Effects of a calcium-channel blocker (CV159) on hepatic ischemia/reperfusion injury in rats: evaluation with selective NO/pO2 electrodes and an electron paramagnetic resonance spin-trapping method.

abstract：:Hydroxylysylpyridinoline (HP), an intermolecular cross-linking amino acid, is present only in bone and cartilage collagen. We examined urinary HP levels in order to assess bone collagen metabolism using HPLC. Urinary HP excretion levels (nmol/mmol creatinine) of healthy control groups gradually increased with aging. U...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshihara K,Nemoto S,Nagata M

更新日期：1994-06-01 00:00:00

abstract：:It has been demonstrated that adipose-derived stem cells (ADSCs) secrete cytokines and exhibit diverse pharmacological actions. The present study examined the unknown pharmacological action of ADSCs regarding whitening effects. A conditioned medium of ADSCs (ADSC-CM) was harvested and the whitening effect of ADSC-CM w...

journal_title：Biological & pharmaceutical bulletin

authors： Kim WS,Park SH,Ahn SJ,Kim HK,Park JS,Lee GY,Kim KJ,Whang KK,Kang SH,Park BS,Sung JH

更新日期：2008-04-01 00:00:00

abstract：:Ras, a small G-protein, physiologically directs cell proliferation and cell cycle via regulation of mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling cascade. Dysregulation of Ras/MEK/ERK signaling has been reported to cause tumorigenesis and gliomas. Nobiletin, a citr...

journal_title：Biological & pharmaceutical bulletin

authors： Aoki K,Yokosuka A,Mimaki Y,Fukunaga K,Yamakuni T

更新日期：2013-01-01 00:00:00

abstract：:We investigated the gene expression of GAPDH, cytochrome P450 isoforms (CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2E1, CYP3A4, CYP3A5, and CYP3A7), UGT-dependent glucuronosyl transferase isoforms (UGT1A6 and UGT1A9), and ABC transporter (ABCB1) after exposure to 0.1, 0.5, and 2.5% dimethyl sulfoxide (DMSO). GAPDH mRNA levels...

journal_title：Biological & pharmaceutical bulletin

authors： Nishimura M,Ueda N,Naito S

更新日期：2003-07-01 00:00:00

abstract：:To elucidate insecticidal activity of spider toxins, metal ions in venoms and in the bodies were determined by thin layer chromatography, spark source mass spectrometry, ion chromatography, inductively coupled plasma emission spectrometry and atomic absorption spectrometry. Two kinds of spiders were used, Nephila clav...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshioka M,Narai N,Shinkai A,Tokuda T,Saito K,Shioya M,Tokoro N,Kono Y

更新日期：1994-04-01 00:00:00

abstract：:The objectives of the present study were to assess pharmacokinetics, pharmacodynamics, tolerability and safety of intravenous administration of bivalirudin, a direct thrombin inhibitor, in healthy Chinese subjects. 48 subjects were equally divided into 4 groups (0.5 mg/kg, 0.75 mg/kg, 1.05 mg/kg intravenous bolus, and...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang D,Wang Z,Zhao X,Lu W,Gu J,Cui Y

更新日期：2011-01-01 00:00:00

abstract：:T cells play a principal role in cellular immunity and govern the regulatory mechanism in humoral immunity. Therefore, T cells play a key role as either effectors or regulators in the immune network. Mizoribine (MZR), an immunosuppressive agent, suppresses both humoral and cellular immunity by acting on both T cells a...

journal_title：Biological & pharmaceutical bulletin

authors： Kamada H,Inoue N,Takaoka Y,Nakagami K,Mori H,Nagai H

更新日期：1996-09-01 00:00:00

abstract：:We studied the protective effects of Echinacea purpurea against radiation by evaluating changes in the peripheral blood cell count and peripheral blood antioxidant activity. E. purpurea administration had a suppressive effect on radiation-induced leukopenia, especially on lymphocytes and monocytes, and resulted in a f...

journal_title：Biological & pharmaceutical bulletin

authors： Mishima S,Saito K,Maruyama H,Inoue M,Yamashita T,Ishida T,Gu Y

更新日期：2004-07-01 00:00:00

abstract：:Aconitine administered intraperitoneally (i.p.) produces bradycardia mainly by a central muscarinic action. The involvement of hypothalamic regions in the occurrence of aconitine-induced bradycardia was investigated in hypothalamus-lesioned mice. The lesions were made by passing a direct current (1.5 mA, 13 s) through...

journal_title：Biological & pharmaceutical bulletin

authors： Kimura I,Takada M,Nojima H

更新日期：1997-08-01 00:00:00

abstract：:Rapamycin (Rap) has been demonstrated to affect lipid metabolism through stimulating lipolysis, inhibiting de novo lipogenesis and reducing adiposity. In the present study, we investigated rapamycin exposure's influence on adipose tissue browning in high-fat diet-induced fatty mice. Four-week old C57BL/6J mice were fe...

journal_title：Biological & pharmaceutical bulletin

authors： Wang Y,He Z,Li X

更新日期：2017-01-01 00:00:00

abstract：:Biomacromolecules (>40 kDa) have been developed as drug delivery system (DDS) carriers of low-molecular weight drugs to promote these drugs' uptake by cancer tissues via enhanced permeability and retention (EPR) effects. Human serum albumin (HSA) has been found to accumulate in cancer tissues via this EPR effect. HSA ...

journal_title：Biological & pharmaceutical bulletin

authors： Ishima Y

更新日期：2017-01-01 00:00:00

abstract：:Two known diarylheptanoids, oregonin (1), (5S)-1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-one-5-O-beta-D-xylopyranosi de and hirsutanonol (2), (5S)-1,7-bis-(3,4-dihydroxyphenyl)-5-hydroxyheptane-3-one isolated from the bark of Alnus hirsuta var. sibirica, showed significant inhibitory effects on 12-O-tetradecanoylphorbol...

journal_title：Biological & pharmaceutical bulletin

authors： Lee MW,Kim JH,Jeong DW,Ahn KH,Toh SH,Surh YJ

更新日期：2000-04-01 00:00:00

abstract：:Information on the comparative digestibility of food allergens and non-allergenic proteins is crucial when stability to digestion is to be used as a criterion to assess the allergenic potential of novel proteins. Preheating effect on in vitro digestibility has not been fully examined. In this study we investigated the...

journal_title：Biological & pharmaceutical bulletin

authors： Takagi K,Teshima R,Okunuki H,Sawada J

更新日期：2003-07-01 00:00:00

abstract：:Proteasome inhibitors are a novel class of molecular-targeted anti-cancer drugs that suppress the degradation of malfolded proteins, trigger endoplasmic reticulum (ER) stress, and activate apoptosis signals. Glucose-regulated protein 78 (GRP78), a major ER chaperone, is one of the most important molecules for transduc...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumura K,Sakai C,Kawakami S,Yamashita F,Hashida M

更新日期：2014-01-01 00:00:00

abstract：:Darexaban maleate is a novel oral direct factor Xa inhibitor. Darexaban glucuronide (YM-222714) was the major component in plasma after oral administration of darexaban to humans and is the pharmacologically active metabolite. Additionally, YM-222714 N-oxides were detected as minor metabolites in human plasma and urin...

journal_title：Biological & pharmaceutical bulletin

authors： Shiraga T,Yajima K,Teragaki T,Suzuki K,Hashimoto T,Iwatsubo T,Miyashita A,Usui T

更新日期：2012-01-01 00:00:00

abstract：:Transport mechanisms of p-aminohippurate (PAH) were investigated in rat renal brush-border membrane vesicles. The uptake of PAH was stimulated by an inside-positive membrane potential created by K+ and valinomycin. This potential-stimulated uptake of PAH was inhibited by various anion transport inhibitors and was satu...

journal_title：Biological & pharmaceutical bulletin

authors： Ohoka K,Takano M,Okano T,Maeda S,Inui K,Hori R

更新日期：1993-04-01 00:00:00

abstract：:Two acidic polysaccharides, called ginsenan S-IA and ginsenan S-IIA, were isolated from the root of Panax ginseng C. A. Meyer. They were homogeneous on electrophoresis and gel chromatography, and their molecular masses were estimated to be 5.6 x 10(4) and 1.0 x 10(5), respectively. Ginsenan S-IA is composed of L-arabi...

journal_title：Biological & pharmaceutical bulletin

authors： Tomoda M,Hirabayashi K,Shimizu N,Gonda R,Ohara N,Takada K

更新日期：1993-11-01 00:00:00

abstract：:The relation between degranulation and rapid metabolic responses (acidification rate changes) in RBL-2H3 cells was studied using a cytosensor microphysiometer, a silicon-based biosensor system. The metabolic responses in RBL-2H3 cells by antigen stimulation were compared with those by inhibitors of Ca2+ -ATPase. The f...

journal_title：Biological & pharmaceutical bulletin

authors： Furuno T,Ohyama N,Nakanishi M

更新日期：1999-03-01 00:00:00

abstract：:We compared effects of the antiarrhythmic drug bepridil on the electrophysiological parameters in the isolated pulmonary vein preparation from guinea pigs with those in the left atrium. Three pairs of bipolar electrodes were attached to the left atrium, pulmonary vein and junctional region of left atrium and pulmonary...

journal_title：Biological & pharmaceutical bulletin

authors： Takahara A,Takeda K,Hagiwara M,Tanaka H

更新日期：2013-01-01 00:00:00

abstract：:Temozolomide (TMZ) is currently the first-line drug used for clinical postoperative or non-surgical chemotherapy for glioma, but acquired and intrinsic resistance to TMZ limits its application. The anti-proliferative effect of formononetin on human glioma cells had been confirmed. To improve therapeutic effects of TMZ...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang X,Ni Q,Wang Y,Fan H,Li Y

更新日期：2018-08-01 00:00:00

abstract：:The mature form of rat adrenodoxin (Ad) was purified from a heterologous direct expression system in Escherichia coli with a yield of 56 mg/l culture. The purified Ad showed a A414/A280 ratio of 0.91 and the sequence of 10 amino terminal residues was identical with that of authentic rat Ad. By Time of Flight/Mass spec...

journal_title：Biological & pharmaceutical bulletin

authors： Sagara Y,Aramaki H

更新日期：1998-10-01 00:00:00

abstract：:In vivo redox reactions of nitroxyl contrast agents in bile and blood under an oxidative atmosphere were investigated using normal healthy Wistar rats. Differences in intracellular and extracellular volumes in redox environments are discussed. Pharmacokinetic profiles of two nitroxyl contrast agents, 3-carbamoyl-2,2,5...

journal_title：Biological & pharmaceutical bulletin

authors： Okajo A,Ui I,Manda S,Nakanishi I,Matsumoto K,Anzai K,Endo K

更新日期：2009-04-01 00:00:00

abstract：:To elucidate molecular mechanisms of adipocyte differentiation, we previously isolated TC10-like/TC10betaLong (TCL/TC10betaL), regulators of G protein signaling 2 (RGS2), factor for adipocyte differentiation (fad) 104 and fad158, which were transiently expressed in the early phase of adipogenesis. These four genes see...

journal_title：Biological & pharmaceutical bulletin

authors： Kawaji A,Nishizuka M,Osada S,Imagawa M

更新日期：2010-01-01 00:00:00

abstract：:The metabolism of bisphenol A (BPA) was determined for 11 forms of human hepatic cytochromes P450 (CYPs) expressed in the yeast Saccharomyces cerevisiae and for human steroidogenic CYP17 expressed in Escherichia coli. Additionally, the effect of BPA on the progesterone 17alpha-chydroxylase activity of CYP17 was invest...

journal_title：Biological & pharmaceutical bulletin

authors： Niwa T,Fujimoto M,Kishimoto K,Yabusaki Y,Ishibashi F,Katagiri M

更新日期：2001-09-01 00:00:00

abstract：:The effect of zaldaride on acetylcholine-induced colonic electrolyte secretion was examined. The short-circuit current response to acetylcholine was partially reduced by tetrodotoxin, a neuronal blocker, and was completely inhibited by atropine, an acetylcholine M receptor antagonist, in the rat colonic preparations. ...

journal_title：Biological & pharmaceutical bulletin

authors： Aikawa N,Kishibayashi N,Karasawa A,Ohmori K

更新日期：2000-11-01 00:00:00

abstract：:Melatonin has been suggested to play important roles in lipid metabolism as well as circadian rhythm; however, very few studies explored the effects of ramelteon, a selective melatonin receptor agonist, on serum lipid profiles. In this study effects of ramelteon on serum lipid profiles were explored, comparing to thos...

journal_title：Biological & pharmaceutical bulletin

authors： Torii H,Shimizu R,Tanizaki Y,Omiya Y,Yamamoto M,Kamiike S,Yasuda D,Hiraoka Y,Hashida T,Kume N

更新日期：2018-01-01 00:00:00

abstract：:Many anti-epileptic drugs (AEDs) that mainly target ion channels or post-synaptic receptors are in clinical use, but a proportion of patients are resistant to these traditional AEDs and experience repeated severe break-out seizures. Given its involvement in the etiology of epilepsy, the neurotransmitter glycine may se...

journal_title：Biological & pharmaceutical bulletin

authors： Zhao J,Tao H,Xian W,Cai Y,Cheng W,Yin M,Liang G,Li K,Cui L,Zhao B

更新日期：2016-01-01 00:00:00

abstract：:The predictability of serum vancomycin (VCM) concentrations by means of the Bayesian method was evaluated to establish whether the method can be used to select safe and effective VCM treatment regimens for individual patients. Serum VCM concentrations at the trough and 2 h after the end of infusion (peak) were measure...

journal_title：Biological & pharmaceutical bulletin

authors： Teramachi H,Hatakeyama H,Matsushita R,Imai Y,Miyamoto K,Tsuji A

更新日期：2002-10-01 00:00:00

abstract：:This study was conducted to demonstrate the inhibitory effect of saucerneol G (SG), a new lignan, isolated from the aerial part of Saururus chinensis (Saururaceae) on lipopolysaccharide (LPS)-stimulated matrix metalloproteinase-9 (MMP)-9 inductions in RAW 264.7 cells. Aimed at evaluating the mechanism of action by whi...

journal_title：Biological & pharmaceutical bulletin

authors： Lu Y,Hong TG,Jin M,Yang JH,Suh SJ,Piao DG,Ko HK,Seo CS,Chang YC,Kim CH,Son JK,Chang HW

更新日期：2010-01-01 00:00:00

abstract：:The total alkaloid fractions of the methanolic extracts of the leaves, ripe fruits, roots, seeds and stem of Solanum pseudocapsicum were subjected to in-vitro cytotoxicity, short-term toxicity and long-term survival studies. All the five fractions exhibited potent activity. The total alkaloid fraction of leaves was fo...

journal_title：Biological & pharmaceutical bulletin

authors： Vijayan P,Vijayaraj P,Setty PH,Hariharpura RC,Godavarthi A,Badami S,Arumugam DS,Bhojraj S

更新日期：2004-04-01 00:00:00