Abstract:
:The present study investigated the effects of stable agonist for prostaglandin (PG) I2 receptor with PGI1 skeleton, SM-10906, on pro-inflammatory cytokine production by mouse peritoneal macrophages (PEMs) in comparison with PGE1 and PGI2. In mouse PEMs, SM-10906 and PGE1 slightly enhanced interleukin (IL)-6 secretion, but had no effects on tumor necrosis factor-alpha (TNF-alpha) or IL-1 production. SM-10906 concentration-dependently inhibited TNF-alpha, IL-1 and IL-6 releases from lipopolysaccharide-activated mouse PEMs, as with PGE1, PGI2 and cAMP analog. Additionally, SM-10906, PGE1 and PGI2 caused concentration-dependent accumulation of cAMP contents in mouse PEMs. It is concluded that PGI1 analog SM-10906 exerts anti-inflammatory effects on stimulated mouse PEMs by increasing in cAMP levels, as with E-series of PG.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Nishimura T,Yamamoto T,Ueda Y,Yamada K,Hara Ydoi
10.1248/bpb.23.708subject
Has Abstractpub_date
2000-06-01 00:00:00pages
708-11issue
6eissn
0918-6158issn
1347-5215journal_volume
23pub_type
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