Effect of mizoribine on effector T cell-mediated immune responses in mice.

abstract：:Six polyphenolic acid esters were synthesized and their antioxidative properties were evaluated in three model systems [2,2'-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay, 2,2'-azobis(2-amidinopropane)dihydrochloride (AAPH)-induced lipid peroxidation system, and the dye-bleaching assay of peroxynitrit...

journal_title：Biological & pharmaceutical bulletin

authors： Hsu LY,Lin CF,Hsu WC,Hsu WL,Chang TC

更新日期：2005-07-01 00:00:00

abstract：:The total iron-binding capacity (TIBC) and iron contents of diabetic rat serum, as well as the iron-binding capacity of glycated transferrin and oxygen radical production by the glycated proteins were examined. The TIBC and iron content of diabetic rat sera were found to be much lower than those of control rat sera. I...

journal_title：Biological & pharmaceutical bulletin

authors： Fujimoto S,Kawakami N,Ohara A

更新日期：1995-03-01 00:00:00

abstract：:In this study, the skin permeation of liposomes containing psoralen was investigated by in vivo skin microdialysis. Psoralen-loaded nano-sized liposomes were prepared with a mean size of 117.5 nm and a polydispersity index of 0.21, indicating the uniform dispersion of phosphatidylcholine vesicles in the liposomal solu...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang H,Zhang K,Li Z,Zhao J,Zhang Y,Feng N

更新日期：2017-01-01 00:00:00

abstract：:Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with Parkinson's disease. LRRK2 is a large protein with multiple functional domains, including a guanosine 5'-triphosphate (GTP)-binding domain and a protein kinase domain. Recent studies indicated that the members of the Rab GTPase family, Rab8...

journal_title：Biological & pharmaceutical bulletin

authors： Imai M,Kawakami F,Kubo M,Kanzaki M,Maruyama H,Kawashima R,Maekawa T,Kurosaki Y,Kojima F,Ichikawa T

更新日期：2020-01-01 00:00:00

abstract：:We investigated whether poly-L-arginine (PLA) could improve permeation of the hydrophilic compounds, FITC-labeled dextran (MW 3800, FD-4) and pyridoxamine, through ocular surface tissues. Samples of cornea, conjunctiva, or conjunctiva/sclera composite from Japanese white rabbits were mounted in Ussing chambers to meas...

journal_title：Biological & pharmaceutical bulletin

authors： Nemoto E,Takahashi H,Kobayashi D,Ueda H,Morimoto Y

更新日期：2006-01-01 00:00:00

abstract：:We investigated the changes (increase or decrease in peak intensity) in the expression of plasma proteins in spontaneously diabetic WBN/Kob rats that were with complicated diabetic nephropathy, to determine multiple biomarkers in the plasma of diabetic rats. The present study using surface enhanced laser desorption/io...

journal_title：Biological & pharmaceutical bulletin

authors： Kiga C,Nakagawa T,Koizumi K,Sakurai H,Shibagaki Y,Ogawa K,Goto H,Saiki I

更新日期：2005-06-01 00:00:00

abstract：:The antiproliferative constituents in the MeOH extracts of the aerial parts of Lippia dulcis Trev. and Lippia canescens Kunth (Verbenaceae) were investigated. Activity-guided chemical investigation of the MeOH extracts resulted in the isolation of the three bisabolane-type sesquiterpenes [(+)-hernandulcin (1), (-)-epi...

journal_title：Biological & pharmaceutical bulletin

authors： Abe F,Nagao T,Okabe H

更新日期：2002-07-01 00:00:00

abstract：:We examine the pharmacokinetic profile of cyclosporin A (CyA) after intravenous administration to rats prepared as models of various disease states found in patients who receive organ transplantations. After intravenous bolus administration to normal rats, the total blood clearance (CLt) of CyA showed a dose-dependent...

journal_title：Biological & pharmaceutical bulletin

authors： Shibata N,Shimakawa H,Minouchi T,Yamaji A

更新日期：1993-11-01 00:00:00

abstract：:For analyzing the concentrations of drugs in hairs, a new method of digestion of hairs with Biopurase, a protease obtained from Bacillus subtilis, was examined. The concentrations of drugs in hairs were then determined in order to examine the usefulness of the protease for the digestion of hairs. The stability of five...

journal_title：Biological & pharmaceutical bulletin

authors： Fujii J,Higashi A,Nakano M

更新日期：1996-12-01 00:00:00

abstract：:Nonalcoholic steatohepatitis (NASH) is the most frequent cause of liver dysfunction and a common global problem. Gypenosides can decrease pathological modifications of high-fat diet-induced rat atherosclerosis; however, its effect and mechanism on NASH remain unclear. In this study, rats were randomly divided into nor...

journal_title：Biological & pharmaceutical bulletin

authors： Li H,Ying H,Hu A,Hu Y,Li D

更新日期：2017-01-01 00:00:00

abstract：:Collagen-induced arthritis (CIA) is an experimental model of rheumatoid arthritis (RA) used for studying the clinical, immunological and genetic factors of the disease. Many studies of genetic susceptibility to CIA have been performed, usually with two strains of mice, DBA/1 and B10.RIII, since they are highly suscept...

journal_title：Biological & pharmaceutical bulletin

authors： Hida S,Nagi-Miura N,Adachi Y,Ohno N

更新日期：2006-06-01 00:00:00

abstract：:Nitric oxide (NO), an endothelium-dependent relaxing factor, regulates relaxation, proliferation, and migration of smooth muscle cells (SMCs) and most likely attenuates developing vascular disease such as atherosclerosis. We investigated whether or not NO is associated with regulation of aortic elasticity. S-Nitrosogl...

journal_title：Biological & pharmaceutical bulletin

authors： Sugitani H,Wachi H,Tajima S,Seyama Y

更新日期：2001-05-01 00:00:00

abstract：:Spermatogenesis associated 4 (SPATA4) is a testis-specific gene first cloned by our laboratory, and plays an important role in maintaining the physiological function of germ cells. Accumulated evidence suggests that SPATA4 might be associated with apoptosis. Here we established HeLa cells that stably expressed SPATA4 ...

journal_title：Biological & pharmaceutical bulletin

authors： Jiang J,Li L,Xie M,Fuji R,Liu S,Yin X,Li G,Wang Z

更新日期：2015-01-01 00:00:00

abstract：:This study was performed to examine the effects of the antifibrotic agents TJN-331 and tranilast on mesangial expansion in a rat model of anti-Thy1 nephritis. We first investigated the effects of TJN-331 and tranilast on mesangial expansion induced by anti-Thy1 serum in rats, and determined the counts of glomerular ce...

journal_title：Biological & pharmaceutical bulletin

authors： Saegusa Y,Sadakane C,Koseki J,Hasegawa Y,Shindo S,Maruyama H,Kase Y,Takeda S,Takeda H,Hattori T

更新日期：2010-01-01 00:00:00

abstract：:The recent emergence of multidrug-resistant pathogens and/or pharmacokinetics-pharmacodynamics considerations may result in off-label use of a certain class of antibacterials, including tigecycline. This study was performed to clarify the safety profile of tigecycline in the user-derived manner and to compare it with ...

journal_title：Biological & pharmaceutical bulletin

authors： Kadoyama K,Sakaeda T,Tamon A,Okuno Y

更新日期：2012-01-01 00:00:00

abstract：:A new ursane-type triterpenoid, weigelic acid (1), and seven known compounds, ursolic acid (2), ilekudinol A (3), corosolic acid (4), ilekudinol B (5), esculentic acid (6), pomolic acid (7), and asiatic acid (8) were isolated from the leaf and stem of Weigela subsessilis. The structure of the new triterpenoid was esta...

journal_title：Biological & pharmaceutical bulletin

authors： Thuong PT,Min BS,Jin W,Na M,Lee J,Seong R,Lee YM,Song K,Seong Y,Lee HK,Bae K,Kang SS

更新日期：2006-04-01 00:00:00

abstract：:Sauchinone, a biologically active lignan found in Saururus chinensis (Saururaceae), exerts various biological activities against jaundice, inflammatory disease, hepatic steatosis, and oxidative injury. Despite its diverse applications, there exists some information about sauchinone's pharmacokinetics but its tissue di...

journal_title：Biological & pharmaceutical bulletin

authors： Kim YJ,Han SY,Seo JS,Chin YW,Choi YH

更新日期：2015-01-01 00:00:00

abstract：:Three antiinflammatory saponin components were isolated from the alkaline hydrolysate of a butanol-soluble portion of Kalopanax pictus bark extract through an in vivo activity-guided fractionation procedure. The hydrolysate showed inhibition of adjuvant induced arthritis in rats. After further fractionation, the ethyl...

journal_title：Biological & pharmaceutical bulletin

authors： Li DW,Hyun JE,Jeong CS,Kim YS,Lee EB

更新日期：2003-04-01 00:00:00

abstract：:Cell-penetrating peptides (CPPs) have been highly anticipated as an efficient delivery system due to their ability to cross biological membranes and transport various cargoes into cells. In the present study, we have identified adenovirus-derived CPPs using various capsid-mutant adenovirus (Ad) vectors. First, we exam...

journal_title：Biological & pharmaceutical bulletin

authors： Hirai T,Yamagishi Y,Koizumi N,Nonaka M,Mochida R,Shida K,Nomura T,Fujii M,Sakurai F,Mizuguchi H,Watanabe Y,Utoguchi N

更新日期：2017-01-01 00:00:00

abstract：:Nicotine, an addictive substance, is absorbed from the lungs following inhalation of tobacco smoke, and distributed to various tissues such as liver, brain, and retina. Recent in vivo and in vitro studies suggest the involvement of a carrier-mediated transport process in nicotine transport in the lung, liver, and inne...

journal_title：Biological & pharmaceutical bulletin

authors： Tega Y,Yamazaki Y,Akanuma SI,Kubo Y,Hosoya KI

更新日期：2018-01-01 00:00:00

abstract：:The release of hepatic lipase (HTGL), which is responsible for the hydrolysis of lipoprotein triacylglyceride, produced by heparin from the isolated rat hepatocytes in primary culture has been examined. Tyrosine kinase (TK) inhibitors (ST-638 and biochanin A) inhibited the heparin-stimulated release of HTGL activity. ...

journal_title：Biological & pharmaceutical bulletin

authors： Tagashira H,Nakahigashi S,Kerakawati R,Motoyashiki T,Morita T

更新日期：2005-03-01 00:00:00

abstract：:We performed experiments on the cis-inhibition and trans-stimulation effect on pirarubicin uptake in order to clarify the involvement of a carrier in the pirarubicin, daunorubicin and/or doxorubicin transport systems in rat polymorphonuclear leukocytes. The uptake of daunorubicin and doxorubicin was a saturable concen...

journal_title：Biological & pharmaceutical bulletin

authors： Nagasawa K,Nomiyama M,Ohnishi N,Yokoyama T,Iwakawa S,Okumura K

更新日期：1994-09-01 00:00:00

abstract：:Some P450 enzymes are expressed not only in the liver but also in the small intestine, and these enzymes play an important role in first-pass drug metabolism in the small intestine. Cytochrome P450 (CYP)2C19 has been confirmed to exist in the small intestine of white people, but not yet in Japanese. We investigated th...

journal_title：Biological & pharmaceutical bulletin

authors： Hayashi M,Matsumoto N,Takenoshita-Nakaya S,Takeba Y,Watanabe M,Kumai T,Takagi M,Tanaka M,Otsubo T,Kobayashi S

更新日期：2011-01-01 00:00:00

abstract：:Butylbenzyl phthalate (BBzP) is used as a plasticizer to import flexibility to polyvinylchloride plastics. In this study, hydrolysis of BBzP to monobutyl phthalate (MBP) and monobenzyl phthalate (MBzP) in liver microsomes of humans, monkeys, dogs, rats and mice was examined. The kinetics for MBP formation by human, do...

journal_title：Biological & pharmaceutical bulletin

authors： Takahara Y,Kinashi Y,Takahara Y,Hichiya H,Okada K,Murata M,Shigeyama M,Hanioka N

更新日期：2014-01-01 00:00:00

abstract：:The liver contrast effects of Sonazoid in two ultrasonographic imaging modes, gray-scale conventional and harmonic, were examined as a time-related study in normal rabbits, and evaluated quantitatively and visually with tumor-model rabbits to estimate the diagnostic potential. Peak enhancement of vessels and parenchym...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe R,Matsumura M,Chen CJ,Kaneda Y,Ishihara M,Fujimaki M

更新日期：2003-09-01 00:00:00

abstract：:The complete amino acid sequences of [2Fe-2S] ferredoxin from Atropa belladonna and Hyoscyamus niger have been determined by automated Edman degradation of the entire S-carboxymethylcysteinyl proteins and of the peptides obtained by enzymatic digestion. These two ferredoxins exhibited 1-8 differences in their amino ac...

journal_title：Biological & pharmaceutical bulletin

authors： Mino Y,Yukita M,Hiratsuka N,Wariishi H

更新日期：2005-08-01 00:00:00

abstract：:The aim of this study was to evaluate the effect of olmesartan (OLME), an angiotensin II receptor antagonist, on an intestinal mucositis model. Briefly, daily intraperitoneal (i.p.) injections of methotrexate (MTX) 7 mg/kg were administered to rats on 3 consecutive days. A subset of these rats was also pretreated with...

journal_title：Biological & pharmaceutical bulletin

authors： de Araújo AA,Borba PB,de Souza FH,Nogueira AC,Saldanha TS,Araújo TE,da Silva AI,de Araújo Júnior RF

更新日期：2015-01-01 00:00:00

abstract：:The oligopeptide transporter PEPT1 (SLC15A1) is responsible for absorption of peptidic nutrients in the small intestine. Although the L-diastereomer of the beta-lactam antibiotic cephalexin (L-cephalexin) is likely to be transported by PEPT1, there has been no direct demonstration of PEPT1-mediated L-cephalexin transp...

journal_title：Biological & pharmaceutical bulletin

authors： Mitsuoka K,Tamai I,Morohashi Y,Kubo Y,Saitoh R,Tsuji A,Kato Y

更新日期：2009-08-01 00:00:00

abstract：:The induction of a mutant DnaA protein (DnaA E204Q) with decreased intrinsic ATPase activity in cells causes a lethal phenotype. Based on our results that the decreased ATPase activity of DnaA E204Q is activated to the level of a wild-type protein in the presence of partially purified stimulating factors for DnaA ATPa...

journal_title：Biological & pharmaceutical bulletin

authors： Makise M,Sakamoto K,Tsuchiya T,Mizushima T

更新日期：1999-09-01 00:00:00

abstract：:The present study was designed to investigate the modulatory effects of rottlerin on ischemia reperfusion induced myocardial injury. Isolated rat hearts were exposed to 30 min of global ischemia followed by 120 min of reperfusion using Langendorff apparatus. Myocardial injury was assessed in the terms of infarct size,...

journal_title：Biological & pharmaceutical bulletin

authors： Kaur K,Singh M,Singh N,Jaggi AS

更新日期：2008-09-01 00:00:00