Liposomes as immunomodulator--inhibitory effect of liposomes on NO production from macrophages.

Abstract:

:Liposomes have been artificially made into membranous vesicles composed essentially of naturally occurring phospholipids and have been found to serve as a carrier of drugs and an immunological adjuvant. After being intravenously injected, they are quickly removed from the blood circulation and trapped by Kupffer cells of the liver and macrophages of spleen. However, the changes liposomes exert in these cells with which liposomes interact remain unresolved. To clarify this point is very important to assure the safe use of liposomes as drug carriers. Macrophages have many unique functions, and nitric oxide (NO) produced by NO synthase (NOS) which is induced in response to some cytokines and bacterial products such as lipopolysaccharide (LPS) is responsible for the bactericidal, tumoricidal and immune regulatory activities. On the other hand, overexpressed NO is implicated in the development of atherosclerosis, DNA injury, and hypotension associated with septic shock. This article focuses on the effects of liposomes on NO production from LPS-stimulated mice peritoneal macrophages in vitro; we found that liposomes composed of phosphatidylserine inhibit NO production. We also discuss the mechanism of the inhibitory activity of liposomes.

journal_name

Biol Pharm Bull

authors

Aramaki Y

doi

10.1248/bpb.23.1267

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

1267-74

issue

11

eissn

0918-6158

issn

1347-5215

journal_volume

23

pub_type

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