Cannabinoid-Elicited Conditioned Place Preference in a Modified Behavioral Paradigm.

abstract：:Joint hypermobility syndrome (JHS) (also termed hypermobility type Ehlers-Danlos syndrome, hEDS) is a heritable connective tissue disorder that is characterized by generalized joint hypermobility, chronic pain, fatigue, and minor skin changes. Initially, it was reported that there is a small subset of patients with JH...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada K,Watanabe A,Takeshita H,Fujita A,Miyake N,Matsumoto N,Matsumoto KI

更新日期：2019-01-01 00:00:00

abstract：:The lactose transport system of Citrobacter freundii was characterized. Both the lactose transport system and beta-galactosidase were induced with either lactose or isopropyl-beta-D-thiogalactopyranoside (IPTG), the latter being the better inducer. The Km values for methyl-beta-D-thiogalactopyranoside (TMG) transport ...

journal_title：Biological & pharmaceutical bulletin

authors： Okazaki N,Tsuda M,Wilson TH,Tsuchiya T

更新日期：1994-06-01 00:00:00

abstract：:The inhibitory effects of some flavonoids on the infectivity of rotavirus, which predominantly causes sporadic diarrhea in infants and young children, were investigated. Among tested flavonoids, diosmin and hesperidin had the most potent inhibitory activity on rotavirus infection. The fifty percent inhibitory concentr...

journal_title：Biological & pharmaceutical bulletin

authors： Bae EA,Han MJ,Lee M,Kim DH

更新日期：2000-09-01 00:00:00

abstract：:Nicotine, an addictive substance, is absorbed from the lungs following inhalation of tobacco smoke, and distributed to various tissues such as liver, brain, and retina. Recent in vivo and in vitro studies suggest the involvement of a carrier-mediated transport process in nicotine transport in the lung, liver, and inne...

journal_title：Biological & pharmaceutical bulletin

authors： Tega Y,Yamazaki Y,Akanuma SI,Kubo Y,Hosoya KI

更新日期：2018-01-01 00:00:00

abstract：:The aim of this work is to investigate the therapeutic efficacy of VP-343 ((N-[4-[[(2S,3aR)-2-hydroxy-2,3,3a,4-tetrahydropyrrolo[1,2-a]qunoxalin-5(1H)-yl]phenyl]-4'-methyl[1,1'-biphenyl]-2-carboxamide), a selective vasopressin V2 receptor antagonist, using the experimental SIADH (syndrome of inappropriate secretion of...

journal_title：Biological & pharmaceutical bulletin

authors： Naito A,Hasegawa H,Kurasawa T,Ohtake Y,Matsukawa H,Ezure Y,Tsuriya Y,Koike K,Shigenobu K

更新日期：2000-11-01 00:00:00

abstract：:The degradation of 125I-endothelin-1 (125I-ET-1) was examined on cultured porcine aortic endothelial cell (EC) and rat vascular smooth muscle cell (SMC) by HPLC analysis. The degradation of ET-1 was observed on SMC and was slightly observed on EC. Membrane fractions of SMC had a strong potency for the degradation of E...

journal_title：Biological & pharmaceutical bulletin

authors： Edano T,Arai K,Koshi T,Torii T,Ohshima T,Hirata M,Ohkuchi M,Okabe T

更新日期：1994-03-01 00:00:00

abstract：:Five rabbit aldo-keto reductases (AKRs) that participate in the reduction of drug ketones and endogenous ketosteroids have recently been cloned and characterized. Among them, AKR1C30 and AKR1C31 show the highest amino acid sequence identity of 91%, but markedly differ in their substrate specificity and inhibitor sensi...

journal_title：Biological & pharmaceutical bulletin

authors： Endo S,Arai Y,Matsunaga T,Ikari A,El-Kabbani O,Hara A,Kitade Y

更新日期：2014-01-01 00:00:00

abstract：:Zinc (Zn) is an essential heavy metal utilized in numerous biological processes in mammals, including its recently described role as a signaling mediator. The movement of Zn in and out of cells, across membranes, is regulated by two protein families: the zinc-regulated transporter (ZRT), iron-regulated transporter (IR...

journal_title：Biological & pharmaceutical bulletin

authors： Takatani-Nakase T

更新日期：2018-01-01 00:00:00

abstract：:Consuming food at uncommon times during the day might be associated with obesity in experimental animals and humans. We previously reported that mice become obese and their metabolism becomes disrupted when they consume food during the daytime (sleep phase feeding; SPF), but not during the nighttime (active phase feed...

journal_title：Biological & pharmaceutical bulletin

authors： Oishi K,Okauchi H

更新日期：2019-01-01 00:00:00

abstract：:Acute pancreatitis (AP) is one kind of acute surgical abdominal disease in the world. It causes intestinal damage with subsequent bacterial migration, endotoxemia and secondary pancreatic infections. In this investigation, we determined that edaravone (EDA) reduces pancreatic and intestinal injury after AP in mice. Th...

journal_title：Biological & pharmaceutical bulletin

authors： Wang B,Lin W

更新日期：2020-01-01 00:00:00

abstract：:Hypertension is one of the most prevalent diseases worldwide and can cause harmful complications within the vascular system. Further research on vascular responsiveness to different ligands and diverse receptors in various arteries is required to understand the mechanisms underlying the development of these vascular c...

journal_title：Biological & pharmaceutical bulletin

authors： Ando M,Matsumoto T,Kobayashi S,Iguchi M,Taguchi K,Kobayashi T

更新日期：2018-01-01 00:00:00

abstract：:The antitumor activity of fucoidan from Fucus vesiculosus was investigated in human colon carcinoma cells. The crude fucoidan, a polysaccharide composed predominantly of sulfated fucose, markedly inhibited the growth of HCT-15 cells (human colon carcinoma cells). After HCT-15 cells were treated with fucoidan, several ...

journal_title：Biological & pharmaceutical bulletin

authors： Hyun JH,Kim SC,Kang JI,Kim MK,Boo HJ,Kwon JM,Koh YS,Hyun JW,Park DB,Yoo ES,Kang HK

更新日期：2009-10-01 00:00:00

abstract：:Tetramethylpyrazine is the active ingredient of a Chinese herbal medicine. In this study, tetramethylpyrazine was tested for its activities in irradiated bone marrow stromal QXMSC1 cells. The proliferation of QXMSC1 cells was measured by MTS assay kit and flow cytometry. To identify proteins involved in the processes ...

journal_title：Biological & pharmaceutical bulletin

authors： Ma ZC,Tan HL,Xiao CR,Wang YG,Wang SQ,Gao Y

更新日期：2007-02-01 00:00:00

abstract：:To predict the actions of T-3762, a newly developed fluoroquinolone antimicrobial agent, as well as ciprofloxacin (CPFX) and ofloxacin (OFLX), on injection sites when dosed parenterally, their ability to increase cutaneous vascular permeability in dogs and to release histamine from rat peritoneal mast cells was examin...

journal_title：Biological & pharmaceutical bulletin

authors： Furuhata K,Fukuda Y,Soumi K,Arai H,Watanabe Y,Narita H

更新日期：1998-05-01 00:00:00

abstract：:Phospholipase (PL) A2 activity prepared from isolated rat fat pads incubated with sodium orthovanadate (vanadate) was increased in a time- and dose-dependent manner. The increasing effect of vanadate was reduced in the presence of tyrosine kinase inhibitors. Under the inhibition of protein synthesis by cycloheximide, ...

journal_title：Biological & pharmaceutical bulletin

authors： Morita T,Imagawa T,Kanagawa A,Ueki H

更新日期：1995-02-01 00:00:00

abstract：:Cerebral ischemia causes the depletion of oxygen and nutrition from brain tissues, and when persistent, results in irreversible damage to the cell function and survival. The cellular response to ischemic conditions and its mechanisms have been investigated widely in in vivo and in vitro experimental models, yet no stu...

journal_title：Biological & pharmaceutical bulletin

authors： Ujita S,Mizunuma M,Matsuki N,Ikegaya Y

更新日期：2011-01-01 00:00:00

abstract：:The inhibitory effects of five angiotensin-converting enzyme (ACE) inhibitors on the uptake of an aminocephalosporin antibiotic, cefroxadine, by rabbit small intestinal brush-border membrane vesicles were examined in the presence of an inward H+ gradient. Dixon plot analysis showed that all these ACE inhibitors inhibi...

journal_title：Biological & pharmaceutical bulletin

authors： Kitagawa S,Takeda J,Sato S

更新日期：1999-07-01 00:00:00

abstract：:The gas phase of cigarette smoke is important from the viewpoint of human health, because it can pass through alveolar epithelium and enter the circulation. There is no standard method for the preparation of a gas phase extract of cigarette smoke (CSE), although CSE is widely used for research instead of whole cigaret...

journal_title：Biological & pharmaceutical bulletin

authors： Higashi T,Mai Y,Mazaki Y,Horinouchi T,Miwa S

更新日期：2016-01-01 00:00:00

abstract：:The predictability of serum vancomycin (VCM) concentrations by means of the Bayesian method was evaluated to establish whether the method can be used to select safe and effective VCM treatment regimens for individual patients. Serum VCM concentrations at the trough and 2 h after the end of infusion (peak) were measure...

journal_title：Biological & pharmaceutical bulletin

authors： Teramachi H,Hatakeyama H,Matsushita R,Imai Y,Miyamoto K,Tsuji A

更新日期：2002-10-01 00:00:00

abstract：:Defining a quantitative and reliable relationship between in vitro drug release and in vivo absorption is highly desired for rational development, optimization, and evaluation of controlled-release dosage forms and manufacturing process. During the development of once daily extended-release (ER) tablet of glipizide, a...

journal_title：Biological & pharmaceutical bulletin

authors： Ghosh A,Bhaumik UK,Bose A,Mandal U,Gowda V,Chatterjee B,Chakrabarty US,Pal TK

更新日期：2008-10-01 00:00:00

abstract：:There may be cardio-renal interactions in rats of isoproterenol-induced heart failure, which may be associated with renal fibrosis and endothelial-to-mesenchymal transition (EndMT). Since its discovery, relaxin (RLX) which was regarded as a reproductive hormone for a long time, is recently considered an effective anti...

journal_title：Biological & pharmaceutical bulletin

authors： Zheng G,Cai J,Chen X,Chen L,Ge W,Zhou X,Zhou H

更新日期：2017-01-01 00:00:00

abstract：:We investigated a method for the simultaneous screening, identification, and quantitative determination of salicylic acid, acetaminophen, theophylline, barbiturates, and bromvalerylurea, drugs that frequently cause acute poisoning in Japan and therefore require rapid analysis for effective treatment in the clinical se...

journal_title：Biological & pharmaceutical bulletin

authors： Hori Y,Fujisawa M,Shimada K,Hirose Y,Yoshioka T

更新日期：2006-01-01 00:00:00

abstract：:Cancer is one of the leading causes of death in the world. The triterpenoid compound asiatic acid derived from the tropical medicinal plant Centella asiatica displays cytotoxic activity on fibroblast cells and several other kinds of cells. The present work studies asiatic acid-mediated growth inhibition of cancer cell...

journal_title：Biological & pharmaceutical bulletin

authors： Tang XL,Yang XY,Jung HJ,Kim SY,Jung SY,Choi DY,Park WC,Park H

更新日期：2009-08-01 00:00:00

abstract：:We established a highly sensitive method for evaluating P-glycoprotein activity in Caco-2 cells. Using time-lapse confocal laser-scanning microscopy, we measured the change in fluorescence of residual rhodamine 123 in Caco-2 cells. Horizontal fluorescence images of rhodamine 123 in the apical and central parts of thes...

journal_title：Biological & pharmaceutical bulletin

authors： Wakuda H,Nejime N,Tada Y,Kagota S,Umegaki K,Yamada S,Shinozuka K

更新日期：2010-01-01 00:00:00

abstract：:To further enhance the efficiency and potential of plants for phytoremediation of mercury pollution, a genetically engineered tobacco to simultaneously express mercury transporter, mercury transporter (MerT) and mercury chelator, polyphosphate (polyP) was constructed by integrating bacterial merT gene in polyphosphate...

journal_title：Biological & pharmaceutical bulletin

authors： Nagata T,Nakamura A,Akizawa T,Pan-Hou H

更新日期：2009-09-01 00:00:00

abstract：:We investigated whether poly-L-arginine (PLA) could improve permeation of the hydrophilic compounds, FITC-labeled dextran (MW 3800, FD-4) and pyridoxamine, through ocular surface tissues. Samples of cornea, conjunctiva, or conjunctiva/sclera composite from Japanese white rabbits were mounted in Ussing chambers to meas...

journal_title：Biological & pharmaceutical bulletin

authors： Nemoto E,Takahashi H,Kobayashi D,Ueda H,Morimoto Y

更新日期：2006-01-01 00:00:00

abstract：:There are many important considerations in the interactions among the herbal constituents in a prescription of traditional Chinese medicine (TCM). Ephedra Herb [Chinese characters: see text] (Eph) is described a warm and acrid agent in TCM. The combination of Eph and Gypsum [Chinese characters: see text] (Eph-Gyp) sho...

journal_title：Biological & pharmaceutical bulletin

authors： Yuan D,Sunouchi H,Sakurai T,Saito K,Kano Y

更新日期：2002-07-01 00:00:00

abstract：:The purpose of this study was to evaluate the essential oils from sweet basil (Ocimum basilicum, OB) as skin permeation enhancers to promote the percutaneous absorption of drugs. The in vitro and in vivo irritancy of the essential oils was also examined. Terpenes with various carbon numbers (mono-, sesqui-, di-, and t...

journal_title：Biological & pharmaceutical bulletin

authors： Fang JY,Leu YL,Hwang TL,Cheng HC

更新日期：2004-11-01 00:00:00

abstract：:The relation between degranulation and rapid metabolic responses (acidification rate changes) in RBL-2H3 cells was studied using a cytosensor microphysiometer, a silicon-based biosensor system. The metabolic responses in RBL-2H3 cells by antigen stimulation were compared with those by inhibitors of Ca2+ -ATPase. The f...

journal_title：Biological & pharmaceutical bulletin

authors： Furuno T,Ohyama N,Nakanishi M

更新日期：1999-03-01 00:00:00

abstract：:We investigated the psychostimulant, rewarding, and anxiolytic-like effects of pulegone. Possible interactions between pulegone and menthol concerning their psychostimulant effect were also analyzed. General mouse activity after pulegone treatment, and the interacitons between pulegone and menthol, were determined in ...

journal_title：Biological & pharmaceutical bulletin

authors： da Silveira NS,de Oliveira-Silva GL,Lamanes Bde F,Prado LC,Bispo-da-Silva LB

更新日期：2014-01-01 00:00:00