (GR) to normal and epinephrine-induced hyperglycemic mice caused a significant decrease in the blood glucose level 4 h after its administration. The hepatic content of facilitative glucose transporter isoform 2, liver type glucose transporter (GLUT2) protei...

journal_title：Biological & pharmaceutical bulletin

authors： Ohnishi Y,Takagi S,Miura T,Usami M,Kako M,Ishihara E,Yano H,Tanigawa K,Seino Y

更新日期：1996-09-01 00:00:00

abstract：:The nasal absorption of non-glycosylated recombinant human granulocyte colony-stimulating factor produced by Esherichia coli (E. coli-rhG-CSF) was studied in rats. We investigated the effects of the basic conditions of the dosing solution and the enhancing effects of various substances to find means to improve the nas...

journal_title：Biological & pharmaceutical bulletin

authors： Nomura H,Akamisaka S,Maruyama K

更新日期：1996-11-01 00:00:00

abstract：:The present study was conducted to evaluate the effects of Paeoniae Radix (PR), one of the most famous tonic traditional Chinese medicines, on the pharmacokinetics of carbamazepine (CBZ) in rats and to determine the possible interactions between PR and CBZ. The significant decrease in Tmax indicated that simultaneous ...

journal_title：Biological & pharmaceutical bulletin

authors： Chen LC,Chen YF,Chou MH,Lin MF,Yang LL,Yen KY

更新日期：2002-04-01 00:00:00

abstract：:beta 1 and beta 2 adrenoceptor ligand activity has been shown to be down-regulated in failing myocardium. It is the aim of this study to test the hypothesis that also mRNA levels are down-regulated in dilated cardiomyopathy. beta 1 and beta 2 adrenoceptor ligand activities and mRNA expressions were analyzed in left ve...

journal_title：Biological & pharmaceutical bulletin

authors： Sylvén C,Mischa G,Jansson E,Sotonyi P,Fu LX,Waagstein F,Brönnegård M

更新日期：1995-10-01 00:00:00

abstract：:2'-Chloroflavone (CF) and 4'-CF were studied as inducers of cytochrome P-450-mediated monooxygenases in rat hepatic microsomes by comparison with phenobarbital (PB) and 3-methylcholanthrene (MC). As a result of interaction with the substrate 7-ethoxycoumarin (7-EC), 2'-CF-induced microsomes showed a difference spectru...

journal_title：Biological & pharmaceutical bulletin

authors： Kato S,Yamamoto K

更新日期：1993-01-01 00:00:00

abstract：:We demonstrate that glycyrrhizin (GL) enhanced Fas-mediated apoptotic body formation and DNA fragmentation in T cell lines although GL alone did not induce apoptosis. The enhancement effect of Fas-mediated apoptosis by GL was dose-dependent above 0.3 microM. Time course study revealed that simultaneous co-treatment of...

journal_title：Biological & pharmaceutical bulletin

authors： Ishiwata S,Nakashita K,Ozawa Y,Niizeki M,Nozaki S,Tomioka Y,Mizugaki M

更新日期：1999-11-01 00:00:00

abstract：:We investigated the properties of honokiol, a natural rexinoid, as a regulator of retinoid X receptor (RXR) heterodimers with various partner nuclear receptors (NRs), in comparison with those of the synthetic rexinoid bexarotene. Honokiol alone was hardly capable of activating peroxisome proliferator-activated recepto...

journal_title：Biological & pharmaceutical bulletin

authors： Kotani H,Tanabe H,Mizukami H,Amagaya S,Inoue M

更新日期：2012-01-01 00:00:00

abstract：:We examined the action mechanism of oleanolic acid 3-O-monodesmoside, momordin Ic (1), and oleanolic acid 3-O-glucuronide (2) for the inhibitory effect on the increase in serum glucose levels in oral glucose-loaded rats. Although 1 and 2 dose-dependently inhibited the increase in serum glucose levels in oral glucose-l...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuda H,Murakami T,Shimada H,Matsumura N,Yoshikawa M,Yamahara J

更新日期：1997-06-01 00:00:00

abstract：:One hundred and fifteen synthesized mono, di, and trihydroxybenzamide and thiobenzamide derivatives having structures related to euglobals were examined for their inhibitory effects on Epstein-Barr virus (EBV) activation by 12-O-tetradecanoylphorbol-13-acetate (TPA) as a primary screening test for anti-tumor-promoters...

journal_title：Biological & pharmaceutical bulletin

authors： Takasaki M,Konoshima T,Kozuka M,Yoneyama K,Yoshida S,Tokuda H,Nishino H,Iwashima A

更新日期：1995-02-01 00:00:00

abstract：:Vesicular glutamate transporter (VGLUT) is responsible for the active transport of L-glutamate into synaptic vesicles and, thus, plays an essential role in the glutamatergic chemical transmission in the central and peripheral nervous systems. Recent studies indicated that VGLUT is also expressed and localized in vario...

journal_title：Biological & pharmaceutical bulletin

authors： Moriyama Y,Omote H

更新日期：2008-10-01 00:00:00

abstract：:The total alkaloid fractions of the methanolic extracts of the leaves, ripe fruits, roots, seeds and stem of Solanum pseudocapsicum were subjected to in-vitro cytotoxicity, short-term toxicity and long-term survival studies. All the five fractions exhibited potent activity. The total alkaloid fraction of leaves was fo...

journal_title：Biological & pharmaceutical bulletin

authors： Vijayan P,Vijayaraj P,Setty PH,Hariharpura RC,Godavarthi A,Badami S,Arumugam DS,Bhojraj S

更新日期：2004-04-01 00:00:00

abstract：:Recent studies have shown that antibodies with low fucose content in their oligosaccharides exhibit highly potent antibody-dependent cellular cytotoxicity (ADCC). However, composites of therapeutic antibodies produced by conventional production systems using cell lines such as Chinese hamster ovary (CHO) and SP2/0 do ...

journal_title：Biological & pharmaceutical bulletin

authors： Tojo S,Okazaki A,Wakitani M,Shinkawa T,Uchida K,Suzawa T

更新日期：2009-09-01 00:00:00

abstract：:Panaxydol, a polyacetylenic compound derived from Panax ginseng has been reported to suppress the growth of cancer cells. However, the molecular mechanisms underlying cell cycle arrest by this compound in non-small cell lung cancer (NSCLC) are unknown. Our study found that panaxydol treatment induced cell cycle arrest...

journal_title：Biological & pharmaceutical bulletin

authors： Lee JH,Leem DG,Chung KS,Kim KT,Choi SY,Lee KT

更新日期：2018-01-01 00:00:00

abstract：:Skeletal muscle is a major site for glucose metabolism and its injury by cytokines can induce insulin resistance leading to type 2 diabetes. It has been suggested that quercetin may act as an anti-diabetic agent, however, the effects of quercetin on insulin resistance in skeletal muscle remain unknown. We aimed to inv...

journal_title：Biological & pharmaceutical bulletin

authors： Dai X,Ding Y,Zhang Z,Cai X,Bao L,Li Y

更新日期：2013-01-01 00:00:00

abstract：:The aim of the present study was to determine the effect of sulfaphenazole (SP) on the pharmacokinetics of ampiroxicam (AM) which is metabolized by cytochrome P-450 (CYP) 2C9, since SP is a potent inhibitor of CYP 2C9, and so a dramatic pharmacokinetic drug interaction between both drugs is assumed after dosing. Singl...

journal_title：Biological & pharmaceutical bulletin

authors： Ogiso T,Iwaki M,Tanaka H,Kobayashi E,Tanino T,Sawada A,Uno S

更新日期：1999-02-01 00:00:00

abstract：:The first-pass intestinal metabolism of 5-fluorouracil (5-FU) was investigated by single-pass perfusion of the rat small intestine. At the low concentration of 0.06 mg/ml, the fraction of 5-FU absorbed into (i.e., appeared in) the mesenteric venous blood (Fa,b) was about 50% smaller than the fraction absorbed (disappe...

journal_title：Biological & pharmaceutical bulletin

authors： Gu J,Yuasa H,Hayashi Y,Watanabe J

更新日期：1998-08-01 00:00:00

abstract：:The gas phase of cigarette smoke is important from the viewpoint of human health, because it can pass through alveolar epithelium and enter the circulation. There is no standard method for the preparation of a gas phase extract of cigarette smoke (CSE), although CSE is widely used for research instead of whole cigaret...

journal_title：Biological & pharmaceutical bulletin

authors： Higashi T,Mai Y,Mazaki Y,Horinouchi T,Miwa S

更新日期：2016-01-01 00:00:00

abstract：:The metabolism of bisphenol A (BPA) was determined for 11 forms of human hepatic cytochromes P450 (CYPs) expressed in the yeast Saccharomyces cerevisiae and for human steroidogenic CYP17 expressed in Escherichia coli. Additionally, the effect of BPA on the progesterone 17alpha-chydroxylase activity of CYP17 was invest...

journal_title：Biological & pharmaceutical bulletin

authors： Niwa T,Fujimoto M,Kishimoto K,Yabusaki Y,Ishibashi F,Katagiri M

更新日期：2001-09-01 00:00:00

abstract：:In order to isolate a cholesterol-lowering compound from Alpinia katsumadai, an inhibitor for acyl-CoA : cholesterol acyltransferase (ACAT), an enzyme responsible for the cholesterol ester formation in liver, was purified, its chemical structure was determined, and in vivo and in vitro inhibition activities were perfo...

journal_title：Biological & pharmaceutical bulletin

authors： Choi SY,Lee MH,Choi JH,Kim YK

更新日期：2012-01-01 00:00:00

abstract：:Glycosylation is a highly sophisticated post-translational modification of proteins that occurs in the endoplasmic reticulum (ER) and the Golgi apparatus. The vital biological functions served by protein glycosylation can be separated into two types. The first is the role of glycosylation in the extracellular environm...

journal_title：Biological & pharmaceutical bulletin

authors： Yamamoto K

更新日期：2009-05-01 00:00:00

abstract：:P2X7 receptor (P2X7R), a purinergic receptor, is involved in pathophysiological events such as inflammation and cell death, and thus is an attractive target for therapeutic approaches. It is reported that divalent metal cations (DMCs) inhibit P2X7R activation and that there are species differences in their inhibitory ...

journal_title：Biological & pharmaceutical bulletin

authors： Fujiwara M,Ohbori K,Ohishi A,Nishida K,Uozumi Y,Nagasawa K

更新日期：2017-01-01 00:00:00

abstract：:Proteinase-activated receptor-2 (PAR2) may be an important regulator of skin mast cell function during cutaneous inflammation and hypersensitivity. However, little is known of the role of PAR2 in allergic pruritus, because mast cells, which are thought to be responsible for this symptom, can release a number of differ...

journal_title：Biological & pharmaceutical bulletin

authors： Zhu Y,Peng C,Xu JG,Liu YX,Zhu QG,Liu JY,Li FQ,Wu JH,Hu JH

更新日期：2009-07-01 00:00:00

abstract：:When ginsenoside R(c) was anaerobically incubated with human fecal microflora, all specimens metabolized ginsenoside R(c) to compound K and protopanaxadiol. The main metabolite was compound K. Among the bacteria isolated from human fecal microflora, most bacteria, such as Bacteroides sp., Eubacterium sp., and Bifidoba...

journal_title：Biological & pharmaceutical bulletin

authors： Bae EA,Choo MK,Park EK,Park SY,Shin HY,Kim DH

更新日期：2002-06-01 00:00:00

abstract：:OK205 is a traditional Korean prescription containing water-soluble chitosan, glucosamine HCl, chondroitin sulfate, and extract of herbal medicine, and has been used commercially to treat rheumatoid arthritis (RA). Because infiltrated mast cells and their mediators may contribute to the initiation and progression of t...

journal_title：Biological & pharmaceutical bulletin

authors： Choi IY,Jung HS,Kim HR,Lee EJ,Lee EH,Shin TY,Kim HM,Hong SH

更新日期：2004-11-01 00:00:00

abstract：:Controlling axon and dendrite elongation is critical in developing precise neural circuits. Using isolated cultures of dentate granule neurons, we succeeded in simultaneously monitoring the behaviors of axonal and dendritic outgrowth. Our previous study shows that cAMP contributes differentially to Sema3F-induced resp...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada RX,Matsuki N,Ikegaya Y

更新日期：2006-04-01 00:00:00

abstract：:Phenolic compounds, in general, exhibit antioxidant and antibacterial activities. We studied antimicrobial activity of the phenolic antioxidants, propofol (2,6-diisopropylphenol), tocopherol, eugenol, butylated hydroxyanisole (BHA), and several of their dimer compounds. Dipropofol (dimer of 2,6-diisopropylphenol) show...

journal_title：Biological & pharmaceutical bulletin

authors： Ogata M,Tutumimoto Sato K,Kunikane T,Oka K,Seki M,Urano S,Hiramatsu K,Endo T

更新日期：2005-06-01 00:00:00

abstract：:Polysaccharides are involved in biological responses and can activate complement system, which plays an important role in primary host defense mechanisms. We investigated anticomplementary activities from spice plants and selected thyme (Thymus vulgaris L.) as a potent complementary activator. Acidic polysaccharide (T...

journal_title：Biological & pharmaceutical bulletin

authors： Chun H,Shin DH,Hong BS,Cho HY,Yang HC

更新日期：2001-08-01 00:00:00