Hydrocortisone inhibits cellular proliferation by downregulating hepatocyte growth factor synthesis in human osteoblasts.

abstract：:Using the par to rep region of the 24653 bp plasmid pN315, which is present in Staphylococcus aureus strain N315, we constructed three vectors that can be shuttled between Escherichia coli and S. aureus and maintained stably in S. aureus. Due to plasmid incompatibility, the resident plasmid in S. aureus cells can be r...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuo M,Kurokawa K,Lee BL,Sekimizu K

更新日期：2010-01-01 00:00:00

abstract：:The absorption and distribution of ulinastatin following intra-articular administration of [125I]ulinastatin to rabbits were determined and kinetic analysis using a multi-compartment model was performed. At 4 h after administration, the content of radioactivity in the synovial fluid, which was comparable to that of th...

journal_title：Biological & pharmaceutical bulletin

authors： Ohzawa N,Takahashi Y,Ogihara T,Nakai Y,Ishiguro J

更新日期：1997-07-01 00:00:00

abstract：:Berberine is an isoquinoline plant alkaloid with a long history of being used for the treatment of many diseases in Chinese herbal medicine. Berberine has a wide range of biochemical and pharmacological effects, including antitumor activities, but its mechanism of action is not clearly understood. In this study, we in...

journal_title：Biological & pharmaceutical bulletin

authors： Eom KS,Hong JM,Youn MJ,So HS,Park R,Kim JM,Kim TY

更新日期：2008-04-01 00:00:00

abstract：:The major physiologic effect of thyroid hormone is thought to be initiated by the binding of T3 to the DNA binding thyroid hormone receptor (TR). The aim of this study has been to characterize the organ specific expression of thyroid hormone receptor mRNA, as well as its protein distribution and molecular weight in ma...

journal_title：Biological & pharmaceutical bulletin

authors： Shahrara S,Drvota V,Sylvén C

更新日期：1999-10-01 00:00:00

abstract：:The present study investigated whether Astragalus polysaccharide (APS) possessed immunotherapeutic effects on type 1 diabetes mellitus. Diabetic mice induced by multiple low dose streptozotocin (MLD-STZ) were administered either APS (100, 200, 400 mg/kg body weight) or saline intraperitoneally daily, and sacrificed af...

journal_title：Biological & pharmaceutical bulletin

authors： Li RJ,Qiu SD,Chen HX,Tian H,Wang HX

更新日期：2007-03-01 00:00:00

abstract：:The success of arsenic trioxide (ATO) in treatment of acute promyelocytic leukemia (APL) attracts a great deal of attention to researchers to explore its activity of anti-leukemia. However, ATO has unavailable effect on chronic myeloid leukemia (CML), especially multidrug resistant (MDR)-CML, unless using high concent...

journal_title：Biological & pharmaceutical bulletin

authors： Wang X,Zhang X,Xu Z,Wang Z,Yue X,Li H

更新日期：2013-01-01 00:00:00

abstract：:We investigated the effects of restraint and footshock stress and norepinephrine treatment on gastric emptying. The gastric emptying was significantly inhibited by restraint stress. beta(3)-adrenergic antagonist canceled the inhibition of gastric emptying caused by restraint stress, while beta(1)-, beta(2)-, alpha(1)-...

journal_title：Biological & pharmaceutical bulletin

authors： Tsukada F,Nagura Y,Abe S,Sato N,Ohkubo Y

更新日期：2003-03-01 00:00:00

abstract：:The cardiac toxicity of amitriptyline and the effect of the light schedule on it were studied in chick embryos. Fertilized eggs of White Leghorns were incubated under dark conditions and investigated, on two occasions, in the light phase and in the dark phase. Amitriptyline was injected into the air sac of fertilized ...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshiyama Y,Sugiyama T,Kanke M

更新日期：2004-02-01 00:00:00

abstract：:Darexaban maleate is a novel oral direct factor Xa inhibitor. Darexaban glucuronide (YM-222714) was the major component in plasma after oral administration of darexaban to humans and is the pharmacologically active metabolite. Additionally, YM-222714 N-oxides were detected as minor metabolites in human plasma and urin...

journal_title：Biological & pharmaceutical bulletin

authors： Shiraga T,Yajima K,Teragaki T,Suzuki K,Hashimoto T,Iwatsubo T,Miyashita A,Usui T

更新日期：2012-01-01 00:00:00

abstract：:The effect of permeation enhancers on the percutaneous absorption of pentazocine (PTZ) was investigated in excised hairless mice using Franz diffusion cells in vitro. The enhancing effect on the percutaneous absorption of PTZ from the isopropyl myristate (IPM) solution system was improved with glyceryl monocaprylate (...

journal_title：Biological & pharmaceutical bulletin

authors： Furuishi T,Oda S,Saito H,Fukami T,Suzuki T,Tomono K

更新日期：2007-07-01 00:00:00

abstract：:Although macrophage phagocytoses modified low-density lipoprotein (LDL), excessive accumulation of modified LDL induces macrophage foam cell formation, which is a feature of atherosclerotic plaque. Thus, the identification of scavenger receptor for modified LDL will provide better understanding of an atherosclerotic e...

journal_title：Biological & pharmaceutical bulletin

authors： Miki Y,Tachibana Y,Ohminato Y,Fujiwara Y

更新日期：2015-01-01 00:00:00

abstract：:The current Japanese Ministry of Health Labour and Welfare (MHLW)'s Guideline for Bioequivalence Studies of Generic Products uses averaged dissolution rates for the assessment of dissolution similarity between test and reference formulations. This study clarifies how the application of model-independent multivariate c...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshida H,Shibata H,Izutsu KI,Goda Y

更新日期：2017-01-01 00:00:00

abstract：:Early diagnosis of Niemann-Pick diseases (NPDs) is important for better prognosis of such diseases. N-Palmitoyl-O-phosphocholine-serine (PPCS) is a new NPD biomarker possessing high sensitivity, and with its combination with sphingosylphosphocholine (SPC) it may be possible to distinguish NPD-C from NPD-A/B. In this s...

journal_title：Biological & pharmaceutical bulletin

authors： Iwahori A,Maekawa M,Narita A,Kato A,Sato T,Ogura J,Sato Y,Kikuchi M,Noguchi A,Higaki K,Okuyama T,Takahashi T,Eto Y,Mano N

更新日期：2020-09-01 00:00:00

abstract：:To clarify the release properties of anti-cancer drugs from fibrin glue, a study was performed using several anti-cancer drugs with remarkably different physical properties. Concentrated fibrinogen, fibronectin, and coagulation factor XIII were prepared from healthy human plasma according to the cryoprecipitate method...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshida H,Yamaoka Y,Shinoyama M,Kamiya A

更新日期：2000-03-01 00:00:00

abstract：:The relation between degranulation and rapid metabolic responses (acidification rate changes) in RBL-2H3 cells was studied using a cytosensor microphysiometer, a silicon-based biosensor system. The metabolic responses in RBL-2H3 cells by antigen stimulation were compared with those by inhibitors of Ca2+ -ATPase. The f...

journal_title：Biological & pharmaceutical bulletin

authors： Furuno T,Ohyama N,Nakanishi M

更新日期：1999-03-01 00:00:00

abstract：:Seven flavonoids of Stachys chrysantha and Stachys candida have been isolated. The structures of the compounds were elucidated by spectroscopic methods, particularly highfield NMR spectroscopy. The effects of the methanol extracts of these two endemic Greek Stachys sp. and their main flavonoids were examined on arachi...

journal_title：Biological & pharmaceutical bulletin

authors： Skaltsa H,Bermejo P,Lazari D,Silvan AM,Skaltsounis AL,Sanz A,Abad MJ

更新日期：2000-01-01 00:00:00

abstract：:A calcium-induced alginate gel bead (Alg-CS) containing chitosan (CS) and 2-(4-chlorophenoxy)-2-methylpropionic acid (CMP) was prepared. We then investigated (a) CMP release from Alg-CS, and (b) uptake of bile acid into the Alg-CS, within the gastrointestinal tract. Dried Alg-CS gradually swelled in taurocholate solut...

journal_title：Biological & pharmaceutical bulletin

authors： Murata Y,Hirai D,Kofuji K,Miyamoto E,Kawashima S

更新日期：2004-03-01 00:00:00

abstract：:Penicillin binding proteins (PBPs) are penicillin-sensitive DD-peptidases catalyzing the terminal stages of bacterial cell wall assembly. We identified a Dictyostelium discoideum gene that encodes a protein of 522 amino acids showing similarity to Escherichia coli PBP4. The D. discoideum protein conserves three consen...

journal_title：Biological & pharmaceutical bulletin

authors： Yasukawa H,Kuroita T,Tamura K,Yamaguchi K

更新日期：2003-07-01 00:00:00

abstract：:The aim of this work is to investigate the therapeutic efficacy of VP-343 ((N-[4-[[(2S,3aR)-2-hydroxy-2,3,3a,4-tetrahydropyrrolo[1,2-a]qunoxalin-5(1H)-yl]phenyl]-4'-methyl[1,1'-biphenyl]-2-carboxamide), a selective vasopressin V2 receptor antagonist, using the experimental SIADH (syndrome of inappropriate secretion of...

journal_title：Biological & pharmaceutical bulletin

authors： Naito A,Hasegawa H,Kurasawa T,Ohtake Y,Matsukawa H,Ezure Y,Tsuriya Y,Koike K,Shigenobu K

更新日期：2000-11-01 00:00:00

abstract：:The dopamine reuptake inhibitor bupropion and dopamine D2/3 receptor agonist pramipexole have been clinically proven to improve both depression and treatment-resistant depression. We examined its influence on the duration of immobility during the forced swim test in adrenocorticotropic hormone (ACTH)-treated rats and ...

journal_title：Biological & pharmaceutical bulletin

authors： Onoue Y,Kuwatsuka K,Miyazaki I,Asanuma M,Kitamura Y,Sendo T

更新日期：2014-01-01 00:00:00

abstract：:A rat model of early sepsis induced by lipopolysaccharide (LPS) combined with interleukin-2 (IL-2) was developed. The primary aim was to assess the pharmacokinetics of gentamicin and sepsis-induced pathophysiological changes. Moreover, the effects on the glomerular filtration rate and tubular function were studied in ...

journal_title：Biological & pharmaceutical bulletin

authors： Studena S,Martinkova J,Slizova D,Krs O,Senkerik M,Springer D,Chládek J

更新日期：2012-01-01 00:00:00

abstract：:UDP-N-acetylglucosaminyl transferase (OGT) resides in both cytosolic and nuclear compartments and catalyzes O-linked glycosylation of various proteins. In the current study, we have extracted protein from nuclear DNA (chromatin protein) using 0.2% NP-40 detergent. Addition of chromatin protein to either cytosolic or n...

journal_title：Biological & pharmaceutical bulletin

authors： Okuyama R,Marshall S

更新日期：2004-08-01 00:00:00

abstract：:The skeletal renin–angiotensin system (RAS) is involved in the progression of osteoporosis and the active peptide within the RAS, angiotensin II (ANG II), has deleterious effects on bones. This study was performed to investigate whether suppression of the rate-limiting step of the RAS cascade by the renin inhibitor al...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang FY,Yang FJ,Yang JL,Wang L,Zhang Y

更新日期：2014-01-01 00:00:00

abstract：:The number of alkalotolerant intestinal bacteria was 1% of the total flora in humans and 0.8% of those in rats. The beta-glucosidase and beta-glucuronidase activity of these intestinal bacteria was induced by elevating the pH of the medium, but the growth was not changed. The enzyme activity in a medium of pH 7 was 5-...

journal_title：Biological & pharmaceutical bulletin

authors： Kim DH,Kang HJ,Park SH,Kobashi K

更新日期：1994-03-01 00:00:00

abstract：:The performance of milk fat-globule membrane (MFGM) emulsion as an oral dosage form was evaluated in rats using [14C]alpha-linolenic acid as a lipophilic model solute. For emulsions prepared by homogenization alone, the area under the plasma concentration versus time curve (AUC) after oral administration tended to be ...

journal_title：Biological & pharmaceutical bulletin

authors： Yuasa H,Sekiya M,Ozeki S,Watanabe J

更新日期：1994-05-01 00:00:00

abstract：:The antitumor activity of fucoidan from Fucus vesiculosus was investigated in human colon carcinoma cells. The crude fucoidan, a polysaccharide composed predominantly of sulfated fucose, markedly inhibited the growth of HCT-15 cells (human colon carcinoma cells). After HCT-15 cells were treated with fucoidan, several ...

journal_title：Biological & pharmaceutical bulletin

authors： Hyun JH,Kim SC,Kang JI,Kim MK,Boo HJ,Kwon JM,Koh YS,Hyun JW,Park DB,Yoo ES,Kang HK

更新日期：2009-10-01 00:00:00

abstract：:Analgesic activities of Randia siamensis CRAIB (R. siamensis) extract and pseudoginsenoside-RP1, a constituent of the extract, were examined in the writhing test, hot plate test and Randall-Selitto test. Oral administration of R. siamensis extract dose-dependently decreased the number of writhings and stretchings indu...

journal_title：Biological & pharmaceutical bulletin

authors： Reanmongkol W,Matsumoto K,Itharat A,Watanabe H

更新日期：1994-09-01 00:00:00

abstract：:Butylbenzyl phthalate (BBzP) is used as a plasticizer to import flexibility to polyvinylchloride plastics. In this study, hydrolysis of BBzP to monobutyl phthalate (MBP) and monobenzyl phthalate (MBzP) in liver microsomes of humans, monkeys, dogs, rats and mice was examined. The kinetics for MBP formation by human, do...

journal_title：Biological & pharmaceutical bulletin

authors： Takahara Y,Kinashi Y,Takahara Y,Hichiya H,Okada K,Murata M,Shigeyama M,Hanioka N

更新日期：2014-01-01 00:00:00

abstract：:Formation of DNA breaking hydroxyfuranone and hydroxypyranone derivatives in the Maillard reaction of glucose and bovine serum albumin (BSA) under physiological conditions was investigated. A mixture of glucose and BSA was incubated at 37 degrees C in water or in 1 M phosphate buffer (pH 7.4). The ethyl acetate/2-prop...

journal_title：Biological & pharmaceutical bulletin

authors： Hiramoto K,Ishihara A,Sakui N,Daishima S,Kikugawa K

更新日期：1998-02-01 00:00:00

abstract：:We previously prepared 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) solutions containing disulfiram (DSF) and hydroxypropylmethylcellulose (HPMC, DSF solutions), and found the instillation of this DSF solutions delayed lens opacification in ICR/f rats, a recessive-type hereditary cataractous strain. In this study, we ...

journal_title：Biological & pharmaceutical bulletin

authors： Nagai N,Inomata M,Ito Y

更新日期：2008-07-01 00:00:00