Antibacterial activity of dipropofol and related compounds.

Abstract:

:Phenolic compounds, in general, exhibit antioxidant and antibacterial activities. We studied antimicrobial activity of the phenolic antioxidants, propofol (2,6-diisopropylphenol), tocopherol, eugenol, butylated hydroxyanisole (BHA), and several of their dimer compounds. Dipropofol (dimer of 2,6-diisopropylphenol) showed strong antibacterial activity against gram-positive strains including methicillin resistant Staphylococcus aureus (MRSA) and vancomycin resistant Enterococci (VRE), while propofol and other monomeric and dimeric phenols having methyl or tert-butyl groups showed no remarkable activity. The results indicated that the dimeric structure of 2,6-diisopropylphenol moiety may play an important role in the antibacterial activity.

journal_name

Biol Pharm Bull

authors

Ogata M,Tutumimoto Sato K,Kunikane T,Oka K,Seki M,Urano S,Hiramatsu K,Endo T

doi

10.1248/bpb.28.1120

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

1120-2

issue

6

eissn

0918-6158

issn

1347-5215

pii

JST.JSTAGE/bpb/28.1120

journal_volume

28

pub_type

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