Species Difference in Sensitivity of Human and Mouse P2X7 Receptors to Inhibitory Effects of Divalent Metal Cations.

abstract：:To search for possible anti-tumor-promoters, we carried out a primary screening of 21 cucurbitane triterpenoids using an in vitro assay system. Of these triterpenoids, scandenoside R6 (6), 23,24-dihydrocucurbitacin F (14), 25-acetyl-23,24-dihydrocucurbitacin F (15), 2-O-beta-D-glucopyranosyl-23,24-dihydrocucurbitacin ...

journal_title：Biological & pharmaceutical bulletin

authors： Konoshima T,Takasaki M,Tatsumoto T,Kozuka M,Kasai R,Tanaka O,Nie RL,Tokuda H,Nishino H,Iwashima A

更新日期：1994-05-01 00:00:00

abstract：:This study was conducted to investigate the effects of the extracts of green romaine lettuce (GRE) on sleep enhancement. GRE contains 1071.7 and 199.2 µg/g of extracts of lactucin and lactucopicrin, respectively, known as sleep enhancement substances. When 100 mg/kg of GRE was administered orally, sleep latency and du...

journal_title：Biological & pharmaceutical bulletin

authors： Kim HW,Suh HJ,Choi HS,Hong KB,Jo K

更新日期：2019-01-01 00:00:00

abstract：:We investigated the gene expression of GAPDH, cytochrome P450 isoforms (CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2E1, CYP3A4, CYP3A5, and CYP3A7), UGT-dependent glucuronosyl transferase isoforms (UGT1A6 and UGT1A9), and ABC transporter (ABCB1) after exposure to 0.1, 0.5, and 2.5% dimethyl sulfoxide (DMSO). GAPDH mRNA levels...

journal_title：Biological & pharmaceutical bulletin

authors： Nishimura M,Ueda N,Naito S

更新日期：2003-07-01 00:00:00

abstract：:To analyze the renal handling of therapeutic compounds observed as a non-linear process with a diffusion phenomenon, we employed a non-linear dispersion model described with a partial differential equation and solved it by using the finite difference method with an implicit scheme in a model dependent analysis. In thi...

journal_title：Biological & pharmaceutical bulletin

authors： Aiba T,Kubota S,Koizumi T

更新日期：1999-06-01 00:00:00

abstract：:The enhanced effect of urethane anesthesia on the serum creatine kinase (CPK) level following administration of hypolipidemic agents was examined to develop a convenient experimental screening method for drug-induced myopathy. After oral administration of a hypolipidemic agent to rats, 25% urethane solution was infuse...

journal_title：Biological & pharmaceutical bulletin

authors： Nakai A,Nishikata M,Uchida T,Ichikawa M,Matsuyama K

更新日期：1997-01-01 00:00:00

abstract：:Checkpoint kinase 1 (Chk1) plays important roles in genotoxic stress-induced cell cycle checkpoint and in normal cell cycle progression. Here, we show that Chk1 is cleaved in the treatment of apoptotic dose of etoposide (ETP) or cisplatin (CIS) but not of viable dose in HeLa S3 cells. The cleavage of Chk1 was complete...

journal_title：Biological & pharmaceutical bulletin

authors： Okita N,Kudo Y,Tanuma S

更新日期：2007-02-01 00:00:00

abstract：:We studied in vitro metabolites of 2,4,6,2',4',6'-hexachlorobiphenyl (HCB, IUPAC PCB No. 155) produced by liver microsomes of a phenobarbital (PB)-treated beagle dog. The major metabolites were 3-hydroxy-2,4,6,2',4',6'-HCB (M-1), 4-hydroxy-2,6,2',4',6'-pentachlorobiphenyl (PenCB, M-2) and 3,4-dihydroxy-2,6,2',4',6'-Pe...

journal_title：Biological & pharmaceutical bulletin

authors： Ariyoshi N,Yoshimura H,Oguri K

更新日期：1993-09-01 00:00:00

abstract：:We aimed to identify a novel flavonoid from the in-house natural products to suppress matrix metalloproteases (MMPs), which is responsible for degradation of collagen and other extracellular matrix proteins. Total eight natural products were screened for identification of a novel MMP-9 suppressor using MMP-9 reporter ...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JJ,Korm S,Kim WS,Kim OS,Lee JS,Min HG,Chin YW,Cha HJ

更新日期：2014-01-01 00:00:00

abstract：:The aim of this study was to evaluate the effect of olmesartan (OLME), an angiotensin II receptor antagonist, on an intestinal mucositis model. Briefly, daily intraperitoneal (i.p.) injections of methotrexate (MTX) 7 mg/kg were administered to rats on 3 consecutive days. A subset of these rats was also pretreated with...

journal_title：Biological & pharmaceutical bulletin

authors： de Araújo AA,Borba PB,de Souza FH,Nogueira AC,Saldanha TS,Araújo TE,da Silva AI,de Araújo Júnior RF

更新日期：2015-01-01 00:00:00

abstract：:Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with Parkinson's disease. LRRK2 is a large protein with multiple functional domains, including a guanosine 5'-triphosphate (GTP)-binding domain and a protein kinase domain. Recent studies indicated that the members of the Rab GTPase family, Rab8...

journal_title：Biological & pharmaceutical bulletin

authors： Imai M,Kawakami F,Kubo M,Kanzaki M,Maruyama H,Kawashima R,Maekawa T,Kurosaki Y,Kojima F,Ichikawa T

更新日期：2020-01-01 00:00:00

abstract：:Calprotectin is a calcium- and zinc-binding protein complex that is abundant in cytosol of neutrophils. The concentration of calprotectin in extracellular fluids is greatly increased under various inflammatory conditions in vivo. We recently demonstrated that calprotectin inhibited cell growth and induced apoptosis of...

journal_title：Biological & pharmaceutical bulletin

authors： Mikami M,Kitahara M,Kitano M,Ariki Y,Mimaki Y,Sashida Y,Yamazaki M,Yui S

更新日期：1999-07-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an inflammatory disease with joint dysfunction following cartilage degradation. The level of lysophosphatidic acid (LPA) has been reported to be augmented in human synovial fluid from patients with RA. However, it remains to be elucidated whether LPA participates in cartilage destruction. ...

journal_title：Biological & pharmaceutical bulletin

authors： Mizuno K,Komiya M,Okuyama K,Imada K,Sato T

更新日期：2021-01-01 00:00:00

abstract：:Nanoparticles are used in many fields and in everyday products. Silver nanoparticles are the most frequently used nanoparticles; for example, in food-related products, owing to their antibacterial activity. However, it has been pointed out that they might have unexpected biological effects, and evaluation of their eff...

journal_title：Biological & pharmaceutical bulletin

authors： Maki A,Lin Y,Aoyama M,Sato K,Gao JQ,Tsujino H,Nagano K,Higashisaka K,Tsutsumi Y

更新日期：2020-01-01 00:00:00

abstract：:Acori graminei Rhizoma is one of the best-known traditional herbal medicines frequently used for the treatment of cardiovascular symptoms in Asian countries. The anti-ischemic effect of Acori graminei Rhizoma on ischemia-induced isolated rat heart was investigated through analysis of changes in perfusion pressure, aor...

journal_title：Biological & pharmaceutical bulletin

authors： Kang M,Kim JH,Cho C,Chung HS,Yoon YS,Lee Y,Hong M,Shin M,Bae H

更新日期：2006-03-01 00:00:00

abstract：:Polysaccharides are involved in biological responses and can activate complement system, which plays an important role in primary host defense mechanisms. We investigated anticomplementary activities from spice plants and selected thyme (Thymus vulgaris L.) as a potent complementary activator. Acidic polysaccharide (T...

journal_title：Biological & pharmaceutical bulletin

authors： Chun H,Shin DH,Hong BS,Cho HY,Yang HC

更新日期：2001-08-01 00:00:00

abstract：:The effects of the plant isoflavones, daidzin and genistin, on bone loss in ovariectomized (ovx) rats fed a calcium-deficient diet were investigated. Daidzin and genistin were orally administered to ovx rats for 4 weeks. The femurs of these rats showed significantly lower density, strength (breaking forces), ash weigh...

journal_title：Biological & pharmaceutical bulletin

authors： Ishida H,Uesugi T,Hirai K,Toda T,Nukaya H,Yokotsuka K,Tsuji K

更新日期：1998-01-01 00:00:00

abstract：:Assessment of biological potency and its comparison with clinical effects are important in the quality control of therapeutic glycoproteins. Animal models are usually used for evaluating bioactivity of these compounds. However, alternative methods are required to simplify the bioassay and avoid ethical issues associat...

journal_title：Biological & pharmaceutical bulletin

authors： Yanagihara S,Taniguchi Y,Hosono M,Yoshioka E,Ishikawa R,Shimada Y,Kadoya T,Kutsukake K

更新日期：2010-01-01 00:00:00

abstract：:For the accurate identification of medicinal licorice species, nucleotide sequences of four types of DNA regions were researched for 205 specimens, including three species used as licorice: Glycyrrhiza uralensis, Glycyrrhiza glabra, and Glycyrrhiza inflata. The four DNA regions were the internal transcribed spacer (IT...

journal_title：Biological & pharmaceutical bulletin

authors： Kondo K,Shiba M,Yamaji H,Morota T,Zhengmin C,Huixia P,Shoyama Y

更新日期：2007-08-01 00:00:00

abstract：:The effect of gel-forming (1-->3)-beta-D-glucan on the immunological activities of murine kupffer cells was examined. A branched type gel-forming (1-->3)-beta-D-glucan, GRN, was administered intravenously to mice. GRN associating to kupffer cells was detected by an immunohistochemical technique using anti-GRN antibody...

journal_title：Biological & pharmaceutical bulletin

authors： Adachi Y,Ohno N,Yadomae T

更新日期：1998-03-01 00:00:00

abstract：:Butylbenzyl phthalate (BBzP) is used as a plasticizer to import flexibility to polyvinylchloride plastics. In this study, hydrolysis of BBzP to monobutyl phthalate (MBP) and monobenzyl phthalate (MBzP) in liver microsomes of humans, monkeys, dogs, rats and mice was examined. The kinetics for MBP formation by human, do...

journal_title：Biological & pharmaceutical bulletin

authors： Takahara Y,Kinashi Y,Takahara Y,Hichiya H,Okada K,Murata M,Shigeyama M,Hanioka N

更新日期：2014-01-01 00:00:00

abstract：:Eight new diterpenoids (1-8) have been isolated from the wood of Excoecaria agallocha (Euphorbiaceae) and their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) in Raji cells were examined to search for potent anti-tumor-promoters from natural resources. Of these compounds, the secolabd...

journal_title：Biological & pharmaceutical bulletin

authors： Konoshima T,Konishi T,Takasaki M,Yamazoe K,Tokuda H

更新日期：2001-12-01 00:00:00

abstract：:There are many important considerations in the interactions among the herbal constituents in a prescription of traditional Chinese medicine (TCM). Ephedra Herb [Chinese characters: see text] (Eph) is described a warm and acrid agent in TCM. The combination of Eph and Gypsum [Chinese characters: see text] (Eph-Gyp) sho...

journal_title：Biological & pharmaceutical bulletin

authors： Yuan D,Sunouchi H,Sakurai T,Saito K,Kano Y

更新日期：2002-07-01 00:00:00

abstract：:This study sought to investigate the ameliorating effects of soy 11S protein on the impacts of alcohol consumption in rat hepatocytes and in reducing total cholesterol levels and total lipid levels in the serum. Liver histology and the clinically important enzyme markers (Aspartate Aminotransferase: AST and Alanine Am...

journal_title：Biological & pharmaceutical bulletin

authors： Park KJ,Kim HY,Chang BJ,Lee HH

更新日期：2004-10-01 00:00:00

abstract：:Cephradine-containing ethylcellulose microparticles (MPC) were prepared by the solvent evaporation method. Chitosan-coated MPC (Chi-MPC) were prepared by doping MPC with viscous chitosan solution and subsequently drying. When fluorescein isothiocyanate (FITC)-labeled chitosan-coated ethylcellulose microparticles witho...

journal_title：Biological & pharmaceutical bulletin

authors： Takishima J,Onishi H,Machida Y

更新日期：2002-11-01 00:00:00

abstract：:Doxorubicin (DOX) is a potent antitumor agent, but the cardiotoxicity mediated by the formation of reactive oxygen species limit its clinical use. The present study aims to explore electrocardiographic and biochemical evidence for the cardioprotective effect of two antioxidants, Lycium barbarum polysaccharides (LBP, t...

journal_title：Biological & pharmaceutical bulletin

authors： Xin Y,Zhang S,Gu L,Liu S,Gao H,You Z,Zhou G,Wen L,Yu J,Xuan Y

更新日期：2011-01-01 00:00:00

abstract：:Curcumin is a natural polyphenolic compound abundant in the rhizome of the perennial herb turmeric, Curcuma longa. It is commonly used as a dietary spice and coloring agent in cooking, and is used anecdotally as an herb in traditional Indian and Chinese medicine. It has been reported that curcumin has the potential to...

journal_title：Biological & pharmaceutical bulletin

authors： Mito S,Watanabe K,Harima M,Thandavarayan RA,Veeraveedu PT,Sukumaran V,Suzuki K,Kodama M,Aizawa Y

更新日期：2011-01-01 00:00:00

abstract：:The basal levels of extracellular Zn2+ are in the range of low nanomolar concentrations in the hippocampus and perhaps increase age-dependently. Extracellular Zn2+ dynamics is critical for cognitive activity and excess influx of extracellular Zn2+ into hippocampal neurons is a known cause of cognitive decline. The den...

journal_title：Biological & pharmaceutical bulletin

authors： Takeda A,Tamano H

更新日期：2018-01-01 00:00:00

abstract：:Site-directed mutagenesis was used to investigate the molecular interactions involved in sarpogrelate binding to the human 5-Hydroxytryptamine(5-HT)2C receptor. Based on molecular modeling studies, Aspartic acid (Asp)155[3.32] in transmembrane region III and Serine(Ser)361[7.46] in transmembrane region VII of the 5-HT...

journal_title：Biological & pharmaceutical bulletin

authors： Muntasir HA,Takahashi J,Rashid M,Ahmed M,Komiyama T,Hossain M,Kawakami J,Nashimoto M,Nagatomo T

更新日期：2006-08-01 00:00:00

abstract：:DNA rich in non-methylated CG motifs (CpGs) enhances induction of immune responses against co-administered antigen encoding genes. CpGs are therefore among the promising adjuvants known to date. However, naked plasmid DNA, even which contains CpG motifs, are taken up by antigen presenting cells via the endocytosis pat...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshikawa T,Imazu S,Gao JQ,Hayashi K,Tsuda Y,Okada N,Tsutsumi Y,Akashi M,Mayumi T,Nakagawa S

更新日期：2006-01-01 00:00:00

abstract：:Recent development in carbohydrate markers and functions are described. Identification of carbohydrate epitope for cancer-specific antibody is introduced. This novel approach involves the key glycosyltransferases that synthesize tumor-associated carbohydrate-antigens and elucidate the biosynthetic pathways. This is th...

journal_title：Biological & pharmaceutical bulletin

authors： Fukuda M

更新日期：2012-01-01 00:00:00