Abstract:
:The effect of zaldaride on acetylcholine-induced colonic electrolyte secretion was examined. The short-circuit current response to acetylcholine was partially reduced by tetrodotoxin, a neuronal blocker, and was completely inhibited by atropine, an acetylcholine M receptor antagonist, in the rat colonic preparations. The tetrodotoxin sensitive effect was significantly inhibited by zaldaride, whereas the tetrodotoxin insensitive effect was not affected. Acetylcholine release from synaptosomes of submucosal nerves of guinea-pig colon was significantly reduced by zaldaride. Zaldaride may reduce colonic electrolyte secretion by acetylcholine due to the inhibition of acetylcholine release from synaptosomes of colonic submucosal nerves.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Aikawa N,Kishibayashi N,Karasawa A,Ohmori Kdoi
10.1248/bpb.23.1377subject
Has Abstractpub_date
2000-11-01 00:00:00pages
1377-8issue
11eissn
0918-6158issn
1347-5215journal_volume
23pub_type
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journal_title:Biological & pharmaceutical bulletin
pub_type: 临床试验,杂志文章
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