Involvement of leukotriene B4 in zymosan-induced rat pleurisy: inhibition of leukocyte infiltration by the 5-lipoxygenase inhibitor T-0757.

abstract：:Hepatoprotective activity guided chemical analyses led to the isolation of two dicaffeoyl quinic acid derivatives, methyl 3,4-di-O-caffeoyl quinate (1) and 3,4-di-O-caffeoyl quinic acid (2) from water extract of propolis, and their structures were determined by the use of 2D NMR. These compounds were stronger antihepa...

journal_title：Biological & pharmaceutical bulletin

authors： Basnet P,Matsushige K,Hase K,Kadota S,Namba T

更新日期：1996-04-01 00:00:00

abstract：:To elucidate insecticidal activity of spider toxins, metal ions in venoms and in the bodies were determined by thin layer chromatography, spark source mass spectrometry, ion chromatography, inductively coupled plasma emission spectrometry and atomic absorption spectrometry. Two kinds of spiders were used, Nephila clav...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshioka M,Narai N,Shinkai A,Tokuda T,Saito K,Shioya M,Tokoro N,Kono Y

更新日期：1994-04-01 00:00:00

abstract：:We examined the transport mechanisms of daunorubicin (DNR) and doxorubicin (ADR) in HL60 and HL60/THP cells which were the non-P-glycoprotein-mediated resistant clone of the parent HL60 cells and showed a low degree of resistance, and compared them with those of pirarubicin (THP). In both lines, it appeared that the u...

journal_title：Biological & pharmaceutical bulletin

authors： Nagasawa K,Natazuka T,Nomiyama M,Ohnishi N,Yokoyama T

更新日期：1996-01-01 00:00:00

abstract：:Lymphocyte homing is mediated by a specific interaction between the lymphocyte homing receptor L-selectin and its sulfated glycoprotein ligands, which are expressed on high endothelial venules (HEV) in the lymph nodes. To examine the significance of the sulfation of L-selectin ligands, our group has generated gene-tar...

journal_title：Biological & pharmaceutical bulletin

authors： Kawashima H

更新日期：2006-12-01 00:00:00

abstract：:Liquid intraurethral prostaglandin E1 (PGE1) delivery system was developed using self-microemulsifying drug delivery system (SMEDDS). For this, pseudo-ternary phase diagrams were constructed and characterized. The viscosity of optimized formulation was increased gradually upon the addition of water and it was decrease...

journal_title：Biological & pharmaceutical bulletin

authors： Lee S,Lee J,Choi YW

更新日期：2008-04-01 00:00:00

abstract：:RNA interference (RNAi) is a technology that specifically inhibits gene expression and is carried out by small 21-27-nucleotide double-stranded small interfering RNA (siRNA) or short hairpin RNA (shRNA). RNAi has become a very promising technology for genetic research, however problems remain with the delivery of siRN...

journal_title：Biological & pharmaceutical bulletin

authors： Kawaguchi Y,Danjo K,Okuda T,Okamoto H

更新日期：2009-02-01 00:00:00

abstract：:Cephradine-containing ethylcellulose microparticles (MPC) were prepared by the solvent evaporation method. Chitosan-coated MPC (Chi-MPC) were prepared by doping MPC with viscous chitosan solution and subsequently drying. When fluorescein isothiocyanate (FITC)-labeled chitosan-coated ethylcellulose microparticles witho...

journal_title：Biological & pharmaceutical bulletin

authors： Takishima J,Onishi H,Machida Y

更新日期：2002-11-01 00:00:00

abstract：:This study investigated the effects of compounds isolated from 70% ethanol (EtOH) extraction of Smilax china L. (SCE), a plant belonging to the family Smilacaceae on nicotine-induced endothelial dysfunction (ED) in human umbilical vein endothelial cells. We isolated 10 compounds from ethyl acetate (EtOAc) fraction of ...

journal_title：Biological & pharmaceutical bulletin

authors： Lincha VR,Zhao BT,Woo MH,Yang IJ,Shin HM

更新日期：2016-01-01 00:00:00

abstract：:Glucocorticoids have multiple systemic effects that may influence bone metabolism but also directly affect osteoblasts by decreasing their proliferation. Using human osteoblastic SaM-1 cells, we examined whether the effects of hydrocortisone on cellular proliferation are mediated by hepatocyte growth factor (HGF). Hum...

journal_title：Biological & pharmaceutical bulletin

authors： Tsunashima Y,Kondo A,Matsuda T,Togari A

更新日期：2011-01-01 00:00:00

abstract：:To analyze the renal handling of therapeutic compounds observed as a non-linear process with a diffusion phenomenon, we employed a non-linear dispersion model described with a partial differential equation and solved it by using the finite difference method with an implicit scheme in a model dependent analysis. In thi...

journal_title：Biological & pharmaceutical bulletin

authors： Aiba T,Kubota S,Koizumi T

更新日期：1999-06-01 00:00:00

abstract：:Daikenchuto (DKT) has been widely used for the treatment of postsurgical ileus in Japan. However, its effect on postsurgical adhesion formation has been obscure. In this study, the effect of DKT on postsurgical adhesion formation induced by cecum cauterization or cecum abrasion in mice was investigated. First, the exp...

journal_title：Biological & pharmaceutical bulletin

authors： Wu S,Uyama N,Itou RA,Hatano E,Tsutsui H,Fujimoto J

更新日期：2019-01-01 00:00:00

abstract：:The effects of grifolan (GRN), a gel-forming (1-->6)-branched (1-->3)-beta-D-glucan, on antibody production were examined. Sera from mice that were injected with GRN and trinitrophenyl ovalbumin (TNP-OVA) intraperitoneally showed a significantly increased level of anti-TNP IgG. However, injection of TNP-OVA alone show...

journal_title：Biological & pharmaceutical bulletin

authors： Adachi Y,Suzuki Y,Ohno N,Yadomae T

更新日期：1998-09-01 00:00:00

abstract：:The effect of extracellular calcium on the intracellular calcium level of newborn rat skin basal cells was examined. The intracellular calcium level of basal cells was affected by the extracellular calcium concentration on culture of the cells on a collagen-coated filter, but not on a plate. The intracellular calcium ...

journal_title：Biological & pharmaceutical bulletin

authors： Ohkura K,Hori H,Terada H

更新日期：1998-01-01 00:00:00

abstract：:Tropolone (1). showed strong insecticidal activity on Tyrophagus putrescentiae and Dermatophagoides farinae. The insecticidal effect of 1 on both insects was stronger than that of hinokitiol (2, 4-isopropyltropolone: major component of Thujopsis dolabrata SIEB. et ZUCC. hondai MAKINO). The insecticidal activity of bot...

journal_title：Biological & pharmaceutical bulletin

authors： Morita Y,Matsumura E,Okabe T,Shibata M,Sugiura M,Ohe T,Tsujibo H,Ishida N,Inamori Y

更新日期：2003-10-01 00:00:00

abstract：:Consuming food at uncommon times during the day might be associated with obesity in experimental animals and humans. We previously reported that mice become obese and their metabolism becomes disrupted when they consume food during the daytime (sleep phase feeding; SPF), but not during the nighttime (active phase feed...

journal_title：Biological & pharmaceutical bulletin

authors： Oishi K,Okauchi H

更新日期：2019-01-01 00:00:00

abstract：:Purslane (Portulaca oleracea L.) is popular as a potherb in many areas of Europe, Asia, and the Mediterranean region and is widely distributed around the globe. It has a wide range of pharmacological effects, such as antibacterial, anti-aging, anti-inflammatory, and anti-oxidative properties. Although the extract of p...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JY,Oh HM,Kwak SC,Cheon YH,Lee MS,Rho MC,Oh J

更新日期：2015-01-01 00:00:00

abstract：:The effect of the hypothyroidism induced by thiamazole on toxic interactions between propranolol and disopyramide were studied in chick embryos. Fertilized eggs of White Leghorns were incubated and investigated. 1.2 mg/0.2 ml/egg of thiamazole was injected into the albumen of fertilized eggs on the 9th day of incubati...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshiyama Y,Kanke M

更新日期：2005-10-01 00:00:00

abstract：:The effect of gel-forming (1-->3)-beta-D-glucan on the immunological activities of murine kupffer cells was examined. A branched type gel-forming (1-->3)-beta-D-glucan, GRN, was administered intravenously to mice. GRN associating to kupffer cells was detected by an immunohistochemical technique using anti-GRN antibody...

journal_title：Biological & pharmaceutical bulletin

authors： Adachi Y,Ohno N,Yadomae T

更新日期：1998-03-01 00:00:00

abstract：:Behavioral and psychological symptoms of dementia (BPSD) are commonly seen in patients with Alzheimer's disease (AD) and other forms of senile dementia. BPSD have a serious impact on the quality of life of dementia patients, as well as on that of their caregivers. However, effective drug therapy for BPSD has not been ...

journal_title：Biological & pharmaceutical bulletin

authors： Uchida N,Egashira N,Iwasaki K,Ishibashi A,Tashiro R,Nogami A,Manome N,Abe M,Takasaki K,Mishima K,Takata J,Oishi R,Nishimura R,Fujiwara M

更新日期：2009-03-01 00:00:00

abstract：:Lipid droplets (LDs) are intracellular storage sites of neutral lipids, which accumulate in fatty liver disease. Here, we investigated the effects of fatty acids and glucose on LD formation in a cultured human hepatocyte, HuH7, by adding them to culture media. Fatty acids with carbohydrate chains C12-C18 efficiently i...

journal_title：Biological & pharmaceutical bulletin

authors： Fujimoto Y,Onoduka J,Homma KJ,Yamaguchi S,Mori M,Higashi Y,Makita M,Kinoshita T,Noda J,Itabe H,Takanoa T

更新日期：2006-11-01 00:00:00

abstract：:Novel methods for molecular authentication of Atractylodes-derived crude drugs (Jutsu) were established based on PCR-restriction fragment length polymorphism (RFLP) and direct sequencing of chloroplast trnK. Two regions inside the chloroplast trnK were selected as molecular markers for identification and discriminatio...

journal_title：Biological & pharmaceutical bulletin

authors： Mizukami H,Okabe Y,Kohda H,Hiraoka N

更新日期：2000-05-01 00:00:00

abstract：:Curcumin, a bioactive component in tumeric, has been shown to exert antioxidant, anti-inflammatory, anticarcinogenic, hepatoprotective, and neuroprotective effects, but the effects of curcumin against manganese (Mn)-mediated neurotoxicity have not been studied. This study examined the protective effects of curcumin on...

journal_title：Biological & pharmaceutical bulletin

authors： Park E,Chun HS

更新日期：2017-08-01 00:00:00

abstract：:Epoxyeicosatrienoic acids (EETs) are produced primarily by CYPs from arachidonic acid (AA) and then further metabolized to the corresponding dihydroxyeicosatrienoic acids (DHETs). EETs play important roles in physiological processes such as regulating vasodilation and inflammation. Thus, the drug inhibition of CYP-med...

journal_title：Biological & pharmaceutical bulletin

authors： Mukai Y,Toda T,Takeuchi S,Senda A,Yamashita M,Eliasson E,Rane A,Inotsume N

更新日期：2015-01-01 00:00:00

abstract：:Hepatoprotective effect of celosian, an acidic polysaccharide isolated from the water extract of the seed of Celosia argentea, was investigated using chemical and immunological liver injury models. Celosian inhibited the elevation of serum enzyme (GPT, GOT, LDH) and bilirubin levels on carbon tetrachloride (CC1(4))-in...

journal_title：Biological & pharmaceutical bulletin

authors： Hase K,Kadota S,Basnet P,Takahashi T,Namba T

更新日期：1996-04-01 00:00:00

abstract：:Over-expression of P-glycoprotein (P-gp) in lymphocytes is implicated in the failure of immunosuppressant therapy. We investigated P-gp function in peripheral-blood CD3+, CD4+, and CD8+ cells of 14 healthy subjects and 12 patients with systemic lupus erythematosus (SLE). P-gp function was estimated by the transporter ...

journal_title：Biological & pharmaceutical bulletin

authors： Henmi K,Yoshida M,Yoshikawa N,Hirano T

更新日期：2008-05-01 00:00:00

abstract：:As an attempt to identify bioactive natural products with anti-inflammatory activity, we evaluated the effects of the methanol extract of the semen of Xanthium strumarium L. (MEXS) on lipopolysaccharide (LPS)-induced nitric oxide (NO), prostaglandin E2 (PGE2) and tumor necrosis factor-alpha (TNF-alpha) production in R...

journal_title：Biological & pharmaceutical bulletin

authors： Kim IT,Park YM,Won JH,Jung HJ,Park HJ,Choi JW,Lee KT

更新日期：2005-01-01 00:00:00

abstract：:Daiokanzoto (DKT) and lubiprostone (LPS) are drugs used for constipation, but few studies have compared them. This study examined the effectiveness, adverse events, and medical economic efficiency of DKT and LPS for constipation. Patients who received DKT (DKT group) and those who received LPS (LPS group) during admis...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshida A,Hirose T,Kuroda A,Mitsuoka M,Shinoda Y,Mori K,Kawachi Y,Tanaka K,Takeda A,Sugiyama T,Yoshimura T

更新日期：2019-01-01 00:00:00

abstract：:Oxidative stress is recognized as an important mediator of brain disorders. Nevertheless, there are few antioxidants approved for brain diseases. There are two types of mechanisms as antioxidant systems in vivo, antioxidants and antioxidant enzymes. Antioxidants are consumed by the reaction with reactive oxygen specie...

journal_title：Biological & pharmaceutical bulletin

authors： Kume T

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:To investigate the clinical effects and security of YiSuiShengXueGranule (YSSXG) on treating 156 patients with beta-thalassemia major. METHODS:YSSXG was given orally to 156 patients with beta-thalassemia in GuangXi Autonomous Region (the high incidence area of beta-thalassemia in China) for 3 months as one t...

journal_title：Biological & pharmaceutical bulletin

authors： Fang S,Wu Z,Zhang X,Liu Y,Wang W,Chai L,Cai H,Yi J,Wang L,Chen Y,Lv X,Huang Y,Wang R,Chen P

更新日期：2007-11-01 00:00:00

abstract：:Aconitine administered intraperitoneally (i.p.) produces bradycardia mainly by a central muscarinic action. The involvement of hypothalamic regions in the occurrence of aconitine-induced bradycardia was investigated in hypothalamus-lesioned mice. The lesions were made by passing a direct current (1.5 mA, 13 s) through...

journal_title：Biological & pharmaceutical bulletin

authors： Kimura I,Takada M,Nojima H

更新日期：1997-08-01 00:00:00