Soluble guanylyl cyclase inhibitor prevents Sema3F-induced collapse of axonal and dendritic growth cones of dentate granule cells.

Abstract:

:Controlling axon and dendrite elongation is critical in developing precise neural circuits. Using isolated cultures of dentate granule neurons, we succeeded in simultaneously monitoring the behaviors of axonal and dendritic outgrowth. Our previous study shows that cAMP contributes differentially to Sema3F-induced responses of axons and dendrites, but we report here that the cGMP modulation does not have such a striking axo-dendritic difference. Treatment with Sema3F induced collapse of about 90% growth cones, and pretreatment with 1 muM LY83583, an inhibitor of soluble guanylyl cyclase, partially alleviated the collapse of both axons and dendrites. Thus, unlike cAMP, cGMP modulates axonal and dendritic extension in a similar manner.

journal_name

Biol Pharm Bull

authors

Yamada RX,Matsuki N,Ikegaya Y

doi

10.1248/bpb.29.796

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

796-8

issue

4

eissn

0918-6158

issn

1347-5215

pii

JST.JSTAGE/bpb/29.796

journal_volume

29

pub_type

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