Antihypertensive actions of methylripariochromene A from Orthosiphon aristatus, an Indonesian traditional medicinal plant.

abstract：:We examined the inhibitory effects of N-beta-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine (5-S-GAD), a novel antibacterial substance from the immunized adult Sarcophaga peregrina (flesh fly), on protein phosphorylation using immune complexes of protein tyrosine kinases (PTKs) with anti-PTKs monoclonal antibody. ...

journal_title：Biological & pharmaceutical bulletin

authors： Leem JY,Park HY,Fukazawa H,Uehara Y,Natori S

更新日期：1998-07-01 00:00:00

abstract：:Tropolone (1). showed strong insecticidal activity on Tyrophagus putrescentiae and Dermatophagoides farinae. The insecticidal effect of 1 on both insects was stronger than that of hinokitiol (2, 4-isopropyltropolone: major component of Thujopsis dolabrata SIEB. et ZUCC. hondai MAKINO). The insecticidal activity of bot...

journal_title：Biological & pharmaceutical bulletin

authors： Morita Y,Matsumura E,Okabe T,Shibata M,Sugiura M,Ohe T,Tsujibo H,Ishida N,Inamori Y

更新日期：2003-10-01 00:00:00

abstract：:An alkaloid piperine isolated from the Piper Nigrum was found to inhibit lipid droplet accumulation in mouse macrophages, and especially inhibited cholesteryl ester (CE) synthesis (IC50: 25 microM). The metabolism of cholesterol from lysosome to lipid droplet was inhibited with a similar IC50 (18 microM), indicating t...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuda D,Ohte S,Ohshiro T,Jiang W,Rudel L,Hong B,Si S,Tomoda H

更新日期：2008-06-01 00:00:00

abstract：:Acute pancreatitis (AP) is one kind of acute surgical abdominal disease in the world. It causes intestinal damage with subsequent bacterial migration, endotoxemia and secondary pancreatic infections. In this investigation, we determined that edaravone (EDA) reduces pancreatic and intestinal injury after AP in mice. Th...

journal_title：Biological & pharmaceutical bulletin

authors： Wang B,Lin W

更新日期：2020-01-01 00:00:00

abstract：:Ascorbic acid, present in plasma from humans at concentrations of 50 to 200 mumol/l, has multiple antioxidant properties. Structural modification of this vitamin by the introduction of lipophilic moieties has allowed to the development of ascorbate esters and ethers active as free radical quenchers. Thus, a new series...

journal_title：Biological & pharmaceutical bulletin

authors： Coudert P,Leal F,Duroux E,Rubat C,Couquelet J

更新日期：1996-02-01 00:00:00

abstract：:Skeletal muscle is a major site for glucose metabolism and its injury by cytokines can induce insulin resistance leading to type 2 diabetes. It has been suggested that quercetin may act as an anti-diabetic agent, however, the effects of quercetin on insulin resistance in skeletal muscle remain unknown. We aimed to inv...

journal_title：Biological & pharmaceutical bulletin

authors： Dai X,Ding Y,Zhang Z,Cai X,Bao L,Li Y

更新日期：2013-01-01 00:00:00

abstract：:Possible involvement of the peripheral-type benzodiazepine receptor (PBR) in hemin/protoporphyrin-induced erythroid differentiation of human leukemia K562 cells was investigated by the use of the ligands, diazepam and PK11195. Diazepam itself exhibited differentiation-inducing activity on K562 cells. The PBR-specific ...

journal_title：Biological & pharmaceutical bulletin

authors： Nakajima O,Hashimoto Y,Iwasaki S

更新日期：1995-06-01 00:00:00

abstract：:The present study examined the anti-obesity effects of pine needle extract (PNE) in 3T3-L1 preadipocytes and in vivo studies. PNE treatment suppressed both glycerol-3-phosphate dehydrogenase activity and expression of peroxisome proliferator-activated receptor (PPAR) gamma in cultured 3T3-L1 adipocytes. To investigate...

journal_title：Biological & pharmaceutical bulletin

authors： Jeon JR,Kim JY

更新日期：2006-10-01 00:00:00

abstract：:The success of arsenic trioxide (ATO) in treatment of acute promyelocytic leukemia (APL) attracts a great deal of attention to researchers to explore its activity of anti-leukemia. However, ATO has unavailable effect on chronic myeloid leukemia (CML), especially multidrug resistant (MDR)-CML, unless using high concent...

journal_title：Biological & pharmaceutical bulletin

authors： Wang X,Zhang X,Xu Z,Wang Z,Yue X,Li H

更新日期：2013-01-01 00:00:00

abstract：:A lower serum cholesterol level was recently shown to be one of the causes of stroke in an epidemiological study. Spontaneously hypertensive rats stroke-prone (SHRSP) have lower serum cholesterol levels than normotensive Wistar-Kyoto rats (WKY). To elucidate the mechanisms responsible for the lower serum cholesterol l...

journal_title：Biological & pharmaceutical bulletin

authors： Michihara A,Mido M,Matsuoka H,Mizutani Y

更新日期：2015-01-01 00:00:00

abstract：:We elucidated the protective effect of 7,8-dihydroxyflavone against hydrogen peroxide (H(2)O(2))-induced DNA damage. We found that 7,8-dihydroxyflavone scavenges 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and intracellular reactive oxygen species (ROS). 7,8-Dihydroxyflavone with antioxidant effect prevented the H(2)...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang R,Kang KA,Piao MJ,Ko DO,Wang ZH,Chang WY,You HJ,Lee IK,Kim BJ,Kang SS,Hyun JW

更新日期：2009-02-01 00:00:00

abstract：:Rapamycin (Rap) has been demonstrated to affect lipid metabolism through stimulating lipolysis, inhibiting de novo lipogenesis and reducing adiposity. In the present study, we investigated rapamycin exposure's influence on adipose tissue browning in high-fat diet-induced fatty mice. Four-week old C57BL/6J mice were fe...

journal_title：Biological & pharmaceutical bulletin

authors： Wang Y,He Z,Li X

更新日期：2017-01-01 00:00:00

abstract：:Glycosaminoglycans (GAGs) play important roles in various biological processes such as cell adhesion and signal transduction, as well as promote anti-inflammatory activity. We previously revealed that glycol-split heparin (HP)-aliphatic amine conjugates form self-assembled nanoparticles and suppress the production of ...

journal_title：Biological & pharmaceutical bulletin

authors： Yanamoto S,Babazada H,Sakai S,Higuchi Y,Yamashita F,Hashida M

更新日期：2017-01-01 00:00:00

abstract：:The genetic similarities of four species of Glycyrrhiza plants were determined by DNA analyses of random amplified polymorphic DNA (RAPD) and restriction fragment length polymorphism (RFLP). The phylogenic trees were constructed from the genetic similarities estimated from RAPD and RFLP profiles. These results indicat...

journal_title：Biological & pharmaceutical bulletin

authors： Yamazaki M,Sato A,Shimomura K,Saito K,Murakoshi I

更新日期：1994-11-01 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK) pathway is a major determinant in the control of diverse cellular processes such as proliferation, survival, and motility. This pathway is often upregulated in human cancers and as such represents an attractive target for mechanism-based approaches to cancer treatment. H...

journal_title：Biological & pharmaceutical bulletin

authors： Kohno M,Tanimura S,Ozaki K

更新日期：2011-01-01 00:00:00

abstract：:Spontaneous transfer of protein from either influenza virus-infected or uninfected cells to dimyristoylphosphatidylcholine (DMPC) liposomes was examined. The amount of transferred protein of liposomes incubated with influenza virus-infected cells (I-lipo) was more than that of liposomes incubated with uninfected cells...

journal_title：Biological & pharmaceutical bulletin

authors： Kogure K,Itoh M,Hayashi K,Ueno M

更新日期：1995-08-01 00:00:00

abstract：:Formulations consisting of egg albumin, indomethacin (IND), and olive oil or fatty acids, were prepared by vigorous stirring using a high-speed homogenizer and subsequent freeze-drying. To confirm the anti-inflammatory properties and ulcerogenic effects of the formulations, we examined the action of the formulations o...

journal_title：Biological & pharmaceutical bulletin

authors： Tsuji Y,Kakegawa H,Miyataka H,Matsumoto H,Satoh T

更新日期：1993-07-01 00:00:00

abstract：:In a previous study, we reported that one of the gel-forming (1-->3)-beta-D-glucans, grifolan (from Grifola frondosa, GRN), stimulated cytokine production from macrophages in vitro. However, several other gel-forming (1-->3)-beta-D-glucans, such as sonifilan (SPG) and SSG, did not induce cytokine production from macro...

journal_title：Biological & pharmaceutical bulletin

authors： Okazaki M,Adachi Y,Ohno N,Yadomae T

更新日期：1995-10-01 00:00:00

abstract：:The gastric H+, K+-ATPase is a proton pump that is responsible for gastric acid secretion and that actively transports protons and K+ ions in opposite directions to generate in excess of a million-fold gradient across the membrane under physiological conditions. This pump is also a target molecule of proton pump inhib...

journal_title：Biological & pharmaceutical bulletin

authors： Asano S,Morii M,Takeguchi N

更新日期：2004-01-01 00:00:00

abstract：:Effects of nebracetam, a novel nootorpic agent, on the synaptosomal uptake of neurotransmitter monoamines of the brain regions were examined. Striatal and hippocampal synaptosomes were isolated by the Percoll gradient method, and the striatal dopamine uptake and hippocampal serotonin uptake were measured in the presen...

journal_title：Biological & pharmaceutical bulletin

authors： Takeo S,Hayashi H,Tadokoro M,Takagi K,Miyake K,Takagi N,Oshikawa S

更新日期：1997-04-01 00:00:00

abstract：:We recently isolated a novel lignan, 4-hydroxykobusin from Geranium thunbergii (Liu et al., Arch. Pharm. Res., 29, 1109-1113, 2006). Here, we studied its effect on the expression of inducible nitric oxide synthase (iNOS) gene in RAW264.7 cells. 4-Hydroxykobusin inhibited nitric oxide (NO) production in a concentration...

journal_title：Biological & pharmaceutical bulletin

authors： Pokharel YR,Liu QH,Oh JW,Woo ER,Kang KW

更新日期：2007-06-01 00:00:00

abstract：:Infection of human cell with human immunodeficiency virus type-1 (HIV-1) was suppressed by cellular genetic factor(s) at reverse transcription step. Although same amount of virus adsorbed on both cells, small amount of HIV-1 (IIIB strain) infected HeLa (MAGI/CCR5) cell, while large amount of HIV-1 infected HOS (GHOST/...

journal_title：Biological & pharmaceutical bulletin

authors： Tempaku A

更新日期：2005-05-01 00:00:00

abstract：:The interaction of human leukocyte antigen (HLA) with specific drugs is associated with delayed-type hypersensitivity reactions, which cause severe cutaneous toxicity. Such interactions induce structural alterations in HLA complexes via several different mechanisms such as the hapten theory, p-i concept, and altered p...

journal_title：Biological & pharmaceutical bulletin

authors： Shirayanagi T,Aoki S,Fujimori S,Watanabe K,Aida T,Hirasawa M,Kumagai K,Hoshino T,Ito K

更新日期：2020-01-01 00:00:00

abstract：:We examine the pharmacokinetic profile of cyclosporin A (CyA) after intravenous administration to rats prepared as models of various disease states found in patients who receive organ transplantations. After intravenous bolus administration to normal rats, the total blood clearance (CLt) of CyA showed a dose-dependent...

journal_title：Biological & pharmaceutical bulletin

authors： Shibata N,Shimakawa H,Minouchi T,Yamaji A

更新日期：1993-11-01 00:00:00

abstract：:As an attempt to identify bioactive natural products with anti-inflammatory activity, we evaluated the effects of the methanol extract of the semen of Xanthium strumarium L. (MEXS) on lipopolysaccharide (LPS)-induced nitric oxide (NO), prostaglandin E2 (PGE2) and tumor necrosis factor-alpha (TNF-alpha) production in R...

journal_title：Biological & pharmaceutical bulletin

authors： Kim IT,Park YM,Won JH,Jung HJ,Park HJ,Choi JW,Lee KT

更新日期：2005-01-01 00:00:00

abstract：:To search for possible anti-tumor-promoters, we carried out a primary screening of 21 cucurbitane triterpenoids using an in vitro assay system. Of these triterpenoids, scandenoside R6 (6), 23,24-dihydrocucurbitacin F (14), 25-acetyl-23,24-dihydrocucurbitacin F (15), 2-O-beta-D-glucopyranosyl-23,24-dihydrocucurbitacin ...

journal_title：Biological & pharmaceutical bulletin

authors： Konoshima T,Takasaki M,Tatsumoto T,Kozuka M,Kasai R,Tanaka O,Nie RL,Tokuda H,Nishino H,Iwashima A

更新日期：1994-05-01 00:00:00

abstract：:We have previously reported that restraint stress inhibits small intestinal motility in rats, and that the adrenergic beta3-antagonist SR59230A administration recovered the inhibition. In the present study, we compared the effects of restraint stress and norepinephrine on small intestinal motility using alpha- and bet...

journal_title：Biological & pharmaceutical bulletin

authors： Tsukada F,Sawamura K,Kohno H,Ohkubo Y

更新日期：2002-01-01 00:00:00

abstract：:The human adenovirus type 5 (Ad5) early-region 1A (E1A) proteins have been shown to have strong tumor-suppressive activities in human tumor cells and to enhance the sensitivity of a variety of malignant tumors to apoptosis induced by ionizing radiation and chemotherapeutic agents. However, the inherent limitations of ...

journal_title：Biological & pharmaceutical bulletin

authors： Ma Y,Zhou X,Zhao Q,Li Y,Liu Y,Wang Z,Zhang Y

更新日期：2003-02-01 00:00:00

abstract：:The effect of aging on the intestinal transport of hydrophilic drugs (and probe compounds) was investigated in the rat small intestine. Passive transport was suggested to be unchanged with aging from 8 (young) to 54 (old) and further to 101 (very old) weeks old, as shown for D-xylose and urea in single-pass intestinal...

journal_title：Biological & pharmaceutical bulletin

authors： Yuasa H,Soga N,Kimura Y,Watanabe J

更新日期：1997-11-01 00:00:00

abstract：:The fat-specific protein 27 (Fsp27) gene belongs to the cell death-inducing DNA fragmentation factor 45-like effector family. Fsp27 is highly expressed in adipose tissue as well as the fatty liver of ob/ob mice. Fsp27 is directly regulated by the peroxisome proliferator-activated receptor γ (PPARγ) in livers of geneti...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuo K,Matsusue K,Aibara D,Takiguchi S,Gonzalez FJ,Yamano S

更新日期：2017-01-01 00:00:00