Abstract:
:A biologically active quinone that exhibits a growth-inhibitory effect on rat liver cancer cells was isolated from the nest of a social wasp, Vespa simillima (Vespinae, Vespidae). The structure was unambiguously determined by NMR and synthetic experiments and identified as being 7,8-seco-para-ferruginone. The synthetic quinone showed potent growth-inhibitory effects on rat hepatoma cells (IC50 value=1.9 microM). Morphological analyses of dRLh84 cells using the synthetic compound were tested. Chromatin coagulation was induced by the synthetic compound at 31.6 muM.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Fujiwara Y,Mangetsu M,Yang P,Kofujita H,Suzuki K,Ohfune Y,Shinada Tdoi
10.1248/bpb.31.722subject
Has Abstractpub_date
2008-04-01 00:00:00pages
722-5issue
4eissn
0918-6158issn
1347-5215pii
JST.JSTAGE/bpb/31.722journal_volume
31pub_type
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