Molecular and cellular regulation of the gastric proton pump.

abstract：:Tetramethylpyrazine is the active ingredient of a Chinese herbal medicine. In this study, tetramethylpyrazine was tested for its activities in irradiated bone marrow stromal QXMSC1 cells. The proliferation of QXMSC1 cells was measured by MTS assay kit and flow cytometry. To identify proteins involved in the processes ...

journal_title：Biological & pharmaceutical bulletin

authors： Ma ZC,Tan HL,Xiao CR,Wang YG,Wang SQ,Gao Y

更新日期：2007-02-01 00:00:00

abstract：:Carvedilol, an alpha- and beta-adrenergic blocking drug, is mainly metabolized by CYP2D6, UGT1A1, UGT2B4 and UGT2B7. This drug is administered orally as a racemic mixture of R(+)- and S(-)-enantiomers. It has been reported that CYP2D6 prefers metabolizing S-carvedilol to R-carvedilol stereoselectively. On the other ha...

journal_title：Biological & pharmaceutical bulletin

authors： Takekuma Y,Takenaka T,Yamazaki K,Ueno K,Sugawara M

更新日期：2007-11-01 00:00:00

abstract：:Puerarin (daidzein 8-C-glucoside) is an isoflavone C-glucoside contained in the roots of Pueraria lobata OHWI. We have previously isolated the human intestinal bacterium, strain PUE, which metabolizes puerarin to daidzein, though the enzyme which cleaves C-glycosidic bond has not been clarified. Here, we identified on...

journal_title：Biological & pharmaceutical bulletin

authors： Nakamura K,Zhu S,Komatsu K,Hattori M,Iwashima M

更新日期：2019-03-01 00:00:00

abstract：:In the process of lipolysis, adipocytes are stimulated by catecholamines through beta(1), beta(2), and beta(3) adrenergic receptors (ARs). So far, beta(2) and beta(3) AR polymorphisms have been reported related to obesity. However, the relation of beta(1)AR polymorphisms to obesity has not been evaluated. In the prese...

journal_title：Biological & pharmaceutical bulletin

authors： Nonen S,Yamamoto I,Liu J,Maeda M,Motomura T,Igarashi T,Fujio Y,Azuma J

更新日期：2008-02-01 00:00:00

abstract：:The number of spleen Mac-1-positive cells was markedly increased in methylcholanthrene-induced Meth-A fibrosarcoma (Meth-A)-implanted mice. When the sera of Meth-A-implanted mice were added to normal bone marrow cells, granulocyte and macrophage colony stimulating factor (GM-CSF)-dependent growth of bone marrow cells ...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe T,Okada A,Mikami T,Matsumoto T,Suzuki M

更新日期：1995-12-01 00:00:00

abstract：:The potential hair growth-promoting activity of rice bran supercritical CO2 extract (RB-SCE) and major components of RB-SCE, linoleic acid, policosanol, γ-oryzanol, and γ-tocotrienol, were evaluated with the histological morphology and mRNA expression levels of cell growth factors using real-time reverse transcriptase...

journal_title：Biological & pharmaceutical bulletin

authors： Choi JS,Jeon MH,Moon WS,Moon JN,Cheon EJ,Kim JW,Jung SK,Ji YH,Son SW,Kim MR

更新日期：2014-01-01 00:00:00

abstract：:The characteristics of the binding of human lactoferrin (LF) to the cells of a human monocytic leukemia cell line, THP-1, were investigated. 125I-Labeled LF (125I-LF) bound to THP-1 cells, and the binding increased markedly as the cells matured into macrophages (THP-1 macrophages) by stimulation with phorbol 12-myrist...

journal_title：Biological & pharmaceutical bulletin

authors： Eda S,Kikugawa K,Beppu M

更新日期：1996-02-01 00:00:00

abstract：:The effect of pH on the microenvironment surrounding 34Cys in human serum albumin (HSA) has been studied using acrylodan, a Cys-specific fluorescence probe. The reactivity of 34Cys with 5,5'-dithiobis(2-nitro benzoic acid) (DTNB) followed a pseudo-first-order reaction, and the increase in reactivity was dependent on p...

journal_title：Biological & pharmaceutical bulletin

authors： Narazaki R,Maruyama T,Otagiri M

更新日期：1997-04-01 00:00:00

abstract：:Effects of epidermal growth factor (EGF) on the expression of alpha(2)-adrenergic responses were examined in primary cultures of adult rat hepatocytes. The alpha(2)-responses were assessed by the inhibition of the rate of forskolin-stimulated cAMP formation by the selective alpha(2)-adrenergic agonists, oxymetazoline ...

journal_title：Biological & pharmaceutical bulletin

authors： Ogihara M

更新日期：1996-04-01 00:00:00

abstract：:Dihydropyrazines (DHPs), which are derived from sugars, inhibit the growth of Escherichia coli. Addition of copper(II) ion (Cu2+) accelerates the effect of DHPs, resulting in cell death. Investigation of the lethal effect in several DNA repair-deficient or detoxifying enzyme-deficient mutant strains and radical scaven...

journal_title：Biological & pharmaceutical bulletin

authors： Takeda O,Takechi S,Katoh T,Yamaguchi T

更新日期：2005-07-01 00:00:00

abstract：:Ty2 retrotransposons are the mobile genetic elements of the yeast Saccharomyces cerevisiae. Transcriptional regulation of Ty2-917 requires a complex set of cis acting elements which are located both upstream and downstream of the transcription initiation site. Previously, the glycolysis regulatory protein Gcr1p has be...

journal_title：Biological & pharmaceutical bulletin

authors： Türkel S

更新日期：2002-09-01 00:00:00

abstract：:The pharmacokinetics of ketotifen fumarate (KF) was examined after administration in rabbits through four different routes (intravenous, intranasal, oral and rectal). The time-course of the plasma concentration of KF after intravenous administration (1 mg/kg dose) fitted a two-compartment open model. KF was rapidly ab...

journal_title：Biological & pharmaceutical bulletin

authors： Yagi N,Taniuchi Y,Hamada K,Sudo J,Sekikawa H

更新日期：2002-12-01 00:00:00

abstract：:Regulating γ-aminobutyric acid (GABA) uptake transport on the plasma membranes is required for its efficient clearance from the brain interstitial fluid. The purpose of this study was to clarify the assembly of taurine transporter (TauT/Slc6a6) and PSD-95/Disc-large/Zo-1 (PDZ) domain of Na+-H+ exchanger regulatory fac...

journal_title：Biological & pharmaceutical bulletin

authors： Tachikawa M,Yokoyama R,Akanuma SI,Hosoya KI

更新日期：2018-01-01 00:00:00

abstract：:Two conjugates of marine polysaccharide (MPS) and bovine serum albumin (BSA) were prepared using two methods, periodate oxidation and reductive amination, with the intent of enhancing its immunogenicity. Sera samples from Balb/c mice immunized with the products named MPS-BSAp and MPS-BSAr respectively were evaluated b...

journal_title：Biological & pharmaceutical bulletin

authors： Gan L,Xin X,Geng M,Ding J

更新日期：2004-10-01 00:00:00

abstract：:An extract of the leaves of Apocynum venetum L. (Apocynaceae) markedly shortened the immobility time of male rats in a forced swimming test (FST) in a dose range of 30-125 mg/kg, indicating a possible antidepressant activity. This effect was comparable to that of the tricyclic antidepressant imipramine (20 mg/kg). Nei...

journal_title：Biological & pharmaceutical bulletin

authors： Butterweck V,Nishibe S,Sasaki T,Uchida M

更新日期：2001-07-01 00:00:00

abstract：:Several neurological disorders such as Alzheimer's and Parkinson's diseases have been attributed to gamma-aminobutyric acid (GABA) depletion in the brain. In order to provide a pharmacological basis for the neuroprotective actions of the enhanced accumulation of GABA in mulberry leaves (ML) against cerebral ischemia i...

journal_title：Biological & pharmaceutical bulletin

authors： Kang TH,Oh HR,Jung SM,Ryu JH,Park MW,Park YK,Kim SY

更新日期：2006-02-01 00:00:00

abstract：:Plant phenolic compounds isolated from a 70% aqueous acetone extract of the leaves of Malus doumeri A. CHEV. var. formosana (KAWAK. & KOIDZ.) S. S. YING, a type of Taiwanese indigenous plant, were evaluated for potential application in the field of skin care. A phytochemical investigation of the active fractions resul...

journal_title：Biological & pharmaceutical bulletin

authors： Leu SJ,Lin YP,Lin RD,Wen CL,Cheng KT,Hsu FL,Lee MH

更新日期：2006-04-01 00:00:00

abstract：:We developed binary and ternary complexes based on polymers and liposomes for safe and effective delivery of small interfering RNA (siRNA). Anti-luciferase siRNA was used as a model of nucleic acid medicine. The binary complexes of siRNA were prepared with cationic polymers and cationic liposomes such as polyethylenim...

journal_title：Biological & pharmaceutical bulletin

authors： Kodama Y,Harauchi S,Kawanabe S,Ichikawa N,Nakagawa H,Muro T,Higuchi N,Nakamura T,Kitahara T,Sasaki H

更新日期：2013-01-01 00:00:00

abstract：:In a previous report, we had demonstrated the antioxidant activity of the sialic acid N-acetylneuraminic acid (Neu5Ac, NANA). This activity can counteract the cytotoxicity of hydrogen peroxide (H2O2), and the antitoxicity is a result of a direct chemical reaction, whereby NANA reduces H2O2 in the culture media. The in...

journal_title：Biological & pharmaceutical bulletin

authors： Iijima R,Takahashi H,Ikegami S,Yamazaki M

更新日期：2007-03-01 00:00:00

abstract：:Twelve species of pyridobenzazoles and pyrimidobenzimidazole were examined as inhibitors of the replication of respiratory syncytial virus (RSV) in HeLa cells. From the pyridobenzazoles studied, 2-benzamido-4-cyano-1-oxo-1H,5H-pyrido[1,2-alpha]benzimidazol emerged as a potent inhibitor of the RSV. Based on its inhibit...

journal_title：Biological & pharmaceutical bulletin

authors： Chiba T,Shigeta S,Numazaki Y

更新日期：1995-08-01 00:00:00

abstract：:Utilizing starch-containing alginate beads, a novel drug delivery system (DDS) was developed. With the starch inside, the composite bead could be dried in its original bead shape and handled in the dried state. By employing alginate multi-coating strategy on the starch-alginate beads, detained or controlled release wa...

journal_title：Biological & pharmaceutical bulletin

authors： Kim YJ,Park HG,Yang YL,Yoon Y,Kim S,Oh E

更新日期：2005-02-01 00:00:00

abstract：:This study was designed to evaluate the protective effect of kolaviron (KV), a biflavonoid from Garcinia kola seeds, against gamma-radiation (5 Gy)-induced oxidative stress in brain of Wistar rats. Vitamin C (VC) served as standard antioxidant. Forty-four rats were divided into 4 groups of 11 animals each. One group w...

journal_title：Biological & pharmaceutical bulletin

authors： Adaramoye OA

更新日期：2010-01-01 00:00:00

abstract：:Bupleuri Radix (Chai-hu in Chinese and Saiko in Japanese) is one of the most important traditional Chinese crude drugs for treating hepatitis malaria and intermittent fever. B. kaoi is one of the Bupleurum spp. families locally found in Taiwan. The effects of saponin-enriched fraction (SEF) from Bupleurum Kaoi in huma...

journal_title：Biological & pharmaceutical bulletin

authors： Hsu YL,Kuo PL,Weng TC,Yen MH,Chiang LC,Lin CC

更新日期：2004-07-01 00:00:00

abstract：:Permeation enhancement of ketoprofen (KP) from supersaturated systems and the effects of antinucleant polymers on both stability and permeation of supersaturated KP were investigated using silicone membrane as a skin model. The supersaturation was prepared by the cosolvent technique with water and propylene glycol (PG...

journal_title：Biological & pharmaceutical bulletin

authors： Kumprakob U,Kawakami J,Adachi I

更新日期：2005-09-01 00:00:00

abstract：:Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by disabling fatigue of at least 6 months, in addition to symptoms such as muscle pain and muscle weakness. There is no treatment provides long-term benefits to most patients. Recently, clinical research suggested the involvement of pyruvate ...

journal_title：Biological & pharmaceutical bulletin

authors： Ohba T,Domoto S,Tanaka M,Nakamura S,Shimazawa M,Hara H

更新日期：2019-01-01 00:00:00

abstract：:Depression and related mood disorders are among the world's greatest public health problems. Previous studies have demonstrated that astilbin (AST) has broad pharmacological functions which may modulate numerous pathways, such as antioxidant, scavenging free radicals, anti-inflammatory and so on, similarly to some of ...

journal_title：Biological & pharmaceutical bulletin

authors： Lv QQ,Wu WJ,Guo XL,Liu RL,Yang YP,Zhou DS,Zhang JX,Liu JY

更新日期：2014-01-01 00:00:00

abstract：:Zinc (Zn) is an essential heavy metal utilized in numerous biological processes in mammals, including its recently described role as a signaling mediator. The movement of Zn in and out of cells, across membranes, is regulated by two protein families: the zinc-regulated transporter (ZRT), iron-regulated transporter (IR...

journal_title：Biological & pharmaceutical bulletin

authors： Takatani-Nakase T

更新日期：2018-01-01 00:00:00

abstract：:In brain ischemia, cell destructive necrosis occurs in the core, which in turn links to cell death expansion in the vicinity. Apoptosis, on the other hand, occurs in the surroundings of the core, called the penumbra, several days later. As cells showing apoptosis disappear by microglial phagocytosis in the brain, cell...

journal_title：Biological & pharmaceutical bulletin

authors： Ueda H,Fujita R

更新日期：2004-07-01 00:00:00

abstract：:Human pluripotent stem cells (hPSCs), i.e. human embryonic stem cells and human induced pluripotent stem cells, are able to self-renew and differentiate into multiple cell types. Because of these abilities, numerous attempts have been made to utilize hPSCs in regenerative medicine/cell therapy. hPSCs are, however, als...

journal_title：Biological & pharmaceutical bulletin

authors： Kuroda T,Yasuda S,Sato Y

更新日期：2013-01-01 00:00:00

abstract：:The overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) switches the function of NO from a physiological neuromodulator to a neurotoxic effector in central nervous system (CNS) after brain injury. From the methanol extracts of Psoralea corylifolia, we purified two inhibitors of NO production ...

journal_title：Biological & pharmaceutical bulletin

authors： Lee MH,Kim JY,Ryu JH

更新日期：2005-12-01 00:00:00