Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE).

abstract：:We examined the inhibitory effects of N-beta-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine (5-S-GAD), a novel antibacterial substance from the immunized adult Sarcophaga peregrina (flesh fly), on protein phosphorylation using immune complexes of protein tyrosine kinases (PTKs) with anti-PTKs monoclonal antibody. ...

journal_title：Biological & pharmaceutical bulletin

authors： Leem JY,Park HY,Fukazawa H,Uehara Y,Natori S

更新日期：1998-07-01 00:00:00

abstract：:The gastric H+, K+-ATPase is a proton pump that is responsible for gastric acid secretion and that actively transports protons and K+ ions in opposite directions to generate in excess of a million-fold gradient across the membrane under physiological conditions. This pump is also a target molecule of proton pump inhib...

journal_title：Biological & pharmaceutical bulletin

authors： Asano S,Morii M,Takeguchi N

更新日期：2004-01-01 00:00:00

abstract：:Antioxidant property and hematopoietic repair capacity are important characteristics of radioprotective agents. Some studies have demonstrated that 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG), a molecule isolated from the waterlily, has antioxidant, hematopoietic repair, and anti-inflammatory activities. In this st...

journal_title：Biological & pharmaceutical bulletin

authors： Bing SJ,Kim MJ,Park E,Ahn G,Kim DS,Ko RK,Lee NH,Shin T,Park JW,Jee Y

更新日期：2010-01-01 00:00:00

abstract：:We describe herein the development of a high affinity and specific DNA aptamer as a new ligand for use in liposomal nanoparticles to target cultured mouse tumor endothelial cells (mTECs). Active targeted nanotechnology based drug delivery systems are currently of great interest, due to their potential for reducing sid...

journal_title：Biological & pharmaceutical bulletin

authors： Ara MN,Matsuda T,Hyodo M,Sakurai Y,Ohga N,Hida K,Harashima H

更新日期：2014-01-01 00:00:00

abstract：:A novel type of arylsulfate sulfotransferase (ASST) from a predominant human intestinal bacterium catalyzes the stoichiometric transfer of a sulfate group from phenolic sulfate esters to phenols. We clarified that polyphenols were better substrates of this enzyme than the corresponding glycosides. Additionally, a coum...

journal_title：Biological & pharmaceutical bulletin

authors： Konishi-Imamura L,Sato M,Dohi K,Kadota S,Namba T,Kobashi K

更新日期：1994-08-01 00:00:00

abstract：:The degradation of 125I-endothelin-1 (125I-ET-1) was examined on cultured porcine aortic endothelial cell (EC) and rat vascular smooth muscle cell (SMC) by HPLC analysis. The degradation of ET-1 was observed on SMC and was slightly observed on EC. Membrane fractions of SMC had a strong potency for the degradation of E...

journal_title：Biological & pharmaceutical bulletin

authors： Edano T,Arai K,Koshi T,Torii T,Ohshima T,Hirata M,Ohkuchi M,Okabe T

更新日期：1994-03-01 00:00:00

abstract：:The present study assessed the safety/toxicity of Senecio scandens, a well-known Chinese herb that is used as an anti-inflammatory, antibiosis, and antipyretic drug. A 90-d subchronic oral toxicity study of S. scandens was performed in Wistar rats. The extract of S. scandens was administered orally to male and female ...

journal_title：Biological & pharmaceutical bulletin

authors： Wang XK,Zhao Y,Liu T,Yi Y,Li CY,Wang HJ,Wang CH,Wang ZT,Ye ZG,Liang AH

更新日期：2015-01-01 00:00:00

abstract：:The effects of various absorption promoters on the pulmonary absorption of drugs with different molecular weights were examined in rats. Phenol red and fluorescein isothiocyanate-labeled dextrans (FDs) with various molecular weights were used as model drugs and the absorption promoters used in this study were sodium g...

journal_title：Biological & pharmaceutical bulletin

authors： Morita T,Yamamoto A,Hashida M,Sezaki H

更新日期：1993-03-01 00:00:00

abstract：:Nanoparticles are used in many fields and in everyday products. Silver nanoparticles are the most frequently used nanoparticles; for example, in food-related products, owing to their antibacterial activity. However, it has been pointed out that they might have unexpected biological effects, and evaluation of their eff...

journal_title：Biological & pharmaceutical bulletin

authors： Maki A,Lin Y,Aoyama M,Sato K,Gao JQ,Tsujino H,Nagano K,Higashisaka K,Tsutsumi Y

更新日期：2020-01-01 00:00:00

abstract：:Astilbin, a dihydroflavonol rhamnoside isolated from the leaves of Engelhardtia chrysolepis, enhanced the vanadate-stimulated release of lipoprotein lipase (LPL) activity from rat isolated fat pads. N-[2-(Methyl-amino)ethyl]-5-isoquinolinesulfonamide (H-8), a potent inhibitor of cAMP-dependent protein kinase (PKA), ma...

journal_title：Biological & pharmaceutical bulletin

authors： Motoyashiki T,Miyake M,Morita T,Mizutani K,Masuda H,Ueki H

更新日期：1998-05-01 00:00:00

abstract：:Onset of cancer and neurodegenerative disease occurs by abnormal cell growth and neuronal cell death, respectively, and the number of patients with both diseases has been increasing in parallel with an increase in mean lifetime, especially in developed countries. Although both diseases are sporadic, about 10% of the d...

journal_title：Biological & pharmaceutical bulletin

authors： Ariga H

更新日期：2015-01-01 00:00:00

abstract：:Effects of supplemented docosahexaenoic acid (DHA), given as diacylglycerol (DG) rich in DHA (DHA-DG), triacylglycerol (TG) rich in DHA (DHA-TG) or fish oil concentrate (DHA-70), on the serum concentration of TG and its bioavailability in the rats with diet-induced hyperlipidemia were studied. Hypertriglyceridemia was...

journal_title：Biological & pharmaceutical bulletin

authors： Tamai T,Murota I,Maruyama K,Baba T,Toyama T,Watanabe N,Kudo N,Kawashima Y

更新日期：2007-12-01 00:00:00

abstract：:It has been demonstrated that adipose-derived stem cells (ADSCs) secrete cytokines and exhibit diverse pharmacological actions. The present study examined the unknown pharmacological action of ADSCs regarding whitening effects. A conditioned medium of ADSCs (ADSC-CM) was harvested and the whitening effect of ADSC-CM w...

journal_title：Biological & pharmaceutical bulletin

authors： Kim WS,Park SH,Ahn SJ,Kim HK,Park JS,Lee GY,Kim KJ,Whang KK,Kang SH,Park BS,Sung JH

更新日期：2008-04-01 00:00:00

abstract：:The effective antigen (Ag) uptake by microfold cells (M-cells) is important for the induction of an efficient mucosal immune responses. Here, we show that 10-hydroxydecanoic acid (10-HDAA) from royal jelly (RJ) potentially supports M-cell differentiation and induces effective antigen-specific mucosal immune responses ...

journal_title：Biological & pharmaceutical bulletin

authors： Isayama T,Etoh H,Kishimoto N,Takasaki T,Kuratani A,Ikuta T,Tatefuji T,Takamune N,Muneoka A,Takahashi Y,Misumi S

更新日期：2020-01-01 00:00:00

abstract：:This paper deals with the effects of elenoside, (3-hidroxymethyl-1-methoxy-5,6-methylene-dioxy-4-(3,4-methylenedioxyphenyl)-2-naftoic acid lactone-beta-D-glucoside) an arylnaphthalene lignan with broad spectrum cytotoxicity in a human tumor cell line panel, isolated from Justicia hyssopifolia (Acanthaceae) grown in th...

journal_title：Biological & pharmaceutical bulletin

authors： Navarro E,Alonso SJ,Trujillo J,Jorge E,Pérez C,Hernández-Calzadilla C

更新日期：2002-08-01 00:00:00

abstract：:The permeability of murine leukemia L1210 cells toward non-permeant fluorescent Lucifer Yellow (LY) was evaluated by flow cytometry following vortex-stirring of cells with LY in the presence of high molecular weight polyacrylic acid (A-119). Permeabilization by this technique was greatly enhanced in growth phase cells...

journal_title：Biological & pharmaceutical bulletin

authors： Noda Y,Shimizu N,Kawazoe Y

更新日期：1996-12-01 00:00:00

abstract：:The induction of lymphangiogenesis is an important process to promote cancer growth and cancer metastasis via the lymphatic system. Identifying the compounds that can prevent lymphangiogenesis for cancer therapy is urgently required. Chrysin, 5,7-dihydroxyflavone, a natural flavone extracted from Thai propolis, was us...

journal_title：Biological & pharmaceutical bulletin

authors： Prangsaengtong O,Athikomkulchai S,Xu J,Koizumi K,Inujima A,Shibahara N,Shimada Y,Tadtong S,Awale S

更新日期：2016-01-01 00:00:00

abstract：:Nicotiflorin is a single component extracted from traditional Chinese medicine Flos Carthami. In this study, we investigated its neuroprotection in permanent focal cerebral ischemia model in rats, and in an in vitro model of ischemia. At doses of 2.5, 5 and 10 mg/kg, nicotiflorin administered immediately after the ons...

journal_title：Biological & pharmaceutical bulletin

authors： Li R,Guo M,Zhang G,Xu X,Li Q

更新日期：2006-09-01 00:00:00

abstract：:In this study, the effects of N-acyl taurates (NATs) on the intestinal absorption of curcumin (CUR), a water-insoluble and poorly absorbed compound, were examined in rats. Sodium methyl lauroyl taurate (LMT) and sodium methyl cocoyl taurate (CMT) were the most effective in increasing the solubility and intestinal abso...

journal_title：Biological & pharmaceutical bulletin

authors： Li X,Kawamura A,Sato Y,Morishita M,Kusamori K,Katsumi H,Sakane T,Yamamoto A

更新日期：2017-01-01 00:00:00

abstract：:The performance of milk fat-globule membrane (MFGM) emulsion as an oral dosage form was evaluated in rats using [14C]alpha-linolenic acid as a lipophilic model solute. For emulsions prepared by homogenization alone, the area under the plasma concentration versus time curve (AUC) after oral administration tended to be ...

journal_title：Biological & pharmaceutical bulletin

authors： Yuasa H,Sekiya M,Ozeki S,Watanabe J

更新日期：1994-05-01 00:00:00

abstract：:To predict the actions of T-3762, a newly developed fluoroquinolone antimicrobial agent, as well as ciprofloxacin (CPFX) and ofloxacin (OFLX), on injection sites when dosed parenterally, their ability to increase cutaneous vascular permeability in dogs and to release histamine from rat peritoneal mast cells was examin...

journal_title：Biological & pharmaceutical bulletin

authors： Furuhata K,Fukuda Y,Soumi K,Arai H,Watanabe Y,Narita H

更新日期：1998-05-01 00:00:00

abstract：:In order to clarify the arrhythmogenic effects of nonsedating antihistamines, we examined the effects of astemizole, a nonsedating antihistamine, on ventricular activation and RT intervals in a canine myocardial infarction model. Myocardial infarction was produced by two-stage ligation of the left anterior descending ...

journal_title：Biological & pharmaceutical bulletin

authors： Nishimoto M,Hashimoto H,Ohmura T,Ikeda Y,Watanabe S,Ohashi K,Umemura K,Nakashima M

更新日期：1997-09-01 00:00:00

abstract：:Hypertension is one of the most prevalent diseases worldwide and can cause harmful complications within the vascular system. Further research on vascular responsiveness to different ligands and diverse receptors in various arteries is required to understand the mechanisms underlying the development of these vascular c...

journal_title：Biological & pharmaceutical bulletin

authors： Ando M,Matsumoto T,Kobayashi S,Iguchi M,Taguchi K,Kobayashi T

更新日期：2018-01-01 00:00:00

abstract：:Medicinal plants with reported anti-inflammatory activity could have the potential use as anti-allergens and inhibitors of allergic contact dermatitis reactions produced by allergens and chemicals. Some species from the genus Artocarpus were reported to have anti-inflammatory activity. In the Philippines one local sou...

journal_title：Biological & pharmaceutical bulletin

authors： Salonga RB,Hisaka S,Nose M

更新日期：2014-01-01 00:00:00

abstract：:High-resolution deep tissue imaging is possible with two-photon excitation microscopy. With the combined application of two-photon imaging and perfusion with a polar fluorescent tracer, we have established a method to detect exocytic events inside secretory tissues. This method displays the spatiotemporal distribution...

journal_title：Biological & pharmaceutical bulletin

authors： Takahashi N

更新日期：2015-01-01 00:00:00

abstract：:Dermatan sulfate-proteoglycans (DS-PGs) were extracted from rabbit, rat and bovine defatted livers by magnesium chloride extraction and DEAE-cellulose chromatography, and then submitted successively to Asahipak GS-520 gel filtration chromatography, Asahipak ES-502N anion exchange chromatography, and cellulose acetate ...

journal_title：Biological & pharmaceutical bulletin

authors： Koshiishi I,Motoki K,Qiu G,Imanari T

更新日期：1993-04-01 00:00:00

abstract：:We examine the pharmacokinetic profile of cyclosporin A (CyA) after intravenous administration to rats prepared as models of various disease states found in patients who receive organ transplantations. After intravenous bolus administration to normal rats, the total blood clearance (CLt) of CyA showed a dose-dependent...

journal_title：Biological & pharmaceutical bulletin

authors： Shibata N,Shimakawa H,Minouchi T,Yamaji A

更新日期：1993-11-01 00:00:00

abstract：:P2X7 receptor (P2X7R), a purinergic receptor, is involved in pathophysiological events such as inflammation and cell death, and thus is an attractive target for therapeutic approaches. It is reported that divalent metal cations (DMCs) inhibit P2X7R activation and that there are species differences in their inhibitory ...

journal_title：Biological & pharmaceutical bulletin

authors： Fujiwara M,Ohbori K,Ohishi A,Nishida K,Uozumi Y,Nagasawa K

更新日期：2017-01-01 00:00:00

abstract：:Doxorubicin (DOX) is a potent antitumor agent, but the cardiotoxicity mediated by the formation of reactive oxygen species limit its clinical use. The present study aims to explore electrocardiographic and biochemical evidence for the cardioprotective effect of two antioxidants, Lycium barbarum polysaccharides (LBP, t...

journal_title：Biological & pharmaceutical bulletin

authors： Xin Y,Zhang S,Gu L,Liu S,Gao H,You Z,Zhou G,Wen L,Yu J,Xuan Y

更新日期：2011-01-01 00:00:00

abstract：:Ceramide kinase (CerK) and ceramide-1-phosphate (C1P) are involved in various cellular functions, while regulation of the enzyme activity has not been well elucidated. We herein investigated the effects of several glycerophospholipids on human recombinant CerK activity with CaCl2 and MgCl2 by measuring the formation o...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuzaki W,Takahashi H,Nakamura H,Murayama T

更新日期：2016-01-01 00:00:00