Abstract:
:An unknown adenine-related compound (UKC) in rat liver mitochondria was characterized. Based on the sensitivity to periodate oxidation, nuclease P1 digestion, property of fluorescence derivatization, elution behavior on different separation modes of HPLC columns and the mass spectrum of purified UKC, the UKC was identified as adenosine 3'-monophosphate (3'-AMP), an intracellular P-site inhibitor of adenylate cyclase. 3'-AMP may be enzymatically produced from RNA in rat liver mitochondria in temperature- and time-dependent manners. A partial characterization of 3'-AMP forming enzyme is included.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Fujimori H,Pan-Hou Hdoi
10.1248/bpb.21.624subject
Has Abstractpub_date
1998-06-01 00:00:00pages
624-7issue
6eissn
0918-6158issn
1347-5215journal_volume
21pub_type
杂志文章abstract::In the present investigation the chemopreventive action of Panax ginseng extract, EFLA400, in Swiss albino mice has been evaluated. We used a 9-week medium term anticarcinogenicity test model of lung adenomas [Yun et al.1)]. Lung adenomas were induced by single subcutaneous injection in the subscapular region with 0.0...
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