The Role of dihydropyrazines in accelerated death of Escherichia coli on addition of copper(II).

abstract：:The prostacyclin I1 (PGI1) analogue, SM-10906 and its methyl ester, SM-10902, have been compared with the PGI2 analogue, iloprost, with respect to binding to the PGI2 receptor, stimulation of adenylate cyclase activity and inhibition of thrombin-induced Ca2+ mobilization in mastocytoma P-815 cells. SM-10906 displaced ...

journal_title：Biological & pharmaceutical bulletin

authors： Oka M,Negishi M,Yamamoto T,Satoh K,Hirohashi T,Ichikawa A

更新日期：1994-01-01 00:00:00

abstract：:The effects of the angiotensin II type 1 receptor antagonist YM358 on blood pressure were compared to those of the angiotensin converting enzyme inhibitor enalapril in one-kidney, one-clip renal hypertensive rats (1K1C RHR), two-kidney, one-clip renal hypertensive rats (2K1C RHR) and normotensive rats (NTR). Additiona...

journal_title：Biological & pharmaceutical bulletin

authors： Tokioka T,Shibasaki M,Fujimori A,Matsuda-Satoh Y,Uchida W,Inagaki O,Yanagisawa I

更新日期：2000-02-01 00:00:00

abstract：:Angiogenesis, the process of new vessel formation from the pre-existing blood vasculature, is critical for continuous tumor growth and is considered to be a validated antitumor target. The results of our previous study demonstrate the anti-angiogenic potential of an extract of Gleditsia sinensis thorns, which has been...

journal_title：Biological & pharmaceutical bulletin

authors： Lee J,Yi JM,Kim H,Lee YJ,Park JS,Bang OS,Kim NS

更新日期：2014-01-01 00:00:00

abstract：:Novel methods for molecular authentication of Atractylodes-derived crude drugs (Jutsu) were established based on PCR-restriction fragment length polymorphism (RFLP) and direct sequencing of chloroplast trnK. Two regions inside the chloroplast trnK were selected as molecular markers for identification and discriminatio...

journal_title：Biological & pharmaceutical bulletin

authors： Mizukami H,Okabe Y,Kohda H,Hiraoka N

更新日期：2000-05-01 00:00:00

abstract：:The discovery that angiogenesis is a key condition for the growth of a tumor beyond a millimeter or two, brings about a new approach in the treatment of tumors using drugs able to inhibit the formation of new blood vessels. Also, it has been realized that antiangiogenic drugs can be useful in the treatment of other pa...

journal_title：Biological & pharmaceutical bulletin

authors： González RP,Leyva A,Moraes MO

更新日期：2001-10-01 00:00:00

abstract：:The anti-inflammatory effects of 1,6-anhydro-3,4-dideoxy-2-furfuryl-beta-D-threo-3-enopyranose (MT2221) were investigated using animal models and compared with the effects of dexamethasone (DEX) and cyclosporin A (CYA). MT2221 inhibited carrageenan-induced acute inflammation and adjuvant arthritis in rats, as well as ...

journal_title：Biological & pharmaceutical bulletin

authors： Mizukoshi S,Tsukamoto M,Tanaka H,Nakamura K,Kato F

更新日期：1994-08-01 00:00:00

abstract：:We demonstrate that glycyrrhizin (GL) enhanced Fas-mediated apoptotic body formation and DNA fragmentation in T cell lines although GL alone did not induce apoptosis. The enhancement effect of Fas-mediated apoptosis by GL was dose-dependent above 0.3 microM. Time course study revealed that simultaneous co-treatment of...

journal_title：Biological & pharmaceutical bulletin

authors： Ishiwata S,Nakashita K,Ozawa Y,Niizeki M,Nozaki S,Tomioka Y,Mizugaki M

更新日期：1999-11-01 00:00:00

abstract：:In the present investigation the chemopreventive action of Panax ginseng extract, EFLA400, in Swiss albino mice has been evaluated. We used a 9-week medium term anticarcinogenicity test model of lung adenomas [Yun et al.1)]. Lung adenomas were induced by single subcutaneous injection in the subscapular region with 0.0...

journal_title：Biological & pharmaceutical bulletin

authors： Panwar M,Samarth R,Kumar M,Yoon WJ,Kumar A

更新日期：2005-11-01 00:00:00

abstract：:The mature form of rat adrenodoxin (Ad) was purified from a heterologous direct expression system in Escherichia coli with a yield of 56 mg/l culture. The purified Ad showed a A414/A280 ratio of 0.91 and the sequence of 10 amino terminal residues was identical with that of authentic rat Ad. By Time of Flight/Mass spec...

journal_title：Biological & pharmaceutical bulletin

authors： Sagara Y,Aramaki H

更新日期：1998-10-01 00:00:00

abstract：:To develop a piroxicam-loaded gelatin microcapsule with enhanced bioavailability, a gelatin microcapsule encapsulated ethanol and piroxicam has been formulated by using gelatin as a water-soluble polymer shell. The aqueous solubility and bioavailability of piroxicam in piroxicam-loaded microcapsule in rats were then e...

journal_title：Biological & pharmaceutical bulletin

authors： Piao MG,Yang CW,Li DX,Kim JO,Jang KY,Yoo BK,Kim JA,Woo JS,Lyoo WS,Han SS,Lee YB,Kim DD,Yong CS,Choi HG

更新日期：2008-06-01 00:00:00

abstract：:The physiological correlation between casein kinase I (CK-I) and an isoform eta of protein kinase C (C-kinase eta) was investigated in vitro, since it has been reported that (i) cholesterol-3-sulfate (CH-3S) effectively activates C-kinase eta rather than the other isoforms (C-kinase epsilon and C-kinase delta) in vitr...

journal_title：Biological & pharmaceutical bulletin

authors： Okano M,Yokoyama T,Miyanaga T,Ohtsuki K

更新日期：2004-01-01 00:00:00

abstract：:Tubeimoside I (TBMS I), an extract from Chinese herbal medicine Bolbostemma paniculatum (MAXIM.) FRANQUET (Cucurbitaceae) has been shown as a potent anti-tumor agent for a variety of human cancers, but yet to be evaluated for hepatoma that is highly prevalent in Eastern Asian countries including China. Here, we examin...

journal_title：Biological & pharmaceutical bulletin

authors： Wang Y,Deng L,Zhong H,Wang Y,Jiang X,Chen J

更新日期：2011-01-01 00:00:00

abstract：:This study investigated both morphologically and biochemically whether parsley (Petroselinum crispum), which is used as a folk remedy to decrease blood glucose, has any antidiabetic effect on pancreatic B cells of rats. Parsley extract was given to male diabetic rats. In the diabetic group given parsley extract, it wa...

journal_title：Biological & pharmaceutical bulletin

authors： Yanardağ R,Bolkent S,Tabakoğlu-Oğuz A,Ozsoy-Saçan O

更新日期：2003-08-01 00:00:00

abstract：:Povidone-iodine (PVP-I), an antibacterial medicine, was infiltrated in sepiolite (SPL). The available iodine content in this new pharmaceutical product, a sepiolite preparation containing povidone-iodine (PVP-I-SPL), was retained at 98.9 and 98.3% during storage at 40 degrees C for 3 and 6 months, respectively. The ef...

journal_title：Biological & pharmaceutical bulletin

authors： Ohta S,Nagai K,Maruyama M,Inoue H,Katsuyama Y,Atobe O,Ogata H,Yamato S,Tachikawa E,Zenda H

更新日期：1999-01-01 00:00:00

abstract：:Homoeriodictyol-7-O-beta-D-glucopyranoside (HEDT-Glu) was isolated from Viscum coloratum and identified by MS, 1H- and 13C-NMR. A HPLC method was developed for determination of HEDT-Glu in rat plasma and tissues. All biological samples were pretreated by protein precipitation with acetone. Vanillin was selected as int...

journal_title：Biological & pharmaceutical bulletin

authors： Zhao Y,Wang X,Zhao Y,Gao X,Bi K,Yu Z

更新日期：2007-04-01 00:00:00

abstract：:Virus entry, assembly, and budding are important processes in the replication cycle of a virus. Viruses are dependent on host living cells for their replication. Viruses use the proliferative mechanism of host cells for replication of viral components. Lipid rafts, specific membrane microdomains play a critical role i...

journal_title：Biological & pharmaceutical bulletin

authors： Suzuki T,Suzuki Y

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:To investigate the clinical effects and security of YiSuiShengXueGranule (YSSXG) on treating 156 patients with beta-thalassemia major. METHODS:YSSXG was given orally to 156 patients with beta-thalassemia in GuangXi Autonomous Region (the high incidence area of beta-thalassemia in China) for 3 months as one t...

journal_title：Biological & pharmaceutical bulletin

authors： Fang S,Wu Z,Zhang X,Liu Y,Wang W,Chai L,Cai H,Yi J,Wang L,Chen Y,Lv X,Huang Y,Wang R,Chen P

更新日期：2007-11-01 00:00:00

abstract：:Vesicular glutamate transporter (VGLUT) is responsible for the active transport of L-glutamate into synaptic vesicles and, thus, plays an essential role in the glutamatergic chemical transmission in the central and peripheral nervous systems. Recent studies indicated that VGLUT is also expressed and localized in vario...

journal_title：Biological & pharmaceutical bulletin

authors： Moriyama Y,Omote H

更新日期：2008-10-01 00:00:00

abstract：:We previously prepared 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) solutions containing disulfiram (DSF) and hydroxypropylmethylcellulose (HPMC, DSF solutions), and found the instillation of this DSF solutions delayed lens opacification in ICR/f rats, a recessive-type hereditary cataractous strain. In this study, we ...

journal_title：Biological & pharmaceutical bulletin

authors： Nagai N,Inomata M,Ito Y

更新日期：2008-07-01 00:00:00

abstract：:The effects of different combinations of ciprofloxacin (CIP) and norfloxacin (NOR) against Escherichia coli and Staphylococcus aureus were studied using checkerboard, fractional inhibitory concentration (FIC) and time-kill analysis methods. Results obtained by the checkerboard method showed that the more effectives co...

journal_title：Biological & pharmaceutical bulletin

authors： Vitorino GP,Becerra MC,Barrera GD,Caira MR,Mazzieri MR

更新日期：2017-01-01 00:00:00

abstract：:The anti-rhinitis properties of Pleurotus pulmonarius were investigated in BALB/c mice. A single administration of Pleurotus Pulmonarius caused no significant effect on antigen-induced nasal rubbing and sneezing at a dose of 500 mg/kg, but a significant inhibition was observed after 2 weeks of repeated treatment at th...

journal_title：Biological & pharmaceutical bulletin

authors： Yatsuzuka R,Nakano Y,Jiang S,Ueda Y,Kishi Y,Suzuki Y,Yokota E,Rahman A,Ono R,Kohno I,Kamei C

更新日期：2007-08-01 00:00:00

abstract：:Lipid droplets (LDs) are intracellular storage sites of neutral lipids, which accumulate in fatty liver disease. Here, we investigated the effects of fatty acids and glucose on LD formation in a cultured human hepatocyte, HuH7, by adding them to culture media. Fatty acids with carbohydrate chains C12-C18 efficiently i...

journal_title：Biological & pharmaceutical bulletin

authors： Fujimoto Y,Onoduka J,Homma KJ,Yamaguchi S,Mori M,Higashi Y,Makita M,Kinoshita T,Noda J,Itabe H,Takanoa T

更新日期：2006-11-01 00:00:00

abstract：:To search for possible anti-tumor-promoters, we carried out a primary screening of 21 cucurbitane triterpenoids using an in vitro assay system. Of these triterpenoids, scandenoside R6 (6), 23,24-dihydrocucurbitacin F (14), 25-acetyl-23,24-dihydrocucurbitacin F (15), 2-O-beta-D-glucopyranosyl-23,24-dihydrocucurbitacin ...

journal_title：Biological & pharmaceutical bulletin

authors： Konoshima T,Takasaki M,Tatsumoto T,Kozuka M,Kasai R,Tanaka O,Nie RL,Tokuda H,Nishino H,Iwashima A

更新日期：1994-05-01 00:00:00

abstract：:The gas phase of cigarette smoke is important from the viewpoint of human health, because it can pass through alveolar epithelium and enter the circulation. There is no standard method for the preparation of a gas phase extract of cigarette smoke (CSE), although CSE is widely used for research instead of whole cigaret...

journal_title：Biological & pharmaceutical bulletin

authors： Higashi T,Mai Y,Mazaki Y,Horinouchi T,Miwa S

更新日期：2016-01-01 00:00:00

abstract：:The tissue distribution and disposition of carnitine, which plays an important role in the transport of long-chain fatty acids across the mitochondrial inner membrane for beta-oxidation, are well controlled by carnitine transporter organic cation/carnitine transporter 2 (OCTN2). Since little information is available o...

journal_title：Biological & pharmaceutical bulletin

authors： Maeda T,Wakasawa T,Funabashi M,Fukushi A,Fujita M,Motojima K,Tamai I

更新日期：2008-06-01 00:00:00

abstract：:The effects of two saline cathartics (sodium chloride and sodium citrate) on the adsorptive capacity of activated charcoal (AC) for rifampicin were studied. Solutions of rifampicin alone and rifampicin with 7.5 mg/ml cathartic solution were vortex-mixed for 30 s with different quantities of AC. These were incubated fo...

journal_title：Biological & pharmaceutical bulletin

authors： Orisakwe OE,Afonne OJ,Agbasi PU,Ilondu NA,Ofoefule SI,Obi E

更新日期：2001-06-01 00:00:00

abstract：:Two fractions of neutral alpha-glucosidase were partially purified from the insoluble fraction of bovine lens. This is the first report of such an event to the best of our knowledge. The apparent native molecular weights of these fractions were 121 kDa (fraction-I) and 254 kDa (fraction-II). Both fractions contained t...

journal_title：Biological & pharmaceutical bulletin

authors： Kamei A,Fujiyama O

更新日期：1995-08-01 00:00:00

abstract：:Candida albicans is the most important human fungal pathogen. Amphotericin (AmB) is a gold standard of antifungal treatment for fungi, but the severe side effect of this drug restricts its clinical application. In this study, the interaction of AmB and baicalein (BE) was investigated against thirty clinical isolates o...

journal_title：Biological & pharmaceutical bulletin

authors： Fu Z,Lu H,Zhu Z,Yan L,Jiang Y,Cao Y

更新日期：2011-01-01 00:00:00

abstract：:Among the eight inbred mouse strains employed in our preceding report, 12-O-tetradecanoylphorbol 13-acetate (TPA) painting alone induced CD4+ regulatory T (Tr) cells in four strains (e.g., C3H/He) at 6-8 weeks of age, but not in the remaining strains (e.g., C57BL/6, BALB/c). In the present study, the effect of growth ...

journal_title：Biological & pharmaceutical bulletin

authors： Negoro T,Satoh K,Iinuma F,Tobe T,Watanabe M

更新日期：2002-02-01 00:00:00

abstract：:There exist limitations in the detection of exogenous oligosaccharides due to their polydisperse and diversiform nature, and particularly the interference of endogenous glycosaminoglycans (GAGs). Herein, a surface plasmon resonance (SPR) assay for detecting acidic oligosaccharide sugar chain (AOSC), an anti-Alzheimer'...

journal_title：Biological & pharmaceutical bulletin

authors： Guo X,Xin X,Gan L,Nie Q,Geng M

更新日期：2006-01-01 00:00:00