Abstract:
:The forced swimming test (FST) is suggested to produce abnormalities in the serotonergic and hypothalamic-pituitary-adrenal (HPA) axis systems. Therefore, compounds that attenuate these neurobiological alterations may have potential as antidepressants. The behavioral and biochemical effects of psoralen, a major furocoumarin isolated from Psoralea corylifolia, were investigated in the FST model of depression in male mice. Psoralen significantly reduced immobility and increased swimming without altering climbing in the mouse FST. Psoralen remarkably reversed FST-induced alterations in serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels in frontal cortex and hippocampus in mice. Furthermore, psoralen attenuated FST-induced elevations in serum corticotropin-releasing factor (CRF) and corticosterone concentrations to normalize the HPA axis activity. These results suggested that psoralen possessed potent antidepressant-like properties which were at least in part mediated by improving the abnormalities in the serotonergic and the HPA axis systems.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Xu Q,Pan Y,Yi LT,Li YC,Mo SF,Jiang FX,Qiao CF,Xu HX,Lu XB,Kong LD,Kung HFdoi
10.1248/bpb.31.1109subject
Has Abstractpub_date
2008-06-01 00:00:00pages
1109-14issue
6eissn
0918-6158issn
1347-5215pii
JST.JSTAGE/bpb/31.1109journal_volume
31pub_type
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