Rectal absorption of ozagrel from suppositories in rabbits.

abstract：:The current Japanese Ministry of Health Labour and Welfare (MHLW)'s Guideline for Bioequivalence Studies of Generic Products uses averaged dissolution rates for the assessment of dissolution similarity between test and reference formulations. This study clarifies how the application of model-independent multivariate c...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshida H,Shibata H,Izutsu KI,Goda Y

更新日期：2017-01-01 00:00:00

abstract：:Effects of the 5-hydroxytryptamine (5-HT)2A receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on plasma glucagon levels were studied in rats. Systemic injection of DOI induces significant increases in plasma glucagon levels. Hyperglucagonemia induced by DOI was dose-dependently prevented by the 5-HT...

journal_title：Biological & pharmaceutical bulletin

authors： Sugimoto Y,Yamada J

更新日期：2000-12-01 00:00:00

abstract：:A plasmid, pEP2104 (23.9 kilobase pairs), from Staphylococcus aureus carries a gene that specifies inducible resistance to 14-membered (erythromycin, EM, and oleandomycin, OL) and 16-membered macrolide (mycinamicin I and II), but not to all of the latter, and to streptogramin type B antibiotics (partial macrolide- and...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuoka M,Jánosi L,Endou K,Saitoh S,Hashimoto H,Nakajima Y

更新日期：1993-12-01 00:00:00

abstract：:Upon stimulation, endothelial cells release various factors to regulate the vascular tone. In particular, vasorelaxing factors, called endothelium-derived relaxing factors (EDRFs), are altered in the production and/or release, as well as their signaling every vessel and under pathophysiological states, including cardi...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumoto T,Takayanagi K,Kojima M,Katome T,Taguchi K,Kobayashi T

更新日期：2019-01-01 00:00:00

abstract：:It has been suggested that imbalances in gut microbiota are related to diseases associated with metabolism, the central nervous system, etc. Therefore, analysis of short-chain fatty acids (SCFAs) produced by gut microbiota is very important as an indicator of causation, demonstrating the effects on the host due to cha...

journal_title：Biological & pharmaceutical bulletin

authors： Inoue H,Takayama K,Takahara C,Tabuchi N,Okamura N,Narahara N,Kojima E,Date Y,Tsuruta Y

更新日期：2019-01-01 00:00:00

abstract：:In Japan, an increasing number of people suffer from pollenosis, a typical atopic disease. Japanese cedar (Cryptomeria japonica) pollen is the most common allergen that causes pollenosis. Although Cry j 1 and Cry j 2 are the common allergenic proteins contained in the pollen, there is a small population of patients wh...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumura D,Nabe T,Mizutani N,Fujii M,Kohno S

更新日期：2006-06-01 00:00:00

abstract：:This study investigated most suitable transforming factor related to the daily Phenobarbital dose (D) providing a steady-state serum concentration (Ct) and analyzed the influences of concomitant antiepileptic drugs on Ct quantitatively. Data obtained by routine therapeutic drug monitoring from a total of 326 epileptic...

journal_title：Biological & pharmaceutical bulletin

authors： Fukuoka N,Tsukamoto T,Uno J,Kimura M,Morita S

更新日期：2004-12-01 00:00:00

abstract：:Berberine is one of the main alkaloids of Rhizoma coptidis which has been used as a folk medicine to treat diabetes mellitus for more than 1400 years in China. To investigate the chronic effect of berberine on diabetic hyperlipidemic rats, fasted rats were intraperitoneally injected 35 mg/kg streptozotocin. Diabetic r...

journal_title：Biological & pharmaceutical bulletin

authors： Zhou JY,Zhou SW,Zhang KB,Tang JL,Guang LX,Ying Y,Xu Y,Zhang L,Li DD

更新日期：2008-06-01 00:00:00

abstract：:We investigated the changes (increase or decrease in peak intensity) in the expression of plasma proteins in spontaneously diabetic WBN/Kob rats that were with complicated diabetic nephropathy, to determine multiple biomarkers in the plasma of diabetic rats. The present study using surface enhanced laser desorption/io...

journal_title：Biological & pharmaceutical bulletin

authors： Kiga C,Nakagawa T,Koizumi K,Sakurai H,Shibagaki Y,Ogawa K,Goto H,Saiki I

更新日期：2005-06-01 00:00:00

abstract：:Collagen-induced arthritis (CIA) is an experimental model of rheumatoid arthritis (RA) used for studying the clinical, immunological and genetic factors of the disease. Many studies of genetic susceptibility to CIA have been performed, usually with two strains of mice, DBA/1 and B10.RIII, since they are highly suscept...

journal_title：Biological & pharmaceutical bulletin

authors： Hida S,Nagi-Miura N,Adachi Y,Ohno N

更新日期：2006-06-01 00:00:00

abstract：:The lactose transport system of Citrobacter freundii was characterized. Both the lactose transport system and beta-galactosidase were induced with either lactose or isopropyl-beta-D-thiogalactopyranoside (IPTG), the latter being the better inducer. The Km values for methyl-beta-D-thiogalactopyranoside (TMG) transport ...

journal_title：Biological & pharmaceutical bulletin

authors： Okazaki N,Tsuda M,Wilson TH,Tsuchiya T

更新日期：1994-06-01 00:00:00

abstract：:The effective antigen (Ag) uptake by microfold cells (M-cells) is important for the induction of an efficient mucosal immune responses. Here, we show that 10-hydroxydecanoic acid (10-HDAA) from royal jelly (RJ) potentially supports M-cell differentiation and induces effective antigen-specific mucosal immune responses ...

journal_title：Biological & pharmaceutical bulletin

authors： Isayama T,Etoh H,Kishimoto N,Takasaki T,Kuratani A,Ikuta T,Tatefuji T,Takamune N,Muneoka A,Takahashi Y,Misumi S

更新日期：2020-01-01 00:00:00

abstract：:Tetramethylpyrazine is the active ingredient of a Chinese herbal medicine. In this study, tetramethylpyrazine was tested for its activities in irradiated bone marrow stromal QXMSC1 cells. The proliferation of QXMSC1 cells was measured by MTS assay kit and flow cytometry. To identify proteins involved in the processes ...

journal_title：Biological & pharmaceutical bulletin

authors： Ma ZC,Tan HL,Xiao CR,Wang YG,Wang SQ,Gao Y

更新日期：2007-02-01 00:00:00

abstract：:CCAAT/enhancer-binding protein delta (C/EBPdelta) transcription factor is rapidly induced at an early stage of acute phase response. We previously reported that this induction was mainly mediated by acute phase response factor/signal transducers and activators of transcription 3 (APRF/STAT3). Furthermore, the high exp...

journal_title：Biological & pharmaceutical bulletin

authors： Tanabe A,Kumahara C,Osada S,Nishihara T,Imagawa M

更新日期：2000-12-01 00:00:00

abstract：:Oral tolerance is thought to have a role in preventing allergic responses and immune-mediated diseases. Modulation of this tolerance by drugs and chemicals can cause or suppress them. An improved model of oral tolerance to ovalbumin (OVA) in mice was developed to detect modulators of the tolerance and to apply it to s...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JH,Ohsawa M

更新日期：1995-06-01 00:00:00

abstract：:The effects of Eurycoma longifolia JACK were studied on the orientation activities of sexually experienced male rats towards receptive females (mounting, licking, anogenital sniffing), environment (exploration, raring, climbing), themselves (genital grooming, non-genital grooming) and mobility (unrestricted, restricte...

journal_title：Biological & pharmaceutical bulletin

authors： Ang HH,Sim MK

更新日期：1998-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia, with progressive memory impairment. Recently, neprilysin, a β-amyloid (Aβ)-degrading enzyme has become featured as a drug target for AD. Previously, we identified nobiletin from citrus peels as a natural compound possessing anti-dementia activity. In addit...

journal_title：Biological & pharmaceutical bulletin

authors： Kimura J,Shimizu K,Kajima K,Yokosuka A,Mimaki Y,Oku N,Ohizumi Y

更新日期：2018-01-01 00:00:00

abstract：:In order to clarify that squalene monohydroperoxide (SQOOH) correlates with changes in morphology through cytotoxicity and establish in vitro evaluation of the cytotoxicity of lipid hydroperoxide, the effect of SQOOH on cytotoxicity and morphology in normal human epidermal keratinocytes (NHEK(B)) and the Gunze three-d...

journal_title：Biological & pharmaceutical bulletin

authors： Uchino T,Tokunaga H,Onodera H,Ando M

更新日期：2002-05-01 00:00:00

abstract：:Fusion peptide P-9 was isolated from bovine serum albumin by controlled pepsin degradation in the presence of caprylic acid, followed by Sephadex G-75 gel filtration and ion-exchange chromatography of CM-cellulose. By this procedure, P-9 could be strictly separated from peptic fragment P-Phe, which has a molecular wei...

journal_title：Biological & pharmaceutical bulletin

authors： Sato Y,Kaneko K,Mikami K,Mizugaki M,Suzuki Y

更新日期：1999-12-01 00:00:00

abstract：:One hundred and fifteen synthesized mono, di, and trihydroxybenzamide and thiobenzamide derivatives having structures related to euglobals were examined for their inhibitory effects on Epstein-Barr virus (EBV) activation by 12-O-tetradecanoylphorbol-13-acetate (TPA) as a primary screening test for anti-tumor-promoters...

journal_title：Biological & pharmaceutical bulletin

authors： Takasaki M,Konoshima T,Kozuka M,Yoneyama K,Yoshida S,Tokuda H,Nishino H,Iwashima A

更新日期：1995-02-01 00:00:00

abstract：:We have previously reported that INHAT (inhibitor of acetyltransferases) complex subunits, TAF (template activating factor)-Ialpha, TAF-Ibeta and pp32 can inhibit histone acetylation and HAT (histone acetyltransferase)-dependent transcription by binding to histones. Evidences are accumulating that INHAT complex subuni...

journal_title：Biological & pharmaceutical bulletin

authors： Lee IS,Oh SM,Kim SM,Lee DS,Seo SB

更新日期：2006-12-01 00:00:00

abstract：:Carvedilol, an alpha- and beta-adrenergic blocking drug, is mainly metabolized by CYP2D6, UGT1A1, UGT2B4 and UGT2B7. This drug is administered orally as a racemic mixture of R(+)- and S(-)-enantiomers. It has been reported that CYP2D6 prefers metabolizing S-carvedilol to R-carvedilol stereoselectively. On the other ha...

journal_title：Biological & pharmaceutical bulletin

authors： Takekuma Y,Takenaka T,Yamazaki K,Ueno K,Sugawara M

更新日期：2007-11-01 00:00:00

abstract：:D-Aspartate (D-Asp), a free D-amino acid found in mammals, plays crucial roles in the neuroendocrine, endocrine, and central nervous systems. Recent studies have implicated D-Asp in the pathophysiology of infertility and N-methyl-D-Asp receptor-related diseases. D-Asp oxidase (DDO), a degradative enzyme that is stereo...

journal_title：Biological & pharmaceutical bulletin

authors： Katane M,Kawata T,Nakayama K,Saitoh Y,Kaneko Y,Matsuda S,Saitoh Y,Miyamoto T,Sekine M,Homma H

更新日期：2015-01-01 00:00:00

abstract：:Effects of supplemented docosahexaenoic acid (DHA), given as diacylglycerol (DG) rich in DHA (DHA-DG), triacylglycerol (TG) rich in DHA (DHA-TG) or fish oil concentrate (DHA-70), on the serum concentration of TG and its bioavailability in the rats with diet-induced hyperlipidemia were studied. Hypertriglyceridemia was...

journal_title：Biological & pharmaceutical bulletin

authors： Tamai T,Murota I,Maruyama K,Baba T,Toyama T,Watanabe N,Kudo N,Kawashima Y

更新日期：2007-12-01 00:00:00

abstract：:Immune checkpoint inhibitors (ICIs) exert beneficial effects in non-small cell lung cancer (NSCLC) patients. However, ICIs are only advantageous for a limited population of NSCLC patients. Therefore to enhance their effects, combination therapies with ICIs have been developed. To identify preferable chemotherapy to co...

journal_title：Biological & pharmaceutical bulletin

authors： Haruna M,Hirata M,Iwahori K,Kanazawa T,Yamamoto Y,Goto K,Kawashima A,Morimoto-Okazawa A,Funaki S,Shintani Y,Kumanogoh A,Wada H

更新日期：2020-01-01 00:00:00

abstract：:N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is an endogenous peptide released from its precursor (thymosin-β4) by prolyl oligopeptidase. AcSDKP is a natural inhibitor of pluripotent hematopoietic stem cell proliferation and is normally found in human plasma. AcSDKP has been shown to be a potent angiogenic factor an...

journal_title：Biological & pharmaceutical bulletin

authors： Suzuki Y,Katagiri F,Sato F,Fujioka K,Sato Y,Fujioka T,Sato Y,Mimata H,Itoh H

更新日期：2014-01-01 00:00:00

abstract：:Biotin-binding human immunoglobulin G (B-IgG) was quantitatively measured using an F(ab')2anti-human IgG-coated multi-well microplate for the first time. B-IgG was caught by F(ab')2anti-human IgG and was detected by the following detecting reagents: Peroxidase-labeled streptavidin, avidin and peroxidase-biotin, or avi...

journal_title：Biological & pharmaceutical bulletin

authors： Muratsugu M,Muramoto E,Fukui T

更新日期：2003-11-01 00:00:00

abstract：:Two different forms of oxytocinase (L-cystine aminopeptidase, CAP; EC 3.4.11.3) were purified from the 9000 g and 105000 g precipitate fractions of human placenta homogenate by sequential chromatography on columns of hydroxyapatite, DE-32, nickel ion affinity, and Sephadex G-200. One species (CAP-I) purifed from the m...

journal_title：Biological & pharmaceutical bulletin

authors： Itoh C,Watanabe M,Nagamatsu A,Soeda S,Kawarabayashi T,Shimeno H

更新日期：1997-01-01 00:00:00

abstract：:The performance of milk fat-globule membrane (MFGM) emulsion as an oral dosage form was evaluated in rats using [14C]alpha-linolenic acid as a lipophilic model solute. For emulsions prepared by homogenization alone, the area under the plasma concentration versus time curve (AUC) after oral administration tended to be ...

journal_title：Biological & pharmaceutical bulletin

authors： Yuasa H,Sekiya M,Ozeki S,Watanabe J

更新日期：1994-05-01 00:00:00

abstract：:Diosgenyl saponins are the most abundant steroid saponins, and exert a large variety of biological functions. In a previous report, we showed that dioscin was able to induce cytotoxicity and apoptosis in human myeloblast leukemia HL-60 cells. This study further investigated the action mechanisms underlying this effect...

journal_title：Biological & pharmaceutical bulletin

authors： Liu MJ,Wang Z,Ju Y,Zhou JB,Wang Y,Wong RN

更新日期：2004-07-01 00:00:00