Abstract:
:Vesicular glutamate transporter (VGLUT) is responsible for the active transport of L-glutamate into synaptic vesicles and, thus, plays an essential role in the glutamatergic chemical transmission in the central and peripheral nervous systems. Recent studies indicated that VGLUT is also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells. L-Glutamate is stored in VGLUT-containing organelles, secreted upon stimulation, and then acts as a paracrine and/or autocrine modulator to regulate cellular functions. Thus, VGLUT is a key molecule for glutamate signaling and is the core of a novel signaling system.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Moriyama Y,Omote Hdoi
10.1248/bpb.31.1844subject
Has Abstractpub_date
2008-10-01 00:00:00pages
1844-6issue
10eissn
0918-6158issn
1347-5215pii
JST.JSTAGE/bpb/31.1844journal_volume
31pub_type
杂志文章,评审abstract::We examined the effects of ginseng total saponin (GTS) and several ginsenosides injected intrathecally (i.t.) or intracerebroventricularly (i.c.v.) on the antinociception induced by cold water swimming. The tail-flick response was used as an antinociceptive parameter. We found that i.t. injection of GTS time- and dose...
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