Abstract:
:Phenolic compounds, in general, exhibit antioxidant and antibacterial activities. We studied antimicrobial activity of the phenolic antioxidants, propofol (2,6-diisopropylphenol), tocopherol, eugenol, butylated hydroxyanisole (BHA), and several of their dimer compounds. Dipropofol (dimer of 2,6-diisopropylphenol) showed strong antibacterial activity against gram-positive strains including methicillin resistant Staphylococcus aureus (MRSA) and vancomycin resistant Enterococci (VRE), while propofol and other monomeric and dimeric phenols having methyl or tert-butyl groups showed no remarkable activity. The results indicated that the dimeric structure of 2,6-diisopropylphenol moiety may play an important role in the antibacterial activity.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Ogata M,Tutumimoto Sato K,Kunikane T,Oka K,Seki M,Urano S,Hiramatsu K,Endo Tdoi
10.1248/bpb.28.1120subject
Has Abstractpub_date
2005-06-01 00:00:00pages
1120-2issue
6eissn
0918-6158issn
1347-5215pii
JST.JSTAGE/bpb/28.1120journal_volume
28pub_type
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