In a methotrexate-induced model of intestinal mucositis, olmesartan reduced inflammation and induced enteropathy characterized by severe diarrhea, weight loss, and reduced sucrose activity.

abstract：:The purpose of this study was to elucidate the transport mechanism(s) of L-glutamate (L-Glu), a neuroexcitatory neurotransmitter, in the inner blood-retinal barrier (BRB). The L-Glu transport was evaluated by an in vitro uptake study with a conditionally-immortalized rat retinal capillary endothelial cell line, TR-iBR...

journal_title：Biological & pharmaceutical bulletin

authors： Sakurai T,Akanuma S,Usui T,Kubo Y,Tachikawa M,Hosoya K

更新日期：2015-01-01 00:00:00

abstract：:Many lines of evidences have shown that Panax ginseng exhibits beneficial effects on cardiovascular systems. We previously demonstrated that ginsenoside Rg(3) (Rg(3)), one of active ingredients of Panax ginseng, inhibits Ca(2+) channel currents in a stereospecific manner and affects the steady-state activation but not...

journal_title：Biological & pharmaceutical bulletin

authors： Choi SH,Lee JH,Pyo MK,Lee BH,Shin TJ,Hwang SH,Kim BR,Lee SM,Oh JW,Kim HC,Bae CS,Rhim H,Nah SY

更新日期：2009-07-01 00:00:00

abstract：:Homocysteine-inducible endoplasmic reticulum (ER) protein (Herp) is an ER stress-inducible membrane protein involved in ER-associated degradation. Herp expression is maintained at low levels through a strict regulatory mechanism, but the details of this mechanism and the reasons why Herp expression is restricted in th...

journal_title：Biological & pharmaceutical bulletin

authors： Maeda T,Fujita Y,Tanabe-Fujimura C,Zou K,Liu J,Liu S,Kikuchi K,Shen X,Nakajima T,Komano H

更新日期：2018-01-01 00:00:00

abstract：:The aim of the present study was to evaluate the effect of the aqueous extract of seeds of two varieties, namely a country and hybrid variety of Momordica charantia (MCSEt1 and MCSEt2) on oxidative stress in plasma and pancreas of streptozotocin (STZ) induced diabetic rats. Oral administration of each of the seed extr...

journal_title：Biological & pharmaceutical bulletin

authors： Sathishsekar D,Subramanian S

更新日期：2005-06-01 00:00:00

abstract：:The bioavailability of morphine after rectal administration using three types of suppositories containing morphine hydrochloride (10 mg) in different added forms was evaluated in rabbits. Three types of suppositories were constructed with a base material (Witepsol H-15): a conventional suppository containing morphine ...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumoto Y,Watanabe Y,Yamamoto I,Matsumoto M

更新日期：1993-02-01 00:00:00

abstract：:Significant selective cyclooxygenase-2 (COX-2) inhibitory activities were observed for two new 1,4-naphthoquinone sodium salts, sodium 3-hydroxide-2[[sodium 3-hydroxide-1,4-dioxo(2-naphthyl)]ethyl]naphthalene-1,4-dione (impatienolate) (1) and sodium 2-hydroxide-3-(2-hydroxyethyl)naphthalene-1,4-dione (balsaminolate) (...

journal_title：Biological & pharmaceutical bulletin

authors： Oku H,Ishiguro K

更新日期：2002-05-01 00:00:00

abstract：:The effects of exogenously applied gibberellic acid (GA(3)) or brassinolide (BL) on the H(+)-pumps and aquaporin in the vacuolar membrane of rice seedling leaf sheath were investigated. Antibodies against mung bean H(+)-PPase, the B subunit of V-ATPase, and radish tonoplast intrinsic protein (TIP) cross-reacted with t...

journal_title：Biological & pharmaceutical bulletin

authors： Yang S,Maeshima M,Tanaka Y,Komatsu S

更新日期：2003-01-01 00:00:00

abstract：:A sulfated galactan (FG) was isolated from the green alga, Codium fragile. Chemical analysis revealed that FG mainly consisted of D-galactose with pyruvic acid (12.3%) and sulfate (11.0%). Methylation and NMR analyses showed that FG was composed of -->3)-beta-D-Galp-(1-->, beta-D-Galp-(1--> and -->3,6)-beta-D-Galp-(1-...

journal_title：Biological & pharmaceutical bulletin

authors： Ohta Y,Lee JB,Hayashi K,Hayashi T

更新日期：2009-05-01 00:00:00

abstract：:The complete amino acid sequences of [2Fe-2S] ferredoxin from Atropa belladonna and Hyoscyamus niger have been determined by automated Edman degradation of the entire S-carboxymethylcysteinyl proteins and of the peptides obtained by enzymatic digestion. These two ferredoxins exhibited 1-8 differences in their amino ac...

journal_title：Biological & pharmaceutical bulletin

authors： Mino Y,Yukita M,Hiratsuka N,Wariishi H

更新日期：2005-08-01 00:00:00

abstract：:The degradation of 125I-endothelin-1 (125I-ET-1) was examined on cultured porcine aortic endothelial cell (EC) and rat vascular smooth muscle cell (SMC) by HPLC analysis. The degradation of ET-1 was observed on SMC and was slightly observed on EC. Membrane fractions of SMC had a strong potency for the degradation of E...

journal_title：Biological & pharmaceutical bulletin

authors： Edano T,Arai K,Koshi T,Torii T,Ohshima T,Hirata M,Ohkuchi M,Okabe T

更新日期：1994-03-01 00:00:00

abstract：:The convulsant interaction between enoxacin (ENX), a new quinolone antibacterial agent (NQ), and felbinac (FLB), a non-steroidal anti-inflammatory drug (NSAID), in vivo was reproduced as the change of GABA-induced current response in Xenopus oocytes injected with mouse brain mRNA. GABA (10 microM) response was inhibit...

journal_title：Biological & pharmaceutical bulletin

authors： Kawakami J,Shimokawa M,Yamamoto K,Sawada Y,Asanuma A,Yanagisawa K,Iga T

更新日期：1993-07-01 00:00:00

abstract：:Infection of human cell with human immunodeficiency virus type-1 (HIV-1) was suppressed by cellular genetic factor(s) at reverse transcription step. Although same amount of virus adsorbed on both cells, small amount of HIV-1 (IIIB strain) infected HeLa (MAGI/CCR5) cell, while large amount of HIV-1 infected HOS (GHOST/...

journal_title：Biological & pharmaceutical bulletin

authors： Tempaku A

更新日期：2005-05-01 00:00:00

abstract：:The pharmacological profiles of antigen-induced immediate airway response (IAR) in rats are not fully understood. In this study, we established an ovalbumin (OVA)-induced IAR model using noninvasive measurement in rats, and evaluated the effects of commonly used and effective antiasthmatic drugs, i.e. ketotifen (antih...

journal_title：Biological & pharmaceutical bulletin

authors： Miyagawa N,Iwasaki H,Kato T,Tanaka M,Shibata T,Wakitani K

更新日期：2008-12-01 00:00:00

abstract：:Uridine 5'-diphosphate-glucuronosyltransferase (UGT) catalyzes a major phase II reaction in a drug-metabolizing enzyme system. Although the UGT1A subfamily is expressed mainly in the liver, it is also expressed in the brain. The purpose of the present study was to elucidate the effect of β-naphthoflavone (BNF), one of...

journal_title：Biological & pharmaceutical bulletin

authors： Sakakibara Y,Katoh M,Kondo Y,Nadai M

更新日期：2016-01-01 00:00:00

abstract：:We have recently demonstrated that Bak Foong Pills (BFP), a well-known Chinese medicine widely used for treating gynecological disorders, stimulates human colonic epithelial anion secretion, which was mediated by intracellular cAMP and Ca(2+). The present study further investigated the effect of BFP on exocrine pancre...

journal_title：Biological & pharmaceutical bulletin

authors： Tang N,Zhu JX,Zhao WC,Xing Y,Gou YL,Rowlands DK,Chung YW,Chan HC

更新日期：2003-10-01 00:00:00

abstract：:Microanalytical methods were developed for measuring galactosyl-beta-cyclodextrin (Gal-betaCD) and mannosyl (Man)-betaCD in biological matrices of the rat by HPLC with pulsed amperometric detection. Then, using these methods, the absorption, distribution and excretion of intravenously and orally administered Gal-betaC...

journal_title：Biological & pharmaceutical bulletin

authors： Kubota Y,Sanbe H,Koizumi K

更新日期：2000-04-01 00:00:00

abstract：:To enhance tumor magnetic resonance imaging (MRI) signals via the selective accumulation of contrast agents, we prepared folate-modified gadolinium-lipid-based nanoparticles as MRI contrast agents. Folate-modified nanoparticles were comprised of polyethylene glycol (PEG)-lipid, gadolinium diethylenetriamine pentaaceti...

journal_title：Biological & pharmaceutical bulletin

authors： Nakamura T,Kawano K,Shiraishi K,Yokoyama M,Maitani Y

更新日期：2014-01-01 00:00:00

abstract：:In a previous study, we reported that one of the gel-forming (1-->3)-beta-D-glucans, grifolan (from Grifola frondosa, GRN), stimulated cytokine production from macrophages in vitro. However, several other gel-forming (1-->3)-beta-D-glucans, such as sonifilan (SPG) and SSG, did not induce cytokine production from macro...

journal_title：Biological & pharmaceutical bulletin

authors： Okazaki M,Adachi Y,Ohno N,Yadomae T

更新日期：1995-10-01 00:00:00

abstract：:Immediate early genes (IEG) are rapidly but transiently induced directly by intracellular signaling cascades to alter patterns of gene expression. It has been proposed that histone modifications could be the key to the quick alteration of chromatin structure, as this spread occurs too rapidly to be the consequence of ...

journal_title：Biological & pharmaceutical bulletin

authors： Sng JC,Taniura H,Yoneda Y

更新日期：2004-05-01 00:00:00

abstract：:The present study examined the anti-obesity effects of pine needle extract (PNE) in 3T3-L1 preadipocytes and in vivo studies. PNE treatment suppressed both glycerol-3-phosphate dehydrogenase activity and expression of peroxisome proliferator-activated receptor (PPAR) gamma in cultured 3T3-L1 adipocytes. To investigate...

journal_title：Biological & pharmaceutical bulletin

authors： Jeon JR,Kim JY

更新日期：2006-10-01 00:00:00

abstract：:The role of leukotriene B4 (LTB4) in leukocyte infiltration in zymosan-induced rat pleurisy was investigated by studying the effects of 5-lipoxygenase inhibitors, T-0757 and AA-861, and a cyclooxygenase inhibitor, indomethacin, on leukocyte infiltration and LTB4 levels in the inflammatory exudate of rat pleurisy induc...

journal_title：Biological & pharmaceutical bulletin

authors： Kikuchi M,Tsuzurahara K,Naito K

更新日期：1995-09-01 00:00:00

abstract：:D-Aspartate (D-Asp), a free D-amino acid found in mammals, plays crucial roles in the neuroendocrine, endocrine, and central nervous systems. Recent studies have implicated D-Asp in the pathophysiology of infertility and N-methyl-D-Asp receptor-related diseases. D-Asp oxidase (DDO), a degradative enzyme that is stereo...

journal_title：Biological & pharmaceutical bulletin

authors： Katane M,Kawata T,Nakayama K,Saitoh Y,Kaneko Y,Matsuda S,Saitoh Y,Miyamoto T,Sekine M,Homma H

更新日期：2015-01-01 00:00:00

abstract：:Site-directed mutagenesis was used to investigate the molecular interactions involved in sarpogrelate binding to the human 5-Hydroxytryptamine(5-HT)2C receptor. Based on molecular modeling studies, Aspartic acid (Asp)155[3.32] in transmembrane region III and Serine(Ser)361[7.46] in transmembrane region VII of the 5-HT...

journal_title：Biological & pharmaceutical bulletin

authors： Muntasir HA,Takahashi J,Rashid M,Ahmed M,Komiyama T,Hossain M,Kawakami J,Nashimoto M,Nagatomo T

更新日期：2006-08-01 00:00:00

abstract：:Sesamin is a major lignan in sesame seeds, and a recent meta-analysis of controlled trials indicated that sesamin intake decreases blood pressure. The antihypertensive effect of sesamin has been suggested to be due to sesamin-mediated suppression of 20-hydroxyeicosatetraenoic acid production catalyzed by CYP4F2. Howev...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe H,Yamaori S,Kamijo S,Aikawa K,Ohmori S

更新日期：2020-01-01 00:00:00

abstract：:Baculovirus vectors (BVs) enable safe and efficient gene delivery to mammalian cells and are useful in a wide range of applications, including gene therapy and in vivo analysis of gene functions. We previously developed BVs expressing malaria sporozoite surface proteins for targeting liver cells or hepatocytes. Howeve...

journal_title：Biological & pharmaceutical bulletin

authors： Kawai Y,Kawabata C,Sakaguchi M,Tamura T

更新日期：2018-01-01 00:00:00

abstract：:PhiC31 integrase has the potential to achieve long-term transgene expression because of site-specific and unidirectional recombination. In this study, plasmid DNA (pDNA) encoding Gaussia luciferase (Gluc) cDNA was constructed and the optimal condition for long-term gene expression using phiC31 integrase in mouse liver...

journal_title：Biological & pharmaceutical bulletin

authors： Umemoto Y,Kawakami S,Otani Y,Higuchi Y,Yamashita F,Hashida M

更新日期：2012-01-01 00:00:00

abstract：:The possibility of pharmacokinetic interactions between Sho-saiko-to extract powder (TJ-9), the most widely used traditional Chinese herbal (Kampo) medicine in Japan, and carbamazepine (CBZ), an important anti-epileptic drug, was examined in rats. There was no significant difference in the protein binding of CBZ in se...

journal_title：Biological & pharmaceutical bulletin

authors： Ohnishi N,Okada K,Yoshioka M,Kuroda K,Nagasawa K,Takara K,Yokoyama T

更新日期：2002-11-01 00:00:00

abstract：:The local disposition of a drug, which is efficiently eliminated by the liver in spite of very high binding with serum albumin, was investigated using BOF-4272 as a model drug in the hepatic perfusion system. Bovine serum albumin (BSA) labeled with Evans Blue was used as the marker of hepatic blood space. The perfusio...

journal_title：Biological & pharmaceutical bulletin

authors： Nishimura M,Yamaoka K,Naito S,Nakagawa T

更新日期：1996-09-01 00:00:00

abstract：:ICR/f mutation in rat, an inherited disorder, is characterized by the development of cataracts. In this study, we analyzed and compared the crystallins in normal and cataractous rat lenses using gel filtration and two-dimensional gel electrophoresis, and determined the transglutaminase activities and Ca2+ content in t...

journal_title：Biological & pharmaceutical bulletin

authors： Takeuchi N,Kamei A

更新日期：2000-03-01 00:00:00

abstract：:The binding and internalization of fractionated [3H]heparin (FH) was kinetically analyzed in rat liver parenchymal cells to clarify its cellular uptake mechanism. The binding of FH to the cell surface was saturable with the dissociation constant (Kd) of 53.5 nM and a maximum binding capacity (Bmax) of 19.9 pmol/mg pro...

journal_title：Biological & pharmaceutical bulletin

authors： Urano K,Haba M,Yuasa H,Watanabe J

更新日期：1997-06-01 00:00:00