Overproduction in Escherichia coli and characterization of the precise mature form of rat adrenodoxin.

abstract：:Curcumin is a natural polyphenolic compound abundant in the rhizome of the perennial herb turmeric, Curcuma longa. It is commonly used as a dietary spice and coloring agent in cooking, and is used anecdotally as an herb in traditional Indian and Chinese medicine. It has been reported that curcumin has the potential to...

journal_title：Biological & pharmaceutical bulletin

authors： Mito S,Watanabe K,Harima M,Thandavarayan RA,Veeraveedu PT,Sukumaran V,Suzuki K,Kodama M,Aizawa Y

更新日期：2011-01-01 00:00:00

abstract：:P-Glycoprotein (ABCB1-type P-gp), a membrane protein encoded by the multi drug resistant gene (MDR1), expressing on the blood brain barrier protects the brain from many drugs including dexamethasone. Psychiatric disorders, schizophrenia and depression, have known to have abnormal hypothalamus-pituitary-adrenal (HPA) a...

journal_title：Biological & pharmaceutical bulletin

authors： Qian W,Homma M,Itagaki F,Tachikawa H,Kawanishi Y,Mizukami K,Asada T,Inomata S,Honda K,Ohkohchi N,Kohda Y

更新日期：2006-12-01 00:00:00

abstract：:Nicotiflorin is a single component extracted from traditional Chinese medicine Flos Carthami. In this study, we investigated its neuroprotection in permanent focal cerebral ischemia model in rats, and in an in vitro model of ischemia. At doses of 2.5, 5 and 10 mg/kg, nicotiflorin administered immediately after the ons...

journal_title：Biological & pharmaceutical bulletin

authors： Li R,Guo M,Zhang G,Xu X,Li Q

更新日期：2006-09-01 00:00:00

abstract：:The purpose of this study was to elucidate the transport mechanism(s) of L-glutamate (L-Glu), a neuroexcitatory neurotransmitter, in the inner blood-retinal barrier (BRB). The L-Glu transport was evaluated by an in vitro uptake study with a conditionally-immortalized rat retinal capillary endothelial cell line, TR-iBR...

journal_title：Biological & pharmaceutical bulletin

authors： Sakurai T,Akanuma S,Usui T,Kubo Y,Tachikawa M,Hosoya K

更新日期：2015-01-01 00:00:00

abstract：:Daiokanzoto (DKT), a Kampo medicine that includes the combination of two crude drugs (rhubarb and glycyrrhiza), is clinically effective for constipation. The aim of this study is to clarify the influence of glycyrrhiza, three glycyrrhiza constituents (glycyrrhizin, liquiritin, and liquiritin apioside), and eight antib...

journal_title：Biological & pharmaceutical bulletin

authors： Matsui E,Takayama K,Sato E,Okamura N

更新日期：2011-01-01 00:00:00

abstract：:The forced swimming test (FST) is suggested to produce abnormalities in the serotonergic and hypothalamic-pituitary-adrenal (HPA) axis systems. Therefore, compounds that attenuate these neurobiological alterations may have potential as antidepressants. The behavioral and biochemical effects of psoralen, a major furoco...

journal_title：Biological & pharmaceutical bulletin

authors： Xu Q,Pan Y,Yi LT,Li YC,Mo SF,Jiang FX,Qiao CF,Xu HX,Lu XB,Kong LD,Kung HF

更新日期：2008-06-01 00:00:00

abstract：:The effect of the Dynorphin A analog, E2078, on the physicochemical properties of lipid membranes was investigated. E2078 induces the leakage of calcein, especially out of negatively-charged vesicles. The peptide binds to dipalmitoylphosphatidylglycerol sonicated vesicles according to the Lamgmuir isotherm, with a bin...

journal_title：Biological & pharmaceutical bulletin

authors： Asai Y,Watanabe S

更新日期：1999-05-01 00:00:00

abstract：:Microglia activation-mediated neuroinflammation plays an important role in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and human immunodeficiency virus (HIV)-associated dementia. Inhibition of microglia activation may alleviate neurodegeneration ...

journal_title：Biological & pharmaceutical bulletin

authors： Zhou X,Gan P,Hao L,Tao L,Jia J,Gao B,Liu JY,Zheng LT,Zhen X

更新日期：2014-01-01 00:00:00

abstract：:In order to clarify the arrhythmogenic effects of nonsedating antihistamines, we examined the effects of astemizole, a nonsedating antihistamine, on ventricular activation and RT intervals in a canine myocardial infarction model. Myocardial infarction was produced by two-stage ligation of the left anterior descending ...

journal_title：Biological & pharmaceutical bulletin

authors： Nishimoto M,Hashimoto H,Ohmura T,Ikeda Y,Watanabe S,Ohashi K,Umemura K,Nakashima M

更新日期：1997-09-01 00:00:00

abstract：:The hypoglycemic and hypolipidemic effect of docosahexaenoic acid (DHA; C22: 6omega-3) ethyl ester was examined in KK-Ay mice and neonatal streptozotocin-induced diabetic (NSZ) which are respectively obese and lean animal models of non-insulin-dependent diabetes mellitus (NIDDM), and in ddY normal mice. Single adminis...

journal_title：Biological & pharmaceutical bulletin

authors： Shimura T,Miura T,Usami M,Ishihara E,Tanigawa K,Ishida H,Seino Y

更新日期：1997-05-01 00:00:00

abstract：:A rat model of early sepsis induced by lipopolysaccharide (LPS) combined with interleukin-2 (IL-2) was developed. The primary aim was to assess the pharmacokinetics of gentamicin and sepsis-induced pathophysiological changes. Moreover, the effects on the glomerular filtration rate and tubular function were studied in ...

journal_title：Biological & pharmaceutical bulletin

authors： Studena S,Martinkova J,Slizova D,Krs O,Senkerik M,Springer D,Chládek J

更新日期：2012-01-01 00:00:00

abstract：:We investigated the relationship between noradrenaline (NAd)-induced contractions, endothelial function, and hypertension in femoral arteries isolated from spontaneously hypertensive rats (SHR). In the femoral arteries of SHR, vs. age-matched control Wistar Kyoto (WKY) rats, contractions induced by NAd were increased....

journal_title：Biological & pharmaceutical bulletin

authors： Matsumoto T,Watanabe S,Iguchi M,Ando M,Oda M,Nagata M,Yamada K,Taguchi K,Kobayashi T

更新日期：2016-01-01 00:00:00

abstract：:It is known that the onset of major depressive disorder (MDD) would be associated with genetic factors. To investigate the susceptibility to psychiatric disorders, e.g. MDD, schizophrenia etc., it is necessary to compare the genetic differences of objective polymorphisms between in patients and in relative contol subj...

journal_title：Biological & pharmaceutical bulletin

authors： Inoue K,Ando N,Suzuki E,Hayashi H,Tsuji D,Itoh K

更新日期：2012-01-01 00:00:00

abstract：:To explore the role of the abnormal expression of the bile salt export pump (BSEP) and multidrug resistance protein 2 (MRP2) in isoniazid (INH)-induced liver injury, we assessed the liver injury induced by INH in rats and HepG2 cells in vitro. The regulatory pathways via Sirtuin 1 (SIRT1) and farnesoid X receptor (FXR...

journal_title：Biological & pharmaceutical bulletin

authors： Qu X,Zhang Y,Zhang S,Zhai J,Gao H,Tao L,Song Y

更新日期：2018-01-01 00:00:00

abstract：:Follistatin (FS, an activin-binding protein) and activin A (homodimer of inhibin betaA chain) promote and inhibit cell proliferation in rat liver, respectively. The roles of activin AB (heterodimer of inhibin betaA and betaB) and activin B (homodimer of inhibin betaB) in rat liver have not been elucidated yet. In this...

journal_title：Biological & pharmaceutical bulletin

authors： Kobayashi T,Niimi S,Hashimoto O,Hayakawa T

更新日期：2000-06-01 00:00:00

abstract：:The aim of this study was to evaluate the effect of olmesartan (OLME), an angiotensin II receptor antagonist, on an intestinal mucositis model. Briefly, daily intraperitoneal (i.p.) injections of methotrexate (MTX) 7 mg/kg were administered to rats on 3 consecutive days. A subset of these rats was also pretreated with...

journal_title：Biological & pharmaceutical bulletin

authors： de Araújo AA,Borba PB,de Souza FH,Nogueira AC,Saldanha TS,Araújo TE,da Silva AI,de Araújo Júnior RF

更新日期：2015-01-01 00:00:00

abstract：:Salt-sensitive hypertension induces renal injury via decreased blood flow in the renal artery (RA), and ion channel dysfunction in RA myocytes (RAMs) may be involved in the higher renal vascular resistance. We examined the effects of several voltage-gated K+ (KV) channel blockers on the resting tension in endothelium-...

journal_title：Biological & pharmaceutical bulletin

authors： Ogiwara K,Ohya S,Suzuki Y,Yamamura H,Imaizumi Y

更新日期：2017-01-01 00:00:00

abstract：:A high performance liquid chromatography (HPLC) method was developed for the first time to quantify simultaneously the six major active ingredients in Acanthopanax senticosus (Rupr. et Maxim.) Harms, namely protocatechuic acid, syringin, chlorogenic acid, caffeic acid, liriodendrin and isofraxidin. The analysis was pe...

journal_title：Biological & pharmaceutical bulletin

authors： Li Q,Jia Y,Xu L,Wang X,Shen Z,Liu Y,Bi K

更新日期：2006-03-01 00:00:00

abstract：:To clarify the release properties of anti-cancer drugs from fibrin glue, a study was performed using several anti-cancer drugs with remarkably different physical properties. Concentrated fibrinogen, fibronectin, and coagulation factor XIII were prepared from healthy human plasma according to the cryoprecipitate method...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshida H,Yamaoka Y,Shinoyama M,Kamiya A

更新日期：2000-03-01 00:00:00

abstract：:When ginsenoside R(c) was anaerobically incubated with human fecal microflora, all specimens metabolized ginsenoside R(c) to compound K and protopanaxadiol. The main metabolite was compound K. Among the bacteria isolated from human fecal microflora, most bacteria, such as Bacteroides sp., Eubacterium sp., and Bifidoba...

journal_title：Biological & pharmaceutical bulletin

authors： Bae EA,Choo MK,Park EK,Park SY,Shin HY,Kim DH

更新日期：2002-06-01 00:00:00

abstract：:Depression and related mood disorders are among the world's greatest public health problems. Previous studies have demonstrated that astilbin (AST) has broad pharmacological functions which may modulate numerous pathways, such as antioxidant, scavenging free radicals, anti-inflammatory and so on, similarly to some of ...

journal_title：Biological & pharmaceutical bulletin

authors： Lv QQ,Wu WJ,Guo XL,Liu RL,Yang YP,Zhou DS,Zhang JX,Liu JY

更新日期：2014-01-01 00:00:00

abstract：:Recent studies have shown that antibodies with low fucose content in their oligosaccharides exhibit highly potent antibody-dependent cellular cytotoxicity (ADCC). However, composites of therapeutic antibodies produced by conventional production systems using cell lines such as Chinese hamster ovary (CHO) and SP2/0 do ...

journal_title：Biological & pharmaceutical bulletin

authors： Tojo S,Okazaki A,Wakitani M,Shinkawa T,Uchida K,Suzawa T

更新日期：2009-09-01 00:00:00

abstract：:Mouse brain microsomes contain an amidase that catalyzes the hydrolysis of N-arachidonylethanolamide to arachidonic acid and ethanolamine. The enzymatic activity is dependent on the protein concentration of the microsomes and observed over a wide range of pH, 7.4 to 9.5. Kinetic analysis indicated that K(m) (microM) a...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe K,Kayano Y,Matsunaga T,Yamamoto I,Yoshimura H

更新日期：1996-08-01 00:00:00

abstract：:Previously, we reported that dibenzylbutyrolactone lignans (DBLLs) from the fruit of Forsythia koreana NAKAI (Oleaceae) has anti-inflammatory, antioxidant, and anti-asthmatic effects. In this study, to clarify the anti-inflammatory mechanisms of DBLL, we evaluated the effects of DBLLs on lipopolysaccharide-stimulated ...

journal_title：Biological & pharmaceutical bulletin

authors： Lee JY,Cho BJ,Park TW,Park BE,Kim SJ,Sim SS,Kim CJ

更新日期：2010-01-01 00:00:00

abstract：:Biotin-binding human immunoglobulin G (B-IgG) was quantitatively measured using an F(ab')2anti-human IgG-coated multi-well microplate for the first time. B-IgG was caught by F(ab')2anti-human IgG and was detected by the following detecting reagents: Peroxidase-labeled streptavidin, avidin and peroxidase-biotin, or avi...

journal_title：Biological & pharmaceutical bulletin

authors： Muratsugu M,Muramoto E,Fukui T

更新日期：2003-11-01 00:00:00

abstract：:The inhibitory effects of various sulfated compounds on the activities of sialidases purified from porcine liver and human placenta were investigated. Among the sulfated compounds tested, heparin, dextran sulfate, condroitin sulfates and sulfatide significantly inhibited the 4-methylumbelliferyl-alpha-N-acetylneuramin...

journal_title：Biological & pharmaceutical bulletin

authors： Nagaoka M,Shiraishi T,Furuhata K,Uda Y

更新日期：1998-11-01 00:00:00

abstract：:Two known diarylheptanoids, oregonin (1), (5S)-1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-one-5-O-beta-D-xylopyranosi de and hirsutanonol (2), (5S)-1,7-bis-(3,4-dihydroxyphenyl)-5-hydroxyheptane-3-one isolated from the bark of Alnus hirsuta var. sibirica, showed significant inhibitory effects on 12-O-tetradecanoylphorbol...

journal_title：Biological & pharmaceutical bulletin

authors： Lee MW,Kim JH,Jeong DW,Ahn KH,Toh SH,Surh YJ

更新日期：2000-04-01 00:00:00

abstract：:In the present study, we evaluated the effect of the novel acid pump antagonist 7-(4-fluorobenzyloxy)-2,3-dimethyl-1-{[(1S,2S)-2-methylcyclopropyl]methyl}-1H-pyrrolo[2,3-d]pyridazine (CS-526) on the intragastric acidity of cynomolgus monkeys. The study was performed in a crossover manner with five male animals. CS-526...

journal_title：Biological & pharmaceutical bulletin

authors： Ito K,Kinoshita K,Yamamura N,Tomizawa A,Inaba F,Morikawa-Inomata Y,Tabata K,Shibakawa N

更新日期：2009-12-01 00:00:00

abstract：:One hundred and fifteen synthesized mono, di, and trihydroxybenzamide and thiobenzamide derivatives having structures related to euglobals were examined for their inhibitory effects on Epstein-Barr virus (EBV) activation by 12-O-tetradecanoylphorbol-13-acetate (TPA) as a primary screening test for anti-tumor-promoters...

journal_title：Biological & pharmaceutical bulletin

authors： Takasaki M,Konoshima T,Kozuka M,Yoneyama K,Yoshida S,Tokuda H,Nishino H,Iwashima A

更新日期：1995-02-01 00:00:00

abstract：:Polygonum multiflorum is widely used in the prevention and treatment of hyperlipidemia in traditional Chinese Medicine. In this study, the effects and relevant mechanisms of lipid-regulation by raw Polygonum multiflorum (RPM) were investigated. The results indicated that the basal plasma lipids, such as low-density li...

journal_title：Biological & pharmaceutical bulletin

authors： Xian Z,Liu Y,Xu W,Duan F,Guo Z,Xiao H

更新日期：2017-01-01 00:00:00