Abstract:
:The anti-rhinitis properties of Pleurotus pulmonarius were investigated in BALB/c mice. A single administration of Pleurotus Pulmonarius caused no significant effect on antigen-induced nasal rubbing and sneezing at a dose of 500 mg/kg, but a significant inhibition was observed after 2 weeks of repeated treatment at this dose, and at a dose of 200 mg/kg, it also caused a significant inhibition after repeated administration for 4 weeks. Pleurotus pulmonarius showed no significant inhibitory effect on the production of IgE. In addition, Pleurotus pulmonarius caused no inhibition of histamine-induced nasal rubbing and sneezing at a dose of 500 mg/kg, but in vitro study, it inhibited histamine release from rat mast cells induced by compound 48/80 at the soluble supernatant solution of 30 and 100 microg/ml of Pleurotus pulmonarius suspended in PBS. These results demonstrated that Pleurotus pulmonarius may be effective in the relief of symptoms of allergic rhinitis through inhibition of histamine release.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Yatsuzuka R,Nakano Y,Jiang S,Ueda Y,Kishi Y,Suzuki Y,Yokota E,Rahman A,Ono R,Kohno I,Kamei Cdoi
10.1248/bpb.30.1557subject
Has Abstractpub_date
2007-08-01 00:00:00pages
1557-60issue
8eissn
0918-6158issn
1347-5215pii
JST.JSTAGE/bpb/30.1557journal_volume
30pub_type
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