Zinc Transporters and the Progression of Breast Cancers.

abstract：:Small extracellular vesicles (sEVs), including exosomes as typical example, are cell-derived vesicles comprising lipid bilayer with a diameter approximately 100 nm. sEVs are endogenous delivery vehicles that deliver their contents such as nucleic acids and proteins to recipient cells. Because of their potential nature...

journal_title：Biological & pharmaceutical bulletin

authors： Takakura Y,Matsumoto A,Takahashi Y

更新日期：2020-01-01 00:00:00

abstract：:We have studied lysosomal proteases capable of degrading a major form of cytochrome P450 (CYP2B1) which was purified from the liver microsomes of phenobarbital-treated rats. After incubation of CYP2B1 with extracts of triton-filled lysosomes (tritosomes), its proteolysis was measured by a quantitative immunoblot proce...

journal_title：Biological & pharmaceutical bulletin

authors： Tsuji H,Akasaki K

更新日期：1994-05-01 00:00:00

abstract：:Manganese (Mn) plays an important role in the etiology of several neurobehavioral disorders, but there is a lack of data regarding its specific effects on neurotransduction, especially dopaminergic neurotransduction. We investigated the relationship between motor deficits and alterations in the expression of tyrosine ...

journal_title：Biological & pharmaceutical bulletin

authors： Nam J,Kim K

更新日期：2008-10-01 00:00:00

abstract：:Plasmodium falciparum thymidylate kinase (PfTMK) is a potential chemotherapeutic target as it can tolerate a range of substrates, which distinguishes it from other thymidylate kinases. An important step in drug development is to determine the interaction of ligands competing for their target sites in a proposed drug t...

journal_title：Biological & pharmaceutical bulletin

authors： Kandeel M,Kitade Y

更新日期：2011-01-01 00:00:00

abstract：:Chloroplast trnK gene sequences of Cnidium officinale and Ligusticum chuanxiong were determined to establish an effective method for identifying Japanese Senkyu and Chinese Chuanxiong, the two which have the same drug name in Chinese characters, similar external feature, but different botanical origins. Three sites of...

journal_title：Biological & pharmaceutical bulletin

authors： Zhu S,Fushimi H,Han G,Tsuchida T,Uno T,Takano A,Komatsu K

更新日期：2007-03-01 00:00:00

abstract：:In order to treat a hyperammonemic patient with adult-onset type-II citrullinemia (CTLN2), sodium phenylacetate powder was prepared from chemical reagent grade phenylacetic acid in Gunma University Hospital. After purification by recrystalization, phenylacetic acid was neutralized with sodium carbonate and dried at 70...

journal_title：Biological & pharmaceutical bulletin

authors： Honda S,Yamamoto K,Sekizuka M,Oshima Y,Nagai K,Hashimoto G,Kaneko H,Tomomasa T,Konno Y,Horiuchi R

更新日期：2002-09-01 00:00:00

abstract：:Fragility fractures associated with age-related bone loss are of urgent concern worldwide because they reduce QOL and pose financial burdens for health care services. Currently, national data in Japan are limited. This study provides quantitative data for older patients throughout Japan who, although otherwise relativ...

journal_title：Biological & pharmaceutical bulletin

authors： Iihara N,Ohara E,Bando Y,Yoshida T,Ohara M,Kirino Y

更新日期：2019-01-01 00:00:00

abstract：:The effect of extracellular calcium on the intracellular calcium level of newborn rat skin basal cells was examined. The intracellular calcium level of basal cells was affected by the extracellular calcium concentration on culture of the cells on a collagen-coated filter, but not on a plate. The intracellular calcium ...

journal_title：Biological & pharmaceutical bulletin

authors： Ohkura K,Hori H,Terada H

更新日期：1998-01-01 00:00:00

abstract：:Japanese allergic subjects are commonly sensitized to both house dust mite (HDM) and Japanese cedar pollen (JCP) and combined treatment with sublingual immunotherapy (SLIT) tablets is desirable. However, mixing extracts of two non-homologous allergens may compromise allergen stability and affect the clinical outcome. ...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe A,Yamamoto T,Matsuhara H,Matsui H,Nakazawa H,Lund K,Ohashi-Doi K

更新日期：2020-10-01 00:00:00

abstract：:We studied the effects of twelve 5,7-dihydroxyflavone analogs on adipogenesis in 3T3-L1 cells. Among the compounds, luteolin, diosmetin, and chrysoeriol partly inhibited adipogenesis by blocking the accumulation of triacylglycerol in the cells. Conversely, tricetin facilitated triacylglycerol accumulation in the cells...

journal_title：Biological & pharmaceutical bulletin

authors： Nishina A,Ukiya M,Fukatsu M,Koketsu M,Ninomiya M,Sato D,Yamamoto J,Kobayashi-Hattori K,Okubo T,Tokuoka H,Kimura H

更新日期：2015-01-01 00:00:00

abstract：:This study investigated the effects of compounds isolated from 70% ethanol (EtOH) extraction of Smilax china L. (SCE), a plant belonging to the family Smilacaceae on nicotine-induced endothelial dysfunction (ED) in human umbilical vein endothelial cells. We isolated 10 compounds from ethyl acetate (EtOAc) fraction of ...

journal_title：Biological & pharmaceutical bulletin

authors： Lincha VR,Zhao BT,Woo MH,Yang IJ,Shin HM

更新日期：2016-01-01 00:00:00

abstract：:The prostacyclin I1 (PGI1) analogue, SM-10906 and its methyl ester, SM-10902, have been compared with the PGI2 analogue, iloprost, with respect to binding to the PGI2 receptor, stimulation of adenylate cyclase activity and inhibition of thrombin-induced Ca2+ mobilization in mastocytoma P-815 cells. SM-10906 displaced ...

journal_title：Biological & pharmaceutical bulletin

authors： Oka M,Negishi M,Yamamoto T,Satoh K,Hirohashi T,Ichikawa A

更新日期：1994-01-01 00:00:00

abstract：:Monocytes/macrophages are known to be involved in atherogenesis, and the adherence of monocytes to the endothelium is considered an earliest characteristic of atherogenesis. Therefore, we studied the mechanism by which Shosaikoto, a Kampo medicine, shows anti-atherosclerotic action, which has been already shown in hyp...

journal_title：Biological & pharmaceutical bulletin

authors： Shen YR,Inoue M,Ogihara Y

更新日期：1996-01-01 00:00:00

abstract：:We showed previously that transdifferentiation of skin epidermis to mucous epithelium can be induced by treatment with 20 µM retinol for 1 d followed by culture for 4 d without retinol in chick embryonic tarsometatarsal skin. In mouse epidermal cells, 3 µM retinoic acid (an active metabolite of retinol) inhibits epide...

journal_title：Biological & pharmaceutical bulletin

authors： Obinata A,Akimoto Y

更新日期：2011-01-01 00:00:00

abstract：:A lipid fraction obtained by activity-guided fractionation from the hexane extract of Sideritis javalambrensis was evaluated for anti-inflammatory activity. This fraction significantly inhibited paw oedema induced by carrageenan as well as ear oedema induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) in mice after ...

journal_title：Biological & pharmaceutical bulletin

authors： Godo A,de Heras BL,Vivas JM,Villar A

更新日期：2000-10-01 00:00:00

abstract：:The hepatoprotecive effects of recombinant human epidermal growth factor (hEGF) on chemically and immunologically induced experimental liver injury models were examined. The hEGF clearly decreased serum transaminase levels in D-galactosamine (D-GalN) and D-GalN/lipopolysaccharide (LPS)-induced liver injury models unde...

journal_title：Biological & pharmaceutical bulletin

authors： Cho JY,Yeon JD,Kim JY,Yoo ES,Yu YH,Park MH

更新日期：2000-10-01 00:00:00

abstract：:A close relationship between rat liver regeneration and the concentration ratio of spermidine to spermine (spd:spm) was demonstrated by the oral administration of trans-4-methylcyclohexylamine (MCHA), a specific inhibitor of putrescine aminopropyltransferase. A decrease in recovery rate of remnant liver with MCHA, as ...

journal_title：Biological & pharmaceutical bulletin

authors： Kobayashi M,Takao K,Shiota Y,Sugita Y,Takahashi M,Nakae D,Samejima K

更新日期：2006-05-01 00:00:00

abstract：:Carboxamide-methylated light chain (G1L) from human serum IgG inhibited the secretion of tumor necrosis factor (TNF-alpha), one of the inflammatory cytokines, from adherent splenocytes and thioglycolate-induced peritoneal macrophages. The inhibition of TNF-alpha secretion by G1L was associated with disappearance of ty...

journal_title：Biological & pharmaceutical bulletin

authors： Mimura T,Takeuchi K,Hiramatsu K,Tsujikawa K,Kohama Y,Itoh S

更新日期：1995-10-01 00:00:00

abstract：:Recent reports have shown that dimethyl fumarate (DMF) prevents brain damage induced by intracerebral hemorrhage and this beneficial effect is mediated by the nuclear erythroid 2 p45-related factor-2-antioxidant response element (Nrf2-ARE) pathway. However, the downstream mechanism underlying the activation of the Nrf...

journal_title：Biological & pharmaceutical bulletin

authors： Kume T,Suenaga A,Izumi Y,Akaike A

更新日期：2016-01-01 00:00:00

abstract：:Rapamycin (Rap) has been demonstrated to affect lipid metabolism through stimulating lipolysis, inhibiting de novo lipogenesis and reducing adiposity. In the present study, we investigated rapamycin exposure's influence on adipose tissue browning in high-fat diet-induced fatty mice. Four-week old C57BL/6J mice were fe...

journal_title：Biological & pharmaceutical bulletin

authors： Wang Y,He Z,Li X

更新日期：2017-01-01 00:00:00

abstract：:Melatonin has been suggested to play important roles in lipid metabolism as well as circadian rhythm; however, very few studies explored the effects of ramelteon, a selective melatonin receptor agonist, on serum lipid profiles. In this study effects of ramelteon on serum lipid profiles were explored, comparing to thos...

journal_title：Biological & pharmaceutical bulletin

authors： Torii H,Shimizu R,Tanizaki Y,Omiya Y,Yamamoto M,Kamiike S,Yasuda D,Hiraoka Y,Hashida T,Kume N

更新日期：2018-01-01 00:00:00

abstract：:A study of the biliary bile acid composition in porcine fetus compared with that of the adult pig is described. Biles, collected during gestation (weeks 4, 15 to 17 and at birth), aged six months and two years old, were analyzed by gas-liquid chromatography and capillary GC-MS. Bile acids were separated into different...

journal_title：Biological & pharmaceutical bulletin

authors： Kuramoto T,Miyamoto J,Konishi M,Hoshita T,Masul T,Une M

更新日期：2000-10-01 00:00:00

abstract：:Transient receptor potential vanilloid 1 (TRPV1) is primarily expressed in central and peripheral terminals of non-myelinated primary afferent neurons. We previously showed that AS1928370, a novel TRPV1 antagonist that can prevent ligand-induced activation but not proton-induced activation, ameliorates neuropathic pai...

journal_title：Biological & pharmaceutical bulletin

authors： Watabiki T,Kiso T,Tsukamoto M,Aoki T,Matsuoka N

更新日期：2011-01-01 00:00:00

abstract：:Mouse brain microsomes contain an amidase that catalyzes the hydrolysis of N-arachidonylethanolamide to arachidonic acid and ethanolamine. The enzymatic activity is dependent on the protein concentration of the microsomes and observed over a wide range of pH, 7.4 to 9.5. Kinetic analysis indicated that K(m) (microM) a...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe K,Kayano Y,Matsunaga T,Yamamoto I,Yoshimura H

更新日期：1996-08-01 00:00:00

abstract：:Fusion peptide P-9 was isolated from bovine serum albumin by controlled pepsin degradation in the presence of caprylic acid, followed by Sephadex G-75 gel filtration and ion-exchange chromatography of CM-cellulose. By this procedure, P-9 could be strictly separated from peptic fragment P-Phe, which has a molecular wei...

journal_title：Biological & pharmaceutical bulletin

authors： Sato Y,Kaneko K,Mikami K,Mizugaki M,Suzuki Y

更新日期：1999-12-01 00:00:00

abstract：:The aim of the present study is to discover multidrug resistance-associated protein (MRP) inhibitors with neuroblastoma-selective cytotoxicity by means of fluorescence assay with a membrane-permeable fluorescent dye, Fluo-8 AM, based on our observation that gene expression of Mrp3 in neuroblastoma Neuro2a cells was re...

journal_title：Biological & pharmaceutical bulletin

authors： Nakamichi N,Ishimoto T,Yamauchi Y,Masuo Y,Kato Y

更新日期：2016-01-01 00:00:00

abstract：:Chinese medicinal prescriptions were screened for their effects on alpha-amylase activity in mouse plasma. Daio-kanzo-to, Hange-koboku-to, Saiko-ka-ryukotsu-borei-to, Saiko-keishi-kankyo-to and Mao-to changed the activity in isolated mouse plasma greatly and concentration dependently. However, no prescription influenc...

journal_title：Biological & pharmaceutical bulletin

authors： Kobayashi K,Funayama N,Suzuki R,Yoshizaki F

更新日期：2002-08-01 00:00:00

abstract：:Essential elements (Ca, Mg, Zn, Cu, Fe, Cr, Mn and V) and non-essential elements (As, Cd, Hg and Pb) were measured in scalp hair samples of 45 diabetic subjects and 59 control subjects in Japan using inductively coupled plasma mass spectrometry. All diabetic subjects took insulin and/or antidiabetic agents, with glyca...

journal_title：Biological & pharmaceutical bulletin

authors： Hotta Y,Fujino R,Kimura O,Endo T

更新日期：2018-01-01 00:00:00

abstract：:RS-7897 is a novel antianginal nitrate containing an L-2-oxothiazolidine-4-carboxylic acid (OTCA) and unlike other organic nitrates does not induce nitrate tolerance. OTCA is known to be converted to L-cysteine (L-Cys) by rat 5-oxo-prolinase (5-OPase) and was detected in the plasma of RS-7897-treated dogs. Nitrate tol...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe T,Abe K,Ishikawa H,Iijima Y

更新日期：2004-03-01 00:00:00

abstract：:To clarify the release properties of anti-cancer drugs from fibrin glue, a study was performed using several anti-cancer drugs with remarkably different physical properties. Concentrated fibrinogen, fibronectin, and coagulation factor XIII were prepared from healthy human plasma according to the cryoprecipitate method...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshida H,Yamaoka Y,Shinoyama M,Kamiya A

更新日期：2000-03-01 00:00:00