Inhibitors of skin-tumor promotion. XIII. Inhibitory effects of euglobals and their related compounds on Epstein-Barr virus activation and on two-stage carcinogenesis of mouse skin tumors. (2).

abstract：:There are some highly cytotoxic anticancer compounds inducing differentiation of cancer cells to normal cells at below highly cytotoxic concentration. Naphthoquinone derivatives having cytotoxic effects on cancer cell were tested to learn whether they have differentiation inducing activity in human leukemia HL-60 cell...

journal_title：Biological & pharmaceutical bulletin

authors： Bae KA,Choung SY

更新日期：1996-06-01 00:00:00

abstract：:To explore the role of the abnormal expression of the bile salt export pump (BSEP) and multidrug resistance protein 2 (MRP2) in isoniazid (INH)-induced liver injury, we assessed the liver injury induced by INH in rats and HepG2 cells in vitro. The regulatory pathways via Sirtuin 1 (SIRT1) and farnesoid X receptor (FXR...

journal_title：Biological & pharmaceutical bulletin

authors： Qu X,Zhang Y,Zhang S,Zhai J,Gao H,Tao L,Song Y

更新日期：2018-01-01 00:00:00

abstract：:Schizophyllan (SPG) is used to treat cervical cancer in combination with irradiation to enhance the immunological surveillance system. Dectin-1 is a cell surface receptor for 1,3-beta-glucan. In this study, we prepared two anti-Dectin-1 monoclonal antibodies, 4B2 and SC30 having a K(D) of 7.04 x 10(-8) M and 1.55 x 10...

journal_title：Biological & pharmaceutical bulletin

authors： Ikeda Y,Adachi Y,Ishii T,Tamura H,Aketagawa J,Tanaka S,Ohno N

更新日期：2007-08-01 00:00:00

abstract：:In the investigation of chemical constituents in antiosteoporotic active fraction, 90% ethanol fraction of water extract of the rhizomes of Dioscorea spongiosa, twenty-two glycosides were isolated and their structures were elucidated. In order to know the role of each compound played in the fraction and to find the ex...

journal_title：Biological & pharmaceutical bulletin

authors： Yin J,Han N,Liu Z,Song S,Kadota S

更新日期：2010-01-01 00:00:00

abstract：:We describe herein the development of a high affinity and specific DNA aptamer as a new ligand for use in liposomal nanoparticles to target cultured mouse tumor endothelial cells (mTECs). Active targeted nanotechnology based drug delivery systems are currently of great interest, due to their potential for reducing sid...

journal_title：Biological & pharmaceutical bulletin

authors： Ara MN,Matsuda T,Hyodo M,Sakurai Y,Ohga N,Hida K,Harashima H

更新日期：2014-01-01 00:00:00

abstract：:Ethyl sulfate, a minor and direct ethanol metabolite in adult human body, has been implicated as a biomarker for alcohol consumption and in utero exposure to ethanol. To understand better the physiological relevance of the sulfation of ethanol, it is important to clarify the cytosolic sulfotransferase (SULT) enzymes t...

journal_title：Biological & pharmaceutical bulletin

authors： Kurogi K,Davidson G,Mohammed YI,Williams FE,Liu MY,Sakakibara Y,Suiko M,Liu MC

更新日期：2012-01-01 00:00:00

abstract：:Purslane (Portulaca oleracea L.) is popular as a potherb in many areas of Europe, Asia, and the Mediterranean region and is widely distributed around the globe. It has a wide range of pharmacological effects, such as antibacterial, anti-aging, anti-inflammatory, and anti-oxidative properties. Although the extract of p...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JY,Oh HM,Kwak SC,Cheon YH,Lee MS,Rho MC,Oh J

更新日期：2015-01-01 00:00:00

abstract：:Alpha1-adrenoceptor antagonists are clinically useful for the improvement of urinary obstruction due to benign prostatic hyperplasia (BPH), and their therapeutic effects are mediated through the blockade of prostatic alpha(1)-adrenoceptors. The present study was undertaken to predict the magnitude and duration of alph...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada S,Kato Y,Okura T,Kagawa Y,Kawabe K

更新日期：2007-07-01 00:00:00

abstract：:A plasmid-cured strain of the marine Vibrio alginolyticus 138-2 retains a respiration-driven Na+ pump. Examinations of several strains of V. alginolyticus and V. parahaemolyticus revealed that these murine Vibrio always possessed the respiration-driven Na+ pump irrespective of the presence or absence of plasmids. Thes...

journal_title：Biological & pharmaceutical bulletin

authors： Nakamura T,Hayashi S,Yamanaka R,Hamashima H,Arai T,Unemoto T

更新日期：1993-08-01 00:00:00

abstract：:The medial prefrontal cortex (mPFC) plays critical roles in the development of cocaine addiction. Numerous studies have reported about the effects of cocaine on neuronal and synaptic activities in the nucleus accumbens and ventral tegmental area, which are brain regions associated with cocaine addiction; however, a li...

journal_title：Biological & pharmaceutical bulletin

authors： Sasase H,Izumi S,Deyama S,Hinoi E,Kaneda K

更新日期：2019-01-01 00:00:00

abstract：:Vesicular glutamate transporter (VGLUT) is responsible for the active transport of L-glutamate into synaptic vesicles and, thus, plays an essential role in the glutamatergic chemical transmission in the central and peripheral nervous systems. Recent studies indicated that VGLUT is also expressed and localized in vario...

journal_title：Biological & pharmaceutical bulletin

authors： Moriyama Y,Omote H

更新日期：2008-10-01 00:00:00

abstract：:The permeability of insulin across Xenopus pulmonary membrane and the effects of various absorption enhancers on insulin permeability were examined using an in vitro Ussing chamber technique. Absorption enhancers used in this study were sodium caprate (NaCap), sodium glycocholate (NaGC), sodium salicylate (NaSal) and ...

journal_title：Biological & pharmaceutical bulletin

authors： Yamamoto A,Tanaka H,Okumura S,Shinsako K,Ito M,Yamashita M,Okada N,Fujita T,Muranishi S

更新日期：2001-04-01 00:00:00

abstract：:Homocysteine-inducible endoplasmic reticulum (ER) protein (Herp) is an ER stress-inducible membrane protein involved in ER-associated degradation. Herp expression is maintained at low levels through a strict regulatory mechanism, but the details of this mechanism and the reasons why Herp expression is restricted in th...

journal_title：Biological & pharmaceutical bulletin

authors： Maeda T,Fujita Y,Tanabe-Fujimura C,Zou K,Liu J,Liu S,Kikuchi K,Shen X,Nakajima T,Komano H

更新日期：2018-01-01 00:00:00

abstract：:In the present study, we investigated the neuroprotective effects of kaempferol in the mouse model of Parkinson's disease, which was induced by neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). We confirmed that MPTP led to behavioral deficits, depletion of dopamine and its metabolites, reduction in supe...

journal_title：Biological & pharmaceutical bulletin

authors： Li S,Pu XP

更新日期：2011-01-01 00:00:00

abstract：:We investigated whether poly-L-arginine (PLA) could improve permeation of the hydrophilic compounds, FITC-labeled dextran (MW 3800, FD-4) and pyridoxamine, through ocular surface tissues. Samples of cornea, conjunctiva, or conjunctiva/sclera composite from Japanese white rabbits were mounted in Ussing chambers to meas...

journal_title：Biological & pharmaceutical bulletin

authors： Nemoto E,Takahashi H,Kobayashi D,Ueda H,Morimoto Y

更新日期：2006-01-01 00:00:00

abstract：:The fundamental role that receptor tyrosine kinases play in cancer and other proliferative diseases has provided the impetus for an extensive effort on the part of both academic and pharmaceutical laboratories to develop highly specific inhibitors. In this study, inhibitory activity of previously synthesized arylaceti...

journal_title：Biological & pharmaceutical bulletin

authors： Altuntas TG,Olgen S,Nebioglu D,Akaho E

更新日期：2004-01-01 00:00:00

abstract：:Adult T-cell leukemia (ATL) is a severe chemotherapy-resistant malignancy associated with prolonged infection by the human T cell-lymphotropic virus 1 (HTLV-1). One approach to prevent the onset of ATL is to inhibit the growth/transmission of HTLV-1 infected cells using arsenic trioxide (As(2)O(3)). However, there are...

journal_title：Biological & pharmaceutical bulletin

authors： Nabeshi H,Yoshikawa T,Kamada H,Shibata H,Sugita T,Abe Y,Nagano K,Nomura T,Minowa K,Yamashita T,Itoh N,Yoshioka Y,Tsunoda S,Tsutsumi Y

更新日期：2009-07-01 00:00:00

abstract：:The effects of Ginkgo biloba leaf extract (GBE), one of the most widely used herbal dietary supplements in Japan and the United States, on the pharmacokinetics of nifedipine (NFP), a typical probe of P450 (CYP) 3A, but not a substrate of the multidrug transporter P-glycoprotein (P-gp), were studied using rats. Simulta...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshioka M,Ohnishi N,Sone N,Egami S,Takara K,Yokoyama T,Kuroda K

更新日期：2004-12-01 00:00:00

abstract：:The present study was undertaken to clarify the effect of group I metabotropic glutamate receptor (mGluR) antagonist, (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA) on pentetrazol-induced kindled seizures. The mechanism of the anticonvulsant effect of AIDA was also studied. Mice were anesthetized with pentobarbital; t...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe Y,Kaida Y,Takechi K,Kamei C

更新日期：2010-01-01 00:00:00

abstract：:Fine particulate matter (PM2.5) pollution causes serious health disorders, because PM2.5 becomes deposited in the tracheobronchial and alveoli regions. In the extrathoracic region, there are more deposits of coarse particulate matter than fine particulates. As adverse health issues caused by coarse particulates have n...

journal_title：Biological & pharmaceutical bulletin

authors： Kataoka H,Tanaka K,Tazuya-Murayama K,Yamashita T,Nishikawa JI

更新日期：2021-01-01 00:00:00

abstract：:We examined the transport mechanisms of daunorubicin (DNR) and doxorubicin (ADR) in HL60 and HL60/THP cells which were the non-P-glycoprotein-mediated resistant clone of the parent HL60 cells and showed a low degree of resistance, and compared them with those of pirarubicin (THP). In both lines, it appeared that the u...

journal_title：Biological & pharmaceutical bulletin

authors： Nagasawa K,Natazuka T,Nomiyama M,Ohnishi N,Yokoyama T

更新日期：1996-01-01 00:00:00

abstract：:We investigated the cytotoxicity of eight vitamin K3 (VK3) analogs against neuroblastoma cell lines (IMR-32, LA-N-1, NB-39, and SK-N-SH) and normal cell lines (human umbilical vein endothelial cells (HUVEC) and human dermal fibroblasts (HDF)) using a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) a...

journal_title：Biological & pharmaceutical bulletin

authors： Kitano T,Yoda H,Tabata K,Miura M,Toriyama M,Motohashi S,Suzuki T

更新日期：2012-01-01 00:00:00

abstract：:Lymphocyte homing is mediated by a specific interaction between the lymphocyte homing receptor L-selectin and its sulfated glycoprotein ligands, which are expressed on high endothelial venules (HEV) in the lymph nodes. To examine the significance of the sulfation of L-selectin ligands, our group has generated gene-tar...

journal_title：Biological & pharmaceutical bulletin

authors： Kawashima H

更新日期：2006-12-01 00:00:00

abstract：:There may be cardio-renal interactions in rats of isoproterenol-induced heart failure, which may be associated with renal fibrosis and endothelial-to-mesenchymal transition (EndMT). Since its discovery, relaxin (RLX) which was regarded as a reproductive hormone for a long time, is recently considered an effective anti...

journal_title：Biological & pharmaceutical bulletin

authors： Zheng G,Cai J,Chen X,Chen L,Ge W,Zhou X,Zhou H

更新日期：2017-01-01 00:00:00

abstract：:The present study was designed to determine the effect of delta(9)-tetrahydrocannabinol (THC) on susceptibility to stress. We reported that THC significantly prolonged the immobility time during the forced swim-stress. The selective cannabinoid CB(1) receptor antagonist O-2050 significantly reduced the enhancement of ...

journal_title：Biological & pharmaceutical bulletin

authors： Sano K,Koushi E,Irie K,Higuchi S,Tsuchihashi R,Kinjo J,Egashira N,Oishi R,Uchida N,Nagai H,Nishimura R,Tanaka H,Morimoto S,Mishima K,Iwasaki K,Fujiwara M

更新日期：2009-12-01 00:00:00

abstract：:The purpose of this study was to develop a method for the measurement of the cell kinetics of spleen lymphocytes using the ROSA 26 transgenic mouse ubiquitously expressing beta-galactosidase (beta-gal). Spleen lymphocytes were isolated from ROSA 26 mice and intravenously inoculated into C57BL/6 mice under normal condi...

journal_title：Biological & pharmaceutical bulletin

authors： Hosoya K,Takashima T,Matsuda K,Terasaki T

更新日期：2002-10-01 00:00:00

abstract：:Information on the comparative digestibility of food allergens and non-allergenic proteins is crucial when stability to digestion is to be used as a criterion to assess the allergenic potential of novel proteins. Preheating effect on in vitro digestibility has not been fully examined. In this study we investigated the...

journal_title：Biological & pharmaceutical bulletin

authors： Takagi K,Teshima R,Okunuki H,Sawada J

更新日期：2003-07-01 00:00:00

abstract：:The nasal absorption of non-glycosylated recombinant human granulocyte colony-stimulating factor produced by Esherichia coli (E. coli-rhG-CSF) was studied in rats. We investigated the effects of the basic conditions of the dosing solution and the enhancing effects of various substances to find means to improve the nas...

journal_title：Biological & pharmaceutical bulletin

authors： Nomura H,Akamisaka S,Maruyama K

更新日期：1996-11-01 00:00:00

abstract：:Several Pt(IV) and Pt(II) complexes containing 1R,2R-cyclohexanediamine (1R,2R-dach) as a carrier ligand were synthesized. The cytotoxicities and the uptake of the platinum complexes by leukemia L1210 cells were compared in order to study the correlation between their structures and cytotoxicities. [Pt(II)Cl2(1R,2R-da...

journal_title：Biological & pharmaceutical bulletin

authors： Yamashita T,Hirose J,Noji M,Saito R,Tomida H,Kidani Y

更新日期：1993-10-01 00:00:00

abstract：:It has been suggested that imbalances in gut microbiota are related to diseases associated with metabolism, the central nervous system, etc. Therefore, analysis of short-chain fatty acids (SCFAs) produced by gut microbiota is very important as an indicator of causation, demonstrating the effects on the host due to cha...

journal_title：Biological & pharmaceutical bulletin

authors： Inoue H,Takayama K,Takahara C,Tabuchi N,Okamura N,Narahara N,Kojima E,Date Y,Tsuruta Y

更新日期：2019-01-01 00:00:00