Endothelial nitric oxide-dependent vasorelaxant effect of isotirumalin, a dihydroflavonol from Derris urucu, on the rat aorta.

abstract：:All living organisms on earth are composed of L-amino acids and D-sugars. Therefore the presence and function of D-amino acids in living organisms have not been studied. Recently, however, D-aspartic acid (D-Asp) which is a D-amino acid, has been detected in various proteins from human tissue samples such as eye lens,...

journal_title：Biological & pharmaceutical bulletin

authors： Fujii N

更新日期：2005-09-01 00:00:00

abstract：:Among the eight inbred mouse strains employed in our preceding report, 12-O-tetradecanoylphorbol 13-acetate (TPA) painting alone induced CD4+ regulatory T (Tr) cells in four strains (e.g., C3H/He) at 6-8 weeks of age, but not in the remaining strains (e.g., C57BL/6, BALB/c). In the present study, the effect of growth ...

journal_title：Biological & pharmaceutical bulletin

authors： Negoro T,Satoh K,Iinuma F,Tobe T,Watanabe M

更新日期：2002-02-01 00:00:00

abstract：:The phylogenetic relationship of Cistanche deserticola, C. salsa and C. tubulosa was analyzed by comparing the nucleotide sequences of the plastid rps2 gene and the intergenic spacer region between rpl16 and rpl14. By comparison of sequence data, the Cistanche samples were distinguishable from each other. The results ...

journal_title：Biological & pharmaceutical bulletin

authors： Tomari N,Ishizuka Y,Moriya A,Kojima S,Deyama T,Mizukami H,Tu P

更新日期：2002-02-01 00:00:00

abstract：:We have studied lysosomal proteases capable of degrading a major form of cytochrome P450 (CYP2B1) which was purified from the liver microsomes of phenobarbital-treated rats. After incubation of CYP2B1 with extracts of triton-filled lysosomes (tritosomes), its proteolysis was measured by a quantitative immunoblot proce...

journal_title：Biological & pharmaceutical bulletin

authors： Tsuji H,Akasaki K

更新日期：1994-05-01 00:00:00

abstract：:TRPV2, a member of the transient receptor potential family, has been isolated as a capsaicin-receptor homolog and is thought to respond to noxious heat. Here we show that TRPV2 mRNA is predominantly expressed in the subpopulation of olfactory sensory neurons (OSNs). We carried out histochemical analyses of TRPV2 and i...

journal_title：Biological & pharmaceutical bulletin

authors： Matsui H,Noguchi T,Takakusaki K,Kashiwayanagi M

更新日期：2014-01-01 00:00:00

abstract：:Salazosulfapyridine (SASP) is widely used orally and rectally in the treatment of ulcerative colitis. SASP is mainly metabolized by hydrolysis and the main active metabolite, 5-aminosalicylic acid (5-ASA), has an antiinflammatory effect. In the present study, we prepared suppositories containing 6.5 mmol of SASP and a...

journal_title：Biological & pharmaceutical bulletin

authors： Tokui K,Asai Y,Arakawa T,Matsumoto T,Nabeshima T

更新日期：2002-02-01 00:00:00

abstract：:The tumor microenvironment is one of the key factors contributing to the efficiency of drug delivery to a tumor. It has been reported that lymphangiogenesis is induced in certain tumors. Because the lymphatic system functions as a drainage one, it is possible that tumor lymphatic vessels alter not only the tumor micro...

journal_title：Biological & pharmaceutical bulletin

authors： Shimizu K,Ikeuchi SY,Okajima A,Nakamura G,Muraoka E,Oku N

更新日期：2018-01-01 00:00:00

abstract：:Threohydroxyaspartate (THA) causes glutamate excitotoxicity in motor neurons in organotypic culture of rat spinal cord. Some drugs, including sulforaphane (SF) and riluzole, can protect motor neuron against excitotoxicity. It has been demonstrated that SF is a potent inducer of Phase II enzymes, while riluzole is a cl...

journal_title：Biological & pharmaceutical bulletin

authors： Chang G,Guo Y,Jia Y,Duan W,Li B,Yu J,Li C

更新日期：2010-01-01 00:00:00

abstract：:By means of successive heparin-affinity and glycyrrhizin (GL)-affinity column chromatographies (HPLC), a 55 kDa GL-binding protein (gp55) was purified to apparent homogeneity from the Superdex P-I fraction of Habu snake venom. This gp55 was identified as an apoxin I-like protein, because (i) its 20 N-terminal amino ac...

journal_title：Biological & pharmaceutical bulletin

authors： Abe Y,Shimoyama Y,Munakata H,Ito J,Nagata N,Ohtsuki K

更新日期：1998-09-01 00:00:00

abstract：:Tetramethylpyrazine is the active ingredient of a Chinese herbal medicine. In this study, tetramethylpyrazine was tested for its activities in irradiated bone marrow stromal QXMSC1 cells. The proliferation of QXMSC1 cells was measured by MTS assay kit and flow cytometry. To identify proteins involved in the processes ...

journal_title：Biological & pharmaceutical bulletin

authors： Ma ZC,Tan HL,Xiao CR,Wang YG,Wang SQ,Gao Y

更新日期：2007-02-01 00:00:00

abstract：:The purpose of this study was to determine the high-density lipoprotein (HDL)-associated alpha-tocopherol (alpha-tocopherol-HDL) transport and clarify the contribution of scavenger receptor class B, type I (SR-BI) to the uptake in the human retinal pigment epithelial cell line (ARPE-19 cells). [(3)H]alpha-Tocopherol-H...

journal_title：Biological & pharmaceutical bulletin

authors： Akanuma S,Yamamoto A,Okayasu S,Tachikawa M,Hosoya K

更新日期：2009-06-01 00:00:00

abstract：:A hydroalcoholic (50%) extract of Emblica officinalis (fruit) (EO-50) reduced the severity of hepatic fibrosis induced by carbon tetrachloride (CCl4) and thioacetamide (TAA). Improved liver function was observed by measuring the levels of aspartate aminotransaminase (AST), alanine aminotransferase (ALT), alkaline phos...

journal_title：Biological & pharmaceutical bulletin

authors： Tasduq SA,Mondhe DM,Gupta DK,Baleshwar M,Johri RK

更新日期：2005-07-01 00:00:00

abstract：:The utility of gastrointestinal physiology regulated-dogs (regulated-dogs) was evaluated in a bioavailability study. The gastrointestinal physiology of beagle dogs was regulated with a combined-treatment of intramuscular pentagastrin and intravenous atropine sulfate. Theophylline has been regarded as a drug that is ab...

journal_title：Biological & pharmaceutical bulletin

authors： Sagara K,Kawata M,Mizuta H,Shibata M

更新日期：1994-07-01 00:00:00

abstract：:Electrets are polymeric discs that carry semi permanent electrostatic charge. These provide electrostatic potentials in the range of 500 to 3,000 V. In the current work, the effect of electret exposure on the skin permeability was investigated. Transdermal transport studies were carried out across porcine epidermis in...

journal_title：Biological & pharmaceutical bulletin

authors： Narasimha Sathyanarayana Murthy NS,Boguda VA,Payasada K

更新日期：2008-01-01 00:00:00

abstract：:Reprogramming differentiated cells toward stem cells may have long-term applications in stem-cell research and regenerative medicine. Here we report on the dedifferentiation of human epidermal keratinocytes into their precursor cells in vitro with basic fibroblast growth factor (bFGF) but not external gene interventio...

journal_title：Biological & pharmaceutical bulletin

authors： Sun X,Fu X,Han W,Zhao Y,Liu H,Sheng Z

更新日期：2011-01-01 00:00:00

abstract：:The immunoreactivity (specific binding) of three Gly(A1)-sulfobenzoxadiazole-labeled insulins which have different spacer groups, Gly(A1)-[3-(4-sulfobenzoxadiazol-7-ylthio)propanoyl]-insulin , Gly(A1)-[2-(4-sulfobenzoxadiazol-7-ylthio)acetyl]-insulin, Gly(A1)-[3-carboxy-2(or 3)-(4-sulfobenzoxadiazol-7-ylthio)propanoyl...

journal_title：Biological & pharmaceutical bulletin

authors： Nanami M,Zaitsu K,Ohkura Y

更新日期：1993-05-01 00:00:00

abstract：:Ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-alpha]pyridine) is clinically used as a cerebral vasodilator in Japan. However, the effects of ibudilast on retinal blood vessels have not been fully examined. The aim of this study, therefore, was to examine the effects of ibudilast on retinal blood vessels in rats in v...

journal_title：Biological & pharmaceutical bulletin

authors： Noguchi M,Mori A,Sakamoto K,Nakahara T,Ishii K

更新日期：2009-11-01 00:00:00

abstract：:An efficient protocol for the in vitro germination and propagation of Larrea divaricata CAV. (Jarilla) was established. To determine the effect of different growth regulators on the growth rates and phenol production, apical-node microshoots from in vitro germinated plantlets were incubated on the following media: 1) ...

journal_title：Biological & pharmaceutical bulletin

authors： Palacio L,Baeza MC,Cantero JJ,Cusidó R,Goleniowski ME

更新日期：2008-12-01 00:00:00

abstract：:Apoptotic cells must be recognized early for phagocytosis to ensure that their toxic contents do not damage neighboring cells. In some cases this is achieved via CD43-capped membrane glycoproteins, the sialylpolylactosaminyl chains of which serve as ligands for phagocytosis by macrophages. However, because many additi...

journal_title：Biological & pharmaceutical bulletin

authors： Oguri E,Miki Y,Hirano K,Yamanaka M,Beppu M

更新日期：2012-01-01 00:00:00

abstract：:The possibility of pharmacokinetic interactions between Sho-saiko-to extract powder (TJ-9), the most widely used traditional Chinese herbal (Kampo) medicine in Japan, and carbamazepine (CBZ), an important anti-epileptic drug, was examined in rats. There was no significant difference in the protein binding of CBZ in se...

journal_title：Biological & pharmaceutical bulletin

authors： Ohnishi N,Okada K,Yoshioka M,Kuroda K,Nagasawa K,Takara K,Yokoyama T

更新日期：2002-11-01 00:00:00

abstract：:We reported previously that monkey embryonic stem cells (ESCs) were differentiated into hepatocytes by formation of embryoid bodies (EBs). However, this EB formation method is not always efficient for assays using a large number of samples simultaneously. A dispersion culture system, one of the differentiation methods...

journal_title：Biological & pharmaceutical bulletin

authors： Maruyama J,Matsunaga T,Yamaori S,Sakamoto S,Kamada N,Nakamura K,Kikuchi S,Ohmori S

更新日期：2013-01-01 00:00:00

abstract：:We earlier reported that collagen synthesis in false aged model rats was stimulated by the administration of a methanol extract from the leaves of Eucommia ulmoides OLIVER. When the methanol extract was fractionated to n-hexane, ethyl acetate, acetone and methanol fractions by silica gel chromatography, we discovered ...

journal_title：Biological & pharmaceutical bulletin

authors： Li Y,Metori K,Koike K,Che QM,Takahashi S

更新日期：1999-06-01 00:00:00

abstract：:A protein was purified from rabbit seminal plasma using preparative acrylamide disc electrophoresis, ammonium sulfate precipitation and gel filtration. The protein inhibited the in vitro fertilization of mouse ova inseminated with epididymal sperm and with capacitated sperm. The inhibition was not observed, however, w...

journal_title：Biological & pharmaceutical bulletin

authors： Okabe M,Kishi Y,Ying X,Kohama Y,Mimura T,Li SS

更新日期：1993-05-01 00:00:00

abstract：:Mouth washing after inhalation of corticosteroids is effective for prevention of local adverse effects such as hoarseness and oropharyngeal candidiasis. To establish an optimal procedure for such mouth washing, we investigated the removal rates of drug residues remaining on the oropharyngeal mucosa using various mouth...

journal_title：Biological & pharmaceutical bulletin

authors： Yokoyama H,Yamamura Y,Ozeki T,Iga T,Yamada Y

更新日期：2006-09-01 00:00:00

abstract：:It is known that the onset of major depressive disorder (MDD) would be associated with genetic factors. To investigate the susceptibility to psychiatric disorders, e.g. MDD, schizophrenia etc., it is necessary to compare the genetic differences of objective polymorphisms between in patients and in relative contol subj...

journal_title：Biological & pharmaceutical bulletin

authors： Inoue K,Ando N,Suzuki E,Hayashi H,Tsuji D,Itoh K

更新日期：2012-01-01 00:00:00

abstract：:Since grape extract (GE) contains oligomeric proanthocyanidins and numerous polyphenols, dietary GE supplements may exert protective effects against various diseases. The present study investigated the pharmacological effects of GE derived from Chardonnay in vitro and in vivo. GE (100 µg/mL) completely inhibited tumor...

journal_title：Biological & pharmaceutical bulletin

authors： Ohkita M,Hayashi H,Ito K,Shigematsu N,Tanaka R,Tsutsui H,Matsumura Y

更新日期：2019-01-01 00:00:00

abstract：:Two glucuronides (4'-O-, and 7-O-) and a glucuronyl (7-O-) sulfate (4'-O-) of genistein, two glucuronides (4'-O-, and 7-O-) and a glucuronyl (7-O-) sulfate (4'-O-) of daidzein, 7-O-glucuronides of glycitein, dihydrodaidzein and O-desmethylangolensin were isolated from the urine of volunteer subjects fed soy bean curds...

journal_title：Biological & pharmaceutical bulletin

authors： Kinjo J,Tsuchihashi R,Morito K,Hirose T,Aomori T,Nagao T,Okabe H,Nohara T,Masamune Y

更新日期：2004-02-01 00:00:00

abstract：:Extracellular nucleotides have multiple biological actions in processes such as proliferation, differentiation, chemotaxis, and cytokine secretion through P2X receptors on the cell surface. To determine the biological activity of adenosine triphosphate (ATP) and the expression of P2 nucleotide receptors in murine bone...

journal_title：Biological & pharmaceutical bulletin

authors： Yoon MJ,Lee HJ,Lee YS,Kim JH,Park JK,Chang WK,Shin HC,Kim DK

更新日期：2007-04-01 00:00:00

abstract：:In Parkinson's disease, while dopamine (DA) replacement therapy, such as with L-DOPA (levodopa), improves the symptoms, it does not inhibit the degeneration of DA neurons in the substantia nigra. Numerous studies have suggested that both endogenous and environmental neurotoxins and oxidative stress may participate in ...

journal_title：Biological & pharmaceutical bulletin

authors： Kitamura Y,Kakimura J,Taniguchi T

更新日期：2002-03-01 00:00:00

abstract：:Auditory neuropathy (AN) is a hearing disorder characterized by an abnormal auditory brainstem response (ABR). This study examined experimental AN model induced in mice following increased dosages of pyridoxine. Induced AN was examined for < or =10 weeks following the last pyridoxine treatment. To assess AN, we evalua...

journal_title：Biological & pharmaceutical bulletin

authors： Hong BN,Yi TH,Kim SY,Kang TH

更新日期：2009-04-01 00:00:00